LOCUS       XM_017291875            5845 bp    mRNA    linear   INV 14-APR-2020
DEFINITION  PREDICTED: Drosophila miranda protein argonaute-2 (LOC108159004),
            transcript variant X4, mRNA.
ACCESSION   XM_017291875
VERSION     XM_017291875.2
DBLINK      BioProject: PRJNA623594
KEYWORDS    RefSeq.
SOURCE      Drosophila miranda
  ORGANISM  Drosophila miranda
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_046676.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 14, 2020 this sequence version replaced XM_017291875.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Drosophila miranda Annotation
                                           Release 102
            Annotation Version          :: 102
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5845
                     /organism="Drosophila miranda"
                     /mol_type="mRNA"
                     /strain="MSH22"
                     /db_xref="taxon:7229"
                     /chromosome="3"
                     /sex="male"
                     /tissue_type="Whole body"
     gene            1..5845
                     /gene="LOC108159004"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 31 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 36 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:108159004"
     CDS             533..3415
                     /gene="LOC108159004"
                     /codon_start=1
                     /product="protein argonaute-2 isoform X2"
                     /protein_id="XP_017147364.1"
                     /db_xref="GeneID:108159004"
                     /translation="

MSTERELAPGGPAQLLTHTLPLTFPDLQINTTVGIIGKVYAPPAPGSSVNPTAVTSPSAQNVAAGGATVGATASSAASQVASTLGTTTGTVTAAIATATPTTNPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMVQAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEALEGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPDGYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDIMEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNNDSYVQEFGLAISNSMMEVRGRVLPPPKLQYGGRVSTGITGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYFA"

     misc_feature    896..1285
                     /gene="LOC108159004"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    1313..1465
                     /gene="LOC108159004"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    1466..1828
                     /gene="LOC108159004"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1622..1624,1667..1669,1709..1711,1721..1723,
                     1775..1777,1796..1798,1802..1804)
                     /gene="LOC108159004"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1964..3286
                     /gene="LOC108159004"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(2417..2419,2429..2431,2465..2476,2483..2485,
                     2507..2509,2516..2518,2528..2530,2540..2542)
                     /gene="LOC108159004"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2621..2623,2627..2629,2840..2842,3254..3256)
                     /gene="LOC108159004"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

gcaaatcgcgcgcgcgttagttgtacttttggctgattctcacataacataacgatctcatccaataaaaaaagcacaaatctccgacagacgatttccaatcgaatattctccttgtgttccaagtaattgccaatttttgcaattttctcgcattgcgttttgcgtcgatttgttggtgctttcattttgcagaaactctgtgtttataatcgtcccccactgctgtccccaggagcaccaagagcctgaattaatcagagttaagacgtgtcaatctttgacggagtggaaaaaaagcaggccgacggccattcattcagcaaacaaccagtaaacgcttttaatgagtgcccttccaagaaaagtcataagctgctgtctccaacaagaaaatcgtcaacgaaaactagcttcgatttgtcgctgattggctgatagggggcgagcaagagcaagtcccttcaagtcagctgcaattttgcgataagctgtccatcaacgcctcaaactgacgccgacaccgaccaaaatgtcaacggagcgcgagctggctcctggtgggccagctcagctcctgacgcacacgctgccgttgacatttcccgatctccagatcaacaccaccgtgggcatcattggaaaggtctacgcaccaccagcgccgggttcttcggtcaatcccaccgctgtaaccagcccaagtgcccagaatgtggcagctgggggcgccactgtgggtgcgacggcctcatcagcagcctcccaggtggcgtccaccctgggaaccacaaccgggactgtgactgctgcgattgccaccgctactccgaccaccaatccggatatgcccgtcttcacatgtccgcgtcgccccaatctgggacgcgagggcaggccgatcgtacttcgagccaatcactttcaggtgacgatgcctcgcggctatgtgcatcattacgatatcaacatacagccggacaagtgtccgcgcaaggtgaatcgcgagattatcgagaccatggtgcaggcctacagcaagatctttggcgttctgaaaccggtattcgacggacgcaacaatctgtacacccgcgatcctctgccgatcggtaacgagcgcctcgagctggaggtgacactgcccggcgagggcaaggaccgcatctttcgcgtgacgatcaagtggcaggcccaggtctcgttattcaacctggaggaggctctggagggtcgcacgcgtcaaataccctacgacgccatccttgccctggacgtggtcatgcgtcatctgccgagcatgacctatacgccagtcggacggagctttttcagctcgccggatggctactatcatcctctgggtggtggacgtgaggtctggttcggtttccatcaaagcgtgaggccctcgcaatggaaaatgatgctgaacattgatgtctcggccactgctttctacaaggctcaacccgtgattgactttatgtgcgaggtgctggatatacgcgacatcatggagcagcgcaagccgctcacagactcgcagcgggtcaagttcaccaaggagatcaagggactcaagattgagatcacgcactgtggccagatgcggcgcaagtatcgtgtctgcaatgtaacccgccgaccggctcaaatgcaatcattcccactgcagttggagaatggtcaaactgtggagtgcactgtggccaagtatttcctggacaagtatcgaatgaagttgcgctacccccatctgccgtgcctgcaggtgggacaggagcacaagcacacctatctgccgctcgaggtgtgcaacattgtggctggccagcgatgcatcaaaaagctcaccgatatgcagacatcgacgatgatcaaggccactgcacgctcggcaccggatcgcgagcgtgagatcaacaatctggtgaagcgtgcggactttaacaacgactcgtatgtccaggagttcggtctggccatctccaattcgatgatggaggtgaggggacgagtgctaccgccgcccaagcttcagtatgggggacgtgtgtccactggcatcaccgggcagcagttgtttccgccccagaataaggtgagccttgcctcgcccaaccaaggtgtctgggacatgcgcggcaagcagttcttcacgggcgtggagatcaggatctgggccattgcctgctttgccccgcagcgaacagtgcgcgaggatgccttgaggaacttcacccagcagctgcagaagatctcaaacgacgccggtatgccgataataggccagccctgcttctgcaaatatgctacggggccggatcaagtggagccgatgttccgatacctgaaaatcaccttcccggggctgcagctcgtcgttgttgtgctgcccggcaagaccccggtctatgcggaggtcaagcgcgtgggcgacaccgtcttgggcatggccacccagtgtgtgcaggcgaagaacgtgaacaagacatcgccccagacgctgtccaatctgtgtctgaagataaacgtcaagctgggcggcatcaattcgattctggtgccctccatccggcccaaggtctttaacgagcccgttatcttcctgggagctgacgtcacacacccaccagccggcgataacaagaagccatcgattgccgctgttgttggttcaatggacgcccatccgtcacgatatgcggccactgtgcgagtacagcaacaccgccaggagatcatccaggagctgagcagcatggtgcgcgagctactgattatgttctacaagtcgacgggtggctacaagccccaccgaatcatcctgtaccgggacggcgtctccgagggacagttcccgcatgtgctgcagcacgagttgaccgccataagggaggcgtgcatcaagctagagcccgaatacaggccaggcatcacattcatcgttgtccagaagcgccatcatacgcgactcttctgcgccgagaagaaggagcagagcggcaagtctggcaatataccggccggcaccaccgtcgatgtgggcatcacgcatccaaccgaatttgatttctatctgtgcagtcatcagggcattcaaggcaccagccgtccctcgcactatcacgtgctctgggatgacaatcactttgactccgacgagcttcagtgcctcacgtatcagctgtgccacacctatgtgaggtgcacgcgctccgtcagtataccagctccagcctactatgcccacttggtggcttttcgtgcaaggtatcatctggtggagaaggagcacgactccggcgagggctcacaccagagcggatgctcagaggatcggacaccgggagccatggccagagccatcacggtccatgcagacacgaagaaggtcatgtactttgcctaaaaagtagccaaattaccaaaccacaaaccccaacaaagtaaccccaagaaaaccacaacaaaaatcaaaaattaaaaatcaacttcgaaattcaattcgaataagcaaagagagatggagatagagtacctccccacctccccagtaagcctcccaaatccctcctcaaatcagaaaagccaagcaaagagaaagttttacgtttaagtttagaaagtgagaaagtttaaggagtatataaggaatatcttgcatgcattagttttagggcaaaacgacacaacaaaaacccacagcaaacactcaaacacacacacacagagatcgactcaaggaggactacaaaaacgtgaaaatcgagacacgacaccgtgaagaattgattatagacatagggaataggggatcgggaaggaaatcgaatgttaatgcacaacaaaatgtgaaaattctcaacagaagcatagcaaacaaagcgaaaaggcgaaaggctaaaaaaaaaaatggaaaaccattttaacaaaaactaaacttaaagggaacaaaactacgaacgcaacaccaaaagccaagcagcagcattaattatctatcatcaaacttactacaagaacaccacgagagagagacacaacttttgtaaatgtgggggggaaaccaattaaaaatacaataaattgtataatatatttttacaaataacgaattgaagacaaaagggggggatggaacggatggaatgaacatttgaataagaatgaatgaacgcatacgaccaaaggtttttagtatacaaaaacgaatgaaaaacaaagcacacaaaaaacaattgaatatgtttgctgatcgacgactcacacaacatacaacacacaaaaaccgcaataaaacaccacaccacaccacacaacaacaaattaaaactctgattctctgtactgtgaacgaagaccaccaccaaaatgaaaataaagataaagatgaacatttaagggaaaactaaacaccaataagtggggcactcgactcgacaaaggcattaaagcgctgaaacacaacatagaaaatacgaaacgaaaatgaataaaatacttcaataactaaagtgcagattaaactgaaaacatttaatagtttgtaagatttggctctaccaaaaaaacaaaggaaagaagacggaccggacggatatgatatatatatatatatatatatatatatatggagagagagagagagagagagagagagagagagagagagagcggcataacgataaatccaatttctacaagggacaaaacgtatggtataaacaattgctattaatatttacatagatttatgaccatcaacaaatacactgtactaattataatttttttaaagaatcggggaaataaccaaccaatacgaatgcgataccggaaatacttaagcatatacatacatacgatacatcaattatacatacatatatgtgtatatatataatttgttcaaaagtgcaaataatatgctgatattttgtgttagtctttagttaatctttttttatgctcagcgagacactcccataccgccaacgcccgtaaaacacacacgaactctgagtcccacaggcatatcactcaaatgtccaatccaccctttatttatgtaccttaacccgtaagcttaacttaacgatatttaattgtatttaatattttaaattttttttaaagcaaaaccattatttgttatttcctcgcgtcgctggggcgagagcatcaatgtaatttcgtattaaaaattaactttagccaagtggtgtacgggtaatatagagcaaggaaaccaactccttcccactgcactgtgtgggtggcaacaacatttcaatattttacaaagtagttttaatttgccattaattaaatacaaaaaaagaaacaaaacacaacaaacaaacgacaagagaaaaatgaaatatggaaagatgaataatacatattctatatcgacgacacagttcaagttaacattataatgatttttcattaaaatgctatgcaggaggagagccatctctcgccgtccctcctgcaccagcaccttatttatacttatacttatacttatgtatgtatgctatgtacgagtacaacccacgcaaaccccaacacaatcatcaaattaggcttagttttgccagtcgcataaatgatgtgagaattgtaaaattcaaaagatacatatatatatattatatacattaatttgcatatatacatttataaaactcttacaaattagtctgtaatcttcagagcaaaatcacatttctgatctgatctgatttcttttaattcaattgtaatttgaccgccgtttctatttgttctttgtagtcacgtttcaacacaagggattaaaattttaaattta

//