LOCUS       XM_016159063            3721 bp    mRNA    linear   MAM 28-SEP-2020
DEFINITION  PREDICTED: Rousettus aegyptiacus nuclear factor kappa B subunit 1
            (NFKB1), transcript variant X3, mRNA.
ACCESSION   XM_016159063
VERSION     XM_016159063.2
DBLINK      BioProject: PRJNA665208
KEYWORDS    RefSeq.
SOURCE      Rousettus aegyptiacus (Egyptian rousette)
  ORGANISM  Rousettus aegyptiacus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera;
            Pteropodoidea; Pteropodidae; Rousettinae; Rousettus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_023416285.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Sep 28, 2020 this sequence version replaced XM_016159063.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Rousettus aegyptiacus Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.5
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3721
                     /organism="Rousettus aegyptiacus"
                     /mol_type="mRNA"
                     /isolate="mRouAeg1"
                     /db_xref="taxon:9407"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="muscle"
                     /dev_stage="adult"
                     /geo_loc_name="USA: Berkeley (captive colony)"
                     /collection_date="2017"
                     /collected_by="Sonja Vernes"
     gene            1..3721
                     /gene="NFKB1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 10 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 29 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:107517900"
     CDS             131..3046
                     /gene="NFKB1"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p105 subunit isoform
                     X2"
                     /protein_id="XP_016014549.2"
                     /db_xref="GeneID:107517900"
                     /translation="

MAEDDPYLGGHEQMFHLDPLNHTIFNPELFQPQMPLQTDGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICAVNAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLTDREKEIIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGIWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGGGGAGAGGGGMYGSGGGGGGAGSTGPGYGFPHYGFPPYGGITFHPGTTKSNAGMKHGTIDASSKNDPVYCDKSDDREAVNLSGKVTETTEQDKESGNGGDEAALTYTVGVKEENARFQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTTVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEAVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKILGILLKHKRTALLIDHPNGEGLNAIHIAVMSNSMQCLLLLVAAGADVNAQERKAGRTALHLAVERDNISLAGCLLLEGDAHVDSTTYDGTTPLHVAAGRGSTRLAALLKAAGADPLAENFEPLYDLDDSWEKDGEDEGVIPGTTPLDMATNWQVFDILNGKPYEPEFTSDDLLAQGDMKQLTEDAKLQLYKLLEFPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIRELVEALRQMGYTEAIDVIQAAFGTSGTAAPSPVKTSQVHLLPLSPASTRQQIDELQDDSICDSGVETSFRKLSFTESLTSGSSLLTLNKMPHDYGQDGPIEGKI"

     misc_feature    251..856
                     /gene="NFKB1"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of kappa B1 (NF-kappa B1); Region:
                     RHD-n_NFkB1; cd07935"
                     /db_xref="CDD:143651"
     misc_feature    order(293..295,299..304,308..313,320..331,554..556,
                     560..565,854..856)
                     /gene="NFKB1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143651"
     misc_feature    875..1180
                     /gene="NFKB1"
                     /note="IPT domain of the transcription factor NFkappaB and
                     related transcription factors. NFkappaB is considered a
                     central regulator of stress responses, activated by
                     different stressful conditions, including physical stress,
                     oxidative stress, and exposure to...; Region:
                     IPT_NFkappaB; cd01177"
                     /db_xref="CDD:238582"
     misc_feature    order(878..880,884..892,896..904,1022..1030,1067..1069,
                     1103..1105,1160..1162,1169..1171,1175..1177)
                     /gene="NFKB1"
                     /note="ankyrin protein binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238582"
     misc_feature    order(884..889,893..895,932..934,938..940,944..946,
                     1043..1048,1055..1057,1061..1063)
                     /gene="NFKB1"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238582"
     misc_feature    order(947..949,953..955,1046..1051)
                     /gene="NFKB1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238582"
     misc_feature    1607..2431
                     /gene="NFKB1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1745..1747,1751..1753,1763..1768,1775..1783,
                     1787..1792,1802..1804,1811..1813,1856..1858,1862..1864,
                     1868..1870,1880..1885,1892..1900,1904..1909,1919..1921,
                     1928..1930,1955..1957,1961..1963,1967..1969,1979..1984,
                     1991..1999,2003..2008,2018..2020,2027..2029)
                     /gene="NFKB1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1745..1858
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1862..1957
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2069..2161
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2171..2269
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2567..2791
                     /gene="NFKB1"
                     /note="Death domain of the Nuclear Factor-KappaB1
                     precursor protein p105; Region: Death_NFkB1_p105; cd08797"
                     /db_xref="CDD:260063"
ORIGIN      

cgccccgcgcccggacctgccccgaccgcgccagccgccgccgcctgcttccccggccccaggcccgcgccgccccgcagagggagccgcggcgctcggacaccgaacgcgctcgccgccaggctccagaatggcagaagacgatccatatttgggaggacatgaacaaatgtttcatttggatcctttgaatcatacaatatttaatccagaattatttcaaccacagatgccactgcagacagatggcccataccttcaaatattagagcaacctaaacagagaggatttcgtttccgctacgtctgtgaaggcccatcccatggtggactccctggtgcatctagtgagaagaacaagaagtcctaccctcaagtcaaaatctgcaactatgtgggacctgcaaaggttattgttcagttggtcacaaatggaaaaaacatccacctgcatgcacacagcctggtggggaaacattgtgaggatgggatctgcgctgtgaacgctggacccaaggacatggtggtcggctttgcaaacctgggtatacttcatgtgacaaagaaaaaagtatttgaaacactggaagcacgaatgacagaggcatgtataaggggctacaatcctggacttctggtacatcctgatcttgcctacttgcaagcagaaggtggaggagaccggcagctcactgatcgggaaaaggagattatccgccaggcagctcttcagcagacaaaggagatggacctcagcgtggtgcggctcatgtttacagcttttcttccagacagcaccggcagcttcacaaggcgcctggaacccgtagtgtcagatgccatctacgacagcaaagcccccaatgcgtccaacttgaaaattgtaagaatggacaggacagctggatgtgtaactggaggggaagagatttatcttctctgtgacaaggttcagaaagatgacatccagattcgattttatgaagaggaggaaaatggtggaatctgggaaggatttggagatttttcccccacagacgttcatagacagtttgctatcgtcttcaaaactccaaagtataaagatatcaacattacaaaaccagcctctgtgtttgtccaacttcggaggaaatctgatttggaaaccagtgaaccaaaaccttttctctactaccctgaaatcaaagataaagaggaagtgcagaggaagcggcagaagctcatgcccaatttctcagatagttttggcggcggcggcggtggtgctggggctggaggcggaggcatgtatggcagtggaggtggaggagggggtgctggaagcacgggtccaggatatggcttccctcactatggctttcctccatatggaggaattaccttccatcctggaaccactaaatctaatgctggaatgaagcatggaaccatagacgcctcatctaaaaatgaccctgtatactgtgacaagagtgatgacagagaggctgtaaatctctctgggaaagtaaccgaaaccacagagcaagataaggagtccggcaatgggggcgatgaggctgctctgacgtatacagtgggagtgaaggaagagaacgctaggtttcaggataacctctttctagagaaggctatgcagcttgccaagcggcatgccaatgccctatttgactacgcagtgacaggagatgtgaagatgctgctggctgtccagcgccatctcactacagtgcaggatgagaatggagacagtgtcttacacttagcaatcatccaccttcatgctcaacttgtgagggatctgctggaagtcacgtctggtttgatttctgatgacattatcaacatgagaaatgatctctaccagacgcccttgcacttagcagtgatcaccaaacaggaagctgtggtggaagacttactgagggccggggctgacctgagccttctggaccgcttgggtaactctgttttgcatctagctgccaaagaaggacatgataaaattctcggtattttactcaagcataaaaggacagcactacttattgaccatcccaatggggaaggtctgaacgccattcacatagccgtgatgagcaacagcatgcagtgtctgctgctgctggtggctgcaggggcagacgtcaacgcccaggagcggaaggcagggcgcacggcgctgcacctggctgtggagcgcgacaacatctccttggccggctgcctgcttctggagggtgatgcccatgtagacagcaccacctatgatggaactacaccccttcacgtagcggccggaagagggtccaccaggctggcagctcttctcaaagcagcaggagcagatcccctggcagagaacttcgagcctctctatgacctggatgactcttgggaaaaagatggagaggatgaaggagtcatacctggaaccacacctctagatatggccaccaactggcaggtattcgacatattaaatgggaaaccatatgagccagagtttacatctgatgatttactggcacaaggagacatgaaacagctgaccgaagatgccaagttgcagctctacaagttgctagaatttcctgatccggacaaaaactgggctactctcgcacagaaattaggtctgggaatactcaataatgccttccggttgagtcccgctccctctaaaactctcatggacaactacgaggtctctgggggcacaataagagagctggtagaggccctcagacagatgggctacactgaagccattgacgtgatccaggcggccttcggcacctcaggaactgcagcccccagcccagtgaagacctcgcaggtccacctgctgcctctctcacctgcctccacaagacagcaaatagatgagctccaggacgacagcatctgtgacagcggcgtggagacatccttccgcaagctcagctttacagagtctctgaccagcggcagctcattgctaactcttaacaaaatgccccacgattatgggcaggatggacctatagaaggcaaaatctagccttctggcaattcccaacctgtaaaccaaagttctgaaattctgtggtattgtccctaagaaggtaacgtgcatccatccagcggtgcttggaggaaaacctgccgtcctgaatcgctcttgatttaactcaaagcctttgaaacgtggcttcctttcttggttcttaagtgaatttcagttcggctcacttgcagatagtatctagccgccccagccttcagcgaggctggtgcttcattgggggtgaggtaacttgtggagctttactagctgctttctgtcgtcactgctgccatccctctgctgctgtcattaaaaggtctcacggtccccgcctggcattgtctctggccgtccacagcacagtcattcattcagagtaagaattaagaaaattcttaatattttattaagaatattttagatgagatattttgaaatggaagtgagttggtgtatgataaaaaaaaaaagaaggcttactactttttctaatgtgcttacctctgtgatttgaaaaaaggaacatgtatgtgttaatatttaaacatggttacaatcagtgctgaaaatggtattttcccctttttctgcatttcgctattgtaaatatgttttttagatcaaatactttaaaggaaaaaatggatttataaatgctattttttattt

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