LOCUS       XM_016159061            3724 bp    mRNA    linear   MAM 28-SEP-2020
DEFINITION  PREDICTED: Rousettus aegyptiacus nuclear factor kappa B subunit 1
            (NFKB1), transcript variant X1, mRNA.
ACCESSION   XM_016159061
VERSION     XM_016159061.2
DBLINK      BioProject: PRJNA665208
KEYWORDS    RefSeq.
SOURCE      Rousettus aegyptiacus (Egyptian rousette)
  ORGANISM  Rousettus aegyptiacus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera;
            Pteropodoidea; Pteropodidae; Rousettinae; Rousettus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_023416285.1) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Sep 28, 2020 this sequence version replaced XM_016159061.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Rousettus aegyptiacus Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.5
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3724
                     /organism="Rousettus aegyptiacus"
                     /mol_type="mRNA"
                     /isolate="mRouAeg1"
                     /db_xref="taxon:9407"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="muscle"
                     /dev_stage="adult"
                     /geo_loc_name="USA: Berkeley (captive colony)"
                     /collection_date="2017"
                     /collected_by="Sonja Vernes"
     gene            1..3724
                     /gene="NFKB1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 mRNA, 16 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 29 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:107517900"
     CDS             131..3049
                     /gene="NFKB1"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p105 subunit isoform
                     X1"
                     /protein_id="XP_016014547.2"
                     /db_xref="GeneID:107517900"
                     /translation="

MAEDDPYLGGHEQMFHLDPLNHTIFNPELFQPQMPLQTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICAVNAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLTDREKEIIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGIWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGGGGAGAGGGGMYGSGGGGGGAGSTGPGYGFPHYGFPPYGGITFHPGTTKSNAGMKHGTIDASSKNDPVYCDKSDDREAVNLSGKVTETTEQDKESGNGGDEAALTYTVGVKEENARFQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTTVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEAVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKILGILLKHKRTALLIDHPNGEGLNAIHIAVMSNSMQCLLLLVAAGADVNAQERKAGRTALHLAVERDNISLAGCLLLEGDAHVDSTTYDGTTPLHVAAGRGSTRLAALLKAAGADPLAENFEPLYDLDDSWEKDGEDEGVIPGTTPLDMATNWQVFDILNGKPYEPEFTSDDLLAQGDMKQLTEDAKLQLYKLLEFPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIRELVEALRQMGYTEAIDVIQAAFGTSGTAAPSPVKTSQVHLLPLSPASTRQQIDELQDDSICDSGVETSFRKLSFTESLTSGSSLLTLNKMPHDYGQDGPIEGKI"

     misc_feature    254..859
                     /gene="NFKB1"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of kappa B1 (NF-kappa B1); Region:
                     RHD-n_NFkB1; cd07935"
                     /db_xref="CDD:143651"
     misc_feature    order(296..298,302..307,311..316,323..334,557..559,
                     563..568,857..859)
                     /gene="NFKB1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143651"
     misc_feature    878..1183
                     /gene="NFKB1"
                     /note="IPT domain of the transcription factor NFkappaB and
                     related transcription factors. NFkappaB is considered a
                     central regulator of stress responses, activated by
                     different stressful conditions, including physical stress,
                     oxidative stress, and exposure to...; Region:
                     IPT_NFkappaB; cd01177"
                     /db_xref="CDD:238582"
     misc_feature    order(881..883,887..895,899..907,1025..1033,1070..1072,
                     1106..1108,1163..1165,1172..1174,1178..1180)
                     /gene="NFKB1"
                     /note="ankyrin protein binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238582"
     misc_feature    order(887..892,896..898,935..937,941..943,947..949,
                     1046..1051,1058..1060,1064..1066)
                     /gene="NFKB1"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238582"
     misc_feature    order(950..952,956..958,1049..1054)
                     /gene="NFKB1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238582"
     misc_feature    1610..2434
                     /gene="NFKB1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1748..1750,1754..1756,1766..1771,1778..1786,
                     1790..1795,1805..1807,1814..1816,1859..1861,1865..1867,
                     1871..1873,1883..1888,1895..1903,1907..1912,1922..1924,
                     1931..1933,1958..1960,1964..1966,1970..1972,1982..1987,
                     1994..2002,2006..2011,2021..2023,2030..2032)
                     /gene="NFKB1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1748..1861
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1865..1960
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2072..2164
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2174..2272
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2570..2794
                     /gene="NFKB1"
                     /note="Death domain of the Nuclear Factor-KappaB1
                     precursor protein p105; Region: Death_NFkB1_p105; cd08797"
                     /db_xref="CDD:260063"
ORIGIN      

cgccccgcgcccggacctgccccgaccgcgccagccgccgccgcctgcttccccggccccaggcccgcgccgccccgcagagggagccgcggcgctcggacaccgaacgcgctcgccgccaggctccagaatggcagaagacgatccatatttgggaggacatgaacaaatgtttcatttggatcctttgaatcatacaatatttaatccagaattatttcaaccacagatgccactgcagacagcagatggcccataccttcaaatattagagcaacctaaacagagaggatttcgtttccgctacgtctgtgaaggcccatcccatggtggactccctggtgcatctagtgagaagaacaagaagtcctaccctcaagtcaaaatctgcaactatgtgggacctgcaaaggttattgttcagttggtcacaaatggaaaaaacatccacctgcatgcacacagcctggtggggaaacattgtgaggatgggatctgcgctgtgaacgctggacccaaggacatggtggtcggctttgcaaacctgggtatacttcatgtgacaaagaaaaaagtatttgaaacactggaagcacgaatgacagaggcatgtataaggggctacaatcctggacttctggtacatcctgatcttgcctacttgcaagcagaaggtggaggagaccggcagctcactgatcgggaaaaggagattatccgccaggcagctcttcagcagacaaaggagatggacctcagcgtggtgcggctcatgtttacagcttttcttccagacagcaccggcagcttcacaaggcgcctggaacccgtagtgtcagatgccatctacgacagcaaagcccccaatgcgtccaacttgaaaattgtaagaatggacaggacagctggatgtgtaactggaggggaagagatttatcttctctgtgacaaggttcagaaagatgacatccagattcgattttatgaagaggaggaaaatggtggaatctgggaaggatttggagatttttcccccacagacgttcatagacagtttgctatcgtcttcaaaactccaaagtataaagatatcaacattacaaaaccagcctctgtgtttgtccaacttcggaggaaatctgatttggaaaccagtgaaccaaaaccttttctctactaccctgaaatcaaagataaagaggaagtgcagaggaagcggcagaagctcatgcccaatttctcagatagttttggcggcggcggcggtggtgctggggctggaggcggaggcatgtatggcagtggaggtggaggagggggtgctggaagcacgggtccaggatatggcttccctcactatggctttcctccatatggaggaattaccttccatcctggaaccactaaatctaatgctggaatgaagcatggaaccatagacgcctcatctaaaaatgaccctgtatactgtgacaagagtgatgacagagaggctgtaaatctctctgggaaagtaaccgaaaccacagagcaagataaggagtccggcaatgggggcgatgaggctgctctgacgtatacagtgggagtgaaggaagagaacgctaggtttcaggataacctctttctagagaaggctatgcagcttgccaagcggcatgccaatgccctatttgactacgcagtgacaggagatgtgaagatgctgctggctgtccagcgccatctcactacagtgcaggatgagaatggagacagtgtcttacacttagcaatcatccaccttcatgctcaacttgtgagggatctgctggaagtcacgtctggtttgatttctgatgacattatcaacatgagaaatgatctctaccagacgcccttgcacttagcagtgatcaccaaacaggaagctgtggtggaagacttactgagggccggggctgacctgagccttctggaccgcttgggtaactctgttttgcatctagctgccaaagaaggacatgataaaattctcggtattttactcaagcataaaaggacagcactacttattgaccatcccaatggggaaggtctgaacgccattcacatagccgtgatgagcaacagcatgcagtgtctgctgctgctggtggctgcaggggcagacgtcaacgcccaggagcggaaggcagggcgcacggcgctgcacctggctgtggagcgcgacaacatctccttggccggctgcctgcttctggagggtgatgcccatgtagacagcaccacctatgatggaactacaccccttcacgtagcggccggaagagggtccaccaggctggcagctcttctcaaagcagcaggagcagatcccctggcagagaacttcgagcctctctatgacctggatgactcttgggaaaaagatggagaggatgaaggagtcatacctggaaccacacctctagatatggccaccaactggcaggtattcgacatattaaatgggaaaccatatgagccagagtttacatctgatgatttactggcacaaggagacatgaaacagctgaccgaagatgccaagttgcagctctacaagttgctagaatttcctgatccggacaaaaactgggctactctcgcacagaaattaggtctgggaatactcaataatgccttccggttgagtcccgctccctctaaaactctcatggacaactacgaggtctctgggggcacaataagagagctggtagaggccctcagacagatgggctacactgaagccattgacgtgatccaggcggccttcggcacctcaggaactgcagcccccagcccagtgaagacctcgcaggtccacctgctgcctctctcacctgcctccacaagacagcaaatagatgagctccaggacgacagcatctgtgacagcggcgtggagacatccttccgcaagctcagctttacagagtctctgaccagcggcagctcattgctaactcttaacaaaatgccccacgattatgggcaggatggacctatagaaggcaaaatctagccttctggcaattcccaacctgtaaaccaaagttctgaaattctgtggtattgtccctaagaaggtaacgtgcatccatccagcggtgcttggaggaaaacctgccgtcctgaatcgctcttgatttaactcaaagcctttgaaacgtggcttcctttcttggttcttaagtgaatttcagttcggctcacttgcagatagtatctagccgccccagccttcagcgaggctggtgcttcattgggggtgaggtaacttgtggagctttactagctgctttctgtcgtcactgctgccatccctctgctgctgtcattaaaaggtctcacggtccccgcctggcattgtctctggccgtccacagcacagtcattcattcagagtaagaattaagaaaattcttaatattttattaagaatattttagatgagatattttgaaatggaagtgagttggtgtatgataaaaaaaaaaagaaggcttactactttttctaatgtgcttacctctgtgatttgaaaaaaggaacatgtatgtgttaatatttaaacatggttacaatcagtgctgaaaatggtattttcccctttttctgcatttcgctattgtaaatatgttttttagatcaaatactttaaaggaaaaaatggatttataaatgctattttttattt

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