LOCUS       XM_012723353            4067 bp    mRNA    linear   MAM 10-JUN-2015
DEFINITION  PREDICTED: Condylura cristata ATPase, Cu++ transporting, beta
            polypeptide (ATP7B), transcript variant X3, mRNA.
ACCESSION   XM_012723353
VERSION     XM_012723353.1
DBLINK      BioProject: PRJNA193510
KEYWORDS    RefSeq.
SOURCE      Condylura cristata (star-nosed mole)
  ORGANISM  Condylura cristata
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Talpidae;
            Condylura.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_004567111.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Condylura cristata Annotation
                                           Release 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 6.3
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4067
                     /organism="Condylura cristata"
                     /mol_type="mRNA"
                     /isolate="star-nosed mole 26May11"
                     /db_xref="taxon:143302"
                     /chromosome="Unknown"
                     /sex="female"
     gene            1..4067
                     /gene="ATP7B"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 5 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 1 sample with support for all annotated introns"
                     /db_xref="GeneID:101619368"
     CDS             337..3990
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X3"
                     /protein_id="XP_012578807.1"
                     /db_xref="GeneID:101619368"
                     /translation="

MMPEQERHISAREGASRRIISKLSLSACAREPAMKQTYAFDNIGYEDGLDGVYVSPTASSTISILGMTCQSCVKSIEDRISSLKGIVSIKVSLEQSSAVVKYMPSLISLQQVCHQIEDMGFEASIAEGKAASWPSRSAHALEAVVKLQVEGMTCQSCVSSIEGKIGKLQGVVRVRVSLSNQEAVITYQPYLIQPQDLRDHINDMGFEAVIKNRGAPISLGPIDVERLQGTNPVTPLASVNQNVSNSKTSGHQASHVVTLRVEGMHCRSCVVNIEENIGRLPAVQNIQVSLENSTAQVQYDPSRVSPEALQRAIEALPPGNFKVFLPGGTEGSGTDSRSSSHHSPGPSQGTQMQDVCSTVTLAISGMTCASCVHSIEGTISQRKGVRHISVSLAEGTGTVVCDPLTVSPEELRAAVEDMGFEASVISESCPGSHVGNHNGENSTVPAAADTLGSVWAVSPQAGRLPENLGSTRPRQASITMVPQKCFLQITGMTCASCVSNIERSLQKEDGILSVLVALMAGKAEVKYNPEVIQPLEIAQLIQDLGFDAAVMEDYAGSDGDLELIVTGMTCASCVHNIESKLTRTNGISYASVALATSKAHVKFDPEIIGPRDIVKIIEEIGFHASPAQRNPNAHHLDHKVEIKQWKKSFLCSLVFGIPVMGLMIYMLIPSSQPHESMVLDHNIIPGLSILNLIFFILCTFVQFLGGWYFYIQAYKSLKHRTANMDVLIVLATSIAYVYSFIILVVAIAERAERSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLINATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVVWIIIGFIDFGVVQKYFPIPSQHISQAEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITYGVPKVMRVLLLVDMATLPLRKVLAVVGTAEASSEHPLGVAVTRYCKEELGTETLGYCTDFQSVPGCGIGCKVSSVEGILAHSDHPLGEWPTHLNGVGSVPAETDAASHTFAVLIGNREWMRRNGLTVSSDISDAMTNHEMKGQTAILVAIDGWHQQSLCRGAAFSQGGQGPGAAECREESRHGGRWGQ"

     misc_feature    517..708
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(535..543,550..552)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    772..960
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(790..798,805..807)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1108..1284
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1126..1134,1141..1143)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1414..1605
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1432..1440,1447..1449)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1795..1983
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1810..1818,1825..1827)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2020..2211
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(2038..2046,2053..2055)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2275..>3879
                     /gene="ATP7B"
                     /note="Haloacid Dehalogenase-like Hydrolases; Region:
                     HAD_like; cl21460"
                     /db_xref="CDD:451251"
ORIGIN      

tcctacttttgcctagagcccgccgcgggctggagaccaatgggaggctactgcaagtcgggggtcgattttcccgaggcggagttcagtcccgcccaggctgcggcgtttgggacccacagcatcccggagactagcacggagttccagaggcagttgcgcagagcggacccgacgccggcggtgggcgagccctgggaccagcacctcggacttccgtctgcgcagctcctcctgggcactcgctggaggctgagaatcccattcacagcacactggtcggaggtgatcgttggcctctgggtcggaccgtagaagaaagtggttctccgggggatgatgcctgagcaagagagacatatatcagcaagagaaggggccagtcggagaatcatctctaaactatctttgtccgcttgtgcccgggaaccagccatgaaacagacttacgccttcgataatatcggctacgaggatggtcttgatggtgtgtatgtttccccgacagccagcagcaccatcagcattttgggcatgacctgccagtcctgtgtgaagtcgattgaggacaggatttctagtttgaaaggcattgtgagcattaaggtttccttagaacaaagtagtgctgtagtaaaatacatgccgtcactcataagcctgcaacaggtttgccatcaaattgaggacatgggcttcgaggccagcattgcagaaggaaaggctgcctcctggccctcaaggtctgcacatgccctggaggctgtggtcaaactgcaggtggagggcatgacctgccagtcctgtgtcagctccatagaaggcaagattgggaaactacaaggagtagtgagggtcagggtttcactcagcaaccaagaagcagtcatcacttaccagccctatcttattcaacctcaagacctcagggatcacatcaacgacatggggtttgaagctgtcatcaagaacagaggagcacccataagcctggggccaatcgatgttgaacgtttgcagggcacaaacccagtgacacctctggcttctgtgaaccagaatgtcagtaactctaagacctcaggacaccaagcgagccatgtagtcaccctgagagtggaggggatgcactgtaggtcctgtgtcgtgaatattgaagaaaatataggccgactcccagcggttcaaaatattcaagtgtccctggagaacagcactgctcaagtacagtatgacccttctcgtgtctccccggaggccctacagagggccatcgaggctcttccacccggcaactttaaagttttccttcctggaggcacggaggggagtgggacagatagcaggtcttcctcacatcactcccccggcccgtcccaggggacccagatgcaagatgtatgttcaacagtgacactcgccatttctggcatgacctgtgcatcctgcgtgcactccattgaaggcaccatctcccagaggaaaggcgttcggcatatatcagtctccttggctgaagggacaggaactgttgtctgtgatcctcttacagttagcccagaggaactccgggctgctgtggaagacatggggtttgaggcttcagtaatttctgaaagctgtcctggcagccatgttggaaaccataatggggagaattccacagtgccagctgcagctgatacccttgggtctgtgtgggcagtgtctccgcaggctgggagactccctgaaaatctcggctcaaccaggccccgacaagcctccataacgatggtaccacagaagtgctttttacagatcacaggcatgacctgtgcatcctgtgtgtctaacatagagagaagcctgcagaaagaagatggtatcctttccgtgcttgttgccttaatggctggaaaggcagaggttaagtataatccagaagtcatccagccactcgagatagctcagctcatccaggacttgggcttcgatgcagcagtcatggaagactatgcaggctccgatggcgacctcgagctgattgtcaccgggatgacctgtgcttcctgtgttcacaacattgagtccaaactcacgaggaccaatggcatcagctacgcctctgtggcccttgccaccagcaaagcccatgtgaagtttgatcctgaaattattggtccacgggatattgtcaaaattattgaggaaatcggctttcatgcttccccggcccagagaaaccccaacgctcatcatttggaccacaaggtggaaataaagcagtggaagaagtctttcctgtgcagcctggtgtttggcatccctgttatgggtttaatgatctatatgctgatacctagcagccagccccacgaatctatggtcctagaccacaacatcattccaggactctccattctaaatctaatcttctttattttgtgtacctttgtccagttcctcggtgggtggtacttctacattcaggcctacaaatctctgaagcataggacagccaacatggatgtgctgatcgtgctggccacgagcatcgcttatgtctactccttcatcatcctggtcgtggccatagctgagagggctgagaggagccctgtgaccttctttgacacgcctcccatgctcttcgtgttcattgccctggggcggtggctggaacacgtggcaaagagcaaaacttcagaagcacttgccaaactcatgtctctccaagccacagaagccaccgttgtgactcttggtgaggataacttaatcatcagggaggagcaagtacccatggaactggtgcagcggggtgatatcatcaaggtggttcctgggggaaagtttcctgtggatgggaaagtgctggaaggcaacaccatggctgatgagtctctcatcacaggagaagccatgcccgtcactaagaaacctgggagcacagtcattgcagggtccataaatgcacacggctccgtgctcatcaacgccacccatgtgggcaatgacaccactttggctcagattgtgaagctcgtggaagaggctcagatgtcaaaggcacctattcagcaactggctgaccggtttagtggatattttgtcccatttatcatcatcatttcaactttgacgttggtggtatggattataatcggctttatcgattttggtgttgttcagaaatactttcctatccctagccagcacatctcccaggcagaggtcatcattcggtttgcattccagacatccatcacagtgctgtgtattgcctgcccctgctcactgggcttggccacgcccacagcagtcatggtgggcactggggtggcagcccagaatggcatcctcatcaagggaggcaagcctctggagatggcccacaagataaagactgtgatgtttgacaaaactggcaccatcacctacggagtccccaaagtcatgcgggtccttctgcttgtggacatggccacgctgcccctcaggaaggtgcttgctgtagtggggacggccgaggcgagcagtgagcaccccttgggtgttgcagtcaccagatactgtaaagaggaacttgggacagagaccttgggatactgcacagatttccagtcagtgcccggctgtggaattggctgtaaagtcagcagcgtggaaggcattctggcccatagcgatcacccgctgggcgaatggcctactcacctgaacggggttggcagtgttcctgcggaaacagatgcggcctcccataccttcgcagtgctgattgggaatcgtgaatggatgaggcgcaacggtttaaccgtctctagtgacatcagtgacgctatgaccaatcacgagatgaaaggccagactgccatcctggtggctattgatggttggcatcaacaaagtctttgcagaggtgctgccttctcacaaggtggccaaggtccaggagctgcagaatgcagggaagaaagtcgccatggtgggagatggggtcaatgactccccagccttagcccgggctgacgtgggcatcgccattgggacaggcactgacgtcgccattgaggcagccgacg

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