LOCUS       XM_011226774           14547 bp    mRNA    linear   MAM 26-MAY-2020
DEFINITION  PREDICTED: Ailuropoda melanoleuca argonaute RISC catalytic
            component 2 (AGO2), transcript variant X2, mRNA.
ACCESSION   XM_011226774
VERSION     XM_011226774.3
DBLINK      BioProject: PRJNA633539
KEYWORDS    RefSeq.
SOURCE      Ailuropoda melanoleuca (giant panda)
  ORGANISM  Ailuropoda melanoleuca
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
            Ailuropoda.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_048226.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 26, 2020 this sequence version replaced XM_011226774.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Ailuropoda melanoleuca Annotation
                                           Release 103
            Annotation Version          :: 103
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14547
                     /organism="Ailuropoda melanoleuca"
                     /mol_type="mRNA"
                     /isolate="Jingjing"
                     /db_xref="taxon:9646"
                     /chromosome="9"
                     /sex="female"
                     /tissue_type="blood"
                     /dev_stage="adult"
     gene            1..14547
                     /gene="AGO2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 Protein, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 42 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:100464244"
     CDS             16..2700
                     /gene="AGO2"
                     /codon_start=1
                     /product="protein argonaute-2 isoform X2"
                     /protein_id="XP_011225076.1"
                     /db_xref="GeneID:100464244"
                     /translation="

MRFRFSMETCEHREEEGRSVSGVACGSEGPREPGRAGRTPEKAHECELGKPLFPCVTGVLLAVPVLAPPAPPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLATMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA"

     misc_feature    262..2694
                     /gene="AGO2"
                     /note="protein argonaute; Provisional; Region: PLN03202"
                     /db_xref="CDD:215631"
     misc_feature    271..687
                     /gene="AGO2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:293095"
     misc_feature    718..867
                     /gene="AGO2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:285861"
     misc_feature    868..1230
                     /gene="AGO2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1024..1026,1069..1071,1111..1113,1123..1125,
                     1177..1179,1198..1200,1204..1206)
                     /gene="AGO2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1363..2571
                     /gene="AGO2"
                     /note="Piwi_ago-like: PIWI domain, Argonaute-like
                     subfamily. Argonaute is the central component of the
                     RNA-induced silencing complex (RISC) and related
                     complexes. The PIWI domain is the C-terminal portion of
                     Argonaute and consists of two subdomains, one of...;
                     Region: Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1774..1776,1786..1788,1822..1833,1840..1842,
                     1864..1866,1873..1875,1885..1887,1897..1899)
                     /gene="AGO2"
                     /note="5' RNA guide strand anchoring site; other site"
                     /db_xref="CDD:240015"
     misc_feature    order(1978..1980,1984..1986,2194..2196,2539..2541)
                     /gene="AGO2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

gagaggggtaggggcatgagattcaggttttccatggaaacgtgtgagcacagggaggaggagggaaggagtgtgtcaggggtggcatgtggcagcgagggtccacgggagccgggaagggctggtcgcacaccagagaaggcacacgagtgtgaactaggaaagccgctgtttccctgtgtaaccggcgttctcttggccgttccagtgctcgcacccccagcgccgccaccaccacccatccaaggatatgccttcaagcctccgcctagacccgacttcgggacctctgggagaacaatcaagttacaggccaacttctttgaaatggacattccaaaaattgacatctatcattatgaattggatatcaagccagagaaatgcccacggagagttaacagggaaatagtggaacatatggtccagcactttaaaacacagatctttggggatcggaaaccagtgtttgatggaagaaagaatctctacacagcgatgccccttccaattgggagggataaggtggagctggaggtcacgttgcctggagaaggaaaagaccgcatcttcaaggtgtccattaagtgggtgtcctgcgtgagcttacaggcgttacacgatgcactttcggggcggctgcccagcgtcccctttgagacgatccaggccctggatgtggtcatgaggcatttgccatccatgaggtacacccctgtgggccgctccttttttacggcgtccgagggctgctccaacccccttggcgggggccgggaagtgtggtttggcttccatcagtccgtccgaccttctctttggaaaatgatgttaaatattgatgtctcagcaactgcattttataaggcacagccagtaatcgagtttgtttgtgaagttttggattttaaaagtattgaagaacaacagaaacctctgacagattcccaaagggtaaagtttaccaaagaaatcaaaggtctaaaggtggagataacgcactgcgggcagatgaagaggaagtaccgcgtctgcaacgtgacccggcggcccgccagccaccaaacattcccgctccagcaggagagcggacagacggtggagtgcacagtggcccagtacttcaaggacaggcacaagctggttctgcgctacccccacctcccatgtttacaagttggacaggagcagaaacacacctaccttcccctcgaggtctgtaacatagtggcaggacagagatgtatcaaaaagctcaccgacaatcagacctcaaccatgatcagagcgacggccaggtcagcgccggatcggcaagaggagattagcaagctgatgcgaagtgcaagttttaatacagatccatatgttcgtgaattcggaatcatggtcaaggacgagatgacagacgtgaccgggagggtcctccagccgccctccatcctctacgggggcaggaataaagcaatcgccacccctgtccagggcgtgtgggacatgaggaataagcagtttcacacaggcattgagatcaaagtgtgggccatcgcgtgcttcgccccccagcgccagtgcacggaagtccaccttaaatccttcacggagcagctcagaaagatctcgcgggacgctggaatgccgatccagggccagccttgcttctgtaaatatgcccagggggcggatagcgtggagcccatgttcaggcatctgaagaatacgtatgctggccttcagctggtggtagtcatcctgcctggcaagactcccgtgtatgccgaggtcaagcgcgtgggggacacggtgctggggatggccacacagtgtgtgcagatgaagaatgtgcagaggaccacaccgcagaccttgtccaacctctgcctgaagatcaacgtcaagctgggaggcgtgaacaacatcctgctgccccaggggaggccgcccgtgttccagcagcccgtcatcttcctgggggccgacgtcactcacccacccgctggggacgggaagaagccttccatcgcagctgtcgtgggcagcatggacgcccacccgaaccgctactgcgccaccgtgcgagttcagcagcaccggcaagagatcatccaggacctggccaccatggtccgcgagctgctcatccagttctacaagtccacgcgcttcaagcccacgcgcatcatcttctaccgcgacggcgtctccgagggccagtttcagcaggttctccaccatgagttgctggccattcgcgaggcgtgtattaagctagaaaaggactaccagccgggcatcaccttcatagtggtacagaaaaggcaccacacgcggctgttctgcaccgacaagaacgagagggttgggaaaagtggaaacattccggcaggcacaactgtggacacgaaaatcacccacccgaccgagtttgacttctacctgtgcagtcatgccggcatccagatcctcacctaccagctgtgtcacacctacgtgcgctgcacgcgctccgtgtccatcccggcgccagcatactacgcccacctggtggccttccgggccaggtaccacctggtggacaaagaacacgacagtgctgaaggaagccatacctccgggcagagtaacggacgagaccatcaagcgttggccaaggcagtccaggtccatcaggacacgctgcgcaccatgtactttgcttgacatgttttagtgtttacgattgtgtaccgagttggattcacatgagaccagctacactcagaccaacagatgcccagcccttccgtgacagccagcatcgaacatgagaagtcattgattttagtagattctccattttccagaatgccttccgtcccagatttcagacttggattttgaactgcagacctgtatgagaccccattgtcgcaggaaatatggtttgccaaaatctataagctgcttattaaaatagagtcccgtgtttcctaaaaatctcctaaaaccagtctatgaactcagggctttaaaacatttttaatttatttggtcattcaatttacttgtttttaacacatgattctctatgaaattgatgggctcaaactagctgtgaacgttctcagagagtgaaagcaacagagggcacggctgtggttttaaagccttgagcattctgaggtggtcactaaagtttatgtgagagtgatactagtgtgctcctgacagggctgacacaagctcttcgggaccgagggcaggtggcccgccgaggcgcccaccggcgtcttgtcctgccactgcccacctttcactcagcttgaaataaggagcgggggcagaagatgggccatgtgtgtttacaacatttataggtccagagagattggcagacaagtgccattttaataaaaatttatttaaaaaaaaaaaaagacaatatgccgacagtctaatcataagatttgtcctataggactgtgacatttattttccaaagtttctaaagaatacgggtctgtggtgataaatacagtacaatcctttttcactgttatgtctttaatgtaagagaaaaatatatattatctggtttgcagtattaatgtgatagatagatgctgtttttcattttattgactacggggtgcttattgtgatctgtttagcatatcaagagtgttttggagcctggagactggaccacctcctgtggttctcagtgctgacatgcaggagtgtgcaactgagtcaatgtgaccgccacccctgccccccccccccgcgtagtccgcgtagcctgtaccttcaggagaaccgagcgcgggtgcggtggccgccgccccacctcctgtccccgtgtgttgctcagccgattaagcacaaatggaatgtatttattcttccattcctgggacgtgggtcagagtgtacctctctgtgtctggttctgttagacgagtttcgtgggatctatgcactgaagcgcgcagagagctggcaagccccgctcggaggtggctgactgcaaagcccacagaagagatttgcgttctgggccccagagaaaccgttgcactaagtgcgatgtcatggacaacgtgagaagggtaacaacggacaactctgtttgtgctgagtgggctgtttgtttgtccccatagacactttcttaaaaaaatcaaatccacgttcaatgtagagattctgggaaggagacgagccttcccctagtgctgctttgtgctctgttggttcccctgtccctgctgacggccctccccgagcccagcctcacgtttacctcggcactgcggcagagcgggggtcccgacgggactccccgttctggagaaggcgccggcctctgtggtcctgtctgccggctccggggcgctggaggggcggggagctgcgggcgaagctgcagtgggcgctcggcctagggctggtggcggtgacagaggggtgactatttgtgaagattcatactcggcgtggtgtgtgcgtgtgggtgtcttactaatggcattagcctcttcttgctgtatcttttttgttttgggatttgtttgtttttttggttgggtttttttttcctttcctttttttttttcggtctttttaaatgaacagaagcctctgctctgagaaatgttgcaattccctgtcgttttattggtaaatggcaatttctcctcttttcagaaggataccagtacactcttggcctaaattaccaggagcgttcaaactaaggagggaatcttttcacgaatacacttctgaaatctgagattaggttagttttcagccatttttagggtcatctagaaccacgtgtttcaagggtgtgtttgtgctccccgcagcagggtcctggtggtcgggtgggcggtggtgcttggcgaaaatgccgactcccggatccgatctccacggccggggccgggtgtctgtatttgatgccatcaagcagggctccggggctgcccaaagtccgcagaccccgatccagc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