LOCUS       XM_009486293            4260 bp    mRNA    linear   VRT 25-JUL-2025
DEFINITION  PREDICTED: Pelecanus crispus ATPase copper transporting beta
            (ATP7B), mRNA.
ACCESSION   XM_009486293
VERSION     XM_009486293.2
DBLINK      BioProject: PRJNA1295506
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Pelecanus crispus (Dalmatian pelican)
  ORGANISM  Pelecanus crispus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Neoaves; Aequornithes;
            Pelecaniformes; Pelecanidae; Pelecanus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_134643) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jul 25, 2025 this sequence version replaced XM_009486293.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_030463565.1-RS_2025_07
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 07/24/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4260
                     /organism="Pelecanus crispus"
                     /mol_type="mRNA"
                     /isolate="bPelCri1"
                     /db_xref="taxon:36300"
                     /chromosome="1"
                     /sex="female"
                     /tissue_type="blood"
                     /dev_stage="adult"
                     /geo_loc_name="Denmark: Copenhagen Zoo"
                     /lat_lon="55.6724 N 12.5214 E"
                     /collection_date="2020-06-11"
                     /collected_by="Mads Bertelsen"
     gene            1..4260
                     /gene="ATP7B"
                     /note="ATPase copper transporting beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 9 Proteins"
                     /db_xref="GeneID:104033610"
     CDS             4..4260
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2"
                     /protein_id="XP_009484568.1"
                     /db_xref="GeneID:104033610"
                     /translation="

MKHNFAFDNMGYEESFETAPSPSSQEHIVAVNIVGMTCQSCVQSIEGRISKVKGVVSIKVSLEQNNAVIKYLQSEISPEQICQEIQDMGFDANIAEERLTTATVNLSCLREAVVKLRVEGMTCQSCVTNIEGKIGKLHGVVRIKVSLGNQEAIIAYYPYIIQPDDLKSHISNLGYECTIKSKSAPLKLGVLDLGRLQNAKPQETPASLETGGVDPLVTKMSGTATVAVRIEGMHCKSCVRNIEGNISDLPGIQSIKVSLEHKRAVVQYSPNLITLSALQQAIESLPPGNFKVCLLNGSEVNMGESPSPALLCDLFREPLQDKTRTAVIRIDGMTCNSCVQSIEGTISQRQGVQCIAVSLADGTGTIHYDPAVTNGEELRAAIEDMGFDASVLTGNCFFFYTTAGERRHRSDTSNAAVQPQAPEPPYQGCASDAPPDSPHLDGPNQPSGVTAKKCFLQITGMTCASCVSAIERNLQKEDGIVSVLVALMAGKAEIKYKPEFIQPLEIAQLIQNLGFEATIIEDHAETEGNVELLITGMTCASCVHNIESKLMRTNGILYASVALATCKAHIQFDPEITGPRDIIKTIEEIGFHASVARRVPNAHNLDHKREIQQWRKSFLCSLLFGIPVLILMIYMLIPDGEHHGSMVLEQNLIPGLSILNLLFFVLCTFVQFLGGWYFYVQAYKSLKHKTANMDVLIVLATTIAYVYSCVILMVAIIEKAEKSPVTFFDTPPMLFVFIALGRWLEHIAKSKTSEALAKLISLQATEATVVTLGPDHSIVREEQVAVELVQRGDIVKVVPGGKFPVDGKVIEGSSMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLVNATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADKFSGYFVPFIIIISTVTLIVWIAIGFINFDVIQKYFPNQNKHVSKAELILRFAFQTSITVLSIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITCGVPKVMRVLLLGDTAVLSLKKVLAVVGTAEASSEHPLGLAVTKYCKEELGTQSLGYCTDFQAVPGCGISCKVGGVEAVLGTAEEGLDKLDANRSKDSTSHTYSVLIGNREWMRRNGLHIANDVNDAMTDHETKGQTAILVAIDGVLCGMIAIADTVKQEAALAVHTLKNMGIDVVLITGDNRKTAKAIATQVGIKKVFAEVLPSHKVAKVQELQNGRRKVAMVGDGVNDSPALARADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIRLSKRTVRRIRINLILALIYNLLGIPIAAGVFMPVGLVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDTESYEAQAQGRMKPLTPSQISVHIGMDDRRRDSSRPAPWDQISQVSLSSLTSDKLPRRNGFVEEEGDKWSLLMNGGDEEQYI"

     misc_feature    94..279
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(109..117,124..126)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    346..537
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(364..372,379..381)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    685..858
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(700..708,715..717)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    970..1182
                     /gene="ATP7B"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    1369..1557
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1384..1392,1399..1401)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1594..1785
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1612..1620,1627..1629)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1849..3933
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(2842..2844,2848..2850,3862..3864)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(2974..2982,3184..3186,3313..3321,3409..3411,
                     3529..3537,3595..3597,3604..3606,3613..3615,3670..3672,
                     3679..3681)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

acaatgaaacacaattttgcttttgacaacatgggctatgaagagagctttgaaactgcaccctctccatcttcccaagaacacattgtggcagtcaacattgtgggaatgacttgccaatcttgtgtgcagtcgatagaaggccgaatttccaaggtgaagggtgttgtgagtattaaagtctcccttgaacagaacaatgctgtaataaagtatctgcagtcagaaataagtcctgaacagatttgccaggaaattcaggatatgggctttgatgccaacatagcagaagagaggttgacaacagcgaccgtaaatttgtcgtgcttgagagaagcagtagttaagcttcgggtagaaggcatgacatgccagtcctgtgtcaccaacattgaagggaaaattggaaaactgcatggtgtggtgagaatcaaggtgtcacttggtaaccaggaagccattattgcttactatccttacatcattcagcctgatgacctcaagagccatatcagtaacctggggtatgaatgcaccattaaaagtaaatcagcccctttgaagcttggtgtcctcgatctggggcgcctgcaaaatgcaaaaccccaggagacaccagcaagtctcgagactggtggggtggatccactggtcaccaagatgagtggcacagctacagtggctgtacggatagaaggcatgcactgcaaatcctgtgtcagaaacattgaaggaaatatatcagatcttcctggcatacaaagtattaaagtgtctttggagcataaacgtgctgtggtacagtatagcccaaatttaattaccctgtcagctttgcagcaagctattgaatcccttccacctggaaactttaaagtatgtctccttaatggttcagaagttaatatgggagaatctccatcacctgctttgctatgcgatctcttcagagagccgctgcaagacaagacacgcacagctgtaattaggattgatggcatgacctgcaattcctgcgtacagtccatagaagggaccatatcacagcgacaaggagtgcaatgtatagcagtttctctagctgatgggactgggaccatacattatgatccagctgtcactaatggagaagagttaagagctgccatagaggacatggggtttgatgcttctgtgctgacaggtaactgttttttcttctataccactgctggagaacgtaggcaccggtctgacaccagcaatgctgccgtgcagcctcaagctccagagcctccttatcaaggttgtgcctcagatgctcctccagacagtcctcacctcgatggaccaaaccagcccagcggagtgacagctaaaaagtgttttttacaaatcacaggcatgacctgtgcatcgtgtgtgtctgccattgaaagaaatttgcagaaagaagatggaattgtttcagtgttggtagcactgatggcaggtaaagcagagataaaatacaagccagaattcatacagcctcttgaaatagcacagctgatccagaatttgggttttgaagctaccatcatagaagatcatgcagaaacagaaggaaatgtggagcttcttattacagggatgacttgtgcttcttgtgttcacaatattgaatccaaactcatgagaacaaatggcatactctatgcctcggttgcacttgctacttgcaaagctcacatccagtttgatcctgaaattactggacctcgagatattataaaaacaattgaggaaattggctttcatgcttctgtggctagaagagttccaaatgcacataacctggatcataaaagggaaatacagcagtggaggaaatctttcttgtgcagcctactgtttggtatccctgtcttaatcctaatgatttatatgctaatacccgacggtgagcaccatgggtctatggtgctggaacagaatctcattcctggattatctattttaaatcttctcttctttgtcctgtgcacttttgttcagtttcttggtggatggtatttttacgtacaagcttacaaatcactgaagcacaagacagccaatatggatgtgctcattgtactggccacaacaattgcttatgtgtattcctgtgtgatcctgatggtagcaataattgaaaaggcagagaaaagccctgtcactttctttgacactcctccgatgctgttcgtgttcattgcccttgggagatggctggaacacatagcaaagagtaagacctcagaagctcttgctaaacttatatctcttcaagccacagaagccactgtggtgactcttggacctgaccactcgattgtcagggaggagcaggtagctgttgaactggttcaaaggggtgatattgtaaaggttgttcctggtggaaagttcccagtggatggaaaggtcattgaaggcagttctatggcagatgagtctctcattaccggggaagctatgccagtcactaaaaagcctgggagcacagtgattgctggttctataaatgcacatggctcagttcttgttaatgcaactcatgttggtaatgataccactctggcacaaatcgtgaaattggtggaagaagctcaaatgtcaaaggcacccatacagcaactggcagataagtttagtggatattttgttccatttatcatcatcatttcaacagtgacattgatagtatggatcgcaattggttttataaattttgatgttattcaaaaatattttcctaatcagaacaaacatgtttcaaaagctgaactaatactgaggtttgcatttcaaacctcaatcactgtgctgagcattgcatgcccctgttctttaggcttggctacccccacagctgtgatggtgggcacaggagttgctgcgcagaatggtattctcatcaaaggtggaaaaccactggaaatggcacacaagatcaagactgtgatgtttgataaaactgggaccatcacttgcggagttcctaaagtcatgagggtgcttttgctgggagacacggctgtgctctctctgaagaaggtactggcggtggttggcactgcagaagccagcagtgagcatcctttaggactggcagtcactaaatattgcaaagaggagcttggcactcagagcctaggatactgcaccgacttccaggcagtcccaggctgtggcatcagctgcaaagtcggaggtgttgaggccgtcctgggcacagctgaggagggtctcgataagctggacgctaacaggagcaaggacagcacttctcatacatactcggtgttgattggaaatcgtgagtggatgcgacgtaatggcttgcacattgccaatgacgtaaatgatgcaatgacagaccatgaaacaaaaggacagactgccatactagtggctatagatggtgtattgtgtggaatgattgcaatagcagacactgtgaagcaggaggcagcccttgctgtgcacacgctgaaaaacatgggaatagatgtggtgctgataacaggggacaacagaaaaactgcaaaagccattgctactcaggttggaatcaaaaaagtctttgctgaggttcttccttctcacaaggttgcaaaggtccaggagctccaaaatgggaggaggaaggttgcgatggttggtgatggagtcaatgattcccctgcactagccagggctgacgttggaattgcaattggaacgggcactgatgttgccattgaagcagcagatgttgttcttatccgaaacgacttgctggatgtagttgccagtattcgcttatcaaagagaacagttcgaagaatacgaataaatctgattcttgccttaatttataatctacttggaatacccatagcagcaggtgtgttcatgcctgttggccttgtgcttcagccttggatgggatcagctgcaatggcagcttcttctgtgtctgtcgtgctgtcttccctgcagctgaaatgttataagaagccagacacagaaagttatgaagcacaagctcaaggccgcatgaagccgcttactccttcccaaattagtgttcatattggaatggatgataggaggagggattcatccagaccggctccttgggatcagattagccaagtgtctctctcttccttgacttcagacaagctgccaagacgtaatggttttgttgaggaggaaggggacaagtggtcattgctcatgaatggaggagatgaagaacagtacatctga

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