LOCUS       XM_009436257            5161 bp    mRNA    linear   PRI 11-APR-2023
DEFINITION  PREDICTED: Pan troglodytes NLR family pyrin domain containing 12
            (NLRP12), transcript variant X3, mRNA.
ACCESSION   XM_009436257
VERSION     XM_009436257.4
DBLINK      BioProject: PRJNA945513
KEYWORDS    RefSeq.
SOURCE      Pan troglodytes (chimpanzee)
  ORGANISM  Pan troglodytes
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Pan.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_072417) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Mar 28, 2023 this sequence version replaced XM_009436257.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_028858775.1-RS_2023_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5161
                     /organism="Pan troglodytes"
                     /mol_type="mRNA"
                     /isolate="AG18354"
                     /db_xref="taxon:9598"
                     /chromosome="19"
                     /sex="male"
                     /cell_line="AG18354"
                     /cell_type="lymphoblastoid"
                     /tissue_type="blood"
     gene            1..5161
                     /gene="NLRP12"
                     /note="NLR family pyrin domain containing 12; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 1 long SRA read, 2 Proteins"
                     /db_xref="GeneID:469002"
                     /db_xref="VGNC:VGNC:11242"
     CDS             201..3212
                     /gene="NLRP12"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 12
                     isoform X3"
                     /protein_id="XP_009434532.4"
                     /db_xref="GeneID:469002"
                     /db_xref="VGNC:VGNC:11242"
                     /translation="

MLRTAGRDGLCRLSTNLEELEAVELKKFKLYLGTATELGEGKIPWGRMEKAGPLEMAQLLITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQAQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLISGCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDAQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGIWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDMNCERYYSFIHLSFQEFFAAMYYILDEGERGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQKEFTQQALSHFQVIVVSNIASKMEHMVSSFCLKHCRSAQVLHLYGATYSADGEDRARCSAGTHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACKNLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC"

     misc_feature    249..476
                     /gene="NLRP12"
                     /note="Pyrin death domain found in NALP proteins; Region:
                     Pyrin_NALPs; cd08320"
                     /db_xref="CDD:260032"
     misc_feature    585..800
                     /gene="NLRP12"
                     /note="Fish-specific NACHT associated domain; Region:
                     FISNA; pfam14484"
                     /db_xref="CDD:433982"
     misc_feature    834..1343
                     /gene="NLRP12"
                     /note="NACHT domain; Region: NACHT; pfam05729"
                     /db_xref="CDD:428606"
     misc_feature    1575..1736
                     /gene="NLRP12"
                     /note="NOD2 winged helix domain; Region: NOD2_WH;
                     pfam17779"
                     /db_xref="CDD:436037"
     misc_feature    1740..2081
                     /gene="NLRP12"
                     /note="NLRC4 helical domain HD2; Region: NLRC4_HD2;
                     pfam17776"
                     /db_xref="CDD:436035"
     misc_feature    2310..3131
                     /gene="NLRP12"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; Region:
                     LRR_RI; cd00116"
                     /db_xref="CDD:238064"
     misc_feature    order(2340..2342,2349..2351,2355..2357,2364..2366,
                     2370..2372,2427..2429,2436..2438,2442..2444,2451..2453,
                     2457..2459,2511..2513,2520..2522,2526..2528,2535..2537,
                     2541..2543,2598..2600,2607..2609,2613..2615,2622..2624,
                     2628..2630,2682..2684,2691..2693,2697..2699,2706..2708,
                     2712..2714,2769..2771,2778..2780,2784..2786,2793..2795,
                     2799..2801,2853..2855,2862..2864,2868..2870,2877..2879,
                     2883..2885,2940..2942,2949..2951,2955..2957,2964..2966,
                     2970..2972,3024..3026,3033..3035,3039..3041,3048..3050,
                     3054..3056,3111..3113,3120..3122,3126..3128)
                     /gene="NLRP12"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     misc_feature    2340..2426
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2427..2510
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    order(2448..2450,2619..2621,2703..2705,2874..2876,
                     2952..2954,2958..2960,3036..3038,3123..3125)
                     /gene="NLRP12"
                     /note="Substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238064"
     misc_feature    2511..2597
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2598..2681
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2682..2768
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2769..2852
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2853..2939
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2940..3023
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      

aggagggaactgaagagtgagatagcattatttcagcaaaaggtctttcctccctcgctcactcctccaaccactggctcagcctctctgcccgctgcctgtgaatgatgcaatggaaggtgtgctggggtcgccctgtgtcccgtgcataggagcatctcagcctccaggtcctctcctttggggctcatggcacccccatgctacgaaccgcaggcagggacggcctctgtcgcctgtccaccaacttggaagaactcgaggctgtggaactgaagaagttcaagttatacctggggaccgcgacagagctgggagaaggcaagatcccctggggacgcatggagaaggccggtcccctggaaatggcccagctgctcatcacccacttcgggccagaggaggcctggagattggctctcagcacctttgagcggataaacaggaaggacctgtgggagagaggacagagagaggacctggtgagggataccccacctggtggcccgtcctcacttgggaaccagtcaacatgccttctggaagtctctcttgtcactccaaggaaagatccccaggaaacctacagggactatgtccgcaggaaattccggctcatggaagaccgcaatgcgcgcctaggggaatgtgtcaacctcagccaccggtacacccggctcctgctggtgaaggagcactcaaaccccatgcaggcccagcagcagcttctggacacaggccggggacacgcgaggaccgtgggacaccaggctagccccatcaagatagagaccctctttgagccagacgaggagcgccccgagccaccgcgcaccgtggtcatgcaaggcgcggcagggataggcaagtccatgctggcacacaaggtgatgctggactgggcggacgggaagctcttccaaggcagatttgattatctcttctacatcaactgcagggagatgaaccagagtgccacggaatgcagcatgcaagacctcatctccggctgctggcccgagcccagcgcgcctctccaggagctcatccgagttcccgagcgcctccttttcatcatcgacggcttcgatgagctcaagccttctttccacgatgctcagggaccctggtgcctctgctgggaggagaaacggcccacggagctgcttcttaacagcttaattcggaagaagctgctccctgagctatctttgctcatcaccacacggcccacggctttggagaagctccaccgtctgctggagcaccccaggcatgtggagatcctgggcttctctgaggcagaaaggaaggaatacttctacaagtatttccacaatgcagagcaggcgggccaagtcttcaattacgtgagggacaacgagcctctcttcaccatgtgcttcgtccccctggtgtgctgggtggtgtgtacctgcctccagcagcagctggagggtggggggctgttgagacagacgtccaggaccaccactgcggtgtacatgctctacctgctgagtctgatgcaacccaagcccggggccccgcgcctccagcccccacccaaccagagagggttgtgctccttggcggcagatgggatctggaatcagaaaatcctatttgaggagcaggacctccggaagcacggcctagacggggaagacgtctctgccttcctcaacatgaacatcttccagaaggacatgaactgtgagaggtactacagcttcatccacttgagtttccaggaattctttgcagctatgtactatatcctggacgagggggagcgcggggcaggcccagaccaggacgtgaccaggctgttgaccgagtacgcgttttctgaaaggagcttcctggcactcaccagccgcttcctgtttggactcctgaacgaggagaccaggagccacctggagaagagtctctgctggaaggtctcgccgcacatcaagatggacctgttgcagtggatccaaagcaaagctcagagcgacggctccaccctgcagcagggctccttggagttcttcagctgcttgtacgagatccagaaggagtttacccagcaggccctgagccacttccaggtgatcgtggtcagcaacattgcctccaagatggagcacatggtctcctcgttctgtctgaagcactgcaggagcgcccaggtgctgcacttgtatggcgccacctacagcgcggacggggaagaccgcgcgaggtgctccgcaggaacgcacacgctgttggtgcagctaccagagaggactgttctgctggacgcctacagtgaacatctggcagcggccctgtgcaccaatccaaacctgatagagctgtctctgtaccgaaatgccctgggcagccggggggtgaagctgctctgtcaaggactcagacaccccaactgcaaacttcagaacctgaggctgaagaggtgccgcatctccagctcagcctgcgaggacctctctgcagctctcatagccaataagaatttgacaaggatggatctcagtggcaacggcgttggattcccaggcatgatgctgctttgtgagggcctgcggcatccccagtgcaggctgcagatgattcagttgaggaagtgtcagctggagtccggggcttgtcaggagatggcttctgtgctcggcaccaacccacatctggttgagttggacctgacaggaaatgcactggaggatttgggcctgaggttactatgccagggactgaggcacccagtctgcagactacggactttgtggctgaagatctgccgcctcactgctgctgcctgtgacgagctggcctcaactctcagtgtgaaccagagcctgagagagctggacctgagcctgaatgagctgggggacctcggggtgctgctgctgtgtgagggcctcaggcatcccacgtgcaagctccagaccctccggctggatagctgtggcctcacagccaaggcttgtaagaatctttacttcaccctggggatcaaccagaccttgaccgacctttacctgacgaacaacgccctaggggacacaggcgtccgactgctttgcaagcggctgagccatcctggctgcaaactccgagtcctctggttatttgggatggacctgaataaaatgacccacagtaggttggcagcgcttcgagtaacaaaaccttatttggacattggctgctgaatggtcctatctgctggctctcccctgagatctggacagaggaagatgggagggtgctcatcacccccacagcataatgatcagcctccttcctagagacagactcatgcagattgagatcaaaagtccctctgcttgggatcaaattaatgtttgacagagctggccaggcgtggtggctcatgtatgtaatcccagcacttcgagaggccgaggcaggtggatcacgaggtcaggagtttgagatcagcctggccaagatggtgaaaccctgtctccactaaaaataaaaaaaaattcgccacgcatggtggtgggcacctgtagtcccagctactcaggaggctgagacaggagaatcgcttgaacccgggaggtggaggttgcagtgagccgagatcgcgccactgcactccagcctgggcgacagagtgggactccatctcaaaaaaaaaaaaaaagtttgacggagttttaagggatgaccaactaagagaggtttgatggcccctaacaggaggggtaaagcccaacaggggccaggtgcggtgtctcacgcctgtaacccccgtactttcgaaggtggaggcaagatgggttgcttaagtctaggagttagagaccagcctaagcaacatagcaagactccactattactaattagccaactactattaattagtacaattaattacccaggagtagcagcacatgcctgtagtcccagctactctggggactgaggtgggaagatcgcttgagcccaggaggtcgaggctgcagtgagctgtcattgcaccactgcgccccagcctgggcaacagagggagacggtgaaaaatggccagtaggggccctcagaggccacccagccctgccaagccctggctacatcaggacatagtaatatttgagctctggggtgggtgccactgccatctagtggacgacactaggaatacatgccaacatccagcaaggaatgcacaggacaaagcacttggtccaaaggcaaattgtgccaagttgaggaaagcctgttctcaaatgtcacaggatacatggggcactcagcatttgggaagagactggtatgcaagctaaccctcagaatgcttgttatgccaacagccctgatcctcccttgctggaggggataatgcctgaaatcttaacgtggcaggcatgtcaggatggccccctgcctggaattcactgggccctgccaagaactgacacctacaaggccacgtgtaggctggccataacctattatacactgtgctttcaacaaaaatacagagcctgccagatgcggtggctcacgcctgtaatccaaatactttcggaggtggaggcaggcagatcagctaagatcaggagttcgagaccagcctggccaacatggtgaaacctactaaaaatacaaaaattaggctgggcacggtggctcatgcctgtaatcccagcactttgggaggccgaggcaggcggatcactaggtcaagagatcaataccatcctgactaacacggtgaaaccccatctctactaaaaacacaaaaaattagctgggtgtggtggcatgcacctatagtcccagctgctggggaggctgaggcaggagaatcgcttgcacctgggaggcagaggttgcagtgaaccgagatcgcgccactgcactccagcctgggcgacagagcgagactccatcttaaaaaatatatatatgggtgtggtgactcatacctgtaatcccagcactttgggaggccaaggagggcagatcacctgaggtcgggagttcaagaccagcctgaccaacatggagaaaccccgtctcttaataaaaatatagaattaaccaggcgtgatagccatgcgtgtaatccccgctactcgggaggctgaggcaggagaatcacttgaacctgggaaacagaggttgc

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