LOCUS       XM_008955557           12137 bp    mRNA    linear   PRI 11-JUN-2023
DEFINITION  PREDICTED: Pan paniscus NLR family pyrin domain containing 12
            (NLRP12), transcript variant X2, mRNA.
ACCESSION   XM_008955557
VERSION     XM_008955557.3
DBLINK      BioProject: PRJNA950461
KEYWORDS    RefSeq.
SOURCE      Pan paniscus (pygmy chimpanzee)
  ORGANISM  Pan paniscus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Pan.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_073268) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 18, 2023 this sequence version replaced XM_008955557.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_029289425.1-RS_2023_05
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 05/31/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..12137
                     /organism="Pan paniscus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9597"
                     /chromosome="19"
                     /sex="male"
                     /cell_line="PR00251"
                     /cell_type="fibroblast"
                     /dev_stage="adult"
     gene            1..12137
                     /gene="NLRP12"
                     /note="NLR family pyrin domain containing 12; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 1 Protein"
                     /db_xref="GeneID:100976212"
     CDS             191..3379
                     /gene="NLRP12"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 12
                     isoform X2"
                     /protein_id="XP_008953805.2"
                     /db_xref="GeneID:100976212"
                     /translation="

MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGRMEKAGPLEMAQLLITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQAQQQLLDRGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLISGCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDAQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYLRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGIWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGERGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQKEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKHCRSAQVLHLYGATYSADGEDRARCSAGTHTLLVQLRPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICHLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACKNLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC"

     misc_feature    227..466
                     /gene="NLRP12"
                     /note="Pyrin death domain found in NALP proteins; Region:
                     Pyrin_NALPs; cd08320"
                     /db_xref="CDD:260032"
     misc_feature    575..790
                     /gene="NLRP12"
                     /note="Fish-specific NACHT associated domain; Region:
                     FISNA; pfam14484"
                     /db_xref="CDD:433982"
     misc_feature    824..1333
                     /gene="NLRP12"
                     /note="NACHT domain; Region: NACHT; pfam05729"
                     /db_xref="CDD:428606"
     misc_feature    1565..1726
                     /gene="NLRP12"
                     /note="NOD2 winged helix domain; Region: NOD2_WH;
                     pfam17779"
                     /db_xref="CDD:436037"
     misc_feature    1730..2074
                     /gene="NLRP12"
                     /note="NLRC4 helical domain HD2; Region: NLRC4_HD2;
                     pfam17776"
                     /db_xref="CDD:436035"
     misc_feature    2252..3133
                     /gene="NLRP12"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; Region:
                     LRR_RI; cd00116"
                     /db_xref="CDD:238064"
     misc_feature    order(2252..2254,2261..2263,2267..2269,2276..2278,
                     2282..2284,2336..2338,2345..2347,2351..2353,2360..2362,
                     2366..2368,2423..2425,2432..2434,2438..2440,2447..2449,
                     2453..2455,2507..2509,2516..2518,2522..2524,2531..2533,
                     2537..2539,2594..2596,2603..2605,2609..2611,2618..2620,
                     2624..2626,2678..2680,2687..2689,2693..2695,2702..2704,
                     2708..2710,2765..2767,2774..2776,2780..2782,2789..2791,
                     2795..2797,2849..2851,2858..2860,2864..2866,2873..2875,
                     2879..2881,2936..2938,2945..2947,2951..2953,2960..2962,
                     2966..2968,3020..3022,3029..3031,3035..3037,3044..3046,
                     3050..3052,3107..3109,3116..3118,3122..3124,3131..3133)
                     /gene="NLRP12"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     misc_feature    order(2270..2275,2444..2446,2615..2617,2699..2701,
                     2870..2872,2948..2950,2954..2956,3032..3034,3119..3121)
                     /gene="NLRP12"
                     /note="Substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238064"
     misc_feature    2336..2422
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2423..2506
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2507..2593
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2594..2677
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2678..2764
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2765..2848
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2849..2935
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2936..3019
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    3107..3190
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      

tgaagagtgagaaagcattatttcagcaaaaggtctttcctccctcgctcactcctccaaccactggctcagcctctccgcccgctgcctgtgaatgatgcaatggaaggtatgctggggtcgccctgtgtcccgtgcatagaagcatctcagcctccaggtcctctcctttggggctcacggcacccccatgctacgaaccgcaggcagggacggcctctgtcgcctgtccacctacttggaagaactcgaggctgtggaactgaagaagttcaagttatacctggggaccgcgacagagctgggagaaggcaagatcccctggggacgcatggagaaggccggtcccctggaaatggcccagctgcttatcacccacttcgggccagaggaggcctggaggttggctctcagcacctttgagcggataaacaggaaggacctgtgggagagaggacagagagaggacctggtgagggataccccacctggtggcccgtcctcacttgggaaccagtcaacatgccttctggaagtctctcttgtcactccaaggaaagatccccaggaaacctacagggactatgtccgcaggaaattccggctcatggaagaccgcaatgcgcgcctaggggaatgtgtcaacctcagccaccggtacacccggctcctgctggtgaaggagcactcaaaccccatgcaggcccagcagcagcttctggacagaggccggggacacgcgaggaccgtgggacaccaggctagccccatcaagatagagaccctctttgagccagacgaggagcgccccgagccaccgcgcaccgtggtcatgcaaggcgcggcagggataggcaagtccatgctggcacacaaggtgatgctggactgggcggacgggaagctcttccaaggcagatttgattatctcttctacatcaactgcagggagatgaaccagagtgccacggaatgcagcatgcaagacctcatctccggctgctggcccgagcccagcgcgcctctccaggagctcatccgagttcccgagcgcctccttttcatcatcgacggcttcgatgagctcaagccttctttccacgatgctcagggaccctggtgcctctgctgggaggagaaacggcccacggagctgcttcttaacagcttaattcggaagaagctgctccctgagctatctttgctcatcaccacacggcccacggctttggagaagctccaccgtctgctggagcaccccaggcatgtggagatcctgggcttctctgaggcagaaaggaaggaatacttctacaagtatttccacaatgcagagcaggcgggccaagtcttcaattacctgagggacaacgagcctctcttcaccatgtgcttcgtccccctggtgtgctgggtggtgtgtacctgcctccagcagcagctggagggtggggggctgttgagacagacgtccaggaccaccactgcggtgtacatgctctacctgctgagtctgatgcaacccaagcccggggccccgcgcctccagcccccacccaaccagagagggttgtgctccttggcggcagatgggatctggaatcagaaaatcctatttgaggagcaggacctccggaagcacggcctagacggggaagacgtctctgccttcctcaacatgaacatcttccagaaggacatcaactgtgagaggtactacagcttcatccacttgagtttccaggaattctttgcagctatgtactatatcctggacgagggggagcgcggggcaggcccagaccaggacgtgaccaggctgttgaccgagtacgcgttttctgaaaggagcttcctggcactcaccagccgcttcctgtttggactcctgaacgaggagaccaggagccacctggagaagagtctctgctggaaggtctcgccgcacatcaagatggacctgttgcagtggatccaaagcaaagctcagagcgacggctccaccctgcagcagggctccttggagttcttcagctgcttgtacgagatccagaaggaggagtttatccagcaggccctgagccacttccaggtgatcgtggtcagcaacattgcctccaagatggagcacatggtctcctcgttctgtctgaagcactgcaggagcgcccaggtgctgcacttgtatggcgccacctacagcgcggacggggaagaccgcgcgaggtgctccgcaggaacgcacacgctgttggtgcagctcagaccagagaggactgttctgctggacgcctacagtgaacatctggcagcggccctgtgcaccaatccaaacctgatagagctgtctctgtaccgaaatgccctgggcagccggggggtgaagctgctctgtcaaggactcagacaccccaactgcaaacttcagaacctgaggctgaagaggtgccgcatctccagctcagcctgcgaggacctctctgcagctctcatagccaataagaatttgacaaggatggatctcagtggcaacggcgttggattcccaggcatgatgctgctttgtgagggcctgcggcatccccagtgcaggctgcagatgattcagttgaggaagtgtcagctggagtccggggcttgtcaggagatggcttctgtgctcggcaccaacccacatctggttgagttggacctgacaggaaatgcactggaggatttgggcctgaggttactatgccagggactgaggcacccagtctgcagactacggactttgtggctgaagatctgccacctcactgctgctgcctgtgacgagctggcctcaactctcagtgtgaaccagagcctgagagagctggacctgagcctgaatgagctgggggacctcggggtgctgctgctgtgtgagggcctcaggcatcccacgtgcaagctccagaccctccggttgggcatctgccggctgggctctgccgcctgtgagggtctttctgtggtgctccaggccaaccacaacctccgggagctggacttgagtttcaacgacctgggagactggggcctgtggttgctggctgaggggctgcaacatcctgcctgcagactccagaaactgtggctggatagctgtggcctcacagccaaggcttgtaagaatctttacttcaccctggggatcaaccagaccttgaccgacctttacctgacgaacaacgccctaggggacacaggcgtccgactgctttgcaagcggctgagccatcctggctgcaaactccgagtcctctggttatttgggatggacctgaataaaatgacccacagtaggttggcagcgcttcgagtaacaaaaccttatttggacattggctgctgaatggtcctatctgctggctctcccctgagatctggacagaggaagatgggagggtgctcatcacccccacagcataatgatcagcctccttcctagagacagactcatgcagattgagatcaaaagtccctctgcttgggatcaaattaatgtttgacagagctggccaggcgtggtggctcatgtatgtaatcccagcacttcgagaggccgaggcaggtggatcacgaggtcaggagtttgagatcagcctggccaagatggtgaaaccctgtctccactaaaaataaaaaaaaattcgccacgcatggtggtgggcacctgtagtcccagctactcaggaggctgagacaggagaatcgcttgaacccgggaggtggaggttgcagtgagccgagatcgcgccactgcactccagcctgggcgacagagtgggactccatctcaaaaaaaaaaaaaaagtttgacggagttttaagggatgaccaactaagagaggtttgatggcccctaacaggaggggtaaagcccaacaggggccaggtgcggtgtctcacgcctgtaacccccgtactttcgaaggtggaggcaagatgggttgcttaagtctaggagttagagaccagcctaagcaacatagcaagactccactattactaattagccaactactattaattagtacaattaattacccaggagtagcagcacatgcctgtagtcccagctactctggggactgaggtgggaagatcgcttgagcccaggaggtcgaggctgcagtgagctgtcattgcaccactgcgccccagcctgggcaacagagggagacggtgaaaaatggccagtaggggccctcagaggccacccagccctgccaagccctggctacatcaggacatagtaatatttgagctctggggtgggtgccactgccatctagtggacgacactaggaatacgtgccaacatccagcaaggaatgcacaggacaaagcacttggtccaaaggcaaattgtgccaagttgaggaaagcctgttctcaaatatcacaggatacatggggcactcagcatttgggaagagactggtatgcaagctaaccctcagaatgcttgttatgccaacagccctgatcctcccttgctggaggggataatgcctgaaatcttaacgtggcaggcatgtcaggatggccccctgcctggaattcactgggccctgccaagaactgacacctacaaggccacgtgtaggctggccataacctattatacactgtgctttcaacaaaaatacagagcctgccaggtgcggtggctcacgcctgtaatccaaatactttcggaggcggaggcaggcagatcagctaagatcaggagttcgagaccagcctggccaacatggtgaaacctactaaaaatacaaaaattaggctgggcacggtggctcatgcctgtaatcccagcactttgggaggccgaggcaggcggatcactaggtcaagagatcaataccatcctgactaacacggtgaaaccccatctctactaaaaacacaaaaaattagctgggtgtggtggcatgcacctatagtcccagctgctggggaggctgagg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