LOCUS       XM_008072081            3669 bp    mRNA    linear   PRI 01-JUL-2017
DEFINITION  PREDICTED: Carlito syrichta nuclear factor kappa B subunit 1
            (NFKB1), transcript variant X1, mRNA.
ACCESSION   XM_008072081
VERSION     XM_008072081.2
DBLINK      BioProject: PRJNA236776
KEYWORDS    RefSeq.
SOURCE      Carlito syrichta (Philippine tarsier)
  ORGANISM  Carlito syrichta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Tarsiiformes; Tarsiidae; Carlito.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_007258940.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jul 1, 2017 this sequence version replaced XM_008072081.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Carlito syrichta Annotation Release
                                           101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3669
                     /organism="Carlito syrichta"
                     /mol_type="mRNA"
                     /isolate="Samal-C Ts95f"
                     /db_xref="taxon:1868482"
                     /chromosome="Unknown"
                     /sex="female"
                     /geo_loc_name="USA: Duke University Lemur Center, Durham,
                     NC"
     gene            1..3669
                     /gene="NFKB1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 2 mRNAs, 134 ESTs, 13 Proteins,
                     and 76% coverage of the annotated genomic feature by
                     RNAseq alignments"
                     /db_xref="GeneID:103274648"
     CDS             56..2974
                     /gene="NFKB1"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p105 subunit isoform
                     X1"
                     /protein_id="XP_008070272.2"
                     /db_xref="GeneID:103274648"
                     /translation="

MKRTTSSRMAEDDSYLGRPEQMFHLDPLSHTIFNPEVFQPQMALPTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQVEGGGDRQLTDREKEVIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPPYGFPTYGGITFHHGATKSNAGMKHGTIDTESKNDFEGHDNSDNREAVNLSGKVTVTTEQDKEFGESHDGSDEVTLMYTLGSKEENAMFQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLKVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKILSILLKHKMAALLIDQPNGEGLNAIHLAMMSNSLPCLLLLLAAGVDVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDARVDSITYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAVNWQVFDILNGKPYEPEFISDDSLAQGDMKQLTEDAKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVKELVEALRQMGYTEAIEVIQAASSPVKTTSQAHSLPLSPASTRQKIDELRDNDSICDSGVETSFRKLSFTESLTSGSSLLTLNKMPPDYGQEGKI"

     misc_feature    203..808
                     /gene="NFKB1"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of kappa B1 (NF-kappa B1); Region:
                     RHD-n_NFkB1; cd07935"
                     /db_xref="CDD:143651"
     misc_feature    order(245..247,251..256,260..265,272..283,506..508,
                     512..517,806..808)
                     /gene="NFKB1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143651"
     misc_feature    827..1132
                     /gene="NFKB1"
                     /note="IPT domain of the transcription factor NFkappaB and
                     related transcription factors. NFkappaB is considered a
                     central regulator of stress responses, activated by
                     different stressful conditions, including physical stress,
                     oxidative stress, and exposure to...; Region:
                     IPT_NFkappaB; cd01177"
                     /db_xref="CDD:238582"
     misc_feature    order(830..832,836..844,848..856,974..982,1019..1021,
                     1055..1057,1112..1114,1121..1123,1127..1129)
                     /gene="NFKB1"
                     /note="ankyrin protein binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238582"
     misc_feature    order(836..841,845..847,884..886,890..892,896..898,
                     995..1000,1007..1009,1013..1015)
                     /gene="NFKB1"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238582"
     misc_feature    order(899..901,905..907,998..1003)
                     /gene="NFKB1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238582"
     misc_feature    1565..2353
                     /gene="NFKB1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1703..1705,1709..1711,1721..1726,1733..1741,
                     1745..1750,1760..1762,1769..1771,1814..1816,1820..1822,
                     1826..1828,1838..1843,1850..1858,1862..1867,1877..1879,
                     1886..1888,1913..1915,1919..1921,1925..1927,1937..1942,
                     1949..1957,1961..1966,1976..1978,1985..1987)
                     /gene="NFKB1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1703..1816
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1820..1915
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2129..2218
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2525..2749
                     /gene="NFKB1"
                     /note="Death domain of the Nuclear Factor-KappaB1
                     precursor protein p105; Region: Death_NFkB1_p105; cd08797"
                     /db_xref="CDD:260063"
ORIGIN      

gaaggaacataatgtcctaaattaagaaaaaatatgtaagcatgccattggagatatgaaaagaaccaccagctccagaatggcagaagatgattcatatctgggaaggcctgaacaaatgtttcatttggatcctttgagtcatacaatatttaatccagaagtatttcaaccacagatggcgctgccaacggcagatggcccataccttcaaatattagagcaacctaaacagagaggatttcgtttccgttacgtatgtgaaggcccatcccatggtggactaccaggtgcatctagtgaaaagaacaagaagtcctaccctcaggtcaaaatctgcaattatgtgggaccagcaaaggttattgttcagttggtcacaaatggaaaaaatatccacctgcatgcccacagcctggtggggaaacactgtgaggatgggatctgcactgtaactgctggacccaaggacatggtggtcggctttgcaaacctgggtatacttcatgtgacaaagaaaaaagtatttgaaacactggaagcacgaatgacagaggcgtgtataaggggctataatcctggactcttggtgcaccctgaccttgcctatttgcaagtggaaggtggaggggaccggcagctcacagatcgggaaaaggaggtcatccgccaggcagctcttcagcagacaaaggaaatggacctcagcgtggtgcggcttatgtttacagcttttcttccagacagcactggcagcttcacaaggcgcctagaacccgtagtctcagatgccatctacgacagcaaagctcccaatgcatccaacttgaaaattgtaagaatggacaggacagctgggtgtgtgactggaggggaagaaatttatcttctctgtgacaaagttcaaaaagatgacatccagattcgattttatgaggaagaggaaaatggtggagtctgggaaggatttggagatttttcccccacagacgttcatagacaatttgccattgtcttcaaaactccaaagtataaagatgtcaacattacaaagccagcctctgtgttcgtccaacttcggaggaaatctgatttggaaactagtgaacccaaaccttttctctactaccctgaaatcaaagataaagaggaagtacagaggaaacggcagaagctcatgcccaatttttcagatagtttcggcggtggtagtggagccggagctggaggcggaggcatgtttggtagtggcggtggaggagggggcactggaagtacaggtccaggttatagcttcccaccctatggatttcctacatatggtggaattaccttccatcatggagccactaaatctaatgctgggatgaagcatggaacaatagacactgaatctaaaaatgattttgaaggtcatgacaacagtgataacagagaggctgtaaatctctctgggaaagtcactgtaaccacagagcaagataaggagttcggagagtcccacgatgggagcgatgaggttactctaatgtatacattgggatccaaggaagagaatgctatgtttcaagataacctctttctagaaaaggctatgcagcttgccaagaggcatgccaatgccctttttgactatgcggtgacaggagatgtgaagatgctgctggctgtccagcgccatctcactgctgtacaggatgaaaatggggacagtgtcttacacttagcaatcatccaccttcatgctcagcttgtgagggatctgctaaaagtcacatcgggtttgatttctgatgacattatcaacatgagaaatgatctgtaccagacgcccttgcacttggcagtgatcactaagcaggaagatgtggtggaggacttgctgagggctggtgccgacctgagccttctggaccgcttgggtaactctgttttgcacctagctgccaaagaaggacatgataaaattctcagtatcctactgaagcacaaaatggcagcactacttattgaccaacccaatggggaaggtctgaatgccattcatctagccatgatgagcaacagcctgccatgtctgctgctgctgttagccgccggggtggacgtcaacgctcaggagcagaagtctggacgcacagcgctgcacctggctgtggagcacgacaacatctccttggcgggctgcctgctcctggagggtgatgcccgtgtggacagtatcacctatgatggaactacacctctgcatatagcagctgggagagggtccaccaggctggcagctcttctcaaagcagcaggagcagatcccctagtagagaactttgagcctctctatgacctggatgactcttgggaaaatgctggagaggatgaaggagtcgtgcctggcaccacacctctagacatggctgtcaactggcaggtatttgacatattaaatgggaaaccatatgagccagagtttatatctgatgattcactagcacaaggagacatgaaacagctgactgaagatgcaaagttgcagctctataagttgctagaaattcctgatccagacaaaaactgggctaccctggcacagaaattgggtctggggatacttaataatgccttccgactgagtcctgctccttctaagacgcttatggacaactatgaggtctctggggggacagtcaaagagctggtggaggccctgagacagatgggctacactgaagccattgaagtgatccaggcagcctccagcccagtgaagaccacctcgcaggcccactcgctgcctctctcacctgcctccacaaggcagaaaatagatgagctccgagacaacgacagcatttgtgacagcggcgtggagacatccttccgcaaactcagcttcacagagtctctgaccagcggcagctcattgctaactcttaacaaaatgccccccgattatgggcaggaaggcaaaatttagcctgctggcagtttgtgtaaaccaaagccctaaacttccactgcattgtccaaaagaaggaagcaaagtgcatccaaaggtgctcagaggagagccagcctgcctgaatcatcatcaatttaacttaaggccttttaaacttggcttcctttcttggttcataaatgaattttagcttggctcacttgcagacggtatctagcaatcacagcactggactgagctgatgtagggtggggggcggcagggttaagttgcttactgagctttgccggattgctgctggatcacagttgctttctgttgttgttgctgctgtccctctgctgtgttctcacgatcattaagggtatcactgttcctacccagtgtttttttctagcacaattgtgcattcagattaaggattaagaaaagggatattttaaatcgagactaatttggtgtgcaataaaaaaaaaggcttttcgctttttctattgtgcttatctctgtgatttgaaaaaacatgtatttgtcaatatttaaacatggttacaatcagtgctgaaaatggtattttcccctttttctgcattttgctattgtaaatatgtttttttagatgaaatactttaagaaaaaaatgttggatttataaatgctattttttattttacttttataataaaagaaaaagcaaattgatgacctca

//