LOCUS       XM_004697379            3149 bp    mRNA    linear   MAM 06-DEC-2021
DEFINITION  PREDICTED: Echinops telfairi argonaute RISC catalytic component 2
            (AGO2), mRNA.
ACCESSION   XM_004697379
VERSION     XM_004697379.3
DBLINK      BioProject: PRJNA193504
KEYWORDS    RefSeq.
SOURCE      Echinops telfairi (small Madagascar hedgehog)
  ORGANISM  Echinops telfairi
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Afrotheria; Tenrecidae; Tenrecinae; Echinops.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_022103896.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 6, 2021 this sequence version replaced XM_004697379.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Echinops telfairi Annotation Release
                                           103
            Annotation Version          :: 103
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 9.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3149
                     /organism="Echinops telfairi"
                     /mol_type="mRNA"
                     /isolate="266"
                     /db_xref="taxon:9371"
                     /chromosome="Unknown"
                     /sex="female"
                     /country="Germany: Ludwig Maximilians University, Munich"
     gene            1..3149
                     /gene="AGO2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 25 Proteins, and 95% coverage of
                     the annotated genomic feature by RNAseq alignments"
                     /db_xref="GeneID:101648413"
     CDS             113..2563
                     /gene="AGO2"
                     /codon_start=1
                     /product="protein argonaute-2"
                     /protein_id="XP_004697436.1"
                     /db_xref="GeneID:101648413"
                     /translation="

MDIPKIDIYHYELDIKPEKCPRRVNRYSLRPRAQPGKPDTCGDKRLCPPATEPWQPTGTCLTMCDLHPQVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLSSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKTLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQVLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA"

     misc_feature    <341..481
                     /gene="AGO2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    509..661
                     /gene="AGO2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    662..1024
                     /gene="AGO2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(818..820,863..865,905..907,917..919,971..973,
                     992..994,998..1000)
                     /gene="AGO2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1157..2434
                     /gene="AGO2"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1568..1570,1580..1582,1616..1627,1634..1636,
                     1658..1660,1667..1669,1679..1681,1691..1693)
                     /gene="AGO2"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1772..1774,1778..1780,1988..1990,2402..2404)
                     /gene="AGO2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

gtcttctctggcagcaacaccccccctccaaggatatgccttcaagccccctccgagacccgacttcgggacctctggaagaacaatcaaattacaagccaatttcttcgaaatggacattcccaaaatcgacatctaccactatgaattggacatcaagcctgagaaatgcccacgcagagtcaacaggtattctctcagaccccgcgcacagcctgggaagccagatacctgtggagacaagcgcctgtgccctcctgccacagaaccgtggcagcccactgggacgtgcctgaccatgtgtgatctgcacccacaggtggagctggaggtcaccctgcctggggaaggcaaggaccgcatcttcaaggtgtccatcaagtgggtgtcctgcgtgagcctgcaggcgttacacgatgcactttcagggcggctatccagcgtgcccttcgaaacgatccaggccctggacgtggtcatgcggcacctgccgtccatgaggtacacccctgtgggccgctccttctttaccgcctccgagggctgttccaaccccctgggtgggggccgagaggtctggtttggcttccaccagtccgtccgaccctcgctttggaaaatgatgctgaatattgacgtctctgcaacggccttttataaggcacagcctgtgatcgagttcgtttgtgaagttctggattttaaaagtattgaagaacaacaaaaaactctgacagattcccaaagggtcaagtttaccaaagaaatcaaaggtctaaaggtggagataacgcactgtggccagatgaaaaggaagtaccgagtctgcaacgtgacccggcggcctgccagccaccaaacgttcccgctgcagcaggagagcggccagaccgtggagtgcacggtggcccagtacttcaaggacaggcacaagctggtgctgcgctacccccacctcccatgtttacaagttgggcaggagcagaaacacacctaccttcctctggaggtctgcaacatagtggctggacagaggtgcatcaagaaacttactgacaatcaaacctcaaccatgatcagagcgacggccaggtctgcgcccgaccgccaggaagagatcagcaaactgatgcgaagcgccagtttcaacacagatccctacgtgcgtgaattcggcatcatggtcaaagatgagatgacagacgtgaccgggcgggtcctccagccaccctccatcctctacgggggcaggaacaaggcgattgccacccctgtgcagggtgtctgggacatgcggaacaagcagtttcacacgggcatcgagatcaaggtgtgggccatcgcctgctttgccccccagcgccaatgcactgaagtccacctgaagtccttcacagagcagctgcgcaagatctccagggacgccgggatgcccatccagggccagccgtgtttctgcaagtacgcccagggcgccgacagtgtggagcccatgttccgccacctcaagaacacctacgccggcctgcagctggtcgtggtcatcctgccgggaaagacccctgtctatgctgaagtgaagcgtgtgggtgacaccgtgctggggatggccacgcagtgtgtgcagatgaagaacgtgcagcggaccaccccgcagaccctgtccaacctctgcctgaagatcaacgtcaagctgggaggggtgaacaacatcctgctgccccagggcaggcctccagtcttccagcagccggtcatcttcctgggtgccgacgtcacccacccgcccgctggagacgggaagaagccttcaatcgctgctgtcgtgggcagcatggatgcccaccccaaccgctactgtgccaccgtgcgtgtgcagcagcaccggcaggagatcatccaggacctggcagccatggtgcgcgagctgctcatccagttctacaagtccacgcgcttcaagcccacacgcatcatcttctaccgagacggcgtctccgagggccagttccagcaggtcctgcaccacgagctgctggccatccgagaggcctgcatcaagctggagaaggactaccagccggggatcaccttcatcgtggtccagaaacgccaccacacccgcctcttctgcaccgacaagaacgagcgggtcgggaagagtggaaacatcccagcaggcaccactgtggacacaaagatcacccacccaaccgagtttgatttctacctgtgcagccacgccggcatccagggcacaagccggccctcccactaccacgtcctgtgggacgacaaccggttctcctccgacgagctgcaggtcctcacctaccagctgtgccacacctacgtgcgctgcacgcgctccgtgtccatccctgcgcctgcctactatgcccatctggtggccttccgggccaggtaccacctggtggacaaggagcatgacagtgcggaaggaagccatacctctgggcagagcaacggccgagaccaccaggccctggccaaggccgtgcaggtccaccaggacacgctgcgcaccatgtacttcgcctgacgtgtccgagtgcttgcgacggcataccgagttggattcacacgagaccagctacactcagaccaacagcccagccccccgagacagccagccttggaccatgagacgcccctgcgttcccagactcccacggcccaggaggcctttcgtcccagatttcaaactcggattttgaactgcagacctgtatgagacccccaccccccgcccgccaccttccccccagtgttgtaggaaatagggtttgccaaaatctataagctgcttattaaaaatagaagtccgtgtttcctaaaagaaaaagggaaaaggtagttctcctaaaaccaatcgacaaactcagggctttacaacatttttaatgtatctggtcgttcaagttaacatgtcttttgacccgtggccctccatgaacgcgggtggactccaacgagctgtgaggacccccaagatgagaacaacacagagctcctcctgccccaccctccaccccgtgtcgtcactgcggtgggtgtcacagtgaccctggtggggtcccgggagggcactgtgcccggggtggggggtggggggggtggcgaccgca

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