LOCUS       XM_003830145           11963 bp    mRNA    linear   PRI 11-JUN-2023
DEFINITION  PREDICTED: Pan paniscus NLR family pyrin domain containing 12
            (NLRP12), transcript variant X4, mRNA.
ACCESSION   XM_003830145
VERSION     XM_003830145.4
DBLINK      BioProject: PRJNA950461
KEYWORDS    RefSeq.
SOURCE      Pan paniscus (pygmy chimpanzee)
  ORGANISM  Pan paniscus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Pan.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_073268) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 18, 2023 this sequence version replaced XM_003830145.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_029289425.1-RS_2023_05
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 05/31/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11963
                     /organism="Pan paniscus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9597"
                     /chromosome="19"
                     /sex="male"
                     /cell_line="PR00251"
                     /cell_type="fibroblast"
                     /dev_stage="adult"
     gene            1..11963
                     /gene="NLRP12"
                     /note="NLR family pyrin domain containing 12; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 1 long SRA read, 3 Proteins"
                     /db_xref="GeneID:100976212"
     CDS             191..3205
                     /gene="NLRP12"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 12
                     isoform X4"
                     /protein_id="XP_003830193.2"
                     /db_xref="GeneID:100976212"
                     /translation="

MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGRMEKAGPLEMAQLLITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQAQQQLLDRGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLISGCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDAQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYLRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGIWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGERGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQKEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKHCRSAQVLHLYGATYSADGEDRARCSAGTHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICHLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACKNLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC"

     misc_feature    227..466
                     /gene="NLRP12"
                     /note="Pyrin death domain found in NALP proteins; Region:
                     Pyrin_NALPs; cd08320"
                     /db_xref="CDD:260032"
     misc_feature    575..790
                     /gene="NLRP12"
                     /note="Fish-specific NACHT associated domain; Region:
                     FISNA; pfam14484"
                     /db_xref="CDD:433982"
     misc_feature    824..1333
                     /gene="NLRP12"
                     /note="NACHT domain; Region: NACHT; pfam05729"
                     /db_xref="CDD:428606"
     misc_feature    1565..1726
                     /gene="NLRP12"
                     /note="NOD2 winged helix domain; Region: NOD2_WH;
                     pfam17779"
                     /db_xref="CDD:436037"
     misc_feature    1730..2074
                     /gene="NLRP12"
                     /note="NLRC4 helical domain HD2; Region: NLRC4_HD2;
                     pfam17776"
                     /db_xref="CDD:436035"
     misc_feature    2303..3124
                     /gene="NLRP12"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; Region:
                     LRR_RI; cd00116"
                     /db_xref="CDD:238064"
     misc_feature    order(2333..2335,2342..2344,2348..2350,2357..2359,
                     2363..2365,2420..2422,2429..2431,2435..2437,2444..2446,
                     2450..2452,2504..2506,2513..2515,2519..2521,2528..2530,
                     2534..2536,2591..2593,2600..2602,2606..2608,2615..2617,
                     2621..2623,2675..2677,2684..2686,2690..2692,2699..2701,
                     2705..2707,2762..2764,2771..2773,2777..2779,2786..2788,
                     2792..2794,2846..2848,2855..2857,2861..2863,2870..2872,
                     2876..2878,2933..2935,2942..2944,2948..2950,2957..2959,
                     2963..2965,3017..3019,3026..3028,3032..3034,3041..3043,
                     3047..3049,3104..3106,3113..3115,3119..3121)
                     /gene="NLRP12"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     misc_feature    2333..2419
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2420..2503
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    order(2441..2443,2612..2614,2696..2698,2867..2869,
                     2945..2947,2951..2953,3029..3031,3116..3118)
                     /gene="NLRP12"
                     /note="Substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238064"
     misc_feature    2504..2590
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2591..2674
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2675..2761
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2762..2845
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2846..2932
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2933..3016
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      

tgaagagtgagaaagcattatttcagcaaaaggtctttcctccctcgctcactcctccaaccactggctcagcctctccgcccgctgcctgtgaatgatgcaatggaaggtatgctggggtcgccctgtgtcccgtgcatagaagcatctcagcctccaggtcctctcctttggggctcacggcacccccatgctacgaaccgcaggcagggacggcctctgtcgcctgtccacctacttggaagaactcgaggctgtggaactgaagaagttcaagttatacctggggaccgcgacagagctgggagaaggcaagatcccctggggacgcatggagaaggccggtcccctggaaatggcccagctgcttatcacccacttcgggccagaggaggcctggaggttggctctcagcacctttgagcggataaacaggaaggacctgtgggagagaggacagagagaggacctggtgagggataccccacctggtggcccgtcctcacttgggaaccagtcaacatgccttctggaagtctctcttgtcactccaaggaaagatccccaggaaacctacagggactatgtccgcaggaaattccggctcatggaagaccgcaatgcgcgcctaggggaatgtgtcaacctcagccaccggtacacccggctcctgctggtgaaggagcactcaaaccccatgcaggcccagcagcagcttctggacagaggccggggacacgcgaggaccgtgggacaccaggctagccccatcaagatagagaccctctttgagccagacgaggagcgccccgagccaccgcgcaccgtggtcatgcaaggcgcggcagggataggcaagtccatgctggcacacaaggtgatgctggactgggcggacgggaagctcttccaaggcagatttgattatctcttctacatcaactgcagggagatgaaccagagtgccacggaatgcagcatgcaagacctcatctccggctgctggcccgagcccagcgcgcctctccaggagctcatccgagttcccgagcgcctccttttcatcatcgacggcttcgatgagctcaagccttctttccacgatgctcagggaccctggtgcctctgctgggaggagaaacggcccacggagctgcttcttaacagcttaattcggaagaagctgctccctgagctatctttgctcatcaccacacggcccacggctttggagaagctccaccgtctgctggagcaccccaggcatgtggagatcctgggcttctctgaggcagaaaggaaggaatacttctacaagtatttccacaatgcagagcaggcgggccaagtcttcaattacctgagggacaacgagcctctcttcaccatgtgcttcgtccccctggtgtgctgggtggtgtgtacctgcctccagcagcagctggagggtggggggctgttgagacagacgtccaggaccaccactgcggtgtacatgctctacctgctgagtctgatgcaacccaagcccggggccccgcgcctccagcccccacccaaccagagagggttgtgctccttggcggcagatgggatctggaatcagaaaatcctatttgaggagcaggacctccggaagcacggcctagacggggaagacgtctctgccttcctcaacatgaacatcttccagaaggacatcaactgtgagaggtactacagcttcatccacttgagtttccaggaattctttgcagctatgtactatatcctggacgagggggagcgcggggcaggcccagaccaggacgtgaccaggctgttgaccgagtacgcgttttctgaaaggagcttcctggcactcaccagccgcttcctgtttggactcctgaacgaggagaccaggagccacctggagaagagtctctgctggaaggtctcgccgcacatcaagatggacctgttgcagtggatccaaagcaaagctcagagcgacggctccaccctgcagcagggctccttggagttcttcagctgcttgtacgagatccagaaggaggagtttatccagcaggccctgagccacttccaggtgatcgtggtcagcaacattgcctccaagatggagcacatggtctcctcgttctgtctgaagcactgcaggagcgcccaggtgctgcacttgtatggcgccacctacagcgcggacggggaagaccgcgcgaggtgctccgcaggaacgcacacgctgttggtgcagctaccagagaggactgttctgctggacgcctacagtgaacatctggcagcggccctgtgcaccaatccaaacctgatagagctgtctctgtaccgaaatgccctgggcagccggggggtgaagctgctctgtcaaggactcagacaccccaactgcaaacttcagaacctgaggctgaagaggtgccgcatctccagctcagcctgcgaggacctctctgcagctctcatagccaataagaatttgacaaggatggatctcagtggcaacggcgttggattcccaggcatgatgctgctttgtgagggcctgcggcatccccagtgcaggctgcagatgattcagttgaggaagtgtcagctggagtccggggcttgtcaggagatggcttctgtgctcggcaccaacccacatctggttgagttggacctgacaggaaatgcactggaggatttgggcctgaggttactatgccagggactgaggcacccagtctgcagactacggactttgtggctgaagatctgccacctcactgctgctgcctgtgacgagctggcctcaactctcagtgtgaaccagagcctgagagagctggacctgagcctgaatgagctgggggacctcggggtgctgctgctgtgtgagggcctcaggcatcccacgtgcaagctccagaccctccggctggatagctgtggcctcacagccaaggcttgtaagaatctttacttcaccctggggatcaaccagaccttgaccgacctttacctgacgaacaacgccctaggggacacaggcgtccgactgctttgcaagcggctgagccatcctggctgcaaactccgagtcctctggttatttgggatggacctgaataaaatgacccacagtaggttggcagcgcttcgagtaacaaaaccttatttggacattggctgctgaatggtcctatctgctggctctcccctgagatctggacagaggaagatgggagggtgctcatcacccccacagcataatgatcagcctccttcctagagacagactcatgcagattgagatcaaaagtccctctgcttgggatcaaattaatgtttgacagagctggccaggcgtggtggctcatgtatgtaatcccagcacttcgagaggccgaggcaggtggatcacgaggtcaggagtttgagatcagcctggccaagatggtgaaaccctgtctccactaaaaataaaaaaaaattcgccacgcatggtggtgggcacctgtagtcccagctactcaggaggctgagacaggagaatcgcttgaacccgggaggtggaggttgcagtgagccgagatcgcgccactgcactccagcctgggcgacagagtgggactccatctcaaaaaaaaaaaaaaagtttgacggagttttaagggatgaccaactaagagaggtttgatggcccctaacaggaggggtaaagcccaacaggggccaggtgcggtgtctcacgcctgtaacccccgtactttcgaaggtggaggcaagatgggttgcttaagtctaggagttagagaccagcctaagcaacatagcaagactccactattactaattagccaactactattaattagtacaattaattacccaggagtagcagcacatgcctgtagtcccagctactctggggactgaggtgggaagatcgcttgagcccaggaggtcgaggctgcagtgagctgtcattgcaccactgcgccccagcctgggcaacagagggagacggtgaaaaatggccagtaggggccctcagaggccacccagccctgccaagccctggctacatcaggacatagtaatatttgagctctggggtgggtgccactgccatctagtggacgacactaggaatacgtgccaacatccagcaaggaatgcacaggacaaagcacttggtccaaaggcaaattgtgccaagttgaggaaagcctgttctcaaatatcacaggatacatggggcactcagcatttgggaagagactggtatgcaagctaaccctcagaatgcttgttatgccaacagccctgatcctcccttgctggaggggataatgcctgaaatcttaacgtggcaggcatgtcaggatggccccctgcctggaattcactgggccctgccaagaactgacacctacaaggccacgtgtaggctggccataacctattatacactgtgctttcaacaaaaatacagagcctgccaggtgcggtggctcacgcctgtaatccaaatactttcggaggcggaggcaggcagatcagctaagatcaggagttcgagaccagcctggccaacatggtgaaacctactaaaaatacaaaaattaggctgggcacggtggctcatgcctgtaatcccagcactttgggaggccgaggcaggcggatcactaggtcaagagatcaataccatcctgactaacacggtgaaaccccatctctactaaaaacacaaaaaattagctgggtgtggtggcatgcacctatagtcccagctgctggggaggctgaggcaggagaatcacttgaacctgggagacagaggttgcagtgagccgagataacgccattgcactccagcctgggtgacagagtgagatgccatctcaaaaaaaaaaaaaaaaaggaatccacattcccttggctgggtgcagaggctcacgcttgtaatcccagcactttgggag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