LOCUS       NR_107020                 75 bp    RNA     linear   PRI 08-SEP-2020
DEFINITION  Homo sapiens microRNA 8053 (MIR8053), microRNA.
ACCESSION   NR_107020
VERSION     NR_107020.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 75)
  AUTHORS   Wang HJ, Zhang PJ, Chen WJ, Jie D, Dan F, Jia YH and Xie LX.
  TITLE     Characterization and Identification of novel serum microRNAs in
            sepsis patients with different outcomes
  JOURNAL   Shock 39 (6), 480-487 (2013)
   PUBMED   23612084
REFERENCE   2  (bases 1 to 75)
  AUTHORS   Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright
            AJ.
  TITLE     miRBase: microRNA sequences, targets and gene nomenclature
  JOURNAL   Nucleic Acids Res. 34 (Database issue), D140-D144 (2006)
   PUBMED   16381832
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with miRBase. The reference
            sequence was derived from AC092597.1.
            
            Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs
            that are involved in post-transcriptional regulation of gene
            expression in multicellular organisms by affecting both the
            stability and translation of mRNAs. miRNAs are transcribed by RNA
            polymerase II as part of capped and polyadenylated primary
            transcripts (pri-miRNAs) that can be either protein-coding or
            non-coding. The primary transcript is cleaved by the Drosha
            ribonuclease III enzyme to produce an approximately 70-nt stem-loop
            precursor miRNA (pre-miRNA), which is further cleaved by the
            cytoplasmic Dicer ribonuclease to generate the mature miRNA and
            antisense miRNA star (miRNA*) products. The mature miRNA is
            incorporated into a RNA-induced silencing complex (RISC), which
            recognizes target mRNAs through imperfect base pairing with the
            miRNA and most commonly results in translational inhibition or
            destabilization of the target mRNA. The RefSeq represents the
            predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
            
            Sequence Note: This record represents a predicted microRNA
            stem-loop as defined by miRBase. Some sequence at the 5' and 3'
            ends may not be included in the intermediate precursor miRNA
            produced by Drosha cleavage.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC092597.1         82669-82743         c
FEATURES             Location/Qualifiers
     source          1..75
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p12"
     gene            1..75
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /note="microRNA 8053"
                     /db_xref="GeneID:102467004"
                     /db_xref="HGNC:HGNC:50137"
                     /db_xref="miRBase:MI0025889"
     precursor_RNA   1..75
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /product="microRNA 8053"
                     /db_xref="GeneID:102467004"
                     /db_xref="HGNC:HGNC:50137"
                     /db_xref="miRBase:MI0025889"
     exon            1..75
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /inference="alignment:Splign:2.1.0"
     variation       6
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:967889970"
     ncRNA           11..34
                     /ncRNA_class="miRNA"
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /product="hsa-miR-8053"
                     /db_xref="miRBase:MIMAT0030980"
                     /db_xref="GeneID:102467004"
                     /db_xref="HGNC:HGNC:50137"
                     /db_xref="miRBase:MI0025889"
     variation       14
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1452400649"
     variation       15
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1723787350"
     variation       21
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1577785615"
     variation       22
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376257390"
     variation       24
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1723787922"
     variation       28
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1723788038"
     variation       30
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1010013836"
     variation       35
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:1723788427"
     variation       36
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1723788627"
     variation       39
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1723788809"
     variation       42
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1444597074"
     variation       43
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1162267583"
     variation       44
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1454106978"
     variation       46..47
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="aa"
                     /db_xref="dbSNP:1402531447"
     variation       47
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1287892947"
     variation       50
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1392545819"
     variation       51
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1577785653"
     variation       54
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2475294164"
     variation       54
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="t"
                     /replace="ttgt"
                     /db_xref="dbSNP:1462105553"
     variation       55
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2109641387"
     variation       56
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="t"
                     /replace="taccatttttctctt"
                     /db_xref="dbSNP:1166808724"
     variation       57
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1723790352"
     variation       58
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1365273809"
     variation       62
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1723790731"
     variation       64
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377511159"
     variation       65
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1033090563"
     variation       69
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2475294200"
     variation       71
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1723791330"
     variation       72
                     /gene="MIR8053"
                     /gene_synonym="hsa-mir-8053"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1723791531"
ORIGIN      

gcttttccactggcgattttggaactcaatggcagaaatgtcaagaagagttttatcctttgccgaaagagaaaa

//