LOCUS       NM_177931               2560 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus origin recognition complex, subunit 1 (Orc1),
            mRNA.
ACCESSION   NM_177931
VERSION     NM_177931.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2560)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   2  (bases 1 to 2560)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 2560)
  AUTHORS   Bartke,T., Vermeulen,M., Xhemalce,B., Robson,S.C., Mann,M. and
            Kouzarides,T.
  TITLE     Nucleosome-interacting proteins regulated by DNA and histone
            methylation
  JOURNAL   Cell 143 (3), 470-484 (2010)
   PUBMED   21029866
REFERENCE   4  (bases 1 to 2560)
  AUTHORS   Shen,Z., Sathyan,K.M., Geng,Y., Zheng,R., Chakraborty,A.,
            Freeman,B., Wang,F., Prasanth,K.V. and Prasanth,S.G.
  TITLE     A WD-repeat protein stabilizes ORC binding to chromatin
  JOURNAL   Mol Cell 40 (1), 99-111 (2010)
   PUBMED   20932478
REFERENCE   5  (bases 1 to 2560)
  AUTHORS   Shu,M.Q., Qin,Y.L. and Jiang,M.H.
  TITLE     RNA interference targeting ORC1 gene suppresses the proliferation
            of vascular smooth muscle cells in rats
  JOURNAL   Exp Mol Pathol 84 (3), 206-212 (2008)
   PUBMED   18499104
  REMARK    GeneRIF: ORC1 gene silencing causes rat VSMCs to enter a reversible
            G(0) quiescent, growth arrested state; thus, ORC1 gene may be an
            important new target for suppressing VSMCs proliferation.
REFERENCE   6  (bases 1 to 2560)
  AUTHORS   Siddiqui,K. and Stillman,B.
  TITLE     ATP-dependent assembly of the human origin recognition complex
  JOURNAL   J Biol Chem 282 (44), 32370-32383 (2007)
   PUBMED   17716973
REFERENCE   7  (bases 1 to 2560)
  AUTHORS   Minami,H., Takahashi,J., Suto,A., Saitoh,Y. and Tsutsumi,K.
  TITLE     Binding of AlF-C, an Orc1-binding transcriptional regulator,
            enhances replicator activity of the rat aldolase B origin
  JOURNAL   Mol Cell Biol 26 (23), 8770-8780 (2006)
   PUBMED   16982680
REFERENCE   8  (bases 1 to 2560)
  AUTHORS   Miyake,Y., Mizuno,T., Yanagi,K. and Hanaoka,F.
  TITLE     Novel splicing variant of mouse Orc1 is deficient in nuclear
            translocation and resistant for proteasome-mediated degradation
  JOURNAL   J Biol Chem 280 (13), 12643-12652 (2005)
   PUBMED   15634681
REFERENCE   9  (bases 1 to 2560)
  AUTHORS   Natale,D.A., Li,C.J., Sun,W.H. and DePamphilis,M.L.
  TITLE     Selective instability of Orc1 protein accounts for the absence of
            functional origin recognition complexes during the M-G(1)
            transition in mammals
  JOURNAL   EMBO J 19 (11), 2728-2738 (2000)
   PUBMED   10835370
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB105378.1.
            
            On Jun 3, 2003 this sequence version replaced NM_177931.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB105378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132296, SAMD00132297
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2560
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="origin recognition complex, subunit 1"
                     /db_xref="GeneID:313479"
                     /db_xref="RGD:631435"
     CDS             1..2547
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /codon_start=1
                     /product="origin recognition complex subunit 1"
                     /protein_id="NP_808792.1"
                     /db_xref="GeneID:313479"
                     /db_xref="RGD:631435"
                     /translation="

MPSYVTRQKTRQTFSWVGRPLPNRKQFYQMYKEICMKINGCSEIHIKVGQFVLIQGEDNQKPYVAKLIELFENGSEVPPKKYARVQWFVRFCEIPIPKRHLLGRRPSAQEIFWYDCSDCDNDIHVETIIGPVQVVALAPEDEIPVNQKSEETLFVKLSWNKKNFAPLPPEELAALRRLECQKPLEAKTKSVKSPSWSTAEQEVKRIESSHSTSRSYQDPAHTVTPNAMKSLECGGFTRKPNMRLSRKILCDSLDSQKTCKRRAAFSETTSPPKKPQPGEIKTSSALETLGKNGHTQPFFAKSSMVLRTRGTAVKTTKLTVESALSPVRSRSRYSVAPSVGLTPQYIGRKAKEQETHKEPIHTSLRARRRSSLLTLKRIKQQLWLLDDDKSDQEEEESISSVEVSDSSSEEEDESVPSPPTGKPVGQSRTRRTASKPSSQTPSKSPKKTFRPRPPLHATPQIRDRNLAVQEPASVLEEARLRLHVSAVPDSLPCREQEFQDIYSFVESKLLDGTGGCMYISGVPGTGKTATVHEVIRCLQQAAQTNDVPPFEYVEVNGMKLTEPHQVYVQILQKLTGQKATANHAAELLAKQFCSRGSQKETTVLLVDELDLLWTHKQDVLYNLFDWPTHKGARLVVLTIANTMDLPERIMMNRVASRLGLTRMSFQPYSHSQLKQILVSRLKHLKAFEDDAVQLVARKVAALSGDARRCLDICRRATEICEVSHQRGDSQCLVTVAHLMEAIDEMFSSSYITAIKNSSVLEQSFLRAIIAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSRLGSCRILLVEPSRNDLLLRVRLNVSQNDVLYALKEE"

     misc_feature    127..507
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1
                     is part of the Yeast Sir1-origin recognition complex. The
                     Orc1p BAH doman functions in epigenetic silencing. In
                     vertebrates, a similar ORC...; Region: BAH_Orc1p_animal;
                     cd04719"
                     /db_xref="CDD:240070"
     misc_feature    277..279
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="Histone H4K20me2 binding.
                     /evidence=ECO:0000250|UniProtKB:Q9Z1N2; propagated from
                     UniProtKB/Swiss-Prot (Q80Z32.1); other site"
     misc_feature    565..681
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z32.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    577..579
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13415; propagated from
                     UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site"
     misc_feature    754..756
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z1N2; propagated from
                     UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site"
     misc_feature    781..840
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z32.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    808..810
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13415; propagated from
                     UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site"
     misc_feature    850..852
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13415; propagated from
                     UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site"
     misc_feature    940..942
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q13415; propagated from
                     UniProtKB/Swiss-Prot (Q80Z32.1); acetylation site"
     misc_feature    973..975
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z1N2; propagated from
                     UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site"
     misc_feature    1030..1095
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z32.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1162..1398
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z32.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1210..1212
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13415; propagated from
                     UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site"
     misc_feature    1219..1221
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13415; propagated from
                     UniProtKB/Swiss-Prot (Q80Z32.1); phosphorylation site"
     misc_feature    1276..>1608
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="Predicted ATPase [General function prediction
                     only]; Region: COG3899"
                     /db_xref="CDD:443106"
     misc_feature    <1444..2319
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="origin recognition complex 1 protein; Provisional;
                     Region: PTZ00112"
                     /db_xref="CDD:240274"
     misc_feature    1462..2544
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80Z32.1);
                     Region: Necessary and sufficient for ORC complex assembly.
                     /evidence=ECO:0000250"
     misc_feature    2293..2532
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /note="CDC6, C terminal winged helix domain; Region:
                     Cdc6_C; pfam09079"
                     /db_xref="CDD:462672"
     exon            1..95
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            96..220
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            221..399
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            400..703
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1043
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1148
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1344
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1442
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1544
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1716
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1824
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1974
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2094
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2264
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2352
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2560
                     /gene="Orc1"
                     /gene_synonym="Orc1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgccgtcctatgtcacaaggcagaagaccagacaaactttctcatgggttggcaggccattgccgaatcgaaaacagttctaccaaatgtacaaagaaatttgtatgaaaatcaatggttgttctgagattcacatcaaggttggacagtttgtattgattcaaggggaagataatcaaaagccctatgttgctaaactgattgaattatttgaaaatgggtctgaagttcctcccaagaaatatgcgcgagtacaatggtttgtccgattctgtgagattcctatccctaaaaggcatttgttaggacggagaccttctgcacaggagatattctggtatgactgttctgactgtgataacgacattcatgtggagaccatcattggccctgttcaggtagtggcattagccccagaagacgagatccctgtgaatcagaaaagtgaggagacactgtttgtgaagctgtcctggaataaaaagaactttgcgccactgccaccagaagaacttgcagcattgaggagactggagtgccaaaaacctttagaagccaagactaagagtgttaaaagcccttcctggagcacagcagaacaagaggtcaaaaggattgaatcaagtcattccacttccagatcttaccaggatcctgctcatactgtcactcccaacgcaatgaagtctctggaatgtggtggttttaccaggaagcctaacatgaggctgtcacggaagatcttgtgtgattccttggattctcaaaaaacatgtaaacgaagagcagccttctctgagaccacctcaccacctaaaaagcctcaacctggtgaaatcaagacctcctcagctttggaaactctaggaaaaaatgggcatactcaacccttttttgccaaaagtagcatggttctgagaacccggggcacagctgtgaagaccacaaagcttactgtggagagtgcacttagccctgtcaggagcaggtcgaggtactcagtggcaccctctgtgggtctgacacctcaatacattgggaggaaggcaaaagaacaagaaactcacaaagaacccatccatacttctcttcgtgcccgtagaaggagttctctcttgactttgaagcggattaagcaacagctttggcttctagatgatgataaaagtgaccaagaagaggaagagtccatatcctctgtggaagtgtcagactccagtagtgaggaggaagatgagtctgttccctcccctccaacaggaaaacccgtggggcagtccaggacccggagaactgcctctaagccatcatcacagaccccctccaagtcaccaaagaaaacttttagacctagaccacctcttcatgctactcctcagatccgagacagaaacttggctgtccaagagccagctagtgtgcttgaagaggcccggctcaggctgcatgtttctgccgtgcctgactctcttccctgtcgagagcaggagttccaagacatctacagctttgtggaaagtaaacttcttgatggaaccggagggtgtatgtacatttctggggtccctgggacagggaagacagccactgtgcatgaagtcatacgctgtctgcagcaggcagcacaaacaaatgatgttcctccctttgaatacgttgaggttaatgggatgaagctgacagaaccccaccaggtctatgtgcagattttacagaaactgacaggccagaaggcaacagctaatcatgcagcagaactgctggcaaagcaattctgcagccgagggtcccagaaggaaaccactgtgctgcttgtggatgagcttgaccttctttggactcacaaacaagatgtgttgtacaacctctttgattggcctactcacaaaggagcccggttggtcgtgttgactattgccaataccatggaccttccagagaggatcatgatgaaccgtgtggctagccgcctgggcctcaccaggatgtctttccaaccctactctcacagccaactgaaacaaatcttagtgtcccgactgaagcatttaaaggcctttgaggatgatgccgtccagttggtagccagaaaggtagcagccctttctggagatgcccggcgctgcctggacatctgcaggcgtgccacagagatctgcgaggtttcccatcagcgtggtgactctcagtgcctggtgactgtggcccacttaatggaagctatagatgaaatgttttcctcatcctatattactgccatcaaaaactcttctgtcctggaacagagcttcctgagagccatcattgcggaattccgtcgatcaggactggaggaagctacatttcaacagatatacagtcagcatgtggctctgtgcagaatggagggactgccttacccaaccatgtcagagaccatggccgtgtgctcgcgtctgggttcttgccgcattcttctggtggagcctagcaggaatgacctactccttcgagtgagactcaatgttagccagaatgatgtgctgtatgctctcaaagaagagtgaaggacttaacaaa

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