LOCUS       NM_174798               1895 bp    mRNA    linear   MAM 18-DEC-2022
DEFINITION  Bos taurus msh homeobox 1 (MSX1), mRNA.
ACCESSION   NM_174798
VERSION     NM_174798.2
KEYWORDS    RefSeq.
SOURCE      Bos taurus (cattle)
  ORGANISM  Bos taurus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
REFERENCE   1  (bases 1 to 1895)
  AUTHORS   Tesfaye D, Regassa A, Rings F, Ghanem N, Phatsara C, Tholen E,
            Herwig R, Un C, Schellander K and Hoelker M.
  TITLE     Suppression of the transcription factor MSX1 gene delays bovine
            preimplantation embryo development in vitro
  JOURNAL   Reproduction 139 (5), 857-870 (2010)
   PUBMED   20176746
  REMARK    GeneRIF: Suppression of MSX1 affects oocyte maturation, embryo
            cleavage rate, and expression of numerous genes suggesting
            important role for MSX1 in embryo development.
REFERENCE   2  (bases 1 to 1895)
  AUTHORS   Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D,
            Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G,
            Roberts M, Subramanian P, Yorke JA and Salzberg SL.
  TITLE     A whole-genome assembly of the domestic cow, Bos taurus
  JOURNAL   Genome Biol 10 (4), R42 (2009)
   PUBMED   19393038
REFERENCE   3  (bases 1 to 1895)
  AUTHORS   Ishiwata H, Katsuma S, Kizaki K, Patel OV, Nakano H, Takahashi T,
            Imai K, Hirasawa A, Shiojima S, Ikawa H, Suzuki Y, Tsujimoto G,
            Izaike Y, Todoroki J and Hashizume K.
  TITLE     Characterization of gene expression profiles in early bovine
            pregnancy using a custom cDNA microarray
  JOURNAL   Mol Reprod Dev 65 (1), 9-18 (2003)
   PUBMED   12658628
REFERENCE   4  (bases 1 to 1895)
  AUTHORS   Iimura T, Oida S, Takeda K, Maruoka Y, Shimokawa H, Ibaraki K and
            Sasaki S.
  TITLE     Molecular cloning and sequence of bovine Msx-1 homeobox-containing
            gene cDNA from a bovine odontoblast library
  JOURNAL   DNA Seq 5 (4), 233-237 (1995)
   PUBMED   7626784
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D30750.1.
            
            On Jun 3, 2003 this sequence version replaced NM_174798.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D30750.1, BC120208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03145413, SAMN03145415
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1895
                     /organism="Bos taurus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9913"
                     /chromosome="6"
                     /map="6"
     gene            1..1895
                     /gene="MSX1"
                     /note="msh homeobox 1"
                     /db_xref="BGD:BT23698"
                     /db_xref="GeneID:286872"
                     /db_xref="VGNC:VGNC:31711"
     misc_feature    7..9
                     /gene="MSX1"
                     /note="upstream in-frame stop codon"
     misc_feature    223..225
                     /gene="MSX1"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     MAPAAD"
     CDS             241..1134
                     /gene="MSX1"
                     /note="msh homeobox 1-like protein; msh homeo box homolog
                     1"
                     /codon_start=1
                     /product="homeobox protein MSX-1"
                     /protein_id="NP_777223.1"
                     /db_xref="BGD:BT23698"
                     /db_xref="GeneID:286872"
                     /db_xref="VGNC:VGNC:31711"
                     /translation="

MTSLPLGVKVEDPPFGKPAGGGGGQTPSTTAATAAAMGADAEGAKPKVSPSLLPFSVEALMADHRKPGAKKSVLAASEGAQAAGGSAKPLGARPGSLAAPDAPSSPRPLGHFSVGGLLKLPEDALVKAESPEKPERTPWMQNPRFSPPPSRRLSPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPATFGLSFPLGGPAAVAAPAGASLYGASGPFQRAALPVAPVGLYTAHVGYSMYHLT"

     misc_feature    order(739..753,757..759,808..810,826..828,865..867,
                     871..876,883..888,892..900,904..909)
                     /gene="MSX1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    745..906
                     /gene="MSX1"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(745..747,754..756,874..876,883..888,895..897)
                     /gene="MSX1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
ORIGIN      

agctggtgagcccgagaactccgcctgcgcggcggcggccagcggataaccaggcccggagcgccggagctggccttctgggaaggggcgggaggcgcgcgcggtagagcccgcccggccaggccccggacgctccaagaggccgaccgcgctcccagcacgcccgaagctcatgcccggcggctggccggagctgcggctggaggggtggcccggctctgcatggccccggctgctgacatgacttctttgccactcggtgtcaaagtggaggaccctcccttcggcaagccggcggggggcggcggaggccagacccccagcaccaccgcggccacggcggccgctatgggcgcagacgcggagggggccaagcccaaagtgtccccttcgctcctgcccttcagcgtggaggcgctcatggccgatcacaggaagcccggggcgaagaaaagcgtcctggcggcctcggagggcgcacaggcggcgggtggctccgcgaagcctctaggtgcccgaccgggctcgttggccgccccggatgcgccgtcctcgccgcgaccgctcggccatttctcggtgggaggactcctcaaactgccagaagatgcgctcgtcaaagccgagagccccgagaaacccgagaggaccccgtggatgcagaatccccgcttctccccgcccccgtccaggcggctgagccctccggcctgcaccctgcgcaagcacaagaccaaccgcaagccgcggacgcccttcaccaccgcccagctgctggcgctggagcgcaagttccgccagaagcagtacctgtccatcgccgagcgcgccgagttctccagttcgctcagcctcaccgagacgcaggtgaagatctggtttcagaaccgccgcgccaaggccaagagactgcaggaggccgagctggagaagctgaagatggccgctaaacccatgttgcccccggcaaccttcggcctctccttcccactgggaggccctgccgccgtagcagcccccgcgggcgcctcgctctacggcgcctctggccctttccagcgcgccgcgctgcccgtggcgcccgtgggactctacacagcccacgtgggctacagcatgtaccacctgacatagaaggcccaggttgcctacctagggtgcaagccgatccctccagaaagcaacaggagccttcccacgaggtgctcccttgttcagcaccgcctggcaccttctctttaacgcccacactgctctggtttgtcctccgttgctaccggagtaaactctctgaagtctgattccctcccccaaagtggctgggagggccccatgacgctcttctagaagctagatctatcccttcgagttacagatgggggaactgaggacagagaggtttccaaaggtatccacagtccccagcagagttagtggttggaccagatctagaggccgtgcctcctgcgtggctgcctcctgtccttacacctggcaggaaaaagcacagagaaaattcatgtttgaagattttggaaatgagaacagttggggagaaagagaagaactttgcaggagaggcagatcctgggtcttgccaacagaaaactttaaaagaccttcaacagtaaaacatttgcttttttttggggggggggtagtgatacacagatgcgtgacaaaggtaggttgaagggacctctctcttaccagtaccagaaagaaattgtaaaataaaataaaaattaaaatcttctgtttctatttaacagtacatgtgggtggctctcaagattccctttggaaggggattgttgtaatatactgtatatttgaaattttattatcatttatattatagctatatttgttaaataaattctcgtgccgaattc

//