LOCUS       NM_145880               3390 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus LIM homeobox 1 (Lhx1), mRNA.
ACCESSION   NM_145880
VERSION     NM_145880.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3390)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   2  (bases 1 to 3390)
  AUTHORS   Boualia,S.K., Gaitan,Y., Murawski,I., Nadon,R., Gupta,I.R. and
            Bouchard,M.
  TITLE     Vesicoureteral reflux and other urinary tract malformations in mice
            compound heterozygous for Pax2 and Emx2
  JOURNAL   PLoS One 6 (6), e21529 (2011)
   PUBMED   21731775
REFERENCE   3  (bases 1 to 3390)
  AUTHORS   Palmesino,E., Rousso,D.L., Kao,T.J., Klar,A., Laufer,E., Uemura,O.,
            Okamoto,H., Novitch,B.G. and Kania,A.
  TITLE     Foxp1 and lhx1 coordinate motor neuron migration with axon
            trajectory choice by gating Reelin signalling
  JOURNAL   PLoS Biol 8 (8), e1000446 (2010)
   PUBMED   20711475
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3390)
  AUTHORS   Poche,R.A., Kwan,K.M., Raven,M.A., Furuta,Y., Reese,B.E. and
            Behringer,R.R.
  TITLE     Lim1 is essential for the correct laminar positioning of retinal
            horizontal cells
  JOURNAL   J Neurosci 27 (51), 14099-14107 (2007)
   PUBMED   18094249
REFERENCE   5  (bases 1 to 3390)
  AUTHORS   Kittappa,R., Chang,W.W., Awatramani,R.B. and McKay,R.D.
  TITLE     The foxa2 gene controls the birth and spontaneous degeneration of
            dopamine neurons in old age
  JOURNAL   PLoS Biol 5 (12), e325 (2007)
   PUBMED   18076286
REFERENCE   6  (bases 1 to 3390)
  AUTHORS   Shimono,A. and Behringer,R.R.
  TITLE     Isolation of novel cDNAs by subtractions between the anterior
            mesendoderm of single mouse gastrula stage embryos
  JOURNAL   Dev Biol 209 (2), 369-380 (1999)
   PUBMED   10328927
REFERENCE   7  (bases 1 to 3390)
  AUTHORS   Karavanov,A.A., Karavanova,I., Perantoni,A. and Dawid,I.B.
  TITLE     Expression pattern of the rat Lim-1 homeobox gene suggests a dual
            role during kidney development
  JOURNAL   Int J Dev Biol 42 (1), 61-66 (1998)
   PUBMED   9496787
REFERENCE   8  (bases 1 to 3390)
  AUTHORS   Karavanov,A.A., Saint-Jeannet,J.P., Karavanova,I., Taira,M. and
            Dawid,I.B.
  TITLE     The LIM homeodomain protein Lim-1 is widely expressed in neural,
            neural crest and mesoderm derivatives in vertebrate development
  JOURNAL   Int J Dev Biol 40 (2), 453-461 (1996)
   PUBMED   8793615
REFERENCE   9  (bases 1 to 3390)
  AUTHORS   Richman,D.D. and Bozzette,S.A.
  TITLE     The impact of the syncytium-inducing phenotype of human
            immunodeficiency virus on disease progression
  JOURNAL   J Infect Dis 169 (5), 968-974 (1994)
   PUBMED   7909549
REFERENCE   10 (bases 1 to 3390)
  AUTHORS   Furuyama,T., Inagaki,S., Iwahashi,Y. and Takagi,H.
  TITLE     Distribution of Rlim, an LIM homeodomain gene, in the rat brain
  JOURNAL   Neurosci Lett 170 (2), 266-268 (1994)
   PUBMED   7914684
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 25, 2020 this sequence version replaced NM_145880.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.62734.1,
                                           SRR26643287.25162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-770               JAXUCZ010000010.1  69900307-69901076   c
            771-997             JAXUCZ010000010.1  69898406-69898632   c
            998-1275            JAXUCZ010000010.1  69898037-69898314   c
            1276-1441           JAXUCZ010000010.1  69896583-69896748   c
            1442-3390           JAXUCZ010000010.1  69894288-69896236   c
FEATURES             Location/Qualifiers
     source          1..3390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..3390
                     /gene="Lhx1"
                     /note="LIM homeobox 1"
                     /db_xref="GeneID:257634"
                     /db_xref="RGD:71074"
     exon            1..770
                     /gene="Lhx1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    556..558
                     /gene="Lhx1"
                     /note="upstream in-frame stop codon"
     CDS             601..1821
                     /gene="Lhx1"
                     /note="LIM homeobox protein 1; rlim; homeobox protein
                     Lim-1"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx1"
                     /protein_id="NP_665887.3"
                     /db_xref="GeneID:257634"
                     /db_xref="RGD:71074"
                     /translation="

MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEGGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLDHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLSVNGGASYGNHLSHPPEMNEAAVW"

     misc_feature    610..765
                     /gene="Lhx1"
                     /note="The first LIM domain of Lhx1 (also known as Lim1)
                     and Lhx5; Region: LIM1_Lhx1_Lhx5; cd09367"
                     /db_xref="CDD:188753"
     misc_feature    order(610..612,619..621,673..675,682..684,691..693,
                     700..702,751..753,760..762)
                     /gene="Lhx1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188753"
     misc_feature    787..954
                     /gene="Lhx1"
                     /note="The second LIM domain of Lhx1 (also known as Lim1)
                     and Lhx5; Region: LIM2_Lhx1_Lhx5; cd09375"
                     /db_xref="CDD:188761"
     misc_feature    order(787..789,796..798,853..855,862..864,871..873,
                     880..882,940..942,949..951)
                     /gene="Lhx1"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188761"
     misc_feature    982..1167
                     /gene="Lhx1"
                     /note="propagated from UniProtKB/Swiss-Prot (P63007.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1084..1086
                     /gene="Lhx1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P63007.1); phosphorylation site"
     misc_feature    1141..1311
                     /gene="Lhx1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    <1387..>1746
                     /gene="Lhx1"
                     /note="chromosomal replication initiator protein DnaA;
                     Region: dnaA; cl42516"
                     /db_xref="CDD:455861"
     misc_feature    1480..1716
                     /gene="Lhx1"
                     /note="propagated from UniProtKB/Swiss-Prot (P63007.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            771..997
                     /gene="Lhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1275
                     /gene="Lhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1441
                     /gene="Lhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..3390
                     /gene="Lhx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccctcccaggcccagcgcgggtgcccagagcgtcccgactcgcttcaagaagccggcaatgtaggatccaaagcttttctactcccgtgttttctttccgtgttttttttaagggggaaaccgggtggtgggcagtctgacacgcacacaacctgccttcatactctgacaaaagcagatgcactttgacttctgacagctctacctcaagctggagagaacccagctttcccgaatcctgagctctttgcgtcttccttttcgtctgtttccattttatttatttacgtcccgccgcctctctgggtgaccttcactccttcgcgggctttgggcagaagagccgctttcttgcccgattgagactgattttcctcgcctggtgagcggaggtggcgctgctccaccccgctgccccgggactccggggctgccctctaccagcctggtctctccctcttttgatttgacagtacgggtttttgctttcccgagtacagcgggtttcttctttttggaggagctggttgtcttcagaagtcattccctggactctaattgccctgtcgctccgggcctcaccggaccaaaccaaagaccatggtgcactgtgcgggctgcaaaaggcccattctggaccgtttcctcttgaacgtgctggacagggcctggcatgtcaagtgcgtccagtgctgtgaatgtaaatgcaacctgaccgagaagtgcttctcccgggaaggcaagctctactgtaaaaacgacttcttccgatgtttcggtaccaaatgcgcgggttgtgcgcagggcatctctccaagcgatctggttcggagagcgcgaagcaaagtgtttcacctcaactgcttcacctgcatgatgtgtaacaagcagctctccacgggcgaggagctctacatcatcgatgagaacaagttcgtttgtaaagaggattacctgagtaacagcagtgtcgccaaagagaacagcctccactcggccaccacaggcagtgaccctagtttatctccggattcccaagatccatcgcaggatgatgccaaggactctgaaagtgccaacgtatcggataaggaaggtggtagcaatgagaacgatgaccagaacctaggtgccaagcgcaggggaccgcggaccacgatcaaagccaagcaactggagacgttgaaggcagcctttgcagctacgcctaagcccacacgccatatccgcgagcaattggcccaggagactggcctcaacatgcgtgttatccaggtctggttccagaatcgacgctccaaggagcggaggatgaagcagctaagcgcgctgggtgcgcggcgccacgcctttttccgcagtcctcgccggatgcggcctctggtggaccgcttggagccgggcgaactcatccctaacggccccttctccttttatggagattaccagagtgagtactacggtcctggaggcaactacgacttcttcccgcaaggaccaccgtcctcgcaggcccagacaccagtggacctaccctttgtgccatcatctgggccttcggggacgccccttggaggtctggaccacccgctgcctggccaccatccttccagcgaggcgcagcgattcactgacatcctggcacatcccccaggggactcgcctagtcctgagcccagcttgcccgggcctctccactccatgtctgcggaggtctttgggcccagtccacctttctcatctctgtcggtcaatggtggagccagctacgggaatcacttgtctcaccctcctgaaatgaatgaggcagccgtgtggtagcggggtctcgcatgggccacgggagctcgtggttgtacagagacgagcttttatttcagaaaataggagatttaaaaaaaaaaacattaaaaaaaaaaaaaagcaagcctcctgctccacttccttcagcctcggggaccattctttttggggagactggatggcaaaggggtccaaaacaggatccaaatccgcctcgcagtagagctggtatatccacacagcggctgacaaagcgcagaactggggctccggaaggggaattccgaggcatccccaccttcgcgacctggatctggatccatggacagactccaccagcggctcctctggctaacggaagacgtcttagacagcctcgctcagtcctgggcaatgccaggagcctggggagggagacctacctagaagcgctctgccagatgaggaaggaaaagatgtcaggggcgctccagtccagagggctctagttctagttctgggagatcccttcttagtgttgtctcagagttcagcgatgacaacaaactcttaatagcttcagaaacaccgacctgctgtgcatcaggtgggactatatatatatatattttttgtctatctgggtttttgatttttgttttcgccaaaattgcaaaattctaaatgtaaagccctcagtatcaactattctaccttcacacctctctctctctctctctctttctctctctctctctctctctctctctccctctcccctacacacacacacacacacacacacacacacacacacacacacacacacatgctcactcacactcaacttctttccacagtagggtctccagccagacctcttagtaaaatgacttgaacatcacctctacaaaaaagtattctacctttacatgaaagttaaaaaaaaaaaagactattgaactaaaaacagtcaactgtttacgtataatgttaaattcaggagttcagtgttttaataatatatcctgttttgaaacctcttgttcaaaaacaaaatgttttgagcaatcaaccaaaattgttccttttcttttcctgtagatgttctgacaggtttgcagggcttgcggctcactgtgctagtatgtaaaaaggtgttgtttacacgaggcaaagggaaaacatgatattcagacagttgccaaatagaataaactatagcacaattactgtaatggttgcctggcaccagcaacctgagaaagtgttttaaaaaaaaagtgttacaaggtttaaaaaaaaaacatctttgctaacttttagtcctgttaaacattcatgaaattgttaatatgacttatatagacccacacaggttttatttttgtgtctttaaaataaaagtccaaaatatttaaattttatggtcaaatatgcagtcaacagctgctactttttcctttatatattaaatttctcatatgtcttttattgttctaataaacctaagcttgtgtgacctccagtgcatattagaccattcactgtatgaaagaaaacatgttgaataaatttgtgagtttttaataaaaatagaaaacctga

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