LOCUS       NM_139225                298 bp    mRNA    linear   ROD 22-JUN-2025
DEFINITION  Mus musculus defensin beta 10 (Defb10), mRNA.
ACCESSION   NM_139225
VERSION     NM_139225.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 298)
  AUTHORS   Amid,C., Rehaume,L.M., Brown,K.L., Gilbert,J.G., Dougan,G.,
            Hancock,R.E. and Harrow,J.L.
  TITLE     Manual annotation and analysis of the defensin gene cluster in the
            C57BL/6J mouse reference genome
  JOURNAL   BMC Genomics 10, 606 (2009)
   PUBMED   20003482
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 298)
  AUTHORS   Morrison,G.M., Semple,C.A., Kilanowski,F.M., Hill,R.E. and
            Dorin,J.R.
  TITLE     Signal sequence conservation and mature peptide divergence within
            subgroups of the murine beta-defensin gene family
  JOURNAL   Mol Biol Evol 20 (3), 460-470 (2003)
   PUBMED   12644567
REFERENCE   3  (bases 1 to 298)
  AUTHORS   Schutte,B.C., Mitros,J.P., Bartlett,J.A., Walters,J.D., Jia,H.P.,
            Welsh,M.J., Casavant,T.L. and McCray,P.B. Jr.
  TITLE     Discovery of five conserved beta -defensin gene clusters using a
            computational search strategy
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2129-2133 (2002)
   PUBMED   11854508
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ437645.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ437645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 10.49 cM"
     gene            1..298
                     /gene="Defb10"
                     /gene_synonym="BD-10; Defb7"
                     /note="defensin beta 10"
                     /db_xref="GeneID:246085"
                     /db_xref="MGI:MGI:2179205"
     exon            1..88
                     /gene="Defb10"
                     /gene_synonym="BD-10; Defb7"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    7..9
                     /gene="Defb10"
                     /gene_synonym="BD-10; Defb7"
                     /note="upstream in-frame stop codon"
     CDS             28..249
                     /gene="Defb10"
                     /gene_synonym="BD-10; Defb7"
                     /function="antimicrobial peptide"
                     /note="beta-defensin 10"
                     /codon_start=1
                     /product="beta-defensin 10 precursor"
                     /protein_id="NP_631971.1"
                     /db_xref="CCDS:CCDS40285.1"
                     /db_xref="GeneID:246085"
                     /db_xref="MGI:MGI:2179205"
                     /translation="

MRTLCSLLLICCLLFSYTTPAVGDLKHLILKAQLTRCYKFGGFCHYNICPGNSRFMSNCHPENLRCCKNIKQF"

     sig_peptide     28..96
                     /gene="Defb10"
                     /gene_synonym="BD-10; Defb7"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     97..246
                     /gene="Defb10"
                     /gene_synonym="BD-10; Defb7"
                     /product="Beta-defensin 10. /id=PRO_0000006938"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2I8.1)"
     misc_feature    124..231
                     /gene="Defb10"
                     /gene_synonym="BD-10; Defb7"
                     /note="Beta defensin; Region: Defensin_beta; pfam00711"
                     /db_xref="CDD:459914"
     exon            89..298
                     /gene="Defb10"
                     /gene_synonym="BD-10; Defb7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggagtctgagtgccctttctaccagccatgaggactctctgctctctgctgctgatatgctgcctccttttctcatataccaccccagctgttggagatctaaaacatcttatactcaaagcacaacttacacggtgctacaagttcggagggttctgtcactataatatttgtcctggtaatagcaggtttatgagtaactgtcacccagagaatctccgctgttgcaagaacataaaacaattttaaggaagcacatggaagtcaagtgacagatgtgtaactgatttttaataaa

//