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2021-10-17 14:52:32, GGRNA.v2 : RefSeq release 207 (Jul, 2021)

LOCUS       NM_134432               1958 bp    mRNA    linear   ROD 05-JUL-2021
DEFINITION  Rattus norvegicus angiotensinogen (Agt), mRNA.
ACCESSION   NM_134432
VERSION     NM_134432.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Almeida-Santos AF, de Melo LA, Goncalves SCA, Oliveira Amaral LB,
            Santos RAS, Campagnole-Santos MJ and Kangussu LM.
  TITLE     Alamandine through MrgD receptor induces antidepressant-like effect
            in transgenic rats with low brain angiotensinogen
  JOURNAL   Horm Behav 127, 104880 (2021)
   PUBMED   33129833
  REMARK    GeneRIF: Alamandine through MrgD receptor induces
            antidepressant-like effect in transgenic rats with low brain
            angiotensinogen.
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Honetschlagerova Z, Gawrys O, Jichova S, Skaroupkova P, Kikerlova
            S, Vanourkova Z, Huskova Z, Melenovsky V, Kompanowska-Jezierska E,
            Sadowski J, Kolar F, Novotny J, Hejnova L, Kujal P and Cervenka L.
  TITLE     Renal Sympathetic Denervation Attenuates Congestive Heart Failure
            in Angiotensin II-Dependent Hypertension: Studies with Ren-2
            Transgenic Hypertensive Rats with Aortocaval Fistula
  JOURNAL   Kidney Blood Press Res 46 (1), 95-113 (2021)
   PUBMED   33530085
  REMARK    GeneRIF: Renal Sympathetic Denervation Attenuates Congestive Heart
            Failure in Angiotensin II-Dependent Hypertension: Studies with
            Ren-2 Transgenic Hypertensive Rats with Aortocaval Fistula.
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Pereira VM, Reis FM, Casalechi M and Reis AM.
  TITLE     Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor
            in Rat Polycystic Ovaries
  JOURNAL   Protein Pept Lett 28 (3), 249-254 (2021)
   PUBMED   32851948
  REMARK    GeneRIF: Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas
            Receptor in Rat Polycystic Ovaries.
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Yoo KH, Yim HE and Bae ES.
  TITLE     Angiotensin inhibition and cellular senescence in the developing
            rat kidney
  JOURNAL   Exp Mol Pathol 117, 104551 (2020)
   PUBMED   33010296
  REMARK    GeneRIF: Angiotensin inhibition and cellular senescence in the
            developing rat kidney.
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Haase N, Foster DJ, Cunningham MW, Bercher J, Nguyen T,
            Shulga-Morskaya S, Milstein S, Shaikh S, Rollins J, Golic M, Herse
            F, Kraker K, Bendix I, Serdar M, Napieczynska H, Heuser A, Gellhaus
            A, Thiele K, Wallukat G, Muller DN, LaMarca B and Dechend R.
  TITLE     RNA interference therapeutics targeting angiotensinogen ameliorate
            preeclamptic phenotype in rodent models
  JOURNAL   J Clin Invest 130 (6), 2928-2942 (2020)
   PUBMED   32338644
  REMARK    GeneRIF: RNA interference therapeutics targeting angiotensinogen
            ameliorate preeclamptic phenotype in rodent models.
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS,
            Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM et al.
  TITLE     Molecular basis of human hypertension: role of angiotensinogen
  JOURNAL   Cell 71 (1), 169-180 (1992)
   PUBMED   1394429
REFERENCE   7  (bases 1 to 1958)
  AUTHORS   Hermann K, Rittweger R and Ring J.
  TITLE     Urinary excretion of angiotensin I, II, arginine vasopressin and
            oxytocin in patients with anaphylactoid reactions
  JOURNAL   Clin Exp Allergy 22 (9), 845-853 (1992)
   PUBMED   1422942
REFERENCE   8  (bases 1 to 1958)
  AUTHORS   Mauzy CA, Hwang O, Egloff AM, Wu LH and Chung FZ.
  TITLE     Cloning, expression, and characterization of a gene encoding the
            human angiotensin II type 1A receptor
  JOURNAL   Biochem Biophys Res Commun 186 (1), 277-284 (1992)
   PUBMED   1378723
REFERENCE   9  (bases 1 to 1958)
  AUTHORS   Tucker,B.J., Mundy,C.A., Maciejewski,A.R., Printz,M.P.,
            Ziegler,M.G., Pelayo,J.C. and Blantz,R.C.
  TITLE     Changes in glomerular hemodynamic response to angiotensin II after
            subacute renal denervation in rats
  JOURNAL   J Clin Invest 78 (3), 680-688 (1986)
   PUBMED   3745432
REFERENCE   10 (bases 1 to 1958)
  AUTHORS   Ohkubo,H., Nakayama,K., Tanaka,T. and Nakanishi,S.
  TITLE     Tissue distribution of rat angiotensinogen mRNA and structural
            analysis of its heterogeneity
  JOURNAL   J Biol Chem 261 (1), 319-323 (1986)
   PUBMED   3753601
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078741.1.
            On Aug 8, 2004 this sequence version replaced NM_134432.1.
            
            Summary: plays a role in regulation of blood pressure [RGD, Feb
            2006].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1958
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="angiotensinogen"
                     /db_xref="GeneID:24179"
                     /db_xref="RGD:2069"
     exon            1..170
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="upstream in-frame stop codon"
     exon            171..1029
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1634
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="angiotensin II; serpin A8; angiotensinogen (serpin
                     peptidase inhibitor, clade A, member 8)"
                     /codon_start=1
                     /product="angiotensinogen precursor"
                     /protein_id="NP_602308.1"
                     /db_xref="GeneID:24179"
                     /db_xref="RGD:2069"
                     /translation="
MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYYSKSTCAQLENPSVETLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNPRVGEVLNSILLELQAGEEEQPTESAQQPGSPEVLDVTLSSPFLFAIYERDSGALHFLGRVDNPQNVV"
     sig_peptide     201..272
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    489..1619
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="SERine Proteinase INhibitors (serpins) exhibit
                     conformational polymorphism shifting from native to
                     cleaved, latent, delta, or polymorphic forms. Many
                     serpins, such as antitrypsin and antichymotrypsin,
                     function as serine protease inhibitors which regulate...;
                     Region: SERPIN; cl00137"
                     /db_xref="CDD:294093"
     misc_feature    1083..1085
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P01015.1); glycosylation site"
     misc_feature    1155..1157
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P01015.1); glycosylation site"
     misc_feature    order(1479..1490,1536..1553)
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="reactive center loop; other site"
                     /db_xref="CDD:238101"
     exon            1030..1297
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1442
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1934
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
ccttgctccatcttggctaagcctggattcccatggtcccccgacctgggtcctcccccagcctctgtacagagtagcctgggaatagatccatcttcaccccctcgagtataaataaggctgcttggttcaccaggggatagctgtgcttgtctgggctggagctaaaggacacacagaagcaagtccacagatccgtgatgactcccacgggggcaggcctgaaggccaccatcttctgcatcctgacctgggtcagcctgacagctggggaccgcgtatacatccacccctttcatctcctctactacagcaagagcacctgcgcccagctggagaaccccagtgtggagacgctcccagagccaacctttgagcctgtgcccattcaggccaagacctcccccgtggatgagaagaccctgcgagataagctcgtgctggccactgagaagctagaggctgaggatcggcagcgagctgcccaggtcgcgatgattgccaacttcatgggtttccgcatgtacaagatgctgagtgaggcaagaggtgtagccagtggggccgtcctctctccaccggccctctttggcaccctggtctctttctaccttggatcgttggatcccacggccagccagttgcaggtgctgctgggcgtccctgtgaaggagggagactgcacctcccggctggacggacataaggtcctcactgccctgcaggctgttcagggcttgctggtcacccagggtggaagcagcagccagacacccctgctacagtccaccgtggtgggcctcttcactgccccaggcttgcgcctaaaacagccatttgttgagagcttgggtcccttcacccccgccatcttccctcgctctctggacttatccactgacccagttcttgctgcccagaaaatcaacaggtttgtgcaggctgtgacagggtggaagatgaacttgccactagagggggtcagcacggacagcaccctatttttcaacacctacgttcacttccaagggaagatgagaggcttctcccagctgactgggctccatgagttctgggtggacaacagcacctcagtgtctgtgcccatgctctcgggcactggcaacttccagcactggagtgacgcccagaacaacttctccgtgacacgcgtgcccctgggtgagagtgtcaccctgctgctgatccagccccagtgcgcctcagatctcgacagggtggaggtcctcgtcttccagcacgacttcctgacttggataaagaacccgcctcctcgggccatccgtctgaccctgccgcagctggaaattcggggatcctacaacctgcaggacctgctggctcaggccaagctgtctacccttttgggtgctgaggcaaatctgggcaagatgggtgacaccaacccccgagtgggagaggttctcaacagcatcctccttgaactccaagcaggcgaggaggagcagcccacagagtctgcccagcagcctggctcacccgaggtgctggacgtgaccctgagcagtccgttcctgttcgccatctacgagcgggactcaggtgcgctgcactttctgggcagagtggataacccccaaaatgtggtgtgatgcctcctgtgtagccatggagacaaggccagcgtcagagagctatcctgggcaaaaatcagtgccttcacccctggcttcccgtcactccttccagcaaggcagaggccgtctccttggagatggcgctaactgagaataaatgatgagcagcagcctcctggggtgtgggtttgtttggacactggggtgagagccaggagctggcactctgtataggaggactgccatcctggaaaaaaaaaatggaccaaacaactgtttgtgaaataaaaaaaaaaaaattccctttttatttgaaaaaaaaaaaaaaaaaaaaaaaaa
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]