LOCUS       NM_134432               1958 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus angiotensinogen (Agt), mRNA.
ACCESSION   NM_134432
VERSION     NM_134432.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Toth,D.D., Souder,C.L. 2nd, Patuel,S., English,C.D., Konig,I.,
            Ivantsova,E., Malphurs,W., Watkins,J., Anne Costa,K., Bowden,J.A.,
            Zubcevic,J. and Martyniuk,C.J.
  TITLE     Angiotensin II Alters Mitochondrial Membrane Potential and Lipid
            Metabolism in Rat Colonic Epithelial Cells
  JOURNAL   Biomolecules 14 (8), 974 (2024)
   PUBMED   39199363
  REMARK    GeneRIF: Angiotensin II Alters Mitochondrial Membrane Potential and
            Lipid Metabolism in Rat Colonic Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Zhang,W., Cai,S., Wu,F., Luo,Y., Xiao,H., Yu,D., Zhong,X., Tao,P.
            and Huang,S.
  TITLE     Combining experiments and bioinformatics to identify transforming
            growth factor-beta1 as a key regulator in angiotensin II-induced
            trophoblast senescence
  JOURNAL   Placenta 152, 31-38 (2024)
   PUBMED   38781757
  REMARK    GeneRIF: Combining experiments and bioinformatics to identify
            transforming growth factor-beta1 as a key regulator in angiotensin
            II-induced trophoblast senescence.
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Marunouchi,T., Onda,S., Kurasawa,M. and Tanonaka,K.
  TITLE     Angiotensin II Is Involved in MLKL Activation During the
            Development of Heart Failure Following Myocardial Infarction in
            Rats
  JOURNAL   Biol Pharm Bull 47 (4), 809-817 (2024)
   PUBMED   38583954
  REMARK    GeneRIF: Angiotensin II Is Involved in MLKL Activation During the
            Development of Heart Failure Following Myocardial Infarction in
            Rats.
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Paes-Leme,B., Monteiro,L.D.R.N., Gholami,K., Hoe,S.Z.,
            Ferguson,A.V., Murphy,D., Antunes-Rodrigues,J., Rorato,R.,
            Reis,L.C. and Mecawi,A.S.
  TITLE     Fasting increases circulating angiotensin levels and brain Agtr1a
            expression in male rats
  JOURNAL   J Neuroendocrinol 35 (11), e13334 (2023)
   PUBMED   37667574
  REMARK    GeneRIF: Fasting increases circulating angiotensin levels and brain
            Agtr1a expression in male rats.
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Sykora,M., Kratky,V., Kopkan,L., Tribulova,N. and Szeiffova
            Bacova,B.
  TITLE     Anti-Fibrotic Potential of Angiotensin (1-7) in Hemodynamically
            Overloaded Rat Heart
  JOURNAL   Int J Mol Sci 24 (4), 3490 (2023)
   PUBMED   36834901
  REMARK    GeneRIF: Anti-Fibrotic Potential of Angiotensin (1-7) in
            Hemodynamically Overloaded Rat Heart.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Jeunemaitre,X., Soubrier,F., Kotelevtsev,Y.V., Lifton,R.P.,
            Williams,C.S., Charru,A., Hunt,S.C., Hopkins,P.N., Williams,R.R.,
            Lalouel,J.M. et al.
  TITLE     Molecular basis of human hypertension: role of angiotensinogen
  JOURNAL   Cell 71 (1), 169-180 (1992)
   PUBMED   1394429
REFERENCE   7  (bases 1 to 1958)
  AUTHORS   Hermann,K., Rittweger,R. and Ring,J.
  TITLE     Urinary excretion of angiotensin I, II, arginine vasopressin and
            oxytocin in patients with anaphylactoid reactions
  JOURNAL   Clin Exp Allergy 22 (9), 845-853 (1992)
   PUBMED   1422942
REFERENCE   8  (bases 1 to 1958)
  AUTHORS   Mauzy,C.A., Hwang,O., Egloff,A.M., Wu,L.H. and Chung,F.Z.
  TITLE     Cloning, expression, and characterization of a gene encoding the
            human angiotensin II type 1A receptor
  JOURNAL   Biochem Biophys Res Commun 186 (1), 277-284 (1992)
   PUBMED   1378723
REFERENCE   9  (bases 1 to 1958)
  AUTHORS   Tucker,B.J., Mundy,C.A., Maciejewski,A.R., Printz,M.P.,
            Ziegler,M.G., Pelayo,J.C. and Blantz,R.C.
  TITLE     Changes in glomerular hemodynamic response to angiotensin II after
            subacute renal denervation in rats
  JOURNAL   J Clin Invest 78 (3), 680-688 (1986)
   PUBMED   3745432
REFERENCE   10 (bases 1 to 1958)
  AUTHORS   Ohkubo,H., Nakayama,K., Tanaka,T. and Nakanishi,S.
  TITLE     Tissue distribution of rat angiotensinogen mRNA and structural
            analysis of its heterogeneity
  JOURNAL   J Biol Chem 261 (1), 319-323 (1986)
   PUBMED   3753601
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078741.1.
            
            On Aug 8, 2004 this sequence version replaced NM_134432.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1958
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="angiotensinogen"
                     /db_xref="GeneID:24179"
                     /db_xref="RGD:2069"
     exon            1..170
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    141..143
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="upstream in-frame stop codon"
     exon            171..1029
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1634
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="angiotensin II; serpin A8; angiotensinogen (serpin
                     peptidase inhibitor, clade A, member 8)"
                     /codon_start=1
                     /product="angiotensinogen precursor"
                     /protein_id="NP_602308.1"
                     /db_xref="GeneID:24179"
                     /db_xref="RGD:2069"
                     /translation="

MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYYSKSTCAQLENPSVETLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNPRVGEVLNSILLELQAGEEEQPTESAQQPGSPEVLDVTLSSPFLFAIYERDSGALHFLGRVDNPQNVV"

     sig_peptide     201..272
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     273..1631
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /product="Angiotensinogen. /id=PRO_0000032468"
                     /note="propagated from UniProtKB/Swiss-Prot (P01015.1)"
     misc_feature    282..1625
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="serpin family A member 8, angiotensinogen; Region:
                     serpinA8_AGT; cd02054"
                     /db_xref="CDD:381010"
     misc_feature    order(282..323,474..479,486..488,498..500,507..509,
                     516..521,639..641,648..653,660..665,672..677,1263..1265,
                     1284..1286,1368..1373)
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="renin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:381010"
     misc_feature    1083..1085
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P01015.1); glycosylation site"
     misc_feature    1155..1157
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P01015.1); glycosylation site"
     misc_feature    order(1476..1511,1536..1553)
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="reactive center loop (RCL); other site"
                     /db_xref="CDD:381010"
     exon            1030..1297
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1442
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1934
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccttgctccatcttggctaagcctggattcccatggtcccccgacctgggtcctcccccagcctctgtacagagtagcctgggaatagatccatcttcaccccctcgagtataaataaggctgcttggttcaccaggggatagctgtgcttgtctgggctggagctaaaggacacacagaagcaagtccacagatccgtgatgactcccacgggggcaggcctgaaggccaccatcttctgcatcctgacctgggtcagcctgacagctggggaccgcgtatacatccacccctttcatctcctctactacagcaagagcacctgcgcccagctggagaaccccagtgtggagacgctcccagagccaacctttgagcctgtgcccattcaggccaagacctcccccgtggatgagaagaccctgcgagataagctcgtgctggccactgagaagctagaggctgaggatcggcagcgagctgcccaggtcgcgatgattgccaacttcatgggtttccgcatgtacaagatgctgagtgaggcaagaggtgtagccagtggggccgtcctctctccaccggccctctttggcaccctggtctctttctaccttggatcgttggatcccacggccagccagttgcaggtgctgctgggcgtccctgtgaaggagggagactgcacctcccggctggacggacataaggtcctcactgccctgcaggctgttcagggcttgctggtcacccagggtggaagcagcagccagacacccctgctacagtccaccgtggtgggcctcttcactgccccaggcttgcgcctaaaacagccatttgttgagagcttgggtcccttcacccccgccatcttccctcgctctctggacttatccactgacccagttcttgctgcccagaaaatcaacaggtttgtgcaggctgtgacagggtggaagatgaacttgccactagagggggtcagcacggacagcaccctatttttcaacacctacgttcacttccaagggaagatgagaggcttctcccagctgactgggctccatgagttctgggtggacaacagcacctcagtgtctgtgcccatgctctcgggcactggcaacttccagcactggagtgacgcccagaacaacttctccgtgacacgcgtgcccctgggtgagagtgtcaccctgctgctgatccagccccagtgcgcctcagatctcgacagggtggaggtcctcgtcttccagcacgacttcctgacttggataaagaacccgcctcctcgggccatccgtctgaccctgccgcagctggaaattcggggatcctacaacctgcaggacctgctggctcaggccaagctgtctacccttttgggtgctgaggcaaatctgggcaagatgggtgacaccaacccccgagtgggagaggttctcaacagcatcctccttgaactccaagcaggcgaggaggagcagcccacagagtctgcccagcagcctggctcacccgaggtgctggacgtgaccctgagcagtccgttcctgttcgccatctacgagcgggactcaggtgcgctgcactttctgggcagagtggataacccccaaaatgtggtgtgatgcctcctgtgtagccatggagacaaggccagcgtcagagagctatcctgggcaaaaatcagtgccttcacccctggcttcccgtcactccttccagcaaggcagaggccgtctccttggagatggcgctaactgagaataaatgatgagcagcagcctcctggggtgtgggtttgtttggacactggggtgagagccaggagctggcactctgtataggaggactgccatcctggaaaaaaaaaatggaccaaacaactgtttgtgaaataaaaaaaaaaaaattccctttttatttgaaaaaaaaaaaaaaaaaaaaaaaaa

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