ver.2
Home
|
Help
|
Advanced search
Previous release (v1)
2025-07-02 10:13:37, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_133322 4158 bp mRNA linear ROD 13-OCT-2024
DEFINITION Rattus norvegicus potassium voltage-gated channel subfamily Q
member 2 (Kcnq2), mRNA.
ACCESSION NM_133322
VERSION NM_133322.2
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 4158)
AUTHORS Zhang,Z.X., Tian,Y., Li,S., Jing,H.B., Cai,J., Li,M. and Xing,G.G.
TITLE Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription
repression activated by EREG/EGFR-ERK-Runx1 signaling in bone
cancer pain
JOURNAL Cell Commun Signal 22 (1), 416 (2024)
PUBMED 39192337
REMARK GeneRIF: Involvement of HDAC2-mediated kcnq2/kcnq3 genes
transcription repression activated by EREG/EGFR-ERK-Runx1 signaling
in bone cancer pain.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 4158)
AUTHORS Muller,S., Kartheus,M., Hendinger,E., Hubner,D.C., Schnell,E.,
Rackow,S., Bertsche,A., Kohling,R. and Kirschstein,T.
TITLE Persistent Kv7.2/7.3 downregulation in the rat pilocarpine model of
mesial temporal lobe epilepsy
JOURNAL Epilepsy Res 200, 107296 (2024)
PUBMED 38219422
REMARK GeneRIF: Persistent Kv7.2/7.3 downregulation in the rat pilocarpine
model of mesial temporal lobe epilepsy.
REFERENCE 3 (bases 1 to 4158)
AUTHORS Tonomura,S., Ling,J. and Gu,J.G.
TITLE Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal
ventral nerves of rats
JOURNAL Mol Brain 15 (1), 64 (2022)
PUBMED 35858950
REMARK GeneRIF: Function of KCNQ2 channels at nodes of Ranvier of lumbar
spinal ventral nerves of rats.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 4158)
AUTHORS Kim,K.W., Kim,K., Kim,H.J., Kim,B.I., Baek,M. and Suh,B.C.
TITLE Posttranscriptional modulation of KCNQ2 gene expression by the
miR-106b microRNA family
JOURNAL Proc Natl Acad Sci U S A 118 (47) (2021)
PUBMED 34785595
REMARK GeneRIF: Posttranscriptional modulation of KCNQ2 gene expression by
the miR-106b microRNA family.
REFERENCE 5 (bases 1 to 4158)
AUTHORS Manville,R.W. and Abbott,G.W.
TITLE The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated
Potassium Channels
JOURNAL Cell Physiol Biochem 55 (S3), 157-170 (2021)
PUBMED 34318654
REMARK GeneRIF: The Amyloid Precursor Protein C99 Fragment Modulates
Voltage-Gated Potassium Channels.
REFERENCE 6 (bases 1 to 4158)
AUTHORS Pan,Z., Selyanko,A.A., Hadley,J.K., Brown,D.A., Dixon,J.E. and
McKinnon,D.
TITLE Alternative splicing of KCNQ2 potassium channel transcripts
contributes to the functional diversity of M-currents
JOURNAL J Physiol 531 (Pt 2), 347-358 (2001)
PUBMED 11230508
REFERENCE 7 (bases 1 to 4158)
AUTHORS Jow,F. and Wang,K.
TITLE Cloning and functional expression of rKCNQ2 K(+) channel from rat
brain
JOURNAL Brain Res Mol Brain Res 80 (2), 269-278 (2000)
PUBMED 11038262
REFERENCE 8 (bases 1 to 4158)
AUTHORS Watanabe,H., Nagata,E., Kosakai,A., Nakamura,M., Yokoyama,M.,
Tanaka,K. and Sasai,H.
TITLE Disruption of the epilepsy KCNQ2 gene results in neural
hyperexcitability
JOURNAL J Neurochem 75 (1), 28-33 (2000)
PUBMED 10854243
REFERENCE 9 (bases 1 to 4158)
AUTHORS Schwake,M., Pusch,M., Kharkovets,T. and Jentsch,T.J.
TITLE Surface expression and single channel properties of KCNQ2/KCNQ3,
M-type K+ channels involved in epilepsy
JOURNAL J Biol Chem 275 (18), 13343-13348 (2000)
PUBMED 10788442
REFERENCE 10 (bases 1 to 4158)
AUTHORS Wang,H.S., Pan,Z., Shi,W., Brown,B.S., Wymore,R.S., Cohen,I.S.,
Dixon,J.E. and McKinnon,D.
TITLE KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of
the M-channel
JOURNAL Science 282 (5395), 1890-1893 (1998)
PUBMED 9836639
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from
JAXUCZ010000003.1.
On Nov 26, 2020 this sequence version replaced NM_133322.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF087453.2 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760389,
SAMEA5760393 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-411 JAXUCZ010000003.1 188630892-188631302 c
412-502 JAXUCZ010000003.1 188611121-188611211 c
503-629 JAXUCZ010000003.1 188610066-188610192 c
630-805 JAXUCZ010000003.1 188609559-188609734 c
806-931 JAXUCZ010000003.1 188608372-188608497 c
932-1042 JAXUCZ010000003.1 188606015-188606125 c
1043-1138 JAXUCZ010000003.1 188605380-188605475 c
1139-1233 JAXUCZ010000003.1 188601473-188601567 c
1234-1263 JAXUCZ010000003.1 188599821-188599850 c
1264-1332 JAXUCZ010000003.1 188596782-188596850 c
1333-1362 JAXUCZ010000003.1 188593958-188593987 c
1363-1586 JAXUCZ010000003.1 188585118-188585341 c
1587-1695 JAXUCZ010000003.1 188584334-188584442 c
1696-1827 JAXUCZ010000003.1 188583721-188583852 c
1828-1951 JAXUCZ010000003.1 188579135-188579258 c
1952-4158 JAXUCZ010000003.1 188576356-188578562 c
FEATURES Location/Qualifiers
source 1..4158
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="3"
/map="3q43"
gene 1..4158
/gene="Kcnq2"
/note="potassium voltage-gated channel subfamily Q member
2"
/db_xref="GeneID:170848"
/db_xref="RGD:621504"
exon 1..411
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
misc_feature 98..100
/gene="Kcnq2"
/note="upstream in-frame stop codon"
CDS 116..2674
/gene="Kcnq2"
/note="potassium voltage-gated channel, KQT-like
subfamily, member 2; KQT-like 2; potassium channel subunit
alpha KvLQT2; voltage-gated potassium channel subunit
Kv7.2; potassium channel, voltage-gated KQT-like subfamily
Q, member 2"
/codon_start=1
/product="potassium voltage-gated channel subfamily KQT
member 2"
/protein_id="NP_579856.2"
/db_xref="GeneID:170848"
/db_xref="RGD:621504"
/translation="
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRNYAAPPVMPPAQCPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK"
misc_feature 269..271
/gene="Kcnq2"
/note="Phosphoserine, by PKA.
/evidence=ECO:0000250|UniProtKB:O43526; propagated from
UniProtKB/Swiss-Prot (O88943.1); phosphorylation site"
misc_feature 386..454
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
transmembrane region"
misc_feature 389..1087
/gene="Kcnq2"
/note="Ion transport protein; Region: Ion_trans;
pfam00520"
/db_xref="CDD:459842"
misc_feature 485..550
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
transmembrane region"
misc_feature 605..664
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
transmembrane region"
misc_feature 704..760
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
transmembrane region"
misc_feature 779..1084
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
Region: Mediates interaction with SLC5A3.
/evidence=ECO:0000269|PubMed:28793216"
misc_feature 797..874
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
transmembrane region"
misc_feature 944..961
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
Region: Selectivity filter. /evidence=ECO:0000250"
misc_feature 977..1057
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
transmembrane region"
misc_feature 1064..1681
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
Region: Mediates interaction with calmodulin.
/evidence=ECO:0000250|UniProtKB:O43526"
misc_feature 1325..1522
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1457..2017
/gene="Kcnq2"
/note="KCNQ voltage-gated potassium channel; Region:
KCNQ_channel; pfam03520"
/db_xref="CDD:460954"
misc_feature 1457..1459
/gene="Kcnq2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9Z351; propagated from
UniProtKB/Swiss-Prot (O88943.1); phosphorylation site"
misc_feature 1463..1465
/gene="Kcnq2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9Z351; propagated from
UniProtKB/Swiss-Prot (O88943.1); phosphorylation site"
misc_feature 1475..1477
/gene="Kcnq2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9Z351; propagated from
UniProtKB/Swiss-Prot (O88943.1); phosphorylation site"
misc_feature 1487..1489
/gene="Kcnq2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9Z351; propagated from
UniProtKB/Swiss-Prot (O88943.1); phosphorylation site"
misc_feature 1493..1495
/gene="Kcnq2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9Z351; propagated from
UniProtKB/Swiss-Prot (O88943.1); phosphorylation site"
misc_feature 1580..1582
/gene="Kcnq2"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (O88943.1); phosphorylation site"
misc_feature 1850..1918
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2042..2101
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2057..2323
/gene="Kcnq2"
/note="Unstructured region on Potassium channel subunit
alpha KvLQT2; Region: KCNQ2_u3; pfam16642"
/db_xref="CDD:465213"
misc_feature 2078..2080
/gene="Kcnq2"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (O88943.1); phosphorylation site"
misc_feature 2129..2269
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2357..2659
/gene="Kcnq2"
/note="Ankyrin-G binding motif of KCNQ2-3; Region:
KCNQC3-Ank-G_bd; pfam11956"
/db_xref="CDD:463411"
misc_feature 2456..2458
/gene="Kcnq2"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (O88943.1); phosphorylation site"
misc_feature 2462..2464
/gene="Kcnq2"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (O88943.1); phosphorylation site"
misc_feature 2567..2671
/gene="Kcnq2"
/note="propagated from UniProtKB/Swiss-Prot (O88943.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 412..502
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 503..629
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 630..805
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 806..931
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 932..1042
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 1043..1138
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 1139..1233
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 1234..1263
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 1264..1332
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 1333..1362
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 1363..1586
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 1587..1695
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 1696..1827
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 1828..1951
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
exon 1952..4158
/gene="Kcnq2"
/inference="alignment:Splign:2.1.0"
ORIGIN
agccgcagccgcctcggccatgcggctgccggacccggggcctgggctggggcccgcgccaccccctgcgcgccgcccccgctgagcccgcgccggatagggcgccgccggcaccatggtgcagaagtcgcgcaacggtggcgtgtaccccggcaccagcggggaaaaaaagctcaaggtgggcttcgtggggctggaccccggcgcgcccgactccactcgcgacggcgcgctactcatcgcgggctccgaggcccccaagcgcggcagcgttttgagcaagccgcggacgggcggcgcgggagccgggaagcccccaaagcgcaacgccttctaccgcaagctgcagaatttcctatacaacgtgctagagcggccccgcggttgggcgttcatctaccacgcctacgtgtttcttttagtcttctcctgccttgtgctttccgtgttttccaccatcaaggagtatgagaagagttccgagggggccctctacatcttggaaatcgtgaccatcgtggtattcggtgttgagtactttgtgagaatctgggctgcaggctgctgctgccggtatcgaggctggaggggccggctcaagtttgccaggaagccattctgtgtgatcgacatcatggtgctgattgcctccattgctgtgctggctgctggctcccagggcaatgtctttgccacatctgcacttcggagcttgcggttcttacaaatcttacggatgatccgtatggaccggaggggcggcacctggaagctcctgggatcggtggtctacgctcacagcaaggagctggtgactgcgtggtacattggcttcctctgcctcatcctggcctcgtttctggtgtacttggcagaaaagggtgagaatgaccacttcgacacctacgcggatgcactctggtggggtctgatcaccctgacaaccattggctacggggacaagtaccctcagacctggaacgggaggctgttagcagcgacgtttaccctcattggtgtctcattcttcgctcttcctgctggcattttgggatccggctttgccctgaaagtccaagagcagcatcggcaaaaacactttgagaaacggcggaatcctgcggcaggtctgatccagtctgcctggagattctatgctactaacctctcacgcaccgacctgcactccacgtggcagtactacgagcggacagtcactgtccccatgtacagctcacaaactcaaacctatggggcctccagactcattccgcctctgaaccagctggagctgctgaggaatctcaagagcaaatctggactcaccttcaggaaggagccacagccagagccatcaccaagtcagaaggtcagtttgaaagatcgtgtcttctccagcccccgaggcgtggctgccaaggggaaggggtctccccaggcccagacggtccggcggtcccccagtgcggatcagagtctcgatgacagcccaagcaaggtgcccaagagctggagctttggtgaccgcagccgtgcacgccaggctttccgtatcaagggcgctgcatcccggcagaactcagaagaagcaagcctccctggggaggatatcgtggaggacaacaagagctgtaactgcgagtttgtgactgaagatcttacccctggcctcaaagtcagcatcagagctgtgtgtgttatgcggttcttggtatctaagcgaaagttcaaagagagtctgcgcccatatgacgtgatggatgtcatcgaacagtactcggccggacacttggatatgttgtcccgaatcaagagcctgcagtccagagtggaccagattgtggggcggggcccgacaataacggacaaggaccgcaccaaaggcccagcggagacggaactgcccgaagaccccagcatgatgggacgccttgggaaggtggaaaaacaggtcttgtccatggaaaagaagctagacttcctggtgagcatctacacacagagaatgggcatcccaccagcagagacagaggcctatttcggggccaaggagcctgagccggcaccaccctaccacagcccggaggacagccgtgaccatgcagacaagcatggctgtattattaagattgtccgctccaccagctctacgggccagaggaactacgccgcacccccagtcatgccccctgcccagtgtcccccatccacctcgtggcagcagagccaccagcgccacggcacctcccccgtgggagaccatggctcactggtacgcatcccaccaccccctgcgcacgagcgctcactgtctgcctacagtgggggcaacagagccagtaccgagttcttgaggctggagggcaccccagcctgcaggccctctgaggcagccctgcgggatagcgacacgtccatctccatcccttcggtggaccacgaggagctggagcgttcctttagcggtttcagtatctcccagtccaaggagaacctggatgccctggccagctgttatgcagctgtggcgccgtgcgccaaggtcaggccctacattgcagagggtgagtctgacacagactcagacctctgcacaccgtgtgggccacccccacgctctgccactggtgaaggcccctttggagatgtggcttgggcagggcctaggaagtgagtctgggttgggctgctggccccatgccacacccactcttgttcagttttagagctggagttccagggcctttcttaaagtgacagagcggcatagagtagtgtgggttgtgaggatgctcatgggatctcgctctcagggtcaatgtggagtggaaatgaggcagggttccttagcacatacagtaacattttatagaagttcttttccaaccaggagagggtggttgaggccgggccctggaggcccttgggagctccctatggcagcaaagctagccctgcctagtcttcttgggggacatattgccctgtgagtgaggagggacagcgtgatggttagcctctgtgagtgggggtgtggctgggagcaagtccgtgggaggtagtggtgaaatgaaacaggcccgtctactgctgatagccagtcctgaggcccatgggtctctcagtttagtctgggagctcaggggtatagtaagtcactggaaacggcccactctcacacctgactgcttatccctccatcccgactgcccccagtaaagcattaccagacccactgttgggtgtggctgggcaatgcccctcatccctgggtaacctagctaaagagctgccacaatcttcctccctcttccaggttatgtggatctttccatgggaaccatctttaggtccttctcctggagctgaggaaggagtgaggcctcagggaccaatctggaacttagaattgatccttagactctcttgacttccacctcttaggggaagactcaactcacagccttttctgaaagggtttcttcagcaggttctggctgcctcgtgccaggtactgtagcccagtaggtatgagttgacacttcaaggcctctgctctttcctggtgtggcactggcctccaggctgtggccagcactttaagagaatcaccagataagcagaccagccttagccagggcacctccttgcctgctgcccacttggctctacggattcaggcagggctaaatgacatgacgtcttcaaactgccggctctctctacacgagagcatggcctttgagcctggtcaaggatccttcccaatgaagctggccatccagtcctttatccactagtaggtccctggtctgtggcccctgggtgtttgaggaattgggaacaccttggcctctactctggtgaggaataatccctgtccatcctgtgagtgggcatcttgggccatcagcagctgactttagagggaaacatggtagatataatagagccctcggttgtggccccataatatctggcccagaggtgcctggcattaaatgataacattttggggtgggggccctaaaccctcttgccctcagttttcctggtcactgaggacaagcgctacagagcttgtgcttgggcagagctttatttacttcttccacccttttgaaatgtgtgttctggcaggggtagaggcaacttggg
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]