LOCUS       NM_070776               3217 bp    mRNA    linear   INV 16-MAY-2025
DEFINITION  Caenorhabditis elegans PAZ domain-containing protein (wago-10),
            mRNA.
ACCESSION   NM_070776
VERSION     NM_070776.5
DBLINK      BioProject: PRJNA158
KEYWORDS    RefSeq.
SOURCE      Caenorhabditis elegans
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
            Caenorhabditis.
REFERENCE   1  (bases 1 to 3217)
  AUTHORS   Sulson,J.E. and Waterston,R.
  CONSRTM   Caenorhabditis elegans Sequencing Consortium
  TITLE     Genome sequence of the nematode C. elegans: a platform for
            investigating biology
  JOURNAL   Science 282 (5396), 2012-2018 (1998)
   PUBMED   9851916
  REMARK    Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE   2  (bases 1 to 3217)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAY-2025) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 3217)
  AUTHORS   WormBase.
  CONSRTM   WormBase Consortium
  TITLE     Direct Submission
  JOURNAL   Submitted (01-MAY-2025) WormBase Group, European Bioinformatics
            Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org
REFERENCE   4  (bases 1 to 3217)
  AUTHORS   Sulson,J.E. and Waterston,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger
            Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute
            at Washington University, St. Louis, MO 63110, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by WormBase. This
            record is derived from an annotated genomic sequence (NC_003283).
            
            On May 27, 2020 this sequence version replaced NM_070776.4.
FEATURES             Location/Qualifiers
     source          1..3217
                     /organism="Caenorhabditis elegans"
                     /mol_type="mRNA"
                     /strain="Bristol N2"
                     /db_xref="taxon:6239"
                     /chromosome="V"
     gene            1..3217
                     /gene="wago-10"
                     /locus_tag="CELE_T22H9.3"
                     /db_xref="GeneID:178560"
                     /db_xref="WormBase:WBGene00020707"
     CDS             59..3031
                     /gene="wago-10"
                     /locus_tag="CELE_T22H9.3"
                     /standard_name="T22H9.3"
                     /note="Confirmed by transcript evidence"
                     /codon_start=1
                     /product="PAZ domain-containing protein"
                     /protein_id="NP_503177.1"
                     /db_xref="GeneID:178560"
                     /db_xref="WormBase:WBGene00020707"
                     /translation="

MPTTVQNPSPTGFLPQIPFRIPKRTRRSSEVDVPATKRPAPPLTSSTSLPTRDSFSIIETRDVQLNMFALNISGMPRKIQRFHVDTLIKGKNGKIFNVNHGVLANSGDINSHNKRLAQHALMQKFHKKRRELFGQHDYHILAYDCANTLYLPDGVYLGRNEEECTFKSDDFSPEQWNITSKLSRKKDYTYVMKIRPSGFIYTSGEEASEVANRMELTRCVEIVTSQKLNNSDYCQFGNDTFSFRAQPVSEPDATSEIRSGFAKVSRIVEGRNGKNEMLMAIDTKASPFYKSTSVLNFVCGKYLEKRGSSRNDYRGRGDYNRKKTGGGSTDAPDHQDVAEVERSLEYRENRQQIEEALKGLLVSAAHLKNSTNLIMISRVAETNSETTKFMTNNGEREISVADHYLEAYNYRLKYPKMPLVVSKRFRDECFYPMELLQVAPGQRIKDHKMSAAVQMAMKGQKSTLPQKHVDLVKHVLSRNLKLDRNLYMDAFGIKLESAELVKLQSKILPPPQIKFKDEVYMPKMGNPVFRTNGRFVDPADINAVAIVVFDRAIDMRQAENFCDRLSCYCRENGITVKKSSRDWPIREINSEDSVAIKNAMEKWFSKGVNILVAIAKEKKPDVHDVLKYYEASVGLQTIQVCKQTVDMMLSSGGRQTADNVMRKFNLKCGGTNFFVQIPRSVNGRTVCADAHLLNEKLFERVQFIGFDISHGASRTLFDRSTGKMDGEVSIVGVSYSLSHSTHLGGFAYMQTQKEYKLQKLDEVFPKCVDSYRNHTGRLPSKIVIYRIGAGEGDFKRVKEEVDKIRGTFNRIQPDYRPQLVVIIAQRDSHVRVFPAHITGSKAGQQNVTSGTCVDSVITSLGHQEFILSSQMPLLGTVRPCKYTILTNDPNWTKTEITHLTYFRAFGHQVSYQPPSFPDVLYAAENLAKRGRNNYKVHQRFVNLQAVERSVIAENSDLVSEEMREQLAAAIVDEMSAAINGMTISKRNFWA"

     misc_feature    1097..1375
                     /gene="wago-10"
                     /locus_tag="CELE_T22H9.3"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1178..1180,1223..1225,1256..1258,1268..1270,
                     1322..1324,1343..1345,1349..1351)
                     /gene="wago-10"
                     /locus_tag="CELE_T22H9.3"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    <1490..1603
                     /gene="wago-10"
                     /locus_tag="CELE_T22H9.3"
                     /note="Argonaute linker 2 domain; Region: ArgoL2;
                     pfam16488"
                     /db_xref="CDD:465136"
     misc_feature    1553..2854
                     /gene="wago-10"
                     /locus_tag="CELE_T22H9.3"
                     /note="PIWI domain. Domain found in proteins involved in
                     RNA silencing. RNA silencing refers to a group of related
                     gene-silencing mechanisms mediated by short RNA molecules,
                     including siRNAs, miRNAs, and heterochromatin-related
                     guide RNAs. The central component...; Region: Piwi-like;
                     cd02826"
                     /db_xref="CDD:239208"
     misc_feature    order(1925..1927,1937..1939,1964..1975,1982..1984,
                     2024..2026,2033..2035,2045..2047,2057..2059)
                     /gene="wago-10"
                     /locus_tag="CELE_T22H9.3"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:239208"
     misc_feature    order(2177..2179,2183..2185,2417..2419,2828..2830)
                     /gene="wago-10"
                     /locus_tag="CELE_T22H9.3"
                     /note="active site"
                     /db_xref="CDD:239208"
ORIGIN      

aatttttctttgttttttgttcgaataaatttattgctcctgaaactgtgttcaagttatgccgactaccgtccaaaatccgtccccaactggatttcttccgcagatcccattcagaatacctaaaaggactcgccgcagctctgaagttgatgtccctgcaacgaaaagacccgctccaccgctcacctcttcaacatctcttcccactcgcgactctttttcgatcatcgaaaccagggatgttcagctcaacatgttcgccttaaacatttccgggatgccacgcaagattcaacgtttccacgtggatactctgattaagggaaaaaacggaaagattttcaacgtgaatcatggagttttggcaaattctggagatataaactctcacaacaaacgtctcgcccagcatgcattgatgcagaagttccacaaaaaacgccgagagctttttggccaacacgactatcacatccttgcctacgactgtgcgaacaccctgtacctccccgatggtgtctacctgggccgaaatgaggaagaatgcacgttcaagtccgatgatttttcaccagaacagtggaatatcacttcaaaattgtctcgcaaaaaagattacacgtatgttatgaaaattcggccatccggattcatttacaccagtggtgaggaagcatcggaggtggcaaatcgcatggaattaactcgctgcgttgagatcgtcacttcccagaagctcaacaactctgattactgtcaatttggaaatgacacattctctttccgtgctcaaccagtctccgaaccagatgccacttcagaaatccgatcaggattcgccaaggtctcccgtatcgttgaaggtcgcaacgggaagaatgagatgctcatggcaattgacacaaaagcctctccgttctataaaagcaccagtgtcctgaattttgtgtgcggaaaatatctggagaagaggggaagctcacgcaatgactatcgaggcagaggtgactacaatcggaagaagaccggaggaggatccactgatgctccggatcatcaggatgttgcagaagttgagagatcactggagtaccgcgagaacagacagcagatcgaagaagctcttaagggattgctggtgtcagcggctcatttgaagaattccaccaatttgattatgatctcaagagtagctgagacaaattctgaaaccaccaagttcatgacgaacaatggagaacgcgaaatttccgtcgccgatcactatcttgaagcctacaactaccgactcaagtacccaaaaatgccactggtggtctcgaaacgattcagagacgaatgcttttatccaatggaattgctgcaagttgctccgggacagcgcatcaaagatcacaagatgagtgcggcggtgcagatggcaatgaaaggacagaagtcgacgcttccccagaaacacgtggatcttgtcaagcacgttctctcccgtaatctgaaactggatagaaatctctatatggacgcgtttggaatcaagctggagtccgcggagctggtgaagctgcagtccaagattcttccgccaccacagataaagttcaaggacgaggtgtacatgccgaagatgggcaacccggtcttccgtacgaatggtcgttttgtggatccggctgatatcaatgcagtagccattgtcgtctttgatagggcaattgacatgagacaagcagagaatttctgcgatcgtctgagctgttactgtcgtgagaatggaatcaccgtcaaaaaatcttcgagagactggccgatccgcgagattaacagcgaggacagcgtcgcaatcaagaatgcaatggaaaagtggttcagcaaaggagtgaatattctggttgcaattgccaaagagaagaagcccgatgttcacgatgtcttgaagtattatgaggcttccgtcggcttgcagactattcaggtttgcaagcagaccgtcgatatgatgctgagctccggaggccgtcaaactgcggataacgttatgagaaagttcaatttaaagtgtggaggaacgaatttctttgtccaaattccaagatctgtcaatggaaggactgtctgtgcggatgctcacttgctcaatgagaagctcttcgaacgtgtccagttcatcggattcgatatctcacatggagcttctcgtacgcttttcgaccgtagcacggggaaaatggatggggaagtttcgatcgttggcgtctcctactccttgtctcactcgacacatctcggaggcttcgcctacatgcagactcagaaagaatacaaactgcagaagctcgacgaggtattcccgaaatgtgttgattcgtatcgaaatcatactggccgacttccttcaaaaatcgtcatctatcgaatcggagctggagagggagacttcaagcgagtcaaggaagaagtcgataagattcgaggaacctttaataggatccagcccgactatcgtccgcagctcgtcgtcatcattgctcagagagattctcacgttcgggtctttccggcacacataactgggtcaaaagctggacagcaaaatgtgacgtctggaacttgtgtggatagtgtgatcacttcgttgggccatcaggagttcattttgtcctcgcagatgccgctattgggaaccgtccgtccttgcaagtacacaattctcaccaatgaccccaactggaccaagactgagatcacacatctcacttatttccgagcttttggccatcaagtatcctatcagccaccatcgttccctgatgtgctctacgccgctgagaatctcgccaagagaggaagaaacaactacaaagttcatcaacgattcgttaatttgcaagctgtcgagcgtagtgtgattgcggagaattcggatcttgttagcgaggagatgcgcgagcaactcgccgctgcaattgtcgatgaaatgtccgctgcgatcaatggaatgaccatctcgaaaaggaacttttgggcttgaactcttcatttcccgattttttttttaatcaatttcctgtctttcatccccaacaactcgtatgccatcttgatttttttctctttgaaaatgtgttaatgtgcccaaaaatgaaattgtattgtgttaatgcaagtaatattttattaaatttaatttcaataatagaataaatttttagttttt

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