2025-07-06 03:13:07, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_053602 571 bp mRNA linear ROD 27-DEC-2024 DEFINITION Rattus norvegicus ATP synthase peripheral stalk subunit F6 (Atp5pf), transcript variant 1, mRNA; nuclear gene for mitochondrial product. ACCESSION NM_053602 VERSION NM_053602.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 571) AUTHORS Zhu,C., Zhang,W., Liu,J., Mu,B., Zhang,F., Lai,N., Zhou,J., Xu,A. and Li,Y. TITLE Marine collagen peptides reduce endothelial cell injury in diabetic rats by inhibiting apoptosis and the expression of coupling factor 6 and microparticles JOURNAL Mol Med Rep 16 (4), 3947-3957 (2017) PUBMED 28731155 REFERENCE 2 (bases 1 to 571) AUTHORS Li,N., Yin,J., Cai,W., Liu,J., Zhang,N., Yan,S., Song,L. and Li,X. TITLE Coupling Factor 6 Is Upregulated in Monocrotaline-induced Pulmonary Arterial Hypertension in Rats JOURNAL Am J Med Sci 352 (6), 631-636 (2016) PUBMED 27916219 REMARK GeneRIF: plasma level increased markedly during pathogenesis of pulmonary arterial hypertension (PAH), indicating that CF6 may be involved in the development of PAH REFERENCE 3 (bases 1 to 571) AUTHORS Yin,J., You,S., Li,N., Jiao,S., Hu,H., Xue,M., Wang,Y., Cheng,W., Liu,J., Xu,M., Yan,S. and Li,X. TITLE Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats JOURNAL Respir Res 17 (1), 99 (2016) PUBMED 27491388 REMARK GeneRIF: CF6 shRNA effectively inhibited CF6 expression, abolished lung macrophage infiltration, reversed endothelial dysfunction and vascular remodeling, and ameliorated the severity of pulmonary hypertension and right ventricular dysfunction at 4 weeks both as a pretreatment and rescue intervention Publication Status: Online-Only REFERENCE 4 (bases 1 to 571) AUTHORS He,T., Guan,A., Shi,Y., Ge,Z. and Dai,H. TITLE Mitochondrial coupling factor 6 upregulation in hypertension-induced cardiac hypertrophy JOURNAL Herz 40 (5), 783-787 (2015) PUBMED 25900768 REMARK GeneRIF: CF6 protein was upregulated in cardiac hypertrophy induced by hypertension; further mechanisms involved in this process should be investigated. REFERENCE 5 (bases 1 to 571) AUTHORS Ramm,S., Morissey,B., Hernandez,B., Rooney,C., Pennington,S.R. and Mally,A. TITLE Application of a discovery to targeted LC-MS proteomics approach to identify deregulated proteins associated with idiosyncratic liver toxicity in a rat model of LPS/diclofenac co-administration JOURNAL Toxicology 331, 100-111 (2015) PUBMED 25772430 REFERENCE 6 (bases 1 to 571) AUTHORS Osanai,T., Kamada,T., Fujiwara,N., Katoh,T., Takahashi,K., Kimura,M., Satoh,K., Magota,K., Kodama,S., Tanaka,T. and Okumura,K. TITLE A novel inhibitory effect on prostacyclin synthesis of coupling factor 6 extracted from the heart of spontaneously hypertensive rats JOURNAL J Biol Chem 273 (48), 31778-31783 (1998) PUBMED 9822642 REFERENCE 7 (bases 1 to 571) AUTHORS Higuti,T., Yoshihara,Y., Kuroiwa,K., Kawamura,Y., Toda,H. and Sakiyama,F. TITLE A simple, rapid method for purification of epsilon-subunit, coupling factor 6, subunit d, and subunit e from rat liver H(+)-ATP synthase and determination of the complete amino acid sequence of epsilon-subunit JOURNAL J Biol Chem 267 (31), 22658-22661 (1992) PUBMED 1429613 REFERENCE 8 (bases 1 to 571) AUTHORS Tracer,H.L., Loh,Y.P. and Birch,N.P. TITLE Rat mitochondrial coupling factor 6: molecular cloning of a cDNA encoding the imported precursor JOURNAL Gene 116 (2), 291-292 (1992) PUBMED 1386054 REFERENCE 9 (bases 1 to 571) AUTHORS Yoshihara,Y., Nagase,H., Yamane,T., Oka,H., Tani,I. and Higuti,T. TITLE H(+)-ATP synthase from rat liver mitochondria. A simple, rapid purification method of the functional complex and its characterization JOURNAL Biochemistry 30 (28), 6854-6860 (1991) PUBMED 1829963 REFERENCE 10 (bases 1 to 571) AUTHORS Higuti,T., Osaka,F., Yoshihara,Y., Tsurumi,C., Kawamura,Y., Tani,I., Toda,H., Kakuno,T., Sakiyama,F., Tanaka,K. et al. TITLE cDNA cloning and sequencing for the import precursor of coupling factor 6 in H(+)-ATP synthase from rat liver mitochondria JOURNAL Biochem Biophys Res Commun 171 (3), 1079-1086 (1990) PUBMED 2145831 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X54510.1. On Feb 21, 2013 this sequence version replaced NM_053602.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X54510.1, BG666039.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA5756307, SAMEA5760383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-571 X54510.1 1-571 FEATURES Location/Qualifiers source 1..571 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="11" /map="11q11" gene 1..571 /gene="Atp5pf" /gene_synonym="Atp5j" /note="ATP synthase peripheral stalk subunit F6" /db_xref="GeneID:94271" /db_xref="RGD:621376" exon 1..145 /gene="Atp5pf" /gene_synonym="Atp5j" /inference="alignment:Splign:2.1.0" misc_feature 96..98 /gene="Atp5pf" /gene_synonym="Atp5j" /note="upstream in-frame stop codon" exon 146..325 /gene="Atp5pf" /gene_synonym="Atp5j" /inference="alignment:Splign:2.1.0" CDS 162..488 /gene="Atp5pf" /gene_synonym="Atp5j" /EC_number="3.6.1.14" /note="ATP synthase-coupling factor 6, mitochondrial; ATPase subunit F6; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6" /codon_start=1 /product="ATP synthase-coupling factor 6, mitochondrial precursor" /protein_id="NP_446054.1" /db_xref="GeneID:94271" /db_xref="RGD:621376" /translation="
MTVQRIFRLSSVLRSAVSVHLRRNIGVTAVAFNKELDPVQKLFLDKIREYKAKRLASGGPVDTGPEYQQEVDRELFKLKQMYGKGEMDKFPTFNFEDPKFEVLDKPQS"
misc_feature 162..449 /gene="Atp5pf" /gene_synonym="Atp5j" /note="Mitochondrial ATP synthase coupling factor 6; Region: ATP-synt_F6; pfam05511" /db_xref="CDD:461669" transit_peptide 162..257 /gene="Atp5pf" /gene_synonym="Atp5j" /note="Mitochondrion. /evidence=ECO:0000269|PubMed:1429613; propagated from UniProtKB/Swiss-Prot (P21571.1)" mat_peptide 258..485 /gene="Atp5pf" /gene_synonym="Atp5j" /product="ATP synthase-coupling factor 6, mitochondrial" misc_feature 282..284 /gene="Atp5pf" /gene_synonym="Atp5j" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P18859; propagated from UniProtKB/Swiss-Prot (P21571.1); acetylation site" misc_feature 297..299 /gene="Atp5pf" /gene_synonym="Atp5j" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P18859; propagated from UniProtKB/Swiss-Prot (P21571.1); acetylation site" misc_feature 396..398 /gene="Atp5pf" /gene_synonym="Atp5j" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P97450; propagated from UniProtKB/Swiss-Prot (P21571.1); acetylation site" misc_feature 411..413 /gene="Atp5pf" /gene_synonym="Atp5j" /note="N6-acetyllysine, alternate. /evidence=ECO:0000250|UniProtKB:P97450; propagated from UniProtKB/Swiss-Prot (P21571.1); acetylation site" misc_feature 456..458 /gene="Atp5pf" /gene_synonym="Atp5j" /note="N6-acetyllysine, alternate. /evidence=ECO:0000250|UniProtKB:P18859; propagated from UniProtKB/Swiss-Prot (P21571.1); acetylation site" misc_feature 474..476 /gene="Atp5pf" /gene_synonym="Atp5j" /note="N6-acetyllysine. /evidence=ECO:0000250|UniProtKB:P18859; propagated from UniProtKB/Swiss-Prot (P21571.1); acetylation site" misc_feature 483..485 /gene="Atp5pf" /gene_synonym="Atp5j" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (P21571.1); phosphorylation site" exon 326..450 /gene="Atp5pf" /gene_synonym="Atp5j" /inference="alignment:Splign:2.1.0" exon 451..571 /gene="Atp5pf" /gene_synonym="Atp5j" /inference="alignment:Splign:2.1.0" ORIGIN
gcttcctgtccggtgagcgtcgaacgactgaagcggtggcccatagtgcattgcgatggcgggtaggcgtgtgtaggcggagccagggccggaagtagaacggtggcggcggcggtgactctggcagctcgggactcagtgcaagtaccacagactcaaccatgactgttcagaggatcttcaggctctcctctgtccttcggtcagcagtctctgtgcatttgaggaggaacattggtgttacagctgtggcgtttaataaggaacttgatcctgtacagaaactcttcttggacaagataagagagtacaaagcaaagcgactggcgtctggaggacctgttgatactggcccagaatatcagcaagaggtggacagagagctttttaagcttaaacaaatgtatggtaaaggagagatggataagtttcctaccttcaattttgaggatcccaaatttgaagtcctcgacaaaccccagtcctgaggaacatacaaaccatgtggtaatttgtcatgacttagttgtacaattaatctaaaaaattcaaataaacattcacttcacag
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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