LOCUS       NM_053457               1848 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Rattus norvegicus claudin 11 (Cldn11), mRNA.
ACCESSION   NM_053457
VERSION     NM_053457.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1848)
  AUTHORS   Kato,T., Mizuno,K., Nishio,H., Moritoki,Y., Kamisawa,H.,
            Kurokawa,S., Nakane,A., Maruyama,T., Ando,R., Hayashi,Y. and
            Yasui,T.
  TITLE     Disorganization of claudin-11 and dysfunction of the blood-testis
            barrier during puberty in a cryptorchid rat model
  JOURNAL   Andrology 8 (5), 1398-1408 (2020)
   PUBMED   32196966
  REMARK    GeneRIF: Disorganization of claudin-11 and dysfunction of the
            blood-testis barrier during puberty in a cryptorchid rat model.
REFERENCE   2  (bases 1 to 1848)
  AUTHORS   Berndt,P., Winkler,L., Cording,J., Breitkreuz-Korff,O., Rex,A.,
            Dithmer,S., Rausch,V., Blasig,R., Richter,M., Sporbert,A.,
            Wolburg,H., Blasig,I.E. and Haseloff,R.F.
  TITLE     Tight junction proteins at the blood-brain barrier: far more than
            claudin-5
  JOURNAL   Cell Mol Life Sci 76 (10), 1987-2002 (2019)
   PUBMED   30734065
REFERENCE   3  (bases 1 to 1848)
  AUTHORS   Oh,Y.S., Jo,N.H., Park,J.K. and Gye,M.C.
  TITLE     Changes in Inflammatory Cytokines Accompany Deregulation of
            Claudin-11, Resulting in Inter-Sertoli Tight Junctions in
            Varicocele Rat Testes
  JOURNAL   J Urol 196 (4), 1303-1312 (2016)
   PUBMED   27164517
  REMARK    GeneRIF: An increase in proinflammatory cytokines might be
            responsible for deregulation of Cldn11 in the Sertoli cells in
            varicocele testes, leading to alterations in the permeability of
            the blood-testis barrier and immunological barriers to normal
            spermatogenesis.
REFERENCE   4  (bases 1 to 1848)
  AUTHORS   McCabe,M.J., Foo,C.F., Dinger,M.E., Smooker,P.M. and Stanton,P.G.
  TITLE     Claudin-11 and occludin are major contributors to Sertoli cell
            tight junction function, in vitro
  JOURNAL   Asian J Androl 18 (4), 620-626 (2016)
   PUBMED   26585695
  REMARK    GeneRIF: We provide quantitative evidence that claudin-11
            contributes significantly to Sertoli cell tight junction function
            in vitro. Interestingly, occludin, which is hormonally regulated
            but not implicated in infertility until late adulthood, is also a
            significant contributor to barrier function.
REFERENCE   5  (bases 1 to 1848)
  AUTHORS   Uetsuka,S., Ogata,G., Nagamori,S., Isozumi,N., Nin,F., Yoshida,T.,
            Komune,S., Kitahara,T., Kikkawa,Y., Inohara,H., Kanai,Y. and
            Hibino,H.
  TITLE     Molecular architecture of the stria vascularis membrane transport
            system, which is essential for physiological functions of the
            mammalian cochlea
  JOURNAL   Eur J Neurosci 42 (3), 1984-2002 (2015)
   PUBMED   26060893
REFERENCE   6  (bases 1 to 1848)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   7  (bases 1 to 1848)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   8  (bases 1 to 1848)
  AUTHORS   Florin,A., Maire,M., Bozec,A., Hellani,A., Chater,S., Bars,R.,
            Chuzel,F. and Benahmed,M.
  TITLE     Androgens and postmeiotic germ cells regulate claudin-11 expression
            in rat Sertoli cells
  JOURNAL   Endocrinology 146 (3), 1532-1540 (2005)
   PUBMED   15591150
  REMARK    GeneRIF: claudin-11 expression in rat Sertoli cells is regulated by
            androgens and postmeiotic germ cells
REFERENCE   9  (bases 1 to 1848)
  AUTHORS   Lui,W.Y., Lee,W.M. and Cheng,C.Y.
  TITLE     Transforming growth factor-beta3 perturbs the inter-Sertoli tight
            junction permeability barrier in vitro possibly mediated via its
            effects on occludin, zonula occludens-1, and claudin-11
  JOURNAL   Endocrinology 142 (5), 1865-1877 (2001)
   PUBMED   11316752
REFERENCE   10 (bases 1 to 1848)
  AUTHORS   Gow,A., Southwood,C.M., Li,J.S., Pariali,M., Riordan,G.P.,
            Brodie,S.E., Danias,J., Bronstein,J.M., Kachar,B. and
            Lazzarini,R.A.
  TITLE     CNS myelin and sertoli cell tight junction strands are absent in
            Osp/claudin-11 null mice
  JOURNAL   Cell 99 (6), 649-659 (1999)
   PUBMED   10612400
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053457.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070927.1, SRR26643299.9337.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984041, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               JAXUCZ010000002.1  114149119-114149539 c
            422-586             JAXUCZ010000002.1  114145453-114145617 c
            587-1848            JAXUCZ010000002.1  114136234-114137495 c
FEATURES             Location/Qualifiers
     source          1..1848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..1848
                     /gene="Cldn11"
                     /note="claudin 11"
                     /db_xref="GeneID:84588"
                     /db_xref="RGD:71081"
     exon            1..421
                     /gene="Cldn11"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    118..120
                     /gene="Cldn11"
                     /note="upstream in-frame stop codon"
     CDS             196..819
                     /gene="Cldn11"
                     /codon_start=1
                     /product="claudin-11"
                     /protein_id="NP_445909.2"
                     /db_xref="GeneID:84588"
                     /db_xref="RGD:71081"
                     /translation="

MVATCLQVVGFVTSFVGWIGIIVTTSTNDWVVTCSYTIPTCRKMDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGHEPGVAKYRRAQLAGVLLILLALCAIVATIWFPVCAHREITIVSFGYSLYAGWIGAVMCLVGGCVIVCCSGDAQSFGENRFYYSSGSSSPTHAKSAHV"

     misc_feature    199..261
                     /gene="Cldn11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1);
                     transmembrane region"
     misc_feature    211..711
                     /gene="Cldn11"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    442..504
                     /gene="Cldn11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1);
                     transmembrane region"
     misc_feature    562..624
                     /gene="Cldn11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1);
                     transmembrane region"
     misc_feature    667..729
                     /gene="Cldn11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1);
                     transmembrane region"
     misc_feature    772..774
                     /gene="Cldn11"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site"
     misc_feature    775..777
                     /gene="Cldn11"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site"
     misc_feature    784..786
                     /gene="Cldn11"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site"
     misc_feature    787..789
                     /gene="Cldn11"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site"
     exon            422..586
                     /gene="Cldn11"
                     /inference="alignment:Splign:2.1.0"
     exon            587..1848
                     /gene="Cldn11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtccccgccaggcgcacctgtccccgctgcacgccgtcgcagcagcgctcgcagcctctcctctccactcggagtatcccggagccagcggcttgcgagggcgggagagagcaagcctagggaaggctctgtccaggccggcgcagggggcacagtccgtgtgggtcgagctgcgtggacgtcgctgcggccaccatggtagccacttgcctgcaggtggtgggcttcgtcactagcttcgtgggttggattggcatcatcgtcacaacgtccaccaatgactgggtggtgacctgcagctacaccatccccacctgccgcaaaatggacgaactgggctccaaggggctgtgggccgactgcgtcatggccactggtctctaccactgcaagcccctggtggacatcctcatcctccctggttacgtgcaggcttgtagagccctcatgattgctgcctcagttctgggcctgccggccatcttgctgctgttaacagttctcccctgtatccgaatgggccacgagcctggagtggccaagtacaggcgagcccagctggctggggtgctccttattctgctggctctctgcgccattgtcgccaccatctggtttcctgtatgcgcccaccgcgagatcaccatcgtgagctttggctactcgctgtatgcgggctggatcggtgctgtgatgtgcctggtgggtggctgtgtcatcgtctgctgctccggggatgcacagtcgtttggagaaaaccgtttctattactcttctggctccagctcaccaacgcacgccaagagtgcccatgtctaagagggctgctccactgcccaccgaggtgctgtaaatgctgggcctgggccctgggtttgcttgccacagtggggagaagcccacttccctgccaggcactaaagccaaagttctagaaagtatcctgcctggcattttgcagtcataacaccccacccatccacccacccacccacccaccacctcttggttgccttaaaagaaatctccagctcagataatgcccacatagttttctcctggagttgcaggctgttcgctcctttcctcgggcgttccattgttgttgattaaaaaaatattgtgtttctctcttaaatccaaatgtcttgggaacattgctgacttgggtgtgggttgggagagaaataaaagatgcttttcaaagggttaccagcgacaatggaagcctcgtagagacagcgctcttctctctttcggcttagtttcaaggtcacttacatataagagatagaaacggatagacttggaacacgggtgggaggggaactcggggcattccctccgtgggaaagaagcttctcttttataagttgaggggttgggtctctctctctcttttttttttttagtttgtgattttacatttttctgtatatactttttcaagatcgatcgtttttataaccacgggtttcctgaaattctcaattcaccaatatgaaggaaatgaaccaagcagacgttaatatgcaataagtaatagtacggagattataactttaactgaccacccccagtttccaggtttgtatgctgtagtttttaattctacggttgcgtatgctttgaattaacacatttaaaaaccctttctccccttctatctctgtctccattctgttagcgatcttgaagcagtgctgtttagcataagttgtactgttgaatttggcttcatgggtgtaaacaccgatggtctgtcagtgtctaagattctgggcactgcaagctcggctcggtgcatttgtttcaggtaaaatctgtgcaataaaataacaaactgtc

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