LOCUS       NM_053457               1848 bp    mRNA    linear   ROD 22-APR-2021
DEFINITION  Rattus norvegicus claudin 11 (Cldn11), mRNA.
ACCESSION   NM_053457
VERSION     NM_053457.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1848)
  AUTHORS   Berndt P, Winkler L, Cording J, Breitkreuz-Korff O, Rex A, Dithmer
            S, Rausch V, Blasig R, Richter M, Sporbert A, Wolburg H, Blasig IE
            and Haseloff RF.
  TITLE     Tight junction proteins at the blood-brain barrier: far more than
            claudin-5
  JOURNAL   Cell Mol Life Sci 76 (10), 1987-2002 (2019)
   PUBMED   30734065
REFERENCE   2  (bases 1 to 1848)
  AUTHORS   Oh YS, Jo NH, Park JK and Gye MC.
  TITLE     Changes in Inflammatory Cytokines Accompany Deregulation of
            Claudin-11, Resulting in Inter-Sertoli Tight Junctions in
            Varicocele Rat Testes
  JOURNAL   J Urol 196 (4), 1303-1312 (2016)
   PUBMED   27164517
  REMARK    GeneRIF: An increase in proinflammatory cytokines might be
            responsible for deregulation of Cldn11 in the Sertoli cells in
            varicocele testes, leading to alterations in the permeability of
            the blood-testis barrier and immunological barriers to normal
            spermatogenesis.
REFERENCE   3  (bases 1 to 1848)
  AUTHORS   McCabe MJ, Foo CF, Dinger ME, Smooker PM and Stanton PG.
  TITLE     Claudin-11 and occludin are major contributors to Sertoli cell
            tight junction function, in vitro
  JOURNAL   Asian J Androl 18 (4), 620-626 (2016)
   PUBMED   26585695
  REMARK    GeneRIF: We provide quantitative evidence that claudin-11
            contributes significantly to Sertoli cell tight junction function
            in vitro. Interestingly, occludin, which is hormonally regulated
            but not implicated in infertility until late adulthood, is also a
            significant contributor to barrier function.
REFERENCE   4  (bases 1 to 1848)
  AUTHORS   Uetsuka S, Ogata G, Nagamori S, Isozumi N, Nin F, Yoshida T, Komune
            S, Kitahara T, Kikkawa Y, Inohara H, Kanai Y and Hibino H.
  TITLE     Molecular architecture of the stria vascularis membrane transport
            system, which is essential for physiological functions of the
            mammalian cochlea
  JOURNAL   Eur J Neurosci 42 (3), 1984-2002 (2015)
   PUBMED   26060893
REFERENCE   5  (bases 1 to 1848)
  AUTHORS   Dietze R, Shihan M, Stammler A, Konrad L and Scheiner-Bobis G.
  TITLE     Cardiotonic steroid ouabain stimulates expression of blood-testis
            barrier proteins claudin-1 and -11 and formation of tight junctions
            in Sertoli cells
  JOURNAL   Mol Cell Endocrinol 405, 1-13 (2015)
   PUBMED   25666991
  REMARK    GeneRIF: Cardiotonic steroids may influence the formation of the
            blood-testis barrier via regulation of Cldn1 and Cldn11 expression.
REFERENCE   6  (bases 1 to 1848)
  AUTHORS   Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J and Blasig
            IE.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   7  (bases 1 to 1848)
  AUTHORS   Werner HB, Kuhlmann K, Shen S, Uecker M, Schardt A, Dimova K,
            Orfaniotou F, Dhaunchak A, Brinkmann BG, Mobius W, Guarente L,
            Casaccia-Bonnefil P, Jahn O and Nave KA.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   8  (bases 1 to 1848)
  AUTHORS   Florin A, Maire M, Bozec A, Hellani A, Chater S, Bars R, Chuzel F
            and Benahmed M.
  TITLE     Androgens and postmeiotic germ cells regulate claudin-11 expression
            in rat Sertoli cells
  JOURNAL   Endocrinology 146 (3), 1532-1540 (2005)
   PUBMED   15591150
  REMARK    GeneRIF: claudin-11 expression in rat Sertoli cells is regulated by
            androgens and postmeiotic germ cells
REFERENCE   9  (bases 1 to 1848)
  AUTHORS   Lui WY, Lee WM and Cheng CY.
  TITLE     Transforming growth factor-beta3 perturbs the inter-Sertoli tight
            junction permeability barrier in vitro possibly mediated via its
            effects on occludin, zonula occludens-1, and claudin-11
  JOURNAL   Endocrinology 142 (5), 1865-1877 (2001)
   PUBMED   11316752
REFERENCE   10 (bases 1 to 1848)
  AUTHORS   Gow A, Southwood CM, Li JS, Pariali M, Riordan GP, Brodie SE,
            Danias J, Bronstein JM, Kachar B and Lazzarini RA.
  TITLE     CNS myelin and sertoli cell tight junction strands are absent in
            Osp/claudin-11 null mice
  JOURNAL   Cell 99 (6), 649-659 (1999)
   PUBMED   10612400
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000067.1.
            On Nov 27, 2020 this sequence version replaced NM_053457.2.
            
            Summary: component of the inter-Sertoli cell tight junctions in the
            testis [RGD, Feb 2006].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070927.1, CB582493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               JACYVU010000067.1  27288252-27288672   c
            422-586             JACYVU010000067.1  27284586-27284750   c
            587-1848            JACYVU010000067.1  27275367-27276628   c
FEATURES             Location/Qualifiers
     source          1..1848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..1848
                     /gene="Cldn11"
                     /note="claudin 11"
                     /db_xref="GeneID:84588"
                     /db_xref="RGD:71081"
     exon            1..421
                     /gene="Cldn11"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    118..120
                     /gene="Cldn11"
                     /note="upstream in-frame stop codon"
     CDS             196..819
                     /gene="Cldn11"
                     /codon_start=1
                     /product="claudin-11"
                     /protein_id="NP_445909.2"
                     /db_xref="GeneID:84588"
                     /db_xref="RGD:71081"
                     /translation="

MVATCLQVVGFVTSFVGWIGIIVTTSTNDWVVTCSYTIPTCRKMDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGHEPGVAKYRRAQLAGVLLILLALCAIVATIWFPVCAHREITIVSFGYSLYAGWIGAVMCLVGGCVIVCCSGDAQSFGENRFYYSSGSSSPTHAKSAHV"

     misc_feature    199..261
                     /gene="Cldn11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1);
                     transmembrane region"
     misc_feature    211..711
                     /gene="Cldn11"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:419754"
     misc_feature    442..504
                     /gene="Cldn11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1);
                     transmembrane region"
     misc_feature    562..624
                     /gene="Cldn11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1);
                     transmembrane region"
     misc_feature    667..729
                     /gene="Cldn11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1);
                     transmembrane region"
     misc_feature    772..774
                     /gene="Cldn11"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site"
     misc_feature    775..777
                     /gene="Cldn11"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site"
     misc_feature    784..786
                     /gene="Cldn11"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site"
     misc_feature    787..789
                     /gene="Cldn11"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site"
     exon            422..586
                     /gene="Cldn11"
                     /inference="alignment:Splign:2.1.0"
     exon            587..1848
                     /gene="Cldn11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtccccgccaggcgcacctgtccccgctgcacgccgtcgcagcagcgctcgcagcctctcctctccactcggagtatcccggagccagcggcttgcgagggcgggagagagcaagcctagggaaggctctgtccaggccggcgcagggggcacagtccgtgtgggtcgagctgcgtggacgtcgctgcggccaccatggtagccacttgcctgcaggtggtgggcttcgtcactagcttcgtgggttggattggcatcatcgtcacaacgtccaccaatgactgggtggtgacctgcagctacaccatccccacctgccgcaaaatggacgaactgggctccaaggggctgtgggccgactgcgtcatggccactggtctctaccactgcaagcccctggtggacatcctcatcctccctggttacgtgcaggcttgtagagccctcatgattgctgcctcagttctgggcctgccggccatcttgctgctgttaacagttctcccctgtatccgaatgggccacgagcctggagtggccaagtacaggcgagcccagctggctggggtgctccttattctgctggctctctgcgccattgtcgccaccatctggtttcctgtatgcgcccaccgcgagatcaccatcgtgagctttggctactcgctgtatgcgggctggatcggtgctgtgatgtgcctggtgggtggctgtgtcatcgtctgctgctccggggatgcacagtcgtttggagaaaaccgtttctattactcttctggctccagctcaccaacgcacgccaagagtgcccatgtctaagagggctgctccactgcccaccgaggtgctgtaaatgctgggcctgggccctgggtttgcttgccacagtggggagaagcccacttccctgccaggcactaaagccaaagttctagaaagtatcctgcctggcattttgcagtcataacaccccacccatccacccacccacccacccaccacctcttggttgccttaaaagaaatctccagctcagataatgcccacatagttttctcctggagttgcaggctgttcgctcctttcctcgggcgttccattgttgttgattaaaaaaatattgtgtttctctcttaaatccaaatgtcttgggaacattgctgacttgggtgtgggttgggagagaaataaaagatgcttttcaaagggttaccagcgacaatggaagcctcgtagagacagcgctcttctctctttcggcttagtttcaaggtcacttacatataagagatagaaacggatagacttggaacacgggtgggaggggaactcggggcattccctccgtgggaaagaagcttctcttttataagttgaggggttgggtctctctctctcttttttttttttagtttgtgattttacatttttctgtatatactttttcaagatcgatcgtttttataaccacgggtttcctgaaattctcaattcaccaatatgaaggaaatgaaccaagcagacgttaatatgcaataagtaatagtacggagattataactttaactgaccacccccagtttccaggtttgtatgctgtagtttttaattctacggttgcgtatgctttgaattaacacatttaaaaaccctttctccccttctatctctgtctccattctgttagcgatcttgaagcagtgctgtttagcataagttgtactgttgaatttggcttcatgggtgtaaacaccgatggtctgtcagtgtctaagattctgggcactgcaagctcggctcggtgcatttgtttcaggtaaaatctgtgcaataaaataacaaactgtc

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