2025-07-11 07:50:47, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_053457 1848 bp mRNA linear ROD 07-DEC-2024 DEFINITION Rattus norvegicus claudin 11 (Cldn11), mRNA. ACCESSION NM_053457 VERSION NM_053457.3 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 1848) AUTHORS Kato,T., Mizuno,K., Nishio,H., Moritoki,Y., Kamisawa,H., Kurokawa,S., Nakane,A., Maruyama,T., Ando,R., Hayashi,Y. and Yasui,T. TITLE Disorganization of claudin-11 and dysfunction of the blood-testis barrier during puberty in a cryptorchid rat model JOURNAL Andrology 8 (5), 1398-1408 (2020) PUBMED 32196966 REMARK GeneRIF: Disorganization of claudin-11 and dysfunction of the blood-testis barrier during puberty in a cryptorchid rat model. REFERENCE 2 (bases 1 to 1848) AUTHORS Berndt,P., Winkler,L., Cording,J., Breitkreuz-Korff,O., Rex,A., Dithmer,S., Rausch,V., Blasig,R., Richter,M., Sporbert,A., Wolburg,H., Blasig,I.E. and Haseloff,R.F. TITLE Tight junction proteins at the blood-brain barrier: far more than claudin-5 JOURNAL Cell Mol Life Sci 76 (10), 1987-2002 (2019) PUBMED 30734065 REFERENCE 3 (bases 1 to 1848) AUTHORS Oh,Y.S., Jo,N.H., Park,J.K. and Gye,M.C. TITLE Changes in Inflammatory Cytokines Accompany Deregulation of Claudin-11, Resulting in Inter-Sertoli Tight Junctions in Varicocele Rat Testes JOURNAL J Urol 196 (4), 1303-1312 (2016) PUBMED 27164517 REMARK GeneRIF: An increase in proinflammatory cytokines might be responsible for deregulation of Cldn11 in the Sertoli cells in varicocele testes, leading to alterations in the permeability of the blood-testis barrier and immunological barriers to normal spermatogenesis. REFERENCE 4 (bases 1 to 1848) AUTHORS McCabe,M.J., Foo,C.F., Dinger,M.E., Smooker,P.M. and Stanton,P.G. TITLE Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro JOURNAL Asian J Androl 18 (4), 620-626 (2016) PUBMED 26585695 REMARK GeneRIF: We provide quantitative evidence that claudin-11 contributes significantly to Sertoli cell tight junction function in vitro. Interestingly, occludin, which is hormonally regulated but not implicated in infertility until late adulthood, is also a significant contributor to barrier function. REFERENCE 5 (bases 1 to 1848) AUTHORS Uetsuka,S., Ogata,G., Nagamori,S., Isozumi,N., Nin,F., Yoshida,T., Komune,S., Kitahara,T., Kikkawa,Y., Inohara,H., Kanai,Y. and Hibino,H. TITLE Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea JOURNAL Eur J Neurosci 42 (3), 1984-2002 (2015) PUBMED 26060893 REFERENCE 6 (bases 1 to 1848) AUTHORS Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and Blasig,I.E. TITLE Structure and function of claudins JOURNAL Biochim Biophys Acta 1778 (3), 631-645 (2008) PUBMED 18036336 REMARK Review article REFERENCE 7 (bases 1 to 1848) AUTHORS Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A., Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W., Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A. TITLE Proteolipid protein is required for transport of sirtuin 2 into CNS myelin JOURNAL J Neurosci 27 (29), 7717-7730 (2007) PUBMED 17634366 REFERENCE 8 (bases 1 to 1848) AUTHORS Florin,A., Maire,M., Bozec,A., Hellani,A., Chater,S., Bars,R., Chuzel,F. and Benahmed,M. TITLE Androgens and postmeiotic germ cells regulate claudin-11 expression in rat Sertoli cells JOURNAL Endocrinology 146 (3), 1532-1540 (2005) PUBMED 15591150 REMARK GeneRIF: claudin-11 expression in rat Sertoli cells is regulated by androgens and postmeiotic germ cells REFERENCE 9 (bases 1 to 1848) AUTHORS Lui,W.Y., Lee,W.M. and Cheng,C.Y. TITLE Transforming growth factor-beta3 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occludin, zonula occludens-1, and claudin-11 JOURNAL Endocrinology 142 (5), 1865-1877 (2001) PUBMED 11316752 REFERENCE 10 (bases 1 to 1848) AUTHORS Gow,A., Southwood,C.M., Li,J.S., Pariali,M., Riordan,G.P., Brodie,S.E., Danias,J., Bronstein,J.M., Kachar,B. and Lazzarini,R.A. TITLE CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice JOURNAL Cell 99 (6), 649-659 (1999) PUBMED 10612400 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAXUCZ010000002.1. On Nov 27, 2020 this sequence version replaced NM_053457.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070927.1, SRR26643299.9337.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN14984041, SAMN16676810 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-421 JAXUCZ010000002.1 114149119-114149539 c 422-586 JAXUCZ010000002.1 114145453-114145617 c 587-1848 JAXUCZ010000002.1 114136234-114137495 c FEATURES Location/Qualifiers source 1..1848 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="2" /map="2q24" gene 1..1848 /gene="Cldn11" /note="claudin 11" /db_xref="GeneID:84588" /db_xref="RGD:71081" exon 1..421 /gene="Cldn11" /inference="alignment:Splign:2.1.0" misc_feature 118..120 /gene="Cldn11" /note="upstream in-frame stop codon" CDS 196..819 /gene="Cldn11" /codon_start=1 /product="claudin-11" /protein_id="NP_445909.2" /db_xref="GeneID:84588" /db_xref="RGD:71081" /translation="
MVATCLQVVGFVTSFVGWIGIIVTTSTNDWVVTCSYTIPTCRKMDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGHEPGVAKYRRAQLAGVLLILLALCAIVATIWFPVCAHREITIVSFGYSLYAGWIGAVMCLVGGCVIVCCSGDAQSFGENRFYYSSGSSSPTHAKSAHV"
misc_feature 199..261 /gene="Cldn11" /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1); transmembrane region" misc_feature 211..711 /gene="Cldn11" /note="PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl21598" /db_xref="CDD:473919" misc_feature 442..504 /gene="Cldn11" /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1); transmembrane region" misc_feature 562..624 /gene="Cldn11" /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1); transmembrane region" misc_feature 667..729 /gene="Cldn11" /note="propagated from UniProtKB/Swiss-Prot (Q99P82.1); transmembrane region" misc_feature 772..774 /gene="Cldn11" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site" misc_feature 775..777 /gene="Cldn11" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site" misc_feature 784..786 /gene="Cldn11" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site" misc_feature 787..789 /gene="Cldn11" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (Q99P82.1); phosphorylation site" exon 422..586 /gene="Cldn11" /inference="alignment:Splign:2.1.0" exon 587..1848 /gene="Cldn11" /inference="alignment:Splign:2.1.0" ORIGIN
gtccccgccaggcgcacctgtccccgctgcacgccgtcgcagcagcgctcgcagcctctcctctccactcggagtatcccggagccagcggcttgcgagggcgggagagagcaagcctagggaaggctctgtccaggccggcgcagggggcacagtccgtgtgggtcgagctgcgtggacgtcgctgcggccaccatggtagccacttgcctgcaggtggtgggcttcgtcactagcttcgtgggttggattggcatcatcgtcacaacgtccaccaatgactgggtggtgacctgcagctacaccatccccacctgccgcaaaatggacgaactgggctccaaggggctgtgggccgactgcgtcatggccactggtctctaccactgcaagcccctggtggacatcctcatcctccctggttacgtgcaggcttgtagagccctcatgattgctgcctcagttctgggcctgccggccatcttgctgctgttaacagttctcccctgtatccgaatgggccacgagcctggagtggccaagtacaggcgagcccagctggctggggtgctccttattctgctggctctctgcgccattgtcgccaccatctggtttcctgtatgcgcccaccgcgagatcaccatcgtgagctttggctactcgctgtatgcgggctggatcggtgctgtgatgtgcctggtgggtggctgtgtcatcgtctgctgctccggggatgcacagtcgtttggagaaaaccgtttctattactcttctggctccagctcaccaacgcacgccaagagtgcccatgtctaagagggctgctccactgcccaccgaggtgctgtaaatgctgggcctgggccctgggtttgcttgccacagtggggagaagcccacttccctgccaggcactaaagccaaagttctagaaagtatcctgcctggcattttgcagtcataacaccccacccatccacccacccacccacccaccacctcttggttgccttaaaagaaatctccagctcagataatgcccacatagttttctcctggagttgcaggctgttcgctcctttcctcgggcgttccattgttgttgattaaaaaaatattgtgtttctctcttaaatccaaatgtcttgggaacattgctgacttgggtgtgggttgggagagaaataaaagatgcttttcaaagggttaccagcgacaatggaagcctcgtagagacagcgctcttctctctttcggcttagtttcaaggtcacttacatataagagatagaaacggatagacttggaacacgggtgggaggggaactcggggcattccctccgtgggaaagaagcttctcttttataagttgaggggttgggtctctctctctcttttttttttttagtttgtgattttacatttttctgtatatactttttcaagatcgatcgtttttataaccacgggtttcctgaaattctcaattcaccaatatgaaggaaatgaaccaagcagacgttaatatgcaataagtaatagtacggagattataactttaactgaccacccccagtttccaggtttgtatgctgtagtttttaattctacggttgcgtatgctttgaattaacacatttaaaaaccctttctccccttctatctctgtctccattctgttagcgatcttgaagcagtgctgtttagcataagttgtactgttgaatttggcttcatgggtgtaaacaccgatggtctgtcagtgtctaagattctgggcactgcaagctcggctcggtgcatttgtttcaggtaaaatctgtgcaataaaataacaaactgtc
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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