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Previous release (v1)
2026-01-22 23:51:50, GGRNA.v2 : RefSeq release 232 (Sep, 2025)
LOCUS NM_031877 2572 bp mRNA linear ROD 28-APR-2025
DEFINITION Mus musculus WASP family, member 1 (Wasf1), transcript variant 1,
mRNA.
ACCESSION NM_031877
VERSION NM_031877.3
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 2572)
AUTHORS Zhang,Y., Kang,H.R., Jun,Y., Kang,H., Bang,G., Ma,R., Ju,S.,
Yoon,D.E., Kim,Y., Kim,K., Kim,J.Y. and Han,K.
TITLE Neurodevelopmental disorder-associated CYFIP2 regulates
membraneless organelles and eIF2alpha phosphorylation via protein
interactors and actin cytoskeleton
JOURNAL Hum Mol Genet 33 (19), 1671-1687 (2024)
PUBMED 38981622
REFERENCE 2 (bases 1 to 2572)
AUTHORS Longatti,A., Ponzoni,L., Moretto,E., Giansante,G., Lattuada,N.,
Colombo,M.N., Francolini,M., Sala,M., Murru,L. and Passafaro,M.
TITLE Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting
Hippocampal Glutamatergic Synapses and Cognition in Mice
JOURNAL Mol Neurobiol 58 (12), 6092-6110 (2021)
PUBMED 34455539
REFERENCE 3 (bases 1 to 2572)
AUTHORS Zhang,Y., Kang,H., Lee,Y., Kim,Y., Lee,B., Kim,J.Y., Jin,C.,
Kim,S., Kim,H. and Han,K.
TITLE Smaller Body Size, Early Postnatal Lethality, and Cortical
Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null
Embryonic Mice
JOURNAL Front Mol Neurosci 11, 482 (2019)
PUBMED 30687000
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 2572)
AUTHORS Chen,Y., Milenkovic,M., Horsfall,W., Salahpour,A., Soderling,S.H.
and Ramsey,A.J.
TITLE Restoring striatal WAVE-1 improves maze exploration performance of
GluN1 knockdown mice
JOURNAL PLoS One 13 (10), e0199341 (2018)
PUBMED 30352064
REMARK GeneRIF: WAVE-1 restoration improves maze exploration performance
of GluN1 knockdown mice
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 2572)
AUTHORS Fan,L., Lu,Y., Shen,X., Shao,H., Suo,L. and Wu,Q.
TITLE Alpha protocadherins and Pyk2 kinase regulate cortical neuron
migration and cytoskeletal dynamics via Rac1 GTPase and WAVE
complex in mice
JOURNAL Elife 7, e35242 (2018)
PUBMED 29911975
REMARK GeneRIF: Data indicate a molecular protocadherin alpha
(Pcdhalpha)/Wiskott-Aldrich syndrome potein Family
(WAVE)/proline-rich tyrosine kinase 2 (Pyk2)/Rac1 axis from
protocadherin cell-surface receptors to actin cytoskeletal dynamics
in cortical neuron migration and dendrite morphogenesis in mouse
brain.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2572)
AUTHORS Soderling,S.H., Langeberg,L.K., Soderling,J.A., Davee,S.M.,
Simerly,R., Raber,J. and Scott,J.D.
TITLE Loss of WAVE-1 causes sensorimotor retardation and reduced learning
and memory in mice
JOURNAL Proc Natl Acad Sci U S A 100 (4), 1723-1728 (2003)
PUBMED 12578964
REMARK GeneRIF: role in causing sensorimotor retardation and reduced
learning and memory in mice
REFERENCE 7 (bases 1 to 2572)
AUTHORS Benachenhou,N., Massy,I. and Vacher,J.
TITLE Characterization and expression analyses of the mouse
Wiskott-Aldrich syndrome protein (WASP) family member Wave1/Scar
JOURNAL Gene 290 (1-2), 131-140 (2002)
PUBMED 12062808
REFERENCE 8 (bases 1 to 2572)
AUTHORS Chalhoub,N., Benachenhou,N. and Vacher,J.
TITLE Physical and transcriptional map of the mouse Chromosome 10
proximal region syntenic to human 6q16-q21
JOURNAL Mamm Genome 12 (12), 887-892 (2001)
PUBMED 11707774
REFERENCE 9 (bases 1 to 2572)
AUTHORS Westphal,R.S., Soderling,S.H., Alto,N.M., Langeberg,L.K. and
Scott,J.D.
TITLE Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an
actin-associated multi-kinase scaffold
JOURNAL EMBO J 19 (17), 4589-4600 (2000)
PUBMED 10970852
REFERENCE 10 (bases 1 to 2572)
AUTHORS Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
TITLE Exchangeable gene trap using the Cre/mutated lox system
JOURNAL Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
PUBMED 10512203
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BY332208.1, BC053423.1 and AF290877.1.
On Apr 23, 2009 this sequence version replaced NM_031877.2.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC016896.1, SRR7974084.2897.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849382, SAMN01164131
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-39 BY332208.1 1-39
40-2173 BC053423.1 1-2134
2174-2548 BC053423.1 2136-2510
2549-2572 AF290877.1 2446-2469
FEATURES Location/Qualifiers
source 1..2572
/organism="Mus musculus"
/mol_type="mRNA"
/db_xref="taxon:10090"
/chromosome="10"
/map="10 22.07 cM"
gene 1..2572
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="WASP family, member 1"
/db_xref="GeneID:83767"
/db_xref="MGI:MGI:1890563"
exon 1..76
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 77..237
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
misc_feature 78..80
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="upstream in-frame stop codon"
CDS 105..1784
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="isoform 1 is encoded by transcript variant 1;
wiskott-Aldrich syndrome protein family member 1; protein
WAVE-1; WASP family protein member 1; WASP family 1; WAS
protein family, member 1; actin-binding protein WASF1"
/codon_start=1
/product="actin-binding protein WASF1 isoform 1"
/protein_id="NP_114083.1"
/db_xref="CCDS:CCDS23801.1"
/db_xref="GeneID:83767"
/db_xref="MGI:MGI:1890563"
/translation="
MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQKQKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDADLLHKHIEVANGPASHYETRPQTYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPTPTCISSATGLIENRPQSPAAGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVAVAALAHPPSGLHPAPSTAPGPHAPLMPPSPPSQVLPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIAVEYSDSEDDSEFDEVDWLE"
misc_feature 612..710
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 921..1304
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1125..1127
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="Asymmetric dimethylarginine, alternate.
/evidence=ECO:0007744|PubMed:24129315;
Omega-N-methylarginine, alternate.
/evidence=ECO:0007744|PubMed:24129315; propagated from
UniProtKB/Swiss-Prot (Q8R5H6.2); methylation site"
misc_feature <1287..>1571
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="Topoisomerase II-associated protein PAT1; Region:
PAT1; pfam09770"
/db_xref="CDD:401645"
misc_feature 1338..1577
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1557..1781
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="Wiskott Aldrich syndrome homology region 2 (WH2
motif) found in Wiskott-Aldrich Syndrome Protein Family
Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1); Region:
WH2_WAVE-1; cd22071"
/db_xref="CDD:409214"
misc_feature 1569..1571
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q92558; propagated from
UniProtKB/Swiss-Prot (Q8R5H6.2); phosphorylation site"
misc_feature order(1593..1598,1602..1610,1614..1622,1635..1646)
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="actin-binding motif [polypeptide binding]; other
site"
/db_xref="CDD:409214"
misc_feature order(1596..1601,1605..1610,1617..1622,1638..1643,
1695..1700,1707..1712,1719..1721,1731..1733)
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="Nap1 binding interface [polypeptide binding]; other
site"
/db_xref="CDD:409214"
misc_feature 1635..1646
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="actin-binding sequence [structural motif]; Region:
actin-binding sequence"
/db_xref="CDD:409214"
exon 238..372
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 373..526
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 527..644
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 645..817
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 818..997
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 998..1626
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 1627..2550
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
regulatory 2527..2532
/regulatory_class="polyA_signal_sequence"
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="hexamer: AATAAA"
polyA_site 2550
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="major polyA site"
ORIGIN
tcccccaaagtgcggatcgggcaataccacagagcctcaggacagggggaagcgccgtcctcttgcccacggacgggtgagctggttcagtggctgagctcaagatgccgttggtgaaaagaaacatcgaccctcggcacttgtgccacacagcactgcccaggggcattaagaacgaactggaatgtgtaaccaacatttccctggcaaatataattagacaactgagtagcctaagtaagtatgctgaagacatatttggagaattattcaatgaagcacacagtttttccttcagagttaactcgttgcaagagcgcgtggaccgattgtctgttagtgtcacacagcttgatcctaaggaggaagaactgtctttgcaagatataacgatgagaaaggctttccggagctccacaattcaagatcagcagcttttcgaccgcaagacgttgcctattccattgcaagaaacatacgatgtgtgtgagcaacctccgcctctcaatatcctcaccccttacagggatgatggtaaggaagggctgaagttttataccaatccttcatatttctttgatctgtggaaagaaaagatgttgcaagatacagaggacaagaggaaggaaaagagaaagcagaagcagaaaaatctagaccgtcctcatgaaccagagaaagtgccaagagcacctcatgacaggcggcgggaatggcagaagctggcccaaggtccagagctggctgaggatgacgctgacctcctacacaagcatattgaagttgccaatggcccagcctctcattatgagacaaggccacagacatacgtggatcatatggacggatcgtactcactctctgccttgccattcagtcagatgagtgaacttctgaccagagctgaggagagggtcttagtcagaccccatgaacctcctccgcctccaccaatgcatggagcaggagatgcaaagcccacacccacctgtatcagttctgctacaggtttgatagagaatcgcccccagtccccagctgcaggcagaacacctgtgtttgtgagccccactcccccacctcctcccccacctcttccgtctgccttgtccacttcttcactaagagcttcaatgacctcaactcctcccccaccagtccctcctccgcctcctcccccagccactgctttgcaggccccagcagtgcccccacctccggctcctcttcagattgcccctggtgttcttcacccagctcctcctccaattgctcctcctctagtgcagccctctcccccagtagctcgagctgccccagtatgcgagactgtgccagttcacccactcccgcaaggtgaagtgcaggggctgcctccacccccaccaccgcctcctctacctccgcctggcatccggccatcatctcctgtcgcagttgcagctcttgctcatcctccctctgggctccatccagcaccatctactgccccgggtccccatgctccattaatgcctccatctcctccatcacaagttctacctgcctctgagccaaagcgccatccatccaccctgcctgtaatcagtgacgcaaggagtgtgctgctggaagccatccgaaaaggtattcagcttcgcaaagtggaagagcagcgtgaacaggaagcaaaacacgagcggattgaaaacgacgtggccaccatcctgtctcgccgcattgctgtggagtatagcgactcggaagatgactcggagttcgatgaagtagactggctggagtaagaaagccacagtgacttggaagatgactcggagttcgatgaagtagactggatggagtaagacagccgccttgctctgtattgcaaggctgaatgcacatgtccctcgtggcgcttgttctttgaaaatgttcggtcattctagtgttttgcttcctattcctcataatgaataacccttttcctccattatttttgatttctatgaaaagtattagcatatatttcaaactaaatattttgtggcttaccttaatttttccccctggaaaaatataatttggtccaataaactactaagtattaagcatggaaagccgttattagagtagcagattcagtttttgatattccttaattgtgcactttgtgatttttttttttttttttaaatttgaagaacgcaactgagactggaatcttgaaggcagctgtgtctgggaacgagccttattccgtttcttgatgttttaaatgaagaaacactgcctcgattatatgaatacactcagaaggaacatgtagcttgtagtgttgaattctcttaaaggaatggttagctttggttatcattttgttgtttttgaatacttgccttatttgaacgtttagcagaaccccttcccacttatatattgtgtggtacagttttgcttgcctatagaagtttaaatttttccatgtgaaatactcagaataagcatatgtgtgacttacataatgtgagaattacaatctgatgtaataaacggttcattttaaaggctaaaaaaaaaaaaaaaaaaaaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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