LOCUS       NM_031699               3223 bp    mRNA    linear   ROD 02-JUL-2021
DEFINITION  Rattus norvegicus claudin 1 (Cldn1), mRNA.
ACCESSION   NM_031699
VERSION     NM_031699.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3223)
  AUTHORS   Chen M, Hou P, Zhou M, Ren Q, Wang X, Huang L, Hui S, Yi L and Mi
            M.
  TITLE     Resveratrol attenuates high-fat diet-induced non-alcoholic
            steatohepatitis by maintaining gut barrier integrity and inhibiting
            gut inflammation through regulation of the endocannabinoid system
  JOURNAL   Clin Nutr 39 (4), 1264-1275 (2020)
   PUBMED   31189495
REFERENCE   2  (bases 1 to 3223)
  AUTHORS   Berndt P, Winkler L, Cording J, Breitkreuz-Korff O, Rex A, Dithmer
            S, Rausch V, Blasig R, Richter M, Sporbert A, Wolburg H, Blasig IE
            and Haseloff RF.
  TITLE     Tight junction proteins at the blood-brain barrier: far more than
            claudin-5
  JOURNAL   Cell Mol Life Sci 76 (10), 1987-2002 (2019)
   PUBMED   30734065
REFERENCE   3  (bases 1 to 3223)
  AUTHORS   Volksdorf T, Heilmann J, Eming SA, Schawjinski K, Zorn-Kruppa M,
            Ueck C, Vidal-Y-Sy S, Windhorst S, Jucker M, Moll I and Brandner
            JM.
  TITLE     Tight Junction Proteins Claudin-1 and Occludin Are Important for
            Cutaneous Wound Healing
  JOURNAL   Am J Pathol 187 (6), 1301-1312 (2017)
   PUBMED   28412298
REFERENCE   4  (bases 1 to 3223)
  AUTHORS   Wang J, Chen J, Tang Z, Li Y, Hu L and Pan J.
  TITLE     The Effects of Copper on Brain Microvascular Endothelial Cells and
            Claudin Via Apoptosis and Oxidative Stress
  JOURNAL   Biol Trace Elem Res 174 (1), 132-141 (2016)
   PUBMED   27038183
  REMARK    GeneRIF: identified four claudin isoforms (1, 3, 5, and 12) and
            showed that their expression levels were regulated as a group by
            copper
REFERENCE   5  (bases 1 to 3223)
  AUTHORS   Bulldan A, Dietze R, Shihan M and Scheiner-Bobis G.
  TITLE     Non-classical testosterone signaling mediated through ZIP9
            stimulates claudin expression and tight junction formation in
            Sertoli cells
  JOURNAL   Cell Signal 28 (8), 1075-1085 (2016)
   PUBMED   27164415
  REMARK    GeneRIF: in Sertoli cells, testosterone acts through the receptor
            ZIP9 to trigger the non-classical signaling cascade, resulting in
            increased claudin expression and tight junction formation.
REFERENCE   6  (bases 1 to 3223)
  AUTHORS   Duffy HS, John GR, Lee SC, Brosnan CF and Spray DC.
  TITLE     Reciprocal regulation of the junctional proteins claudin-1 and
            connexin43 by interleukin-1beta in primary human fetal astrocytes
  JOURNAL   J Neurosci 20 (23), RC114 (2000)
   PUBMED   11090614
REFERENCE   7  (bases 1 to 3223)
  AUTHORS   Lippoldt A, Liebner S, Andbjer B, Kalbacher H, Wolburg H, Haller H
            and Fuxe K.
  TITLE     Organization of choroid plexus epithelial and endothelial cell
            tight junctions and regulation of claudin-1, -2 and -5 expression
            by protein kinase C
  JOURNAL   Neuroreport 11 (7), 1427-1431 (2000)
   PUBMED   10841351
REFERENCE   8  (bases 1 to 3223)
  AUTHORS   Furuse M, Sasaki H and Tsukita S.
  TITLE     Manner of interaction of heterogeneous claudin species within and
            between tight junction strands
  JOURNAL   J Cell Biol 147 (4), 891-903 (1999)
   PUBMED   10562289
REFERENCE   9  (bases 1 to 3223)
  AUTHORS   Kubota K, Furuse M, Sasaki H, Sonoda N, Fujita K, Nagafuchi A and
            Tsukita S.
  TITLE     Ca(2+)-independent cell-adhesion activity of claudins, a family of
            integral membrane proteins localized at tight junctions
  JOURNAL   Curr Biol 9 (18), 1035-1038 (1999)
   PUBMED   10508613
REFERENCE   10 (bases 1 to 3223)
  AUTHORS   Furuse M, Fujita K, Hiiragi T, Fujimoto K and Tsukita S.
  TITLE     Claudin-1 and -2: novel integral membrane proteins localizing at
            tight junctions with no sequence similarity to occludin
  JOURNAL   J Cell Biol 141 (7), 1539-1550 (1998)
   PUBMED   9647647
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000222.1.
            On Nov 27, 2020 this sequence version replaced NM_031699.2.
            
            Summary: may be involved in maintaining Schwann cell structure
            during myelination [RGD, Feb 2006].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061992.1, FQ220868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               JACYVU010000222.1  53731343-53731744
            403-567             JACYVU010000222.1  53740083-53740247
            568-652             JACYVU010000222.1  53742243-53742327
            653-3223            JACYVU010000222.1  53743932-53746502
FEATURES             Location/Qualifiers
     source          1..3223
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..3223
                     /gene="Cldn1"
                     /note="claudin 1"
                     /db_xref="GeneID:65129"
                     /db_xref="RGD:68422"
     exon            1..402
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..815
                     /gene="Cldn1"
                     /codon_start=1
                     /product="claudin-1"
                     /protein_id="NP_113887.3"
                     /db_xref="GeneID:65129"
                     /db_xref="RGD:68422"
                     /translation="

MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGMKCMRCLEDDEVQKMWMAVIGGIIFVISGLATLVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV"

     misc_feature    192..725
                     /gene="Cldn1"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; pfam00822"
                     /db_xref="CDD:395662"
     misc_feature    201..263
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (P56745.2);
                     transmembrane region"
     misc_feature    423..485
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (P56745.2);
                     transmembrane region"
     misc_feature    525..587
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (P56745.2);
                     transmembrane region"
     misc_feature    669..731
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (P56745.2);
                     transmembrane region"
     misc_feature    747..812
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (P56745.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    807..812
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (P56745.2);
                     Region: Interactions with TJP1, TJP2, TJP3 and PATJ.
                     /evidence=ECO:0000250"
     exon            403..567
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..652
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..3223
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cacttccagactccaccaccgacccggaccagaagccaggagcctcgcccgcagccgcacagggagcaggggtatcagcgctaacctcctggctgagactccatcaccttcggggagcccaagcgcgcactttgcaaactccgctttctgcacctgccactgagcctcagaaaagagccatggccaacgcggggttgcagcttctgggtttcatcctggcttcgctgggatggatcggctctatcgtcagcactgccctgccccaatggaagatttactcctatgctggggacaacatcgtgactgctcaggccatctacgagggactgtggatgtcctgcgtttcgcaaagcaccgggcagatacagtgcaaagtcttcgactccttgctgaatctgaatagtactttgcaggcaaccagagccttgatggtaattggcatcctgctggggctgatcgcaatctttgtgtccaccattggcatgaagtgcatgaggtgcttagaagatgatgaagtgcaaaagatgtggatggctgtcatcgggggcataatatttgtaatttcaggtctggcgacattagtggccacagcatggtatggaaatagaattgttcaagaattctatgaccccatgacccctgtcaatgccaggtatgaatttggccaggctctctttactggctgggctgctgcctccctctgcctcctgggaggtgccctactttcctgctcctgtccccggaaaacaacctcttacccaacaccacggccttatcccaagccaacaccttctagtgggaaagactacgtgtgacagcggcgaaggaagagatcctcctggagcgaatacaaaatggacattgagactagcattgacattaaggcctcaaactgttgactatggttatctaaactgtggtagaacaaaagcaagcatatttttatacgtccccatggctatgagggtcttggctgtgccttaccatctttcctgagtacaggagggaagccttttgcctttgaactgctgcttgccactgagtgatgacactcaaatgggcgaagggtgctccttaagtgtgtatagatatgtacatatacatattttctattaaaaatagacagctagcaatctcttattctccccatattgtaccagcatactttaaatgactataaaatatatacaattccacattgattaaataagctttctggtgtatttttcttttctctatgaacataagtgatcagtcaaatattaccccttcgatcagcatttagtatctttgccataagaccagacttccttacgaactcagactatgttcttttttttttttccattatgtcttctttacatcaaaatatttgttctccatgttttcttttactctaacagctgctttttcagattgttattctgaggcttgattctaactcctgaatctaataatgaactttgagcccatatgttaaaacttaaaaccagtaagaatctcatactgtgtttctgagctgtgggggccaatgttccagagagatgatgtttctccactgacctttcccacacggtccctgcactttggtctgcagctggcttgtttgctttaaaaatatttgtttccctgagtggctaagctgctaaccctgtggttgaaacagttttattgactgcatttttcaggtactaattttccattccagatcctgcaaactgcagctctcctcttccctcctcagctatcttgttttcccacgtataattatcctacagtttagttctttgcagataggtgtggtccatttatctacacaaactgctagacttgccagagtgataatctagtgacaaatattctctctgtagccgtggacaatttacaatccttatacctcgttttcccatctgtcaaattgggataattacacttaaacagctggtagaggtaatgcgagtattaattagttgatatgactctcattctttgaacatgaaatatgcctaagtagtgtttttccttgctcaattagcagttctgaagtcactgaataaaatctacacacatgcctccaatgccgttctgtatctctctttgtcatgagttcatttcctcccatctagctgtgcatggcctgtcattggtgctgtttcattttgatcattctcatctgtagcaaaggcccttcagcagagcaaggtgttgtaatacaaagggtgttgccattgccatgggtagacctggatttgcatcttggtgctatcacttaattactgaggttgggcagaggccctcgattgccctaaatgtattgctccatctagacaacgggttcattaacttctgccatgcctatgtcgcatgagtcaagagggacgcaggcaaacatggttttatgttggaaaacaacatgtcactctataaattaaggaatttaagttaatgggttttgtctttatttttcaaacaataggaaagagaaacatgttaaatagtttctttccttaagaactctcaaatgaggagttccaaagcttactaagttaaactgatcttaagtctttaaggctttcggttgtgagtcagtgtttcagcctatggtccacgctggccaagaactcctgtgccacacaaacatccttctgcctcagcctcacaactgttatgatgacaggaatgagccccatcccactgttacaccctagtttcagaagtttggcctggtacttctattgctaagcaaatgcaatggcggaaagtgacagtgtatggatactctaaaagcataaagcgtgctctttgtgaagtgatactttcaaagtctaatggaagctggcagttctaggagaggttaagaattataacttatggtaaaaccacatggatgaagttatagaaagaatgaagtcttatgtgaatttgtactatgtaagtttgactgtatttagatgtgtaaagtaatcatgcaaagatcttttgccacaattactgtgcctaatgtgtaatgtaaacacatagaaataacacttgctaaactacacaaaattctatattccaaaataatcccatagaagtcttatgtcagaacttacctagatttgatatttttataccctaataccaaacctggaaacagatcaattgatatttgggggctgaggtgggaatttgtataagtactactctttttcaataaattgttggttttttttaattaaaa

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