LOCUS       NM_031699               3223 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus claudin 1 (Cldn1), mRNA.
ACCESSION   NM_031699
VERSION     NM_031699.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3223)
  AUTHORS   Chang,R., Su,Y., Kong,H., Wang,F., Xing,Y., Jiang,L. and Xin,H.
  TITLE     Upregulation of SEMP1 Contributes to Improving the Biological
            Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia
  JOURNAL   Mol Biotechnol 66 (3), 531-543 (2024)
   PUBMED   37277581
  REMARK    GeneRIF: Upregulation of SEMP1 Contributes to Improving the
            Biological Functions of Trophoblast via the PI3K/AKT Pathway in
            Preeclampsia.
REFERENCE   2  (bases 1 to 3223)
  AUTHORS   Ma,T., Gu,J., Zhao,Y., Li,S., Zou,D. and Ge,D.
  TITLE     EZH2-mediated suppression of CLDN1 leads to barrier dysfunction in
            PPI-refractory gastroesophageal reflux disease
  JOURNAL   Dig Liver Dis 54 (6), 776-783 (2022)
   PUBMED   34789399
  REMARK    GeneRIF: EZH2-mediated suppression of CLDN1 leads to barrier
            dysfunction in PPI-refractory gastroesophageal reflux disease.
REFERENCE   3  (bases 1 to 3223)
  AUTHORS   Xie,Y., Tan,J., Qin,Y., Cao,Y., Wang,Y., Li,A., Wang,Z., Qiao,Z.
            and Yan,Z.
  TITLE     MiR-3571 modulates the proliferation and migration of vascular
            smooth muscle cells by targeting claudin 1
  JOURNAL   Int J Med Sci 19 (3), 511-524 (2022)
   PUBMED   35370461
  REMARK    GeneRIF: MiR-3571 modulates the proliferation and migration of
            vascular smooth muscle cells by targeting claudin 1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3223)
  AUTHORS   Ben-Kraiem,A., Sauer,R.S., Norwig,C., Popp,M., Bettenhausen,A.L.,
            Atalla,M.S., Brack,A., Blum,R., Doppler,K. and Rittner,H.L.
  TITLE     Selective blood-nerve barrier leakiness with claudin-1 and
            vessel-associated macrophage loss in diabetic polyneuropathy
  JOURNAL   J Mol Med (Berl) 99 (9), 1237-1250 (2021)
   PUBMED   34018017
  REMARK    GeneRIF: Selective blood-nerve barrier leakiness with claudin-1 and
            vessel-associated macrophage loss in diabetic polyneuropathy.
REFERENCE   5  (bases 1 to 3223)
  AUTHORS   Chen,M., Hou,P., Zhou,M., Ren,Q., Wang,X., Huang,L., Hui,S., Yi,L.
            and Mi,M.
  TITLE     Resveratrol attenuates high-fat diet-induced non-alcoholic
            steatohepatitis by maintaining gut barrier integrity and inhibiting
            gut inflammation through regulation of the endocannabinoid system
  JOURNAL   Clin Nutr 39 (4), 1264-1275 (2020)
   PUBMED   31189495
REFERENCE   6  (bases 1 to 3223)
  AUTHORS   Duffy,H.S., John,G.R., Lee,S.C., Brosnan,C.F. and Spray,D.C.
  TITLE     Reciprocal regulation of the junctional proteins claudin-1 and
            connexin43 by interleukin-1beta in primary human fetal astrocytes
  JOURNAL   J Neurosci 20 (23), RC114 (2000)
   PUBMED   11090614
REFERENCE   7  (bases 1 to 3223)
  AUTHORS   Lippoldt,A., Liebner,S., Andbjer,B., Kalbacher,H., Wolburg,H.,
            Haller,H. and Fuxe,K.
  TITLE     Organization of choroid plexus epithelial and endothelial cell
            tight junctions and regulation of claudin-1, -2 and -5 expression
            by protein kinase C
  JOURNAL   Neuroreport 11 (7), 1427-1431 (2000)
   PUBMED   10841351
REFERENCE   8  (bases 1 to 3223)
  AUTHORS   Furuse,M., Sasaki,H. and Tsukita,S.
  TITLE     Manner of interaction of heterogeneous claudin species within and
            between tight junction strands
  JOURNAL   J Cell Biol 147 (4), 891-903 (1999)
   PUBMED   10562289
REFERENCE   9  (bases 1 to 3223)
  AUTHORS   Kubota,K., Furuse,M., Sasaki,H., Sonoda,N., Fujita,K., Nagafuchi,A.
            and Tsukita,S.
  TITLE     Ca(2+)-independent cell-adhesion activity of claudins, a family of
            integral membrane proteins localized at tight junctions
  JOURNAL   Curr Biol 9 (18), 1035-1038 (1999)
   PUBMED   10508613
REFERENCE   10 (bases 1 to 3223)
  AUTHORS   Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin-1 and -2: novel integral membrane proteins localizing at
            tight junctions with no sequence similarity to occludin
  JOURNAL   J Cell Biol 141 (7), 1539-1550 (1998)
   PUBMED   9647647
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031699.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061992.1, SRR26360190.1055662.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               JAXUCZ010000011.1  87926376-87926777
            403-567             JAXUCZ010000011.1  87935114-87935278
            568-652             JAXUCZ010000011.1  87937274-87937358
            653-3223            JAXUCZ010000011.1  87938963-87941533
FEATURES             Location/Qualifiers
     source          1..3223
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..3223
                     /gene="Cldn1"
                     /note="claudin 1"
                     /db_xref="GeneID:65129"
                     /db_xref="RGD:68422"
     exon            1..402
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..815
                     /gene="Cldn1"
                     /codon_start=1
                     /product="claudin-1"
                     /protein_id="NP_113887.3"
                     /db_xref="GeneID:65129"
                     /db_xref="RGD:68422"
                     /translation="

MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGMKCMRCLEDDEVQKMWMAVIGGIIFVISGLATLVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV"

     misc_feature    192..725
                     /gene="Cldn1"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; pfam00822"
                     /db_xref="CDD:395662"
     misc_feature    201..263
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (P56745.2);
                     transmembrane region"
     misc_feature    423..485
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (P56745.2);
                     transmembrane region"
     misc_feature    525..587
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (P56745.2);
                     transmembrane region"
     misc_feature    669..731
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (P56745.2);
                     transmembrane region"
     misc_feature    747..812
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (P56745.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    807..812
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (P56745.2);
                     Region: Interactions with TJP1, TJP2, TJP3 and PATJ.
                     /evidence=ECO:0000250"
     exon            403..567
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..652
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..3223
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cacttccagactccaccaccgacccggaccagaagccaggagcctcgcccgcagccgcacagggagcaggggtatcagcgctaacctcctggctgagactccatcaccttcggggagcccaagcgcgcactttgcaaactccgctttctgcacctgccactgagcctcagaaaagagccatggccaacgcggggttgcagcttctgggtttcatcctggcttcgctgggatggatcggctctatcgtcagcactgccctgccccaatggaagatttactcctatgctggggacaacatcgtgactgctcaggccatctacgagggactgtggatgtcctgcgtttcgcaaagcaccgggcagatacagtgcaaagtcttcgactccttgctgaatctgaatagtactttgcaggcaaccagagccttgatggtaattggcatcctgctggggctgatcgcaatctttgtgtccaccattggcatgaagtgcatgaggtgcttagaagatgatgaagtgcaaaagatgtggatggctgtcatcgggggcataatatttgtaatttcaggtctggcgacattagtggccacagcatggtatggaaatagaattgttcaagaattctatgaccccatgacccctgtcaatgccaggtatgaatttggccaggctctctttactggctgggctgctgcctccctctgcctcctgggaggtgccctactttcctgctcctgtccccggaaaacaacctcttacccaacaccacggccttatcccaagccaacaccttctagtgggaaagactacgtgtgacagcggcgaaggaagagatcctcctggagcgaatacaaaatggacattgagactagcattgacattaaggcctcaaactgttgactatggttatctaaactgtggtagaacaaaagcaagcatatttttatacgtccccatggctatgagggtcttggctgtgccttaccatctttcctgagtacaggagggaagccttttgcctttgaactgctgcttgccactgagtgatgacactcaaatgggcgaagggtgctccttaagtgtgtatagatatgtacatatacatattttctattaaaaatagacagctagcaatctcttattctccccatattgtaccagcatactttaaatgactataaaatatatacaattccacattgattaaataagctttctggtgtatttttcttttctctatgaacataagtgatcagtcaaatattaccccttcgatcagcatttagtatctttgccataagaccagacttccttacgaactcagactatgttcttttttttttttccattatgtcttctttacatcaaaatatttgttctccatgttttcttttactctaacagctgctttttcagattgttattctgaggcttgattctaactcctgaatctaataatgaactttgagcccatatgttaaaacttaaaaccagtaagaatctcatactgtgtttctgagctgtgggggccaatgttccagagagatgatgtttctccactgacctttcccacacggtccctgcactttggtctgcagctggcttgtttgctttaaaaatatttgtttccctgagtggctaagctgctaaccctgtggttgaaacagttttattgactgcatttttcaggtactaattttccattccagatcctgcaaactgcagctctcctcttccctcctcagctatcttgttttcccacgtataattatcctacagtttagttctttgcagataggtgtggtccatttatctacacaaactgctagacttgccagagtgataatctagtgacaaatattctctctgtagccgtggacaatttacaatccttatacctcgttttcccatctgtcaaattgggataattacacttaaacagctggtagaggtaatgcgagtattaattagttgatatgactctcattctttgaacatgaaatatgcctaagtagtgtttttccttgctcaattagcagttctgaagtcactgaataaaatctacacacatgcctccaatgccgttctgtatctctctttgtcatgagttcatttcctcccatctagctgtgcatggcctgtcattggtgctgtttcattttgatcattctcatctgtagcaaaggcccttcagcagagcaaggtgttgtaatacaaagggtgttgccattgccatgggtagacctggatttgcatcttggtgctatcacttaattactgaggttgggcagaggccctcgattgccctaaatgtattgctccatctagacaacgggttcattaacttctgccatgcctatgtcgcatgagtcaagagggacgcaggcaaacatggttttatgttggaaaacaacatgtcactctataaattaaggaatttaagttaatgggttttgtctttatttttcaaacaataggaaagagaaacatgttaaatagtttctttccttaagaactctcaaatgaggagttccaaagcttactaagttaaactgatcttaagtctttaaggctttcggttgtgagtcagtgtttcagcctatggtccacgctggccaagaactcctgtgccacacaaacatccttctgcctcagcctcacaactgttatgatgacaggaatgagccccatcccactgttacaccctagtttcagaagtttggcctggtacttctattgctaagcaaatgcaatggcggaaagtgacagtgtatggatactctaaaagcataaagcgtgctctttgtgaagtgatactttcaaagtctaatggaagctggcagttctaggagaggttaagaattataacttatggtaaaaccacatggatgaagttatagaaagaatgaagtcttatgtgaatttgtactatgtaagtttgactgtatttagatgtgtaaagtaatcatgcaaagatcttttgccacaattactgtgcctaatgtgtaatgtaaacacatagaaataacacttgctaaactacacaaaattctatattccaaaataatcccatagaagtcttatgtcagaacttacctagatttgatatttttataccctaataccaaacctggaaacagatcaattgatatttgggggctgaggtgggaatttgtataagtactactctttttcaataaattgttggttttttttaattaaaa

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