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2021-10-17 15:16:46, GGRNA.v2 : RefSeq release 207 (Jul, 2021)

LOCUS       NM_022852               1406 bp    mRNA    linear   ROD 02-JUL-2021
DEFINITION  Rattus norvegicus pancreatic and duodenal homeobox 1 (Pdx1), mRNA.
ACCESSION   NM_022852
VERSION     NM_022852.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1406)
  AUTHORS   Yao X, Li K, Liang C, Zhou Z, Wang J, Wang S, Liu L, Yu CL, Song
            ZB, Bao YL, Zheng LH, Sun Y, Wang G, Huang Y, Yi J, Sun L and Li Y.
  TITLE     Tectorigenin enhances PDX1 expression and protects pancreatic
            beta-cells by activating ERK and reducing ER stress
  JOURNAL   J Biol Chem 295 (37), 12975-12992 (2020)
   PUBMED   32690606
  REMARK    GeneRIF: Tectorigenin enhances PDX1 expression and protects
            pancreatic beta-cells by activating ERK and reducing ER stress.
REFERENCE   2  (bases 1 to 1406)
  AUTHORS   Mahdipour E, Salmasi Z and Sabeti N.
  TITLE     Potential of stem cell-derived exosomes to regenerate beta islets
            through Pdx-1 dependent mechanism in a rat model of type 1 diabetes
  JOURNAL   J Cell Physiol 234 (11), 20310-20321 (2019)
   PUBMED   30997693
  REMARK    GeneRIF: that exosomes induce the islet regeneration through
            pancreatic and duodenal homeobox 1 pathway
REFERENCE   3  (bases 1 to 1406)
  AUTHORS   Liang C, Hao F, Yao X, Qiu Y, Liu L, Wang S, Yu C, Song Z, Bao Y,
            Yi J, Huang Y, Wu Y, Zheng L, Sun Y, Wang G, Yang X, Yang S, Sun L
            and Li Y.
  TITLE     Hypericin maintians PDX1 expression via the Erk pathway and
            protects islet beta-cells against glucotoxicity and lipotoxicity
  JOURNAL   Int J Biol Sci 15 (7), 1472-1487 (2019)
   PUBMED   31337977
  REMARK    GeneRIF: PDX1 expression is maintained via the Erk pathway and
            protects islet beta-cells against glucotoxicity and lipotoxicity
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1406)
  AUTHORS   Kornelius E, Li HH, Peng CH, Yang YS, Chen WJ, Chang YZ, Bai YC,
            Liu S, Huang CN and Lin CL.
  TITLE     Liraglutide protects against glucolipotoxicity-induced RIN-m5F
            beta-cell apoptosis through restoration of PDX1 expression
  JOURNAL   J Cell Mol Med 23 (1), 619-629 (2019)
   PUBMED   30353648
  REMARK    GeneRIF: GLP-1 analogue liraglutide restores the expression of PDX1
            by inactivating Mst1.
REFERENCE   5  (bases 1 to 1406)
  AUTHORS   Luo Y, Xu Y, Wang ZY, Li X, Xing WB and Zhang TC.
  TITLE     The Synergy of Two Factors on Insulin Expression
  JOURNAL   Cell Reprogram 20 (1), 49-54 (2018)
   PUBMED   29303357
  REMARK    GeneRIF: Explored whether and how the two factors pdx-1 and
            myocardin affected the differentiation of mesenchymal stem cells
            (MSCs) into insulin-producing cells. In this study, we investigated
            the process of transfecting myocardin and/or pdx-1 in MSCs in
            vitro. The results showed that MSCs were able to secrete insulin
            after cotransfection with myocardin and pdx-1.
REFERENCE   6  (bases 1 to 1406)
  AUTHORS   Sharma S, Leonard J, Lee S, Chapman HD, Leiter EH and Montminy MR.
  TITLE     Pancreatic islet expression of the homeobox factor STF-1 relies on
            an E-box motif that binds USF
  JOURNAL   J Biol Chem 271 (4), 2294-2299 (1996)
   PUBMED   8567692
REFERENCE   7  (bases 1 to 1406)
  AUTHORS   Peers B, Sharma S, Johnson T, Kamps M and Montminy M.
  TITLE     The pancreatic islet factor STF-1 binds cooperatively with Pbx to a
            regulatory element in the somatostatin promoter: importance of the
            FPWMK motif and of the homeodomain
  JOURNAL   Mol Cell Biol 15 (12), 7091-7097 (1995)
   PUBMED   8524276
REFERENCE   8  (bases 1 to 1406)
  AUTHORS   Miller CP, McGehee RE Jr and Habener JF.
  TITLE     IDX-1: a new homeodomain transcription factor expressed in rat
            pancreatic islets and duodenum that transactivates the somatostatin
            gene
  JOURNAL   EMBO J 13 (5), 1145-1156 (1994)
   PUBMED   7907546
REFERENCE   9  (bases 1 to 1406)
  AUTHORS   Leonard J, Peers B, Johnson T, Ferreri K, Lee S and Montminy MR.
  TITLE     Characterization of somatostatin transactivating factor-1, a novel
            homeobox factor that stimulates somatostatin expression in
            pancreatic islet cells
  JOURNAL   Mol Endocrinol 7 (10), 1275-1283 (1993)
   PUBMED   7505393
REFERENCE   10 (bases 1 to 1406)
  AUTHORS   Kerckaert,J.P., Bayard,B., Debray,H., Sautiere,P. and Biserte,G.
  TITLE     Rat alpha-fetoprotein heterogeneity. Comparative chemical study of
            the two electrophoretic variants and their Ricinus lectin-binding
            properties
  JOURNAL   Biochim Biophys Acta 493 (2), 293-303 (1977)
   PUBMED   70227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000224.1.
            On Nov 20, 2020 this sequence version replaced NM_022852.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U04833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               JACYVU010000224.1  3729105-3729635     c
            532-1406            JACYVU010000224.1  3724436-3725310     c
FEATURES             Location/Qualifiers
     source          1..1406
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..1406
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="pancreatic and duodenal homeobox 1"
                     /db_xref="GeneID:29535"
                     /db_xref="RGD:62387"
     exon            1..531
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    66..68
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="upstream in-frame stop codon"
     CDS             126..977
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /function="transcription factor"
                     /note="islet/duodenum homeobox-1; somatostatin
                     transactivating factor 1; IDX-1; IPF-1; STF-1; Insulin
                     promoter factor 1; insulin promotor factor 1; pancreatic
                     and duodenal homeobox gene 1"
                     /codon_start=1
                     /product="pancreas/duodenum homeobox protein 1"
                     /protein_id="NP_074043.4"
                     /db_xref="GeneID:29535"
                     /db_xref="RGD:62387"
                     /translation="
MNSEEQYYAATQLYKDPCAFQRGPVPEFSANPPACLYMGRQPPPPPPPQFAGSLGTLEQGSPPDISPYEVPPLADDPAGAHLHHHLPAQLGLAHPPPGPFPNGTETGGLEEPSRVHLPFPWMKSTKAHAWKSQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTTSGGGGGEEPEQDCAVTSGEELLALPPPPPPGGAVPSGVPAAAREGRLPSGLSASPQPSSIAPLRPQEPR"
     misc_feature    162..344
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="propagated from UniProtKB/Swiss-Prot (P52947.1);
                     Region: Transactivation domain"
     misc_feature    231..368
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="propagated from UniProtKB/Swiss-Prot (P52947.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    477..494
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="propagated from UniProtKB/Swiss-Prot (P52947.1);
                     Region: Antp-type hexapeptide"
     misc_feature    order(564..578,582..584,633..635,651..653,690..692,
                     696..701,708..713,717..725,729..734)
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    570..734
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:395001"
     misc_feature    order(570..572,579..581,699..701,708..713,720..722)
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    576..578
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="Phosphothreonine, by PASK.
                     /evidence=ECO:0000250|UniProtKB:P52946; propagated from
                     UniProtKB/Swiss-Prot (P52947.1); phosphorylation site"
     misc_feature    714..734
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="propagated from UniProtKB/Swiss-Prot (P52947.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000250"
     misc_feature    726..974
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="propagated from UniProtKB/Swiss-Prot (P52947.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    927..929
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P52947.1); phosphorylation site"
     exon            532..1406
                     /gene="Pdx1"
                     /gene_synonym="Idx1; Ipf1; Stf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
agagcagtggagaactgtcaaagcgatctggggtggcgctgagagtccgtgagctgcccagcgcctaaggcctggcttgtagctccctaccccgggctgccggccccgaagtgccggctgccaccatgaatagtgaggagcagtactacgcggccacacagctctacaaggacccgtgcgcattccagaggggtccggtgccagagttcagtgctaatccccctgcgtgcctgtacatgggccgccagcccccacctccgccgccaccccagtttgcaggctcgctgggaacgctggaacagggaagtcccccggacatctccccatacgaagtgcccccgctcgccgatgacccggctggcgcgcacctccaccaccacctcccagctcagctcgggctcgcccatccacctcccggacctttcccgaatggaaccgagactgggggcctggaagagcccagccgcgttcatctccctttcccgtggatgaaatccaccaaagctcacgcgtggaaaagccagtgggcaggaggtgcatacgcagcagaaccggaggagaataagaggacccgtacagcctacactcgggcccagctgctggagctggagaaggaattcttatttaacaaatacatctcccggcctcgccgggtggagctggcagtgatgctcaacttgactgagagacacatcaaaatctggttccaaaaccgtcgcatgaagtggaagaaagaggaagataagaaacgtagtagcgggacaacgagcgggggcggtgggggcgaagagccggagcaggattgtgccgtaacctcgggcgaggagctgctggcattgccaccgccaccacctcccggaggtgctgtgccctcaggcgtccctgctgctgcccgggagggccgactgccttccggccttagtgcgtccccacagccctccagcatcgcgccactgcgaccgcaggaaccccggtgaggaccgcaggctgagggtgagcgggtctgggacccagagtgcggacatgggcatgggcccgggcagctggataagggaggggatcatgaggcttaacctaaacgccacacaaggagaacattcttcttgggggcacaagagccagttgggtatagccagcgagatgctggcagacctctgggaaaaaaaaagacccgagcttctgaaaactttgaggctgcctctcgtgccatgtgaaccgccaggtctgcctctgggactctttcctgggaccaatttagagaatcaggctcccaactgaggacaatgaaaaggttacaaacttgagcggtcccataacagccaccaggcgagctggaccgggtgcctttgactggtcggccgagcaatctaaggttgagaataaagggagctgtttgaggtttcaaa
//

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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]