2025-07-06 10:59:49, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_019381 898 bp mRNA linear ROD 07-FEB-2025 DEFINITION Rattus norvegicus transmembrane BAX inhibitor motif containing 6 (Tmbim6), mRNA. ACCESSION NM_019381 XM_001063712 XM_576343 VERSION NM_019381.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 898) AUTHORS Chen,W., DU,H., Sha,Y., Zhou,Y., Liang,J., Chen,Y., Ma,Q., Wu,X. and Qian,G. TITLE [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway] JOURNAL Nan Fang Yi Ke Da Xue Xue Bao 43 (9), 1469-1475 (2023) PUBMED 37814860 REMARK GeneRIF: [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway]. REFERENCE 2 (bases 1 to 898) AUTHORS Chen,Y., Liu,X., Li,L., He,X., Zheng,F., Zhang,Y., Gao,H., Jin,Z., Wu,D., Wang,Q., Tao,H., Zhao,Y., Liu,W. and Zou,L. TITLE Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner JOURNAL Mol Med 29 (1), 19 (2023) PUBMED 36747144 REMARK GeneRIF: Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner. Publication Status: Online-Only REFERENCE 3 (bases 1 to 898) AUTHORS Liu,J., Zhou,S., Zhang,Y., Li,X., Qian,X., Tao,W., Jin,L. and Zhao,J. TITLE Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats JOURNAL Int J Mol Med 42 (5), 2891-2902 (2018) PUBMED 30226536 REMARK GeneRIF: The present study suggested that Bax inhibitor-1 serves a neuroprotective role in Early brain injury following subarachnoid hemorrhage by attenuating bloodbrain barrier disruption, brain edema and apoptosis mediated by endoplasmic reticulum stress. Erratum:[Int J Mol Med. 2024 Apr;53(4):38. doi: 10.3892/ijmm.2024.5362.. PMID: 38426556] REFERENCE 4 (bases 1 to 898) AUTHORS Liu,J., Zhou,S., Qian,X., Zhang,Y. and Zhao,J. TITLE [Over-expressed Bax inhibitor 1 (BI-1) inhibits apoptosis of hippocampal neurons via endoplasmic reticulum IRE1-JNK pathway in rats with subarachnoid hemorrhage] JOURNAL Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 33 (10), 1316-1322 (2017) PUBMED 29169414 REMARK GeneRIF: Bax inhibitor-1 (BI-1) over-expression improved neurobehavioral score, decreased hippocampal neuron apoptosis rate, and also down-regulated IRE1 protein levels in the rats with subarachnoid hemorrhage (SAH). REFERENCE 5 (bases 1 to 898) AUTHORS Urresti,J., Ruiz-Meana,M., Coccia,E., Arevalo,J.C., Castellano,J., Fernandez-Sanz,C., Galenkamp,K.M., Planells-Ferrer,L., Moubarak,R.S., Llecha-Cano,N., Reix,S., Garcia-Dorado,D., Barneda-Zahonero,B. and Comella,J.X. TITLE Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells JOURNAL J Biol Chem 291 (3), 1221-1234 (2016) PUBMED 26582200 REFERENCE 6 (bases 1 to 898) AUTHORS Chae,H.J., Kim,H.R., Xu,C., Bailly-Maitre,B., Krajewska,M., Krajewski,S., Banares,S., Cui,J., Digicaylioglu,M., Ke,N., Kitada,S., Monosov,E., Thomas,M., Kress,C.L., Babendure,J.R., Tsien,R.Y., Lipton,S.A. and Reed,J.C. TITLE BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress JOURNAL Mol Cell 15 (3), 355-366 (2004) PUBMED 15304216 REFERENCE 7 (bases 1 to 898) AUTHORS Grzmil,M., Thelen,P., Hemmerlein,B., Schweyer,S., Voigt,S., Mury,D. and Burfeind,P. TITLE Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells JOURNAL Am J Pathol 163 (2), 543-552 (2003) PUBMED 12875974 REFERENCE 8 (bases 1 to 898) AUTHORS Jean,J.C., Oakes,S.M. and Joyce-Brady,M. TITLE The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters JOURNAL Genomics 57 (2), 201-208 (1999) PUBMED 10198159 REFERENCE 9 (bases 1 to 898) AUTHORS Xu,Q. and Reed,J.C. TITLE Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast JOURNAL Mol Cell 1 (3), 337-346 (1998) PUBMED 9660918 REFERENCE 10 (bases 1 to 898) AUTHORS Walter,L., Dirks,B., Rothermel,E., Heyens,M., Szpirer,C., Levan,G. and Gunther,E. TITLE A novel, conserved gene of the rat that is developmentally regulated in the testis JOURNAL Mamm Genome 5 (4), 216-221 (1994) PUBMED 8012111 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058478.1. On or before Jan 28, 2007 this sequence version replaced XM_576343.2, XM_001063712.1, NM_019381.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058478.1, FQ218441.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00132261, SAMD00132262 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-898 BC058478.1 7-904 FEATURES Location/Qualifiers source 1..898 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="7" /map="7q36" gene 1..898 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /note="transmembrane BAX inhibitor motif containing 6" /db_xref="GeneID:24822" /db_xref="RGD:3842" exon 1..53 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /inference="alignment:Splign:2.1.0" misc_feature 47..49 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /note="upstream in-frame stop codon" exon 54..138 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /inference="alignment:Splign:2.1.0" CDS 83..796 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /note="testis enhanced gene transcript; Bax inhibitor-1; BI-1; testis-enhanced gene transcript protein; transmembrane BAX inhibitor motif-containing protein 6" /codon_start=1 /product="bax inhibitor 1" /protein_id="NP_062254.2" /db_xref="GeneID:24822" /db_xref="RGD:3842" /translation="
MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHVVTRFIQAGLLSALGALALMICLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALELCIAINPSILPTAFMGTAMIFTCFSLSALYARRRSYLFLGGILMSAMSLMFVSSLGNLFFGSIWLFQANLYMGLLVMCGFVLFDTQLIIEKAEHGDKDYIWHCIDLFLDFVTLFRKLMLILAFNEKDKKKEKK"
misc_feature 128..766 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /note="BAX inhibitor (BI)-1; Region: BI-1; cd10430" /db_xref="CDD:198412" misc_feature 170..232 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /note="propagated from UniProtKB/Swiss-Prot (P55062.2); transmembrane region" misc_feature 239..301 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /note="propagated from UniProtKB/Swiss-Prot (P55062.2); transmembrane region" misc_feature 341..403 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /note="propagated from UniProtKB/Swiss-Prot (P55062.2); transmembrane region" misc_feature 419..481 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /note="propagated from UniProtKB/Swiss-Prot (P55062.2); transmembrane region" misc_feature 500..562 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /note="propagated from UniProtKB/Swiss-Prot (P55062.2); transmembrane region" misc_feature 581..643 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /note="propagated from UniProtKB/Swiss-Prot (P55062.2); transmembrane region" exon 139..247 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /inference="alignment:Splign:2.1.0" exon 248..368 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /inference="alignment:Splign:2.1.0" exon 369..417 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /inference="alignment:Splign:2.1.0" exon 418..515 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /inference="alignment:Splign:2.1.0" exon 516..595 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /inference="alignment:Splign:2.1.0" exon 596..696 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /inference="alignment:Splign:2.1.0" exon 697..772 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /inference="alignment:Splign:2.1.0" exon 773..898 /gene="Tmbim6" /gene_synonym="Ab1-011; Ac1-149; Cc1-27; Tegt" /inference="alignment:Splign:2.1.0" ORIGIN
agcacatccggttttagccgagcggggaagctccgaagaggtgggctaagaagcggaggctgcgctgaacagacttggagccatgaatatatttgatcggaagatcaactttgatgccctcttaaaattttcccacataactccctccacacagcagcacctaaagaaggtctatgccagttttgcactgtgcatgtttgtggcagcagcaggggcctatgtccatgtggtcacacgtttcatccaggctggcctgctctctgccctgggcgccctggccttgatgatttgcctgatggccacacctcacagccatgagacggagcagaagaggctgggactgctcgctggcttcgccttccttacaggagttggcctgggacctgccctggagctgtgcattgccatcaaccccagcatcctccccacggccttcatgggcacggccatgatcttcacctgcttcagcctgagtgccctctacgccaggcgccggagttacctctttttgggaggtatcttgatgtcagccatgagcctcatgttcgtgtcctctctggggaaccttttctttggatccatttggctgttccaggcaaacctgtacatggggctgctggtcatgtgcggctttgtcctcttcgacactcagctcattattgaaaaggctgaacacggagacaaggattacatctggcactgcattgacctcttcttggacttcgttacactcttcaggaagctcatgctgatcttggccttcaatgagaaggacaaaaagaaagagaagaagtgacgtggtgatcgatcggcctctcccagctcgccttctctccctcagccccgtttctttgcacacatcacaggtgtcgtgtcccatgacaatgaaaagcatcag
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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