LOCUS       NM_013601               2162 bp    mRNA    linear   ROD 25-FEB-2020
DEFINITION  Mus musculus msh homeobox 2 (Msx2), mRNA.
ACCESSION   NM_013601
VERSION     NM_013601.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2162)
  AUTHORS   Qin L, Ahn KJ, Wine Lee L, de Charleroy C Jr and Crenshaw EB 3rd.
  TITLE     Analyses with double knockouts of the Bmpr1a and Bmpr1b genes
            demonstrate that BMP signaling is involved in the formation of
            precerebellar mossy fiber nuclei derived from the rhombic lip
  JOURNAL   PLoS ONE 14 (12), e0226602 (2019)
   PUBMED   31869353
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2162)
  AUTHORS   Dasgupta K, Chung JU, Asam K and Jeong J.
  TITLE     Molecular patterning of the embryonic cranial mesenchyme revealed
            by genome-wide transcriptional profiling
  JOURNAL   Dev. Biol. 455 (2), 434-448 (2019)
   PUBMED   31351040
REFERENCE   3  (bases 1 to 2162)
  AUTHORS   Bloomquist RF, Fowler TE, An Z, Yu TY, Abdilleh K, Fraser GJ,
            Sharpe PT and Streelman JT.
  TITLE     Developmental plasticity of epithelial stem cells in tooth and
            taste bud renewal
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 116 (36), 17858-17866 (2019)
   PUBMED   31427537
REFERENCE   4  (bases 1 to 2162)
  AUTHORS   Nallasamy S, Kaya Okur HS, Bhurke A, Davila J, Li Q, Young SL,
            Taylor RN, Bagchi MK and Bagchi IC.
  TITLE     Msx Homeobox Genes Act Downstream of BMP2 to Regulate Endometrial
            Decidualization in Mice and in Humans
  JOURNAL   Endocrinology 160 (7), 1631-1644 (2019)
   PUBMED   31125045
  REMARK    GeneRIF: When conditional, tissue-specific ablation of both Msx1
            and Msx2 was accomplished in the mouse uterus, a dramatically
            impaired decidual response was observed. In the absence of both
            Msx1 and Msx2, uterine stromal cells were able to proliferate, but
            they failed to undergo terminal differentiation
REFERENCE   5  (bases 1 to 2162)
  AUTHORS   Wiegering A, Petzsch P, Kohrer K, Ruther U and Gerhardt C.
  TITLE     GLI3 repressor but not GLI3 activator is essential for mouse eye
            patterning and morphogenesis
  JOURNAL   Dev. Biol. 450 (2), 141-154 (2019)
   PUBMED   30953627
REFERENCE   6  (bases 1 to 2162)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2162)
  AUTHORS   MacKenzie A, Ferguson MW and Sharpe PT.
  TITLE     Expression patterns of the homeobox gene, Hox-8, in the mouse
            embryo suggest a role in specifying tooth initiation and shape
  JOURNAL   Development 115 (2), 403-420 (1992)
   PUBMED   1358591
REFERENCE   8  (bases 1 to 2162)
  AUTHORS   Davidson DR, Crawley A, Hill RE and Tickle C.
  TITLE     Position-dependent expression of two related homeobox genes in
            developing vertebrate limbs
  JOURNAL   Nature 352 (6334), 429-431 (1991)
   PUBMED   1677742
REFERENCE   9  (bases 1 to 2162)
  AUTHORS   Monaghan AP, Davidson DR, Sime C, Graham E, Baldock R, Bhattacharya
            SS and Hill RE.
  TITLE     The Msh-like homeobox genes define domains in the developing
            vertebrate eye
  JOURNAL   Development 112 (4), 1053-1061 (1991)
   PUBMED   1682128
REFERENCE   10 (bases 1 to 2162)
  AUTHORS   Holland PW.
  TITLE     Cloning and evolutionary analysis of msh-like homeobox genes from
            mouse, zebrafish and ascidian
  JOURNAL   Gene 98 (2), 253-257 (1991)
   PUBMED   1673109
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133846.1 and AV230604.1.
            On Sep 14, 2006 this sequence version replaced NM_013601.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133846.1, X59252.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1478              AK133846.1         3-1480
            1479-2159           AK133846.1         1482-2162
            2160-2162           AV230604.1         160-162
FEATURES             Location/Qualifiers
     source          1..2162
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 27.84 cM"
     gene            1..2162
                     /gene="Msx2"
                     /gene_synonym="BB122635; Hox-8; Hox8; Hox8.1"
                     /note="msh homeobox 2"
                     /db_xref="GeneID:17702"
                     /db_xref="MGI:MGI:97169"
     exon            1..449
                     /gene="Msx2"
                     /gene_synonym="BB122635; Hox-8; Hox8; Hox8.1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    20..22
                     /gene="Msx2"
                     /gene_synonym="BB122635; Hox-8; Hox8; Hox8.1"
                     /note="upstream in-frame stop codon"
     CDS             71..874
                     /gene="Msx2"
                     /gene_synonym="BB122635; Hox-8; Hox8; Hox8.1"
                     /note="homeobox protein Hox-8-1; homeo box, msh-like 2;
                     homeobox, msh-like 2"
                     /codon_start=1
                     /product="homeobox protein MSX-2"
                     /protein_id="NP_038629.2"
                     /db_xref="CCDS:CCDS26522.1"
                     /db_xref="GeneID:17702"
                     /db_xref="MGI:MGI:97169"
                     /translation="

MASPTKGGDLFSSDEEGPAVLAGPGPGPGGAEGSAEERRVKVSSLPFSVEALMSDKKPPKESPAVPPDCASAGAVLRPLLLPGHGVRDAHSPGPLVKPFETASVKSENSEDGAPWIQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSGFSLPFPINSPLQAASIYGASYPFHRPVLPIPPVGLYATPVGYGMYHLS"

     misc_feature    order(497..511,515..517,566..568,584..586,623..625,
                     629..634,641..646,650..658,662..667)
                     /gene="Msx2"
                     /gene_synonym="BB122635; Hox-8; Hox8; Hox8.1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    503..664
                     /gene="Msx2"
                     /gene_synonym="BB122635; Hox-8; Hox8; Hox8.1"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:306543"
     misc_feature    order(503..505,512..514,632..634,641..646,653..655)
                     /gene="Msx2"
                     /gene_synonym="BB122635; Hox-8; Hox8; Hox8.1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            450..2162
                     /gene="Msx2"
                     /gene_synonym="BB122635; Hox-8; Hox8; Hox8.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2142..2147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msx2"
                     /gene_synonym="BB122635; Hox-8; Hox8; Hox8.1"
                     /note="putative"
     polyA_site      2159
                     /gene="Msx2"
                     /gene_synonym="BB122635; Hox-8; Hox8; Hox8.1"
                     /note="putative"
ORIGIN      

aaaagttggagtcttcgcttgagagttgccagcggagtcgcgcgccgacagctacgcggcgcagaaagtcatggcttctccgactaaaggcggtgacttgttttcgtcggatgaggagggccccgcggtactggccggcccgggtcccgggcctggaggagccgagggcagcgcagaggaacgcagggtcaaggtctccagcctgcccttcagcgtggaggcgctcatgtccgacaagaagccgcccaaggaatcgcccgcggtgccacccgactgcgcctcggctggcgctgtcctgcggccgctgctgctgccgggacacggcgtccgggacgctcacagtcccgggcctctcgtcaagcccttcgagaccgcctcggtcaagtcggaaaattccgaagacggagcaccgtggatacaggagcccggcagatactccccgccgcccagacatatgagccccaccacctgcaccctgaggaaacacaagaccaaccggaagccacgcacacccttcaccacatcccagcttctagccttggagcgcaagttccgccagaaacagtacctgtccatagcagagcgggccgagttctccagctctctgaaccttacagagacccaggtcaaaatctggttccagaaccgaagggctaaggcgaaaagactgcaagaggcggaactggaaaagctgaaaatggctgccaagcctatgctgccctcaggcttcagtctgcccttccctatcaactcacccctgcaagcagcatccatatacggcgcatcctaccccttccatagacctgtgctccccatcccgcctgttggactctatgccacgccggttggatatggcatgtaccatctatcctaaggaagaccagatggaccagactccaggatggatgtttgcataaaagcatccccctccctctccgagaaggtggtgccaactctgctcctgaatgcgagccttgcattgtcaccctaagcgacagggccacttgatacagagtgaatttgttatttaggtgagaggcactaagacctgttttgttttcataattttccaaatgccccctttcctctcacaaatattggctctgctagtttttatgtataaatatataataaaatataagactttttatatgccagatgtaaaaattcaagttattttaaaaggcaaaatttatatatacatttatccattttctttttttttctagatagcatcttcctaagatattgtgttaagtccatttgctacattttcttaaagggaaagagattaattgcagaatttgcaaggatggtggacttgcttatggaaaacatagcagaagtagacacattccatacaggatgtcacttcagacagattcttgcaagtgaagggggaggtgtaacgtgtttatttgcatttctgtgcacaagaaaaagaaatctcttgatgcacatttgatcctattttttttctctttttctccattccatattattaaatctttgttgttgttttaagatcgatgaaaagaggatgagaataactctgagagttactcagggtaaagtagaaaataggaaactccatgtcaggtccctggagtgagagggggttagaaggtgaaatattgtttgtaagaattgatttctatgaaatgctatctacatcagtcctcacacggtacagaggtgattggaagaggacatggtaaatctcttcttaaaaatgagtgtcttataactgtggcctatattttaaatattcttcaacagtccatagaatgaggaaggaaaacatgccttctctctctctctctctctctctctctctctctctctctctctctctagctctctctgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtactttgtgtgctaaacttcttagggaaatttatatactctaacgtgttgggcagatggagaagccatgtgcttgagttgctggagatggcgttgtcagtcagcacctgggtgtctcaccttcctgtccatctcttcccccagtatatttttatcccgttgaatgggtatcttgtataattttatatattttattgaagagttatttcttatctcttactctgaattaaattaaaatattttattgcagt

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