2024-03-29 16:57:59, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_013601 2162 bp mRNA linear ROD 31-OCT-2023 DEFINITION Mus musculus msh homeobox 2 (Msx2), mRNA. ACCESSION NM_013601 VERSION NM_013601.2 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 2162) AUTHORS Ruspita I, Das P, Miyoshi K, Noma T, Snead ML and Bei M. TITLE Enam expression is regulated by Msx2 JOURNAL Dev Dyn 252 (10), 1292-1302 (2023) PUBMED 37191055 REMARK GeneRIF: Enam expression is regulated by Msx2. REFERENCE 2 (bases 1 to 2162) AUTHORS Wu B, Wu B, Benkaci S, Shi L, Lu P, Park T, Morrow BE, Wang Y and Zhou B. TITLE Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development JOURNAL J Am Heart Assoc 12 (18), e029683 (2023) PUBMED 37702066 REFERENCE 3 (bases 1 to 2162) AUTHORS Qu F, Li W, Xu J, Zhang R, Ke J, Ren X, Meng X, Qin L, Zhang J, Lu F, Zhou X, Luo X, Zhang Z, Wang M, Wu G, Pei D, Chen J, Cui G, Suo S and Peng G. TITLE Three-dimensional molecular architecture of mouse organogenesis JOURNAL Nat Commun 14 (1), 4599 (2023) PUBMED 37524711 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 2162) AUTHORS Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou B. TITLE beta-Catenin regulates endocardial cushion growth by suppressing p21 JOURNAL Life Sci Alliance 6 (9), e202302163 (2023) PUBMED 37385754 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 2162) AUTHORS Redhead Y, Gibbins D, Lana-Elola E, Watson-Scales S, Dobson L, Krause M, Liu KJ, Fisher EMC, Green JBA and Tybulewicz VLJ. TITLE Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes JOURNAL Development 150 (8) (2023) PUBMED 37102702 REFERENCE 6 (bases 1 to 2162) AUTHORS Scott,M.P. TITLE Vertebrate homeobox gene nomenclature JOURNAL Cell 71 (4), 551-553 (1992) PUBMED 1358459 REFERENCE 7 (bases 1 to 2162) AUTHORS MacKenzie A, Ferguson MW and Sharpe PT. TITLE Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape JOURNAL Development 115 (2), 403-420 (1992) PUBMED 1358591 REFERENCE 8 (bases 1 to 2162) AUTHORS Davidson DR, Crawley A, Hill RE and Tickle C. TITLE Position-dependent expression of two related homeobox genes in developing vertebrate limbs JOURNAL Nature 352 (6334), 429-431 (1991) PUBMED 1677742 REFERENCE 9 (bases 1 to 2162) AUTHORS Monaghan AP, Davidson DR, Sime C, Graham E, Baldock R, Bhattacharya SS and Hill RE. TITLE The Msh-like homeobox genes define domains in the developing vertebrate eye JOURNAL Development 112 (4), 1053-1061 (1991) PUBMED 1682128 REFERENCE 10 (bases 1 to 2162) AUTHORS Holland PW. TITLE Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian JOURNAL Gene 98 (2), 253-257 (1991) PUBMED 1673109 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK133846.1 and AV230604.1. On Sep 14, 2006 this sequence version replaced NM_013601.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133846.1, X59252.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1478 AK133846.1 3-1480 1479-2159 AK133846.1 1482-2162 2160-2162 AV230604.1 160-162 FEATURES Location/Qualifiers source 1..2162 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="13" /map="13 27.84 cM" gene 1..2162 /gene="Msx2" /gene_synonym="Hox-8; Hox8; Hox8.1" /note="msh homeobox 2" /db_xref="GeneID:17702" /db_xref="MGI:MGI:97169" exon 1..449 /gene="Msx2" /gene_synonym="Hox-8; Hox8; Hox8.1" /inference="alignment:Splign:2.1.0" misc_feature 20..22 /gene="Msx2" /gene_synonym="Hox-8; Hox8; Hox8.1" /note="upstream in-frame stop codon" CDS 71..874 /gene="Msx2" /gene_synonym="Hox-8; Hox8; Hox8.1" /note="homeobox protein Hox-8-1; homeo box, msh-like 2; homeobox, msh-like 2" /codon_start=1 /product="homeobox protein MSX-2" /protein_id="NP_038629.2" /db_xref="CCDS:CCDS26522.1" /db_xref="GeneID:17702" /db_xref="MGI:MGI:97169" /translation="
MASPTKGGDLFSSDEEGPAVLAGPGPGPGGAEGSAEERRVKVSSLPFSVEALMSDKKPPKESPAVPPDCASAGAVLRPLLLPGHGVRDAHSPGPLVKPFETASVKSENSEDGAPWIQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSGFSLPFPINSPLQAASIYGASYPFHRPVLPIPPVGLYATPVGYGMYHLS"
misc_feature 71..196 /gene="Msx2" /gene_synonym="Hox-8; Hox8; Hox8.1" /note="propagated from UniProtKB/Swiss-Prot (Q03358.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 380..466 /gene="Msx2" /gene_synonym="Hox-8; Hox8; Hox8.1" /note="propagated from UniProtKB/Swiss-Prot (Q03358.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature order(497..511,515..517,566..568,584..586,623..625, 629..634,641..646,650..658,662..667) /gene="Msx2" /gene_synonym="Hox-8; Hox8; Hox8.1" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238039" misc_feature 503..664 /gene="Msx2" /gene_synonym="Hox-8; Hox8; Hox8.1" /note="Homeobox domain; Region: Homeobox; pfam00046" /db_xref="CDD:425441" misc_feature order(503..505,512..514,632..634,641..646,653..655) /gene="Msx2" /gene_synonym="Hox-8; Hox8; Hox8.1" /note="specific DNA base contacts [nucleotide binding]; other site" /db_xref="CDD:238039" exon 450..2162 /gene="Msx2" /gene_synonym="Hox-8; Hox8; Hox8.1" /inference="alignment:Splign:2.1.0" regulatory 2142..2147 /regulatory_class="polyA_signal_sequence" /gene="Msx2" /gene_synonym="Hox-8; Hox8; Hox8.1" /note="putative" polyA_site 2159 /gene="Msx2" /gene_synonym="Hox-8; Hox8; Hox8.1" /note="putative" ORIGIN
aaaagttggagtcttcgcttgagagttgccagcggagtcgcgcgccgacagctacgcggcgcagaaagtcatggcttctccgactaaaggcggtgacttgttttcgtcggatgaggagggccccgcggtactggccggcccgggtcccgggcctggaggagccgagggcagcgcagaggaacgcagggtcaaggtctccagcctgcccttcagcgtggaggcgctcatgtccgacaagaagccgcccaaggaatcgcccgcggtgccacccgactgcgcctcggctggcgctgtcctgcggccgctgctgctgccgggacacggcgtccgggacgctcacagtcccgggcctctcgtcaagcccttcgagaccgcctcggtcaagtcggaaaattccgaagacggagcaccgtggatacaggagcccggcagatactccccgccgcccagacatatgagccccaccacctgcaccctgaggaaacacaagaccaaccggaagccacgcacacccttcaccacatcccagcttctagccttggagcgcaagttccgccagaaacagtacctgtccatagcagagcgggccgagttctccagctctctgaaccttacagagacccaggtcaaaatctggttccagaaccgaagggctaaggcgaaaagactgcaagaggcggaactggaaaagctgaaaatggctgccaagcctatgctgccctcaggcttcagtctgcccttccctatcaactcacccctgcaagcagcatccatatacggcgcatcctaccccttccatagacctgtgctccccatcccgcctgttggactctatgccacgccggttggatatggcatgtaccatctatcctaaggaagaccagatggaccagactccaggatggatgtttgcataaaagcatccccctccctctccgagaaggtggtgccaactctgctcctgaatgcgagccttgcattgtcaccctaagcgacagggccacttgatacagagtgaatttgttatttaggtgagaggcactaagacctgttttgttttcataattttccaaatgccccctttcctctcacaaatattggctctgctagtttttatgtataaatatataataaaatataagactttttatatgccagatgtaaaaattcaagttattttaaaaggcaaaatttatatatacatttatccattttctttttttttctagatagcatcttcctaagatattgtgttaagtccatttgctacattttcttaaagggaaagagattaattgcagaatttgcaaggatggtggacttgcttatggaaaacatagcagaagtagacacattccatacaggatgtcacttcagacagattcttgcaagtgaagggggaggtgtaacgtgtttatttgcatttctgtgcacaagaaaaagaaatctcttgatgcacatttgatcctattttttttctctttttctccattccatattattaaatctttgttgttgttttaagatcgatgaaaagaggatgagaataactctgagagttactcagggtaaagtagaaaataggaaactccatgtcaggtccctggagtgagagggggttagaaggtgaaatattgtttgtaagaattgatttctatgaaatgctatctacatcagtcctcacacggtacagaggtgattggaagaggacatggtaaatctcttcttaaaaatgagtgtcttataactgtggcctatattttaaatattcttcaacagtccatagaatgaggaaggaaaacatgccttctctctctctctctctctctctctctctctctctctctctctctctagctctctctgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtactttgtgtgctaaacttcttagggaaatttatatactctaacgtgttgggcagatggagaagccatgtgcttgagttgctggagatggcgttgtcagtcagcacctgggtgtctcaccttcctgtccatctcttcccccagtatatttttatcccgttgaatgggtatcttgtataattttatatattttattgaagagttatttcttatctcttactctgaattaaattaaaatattttattgcagt
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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