LOCUS       NM_013601               2162 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus msh homeobox 2 (Msx2), mRNA.
ACCESSION   NM_013601
VERSION     NM_013601.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2162)
  AUTHORS   Gupta,I., Yeung,J., Rahimi-Balaei,M., Wu,S.R. and Goldowitz,D.
  TITLE     Msx genes delineate a novel molecular map of the developing
            cerebellar neuroepithelium
  JOURNAL   Front Mol Neurosci 17, 1356544 (2024)
   PUBMED   38742226
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2162)
  AUTHORS   Padmanabhan,A., de Soysa,T.Y., Pelonero,A., Sapp,V., Shah,P.P.,
            Wang,Q., Li,L., Lee,C.Y., Sadagopan,N., Nishino,T., Ye,L., Yang,R.,
            Karnay,A., Poleshko,A., Bolar,N., Linares-Saldana,R., Ranade,S.S.,
            Alexanian,M., Morton,S.U., Jain,M., Haldar,S.M., Srivastava,D. and
            Jain,R.
  TITLE     A genome-wide CRISPR screen identifies BRD4 as a regulator of
            cardiomyocyte differentiation
  JOURNAL   Nat Cardiovasc Res 3 (3), 317-331 (2024)
   PUBMED   39196112
REFERENCE   3  (bases 1 to 2162)
  AUTHORS   Quilez,S., Dumontier,E., Baim,C., Kam,J. and Cloutier,J.F.
  TITLE     Loss of Neogenin alters branchial arch development and leads to
            craniofacial skeletal defects
  JOURNAL   Front Cell Dev Biol 12, 1256465 (2024)
   PUBMED   38404688
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2162)
  AUTHORS   Haller,M., Yin,Y., Haller,G., Li,T., Li,Q., Lamb,L.E. and Ma,L.
  TITLE     Streamlined identification of clinically and functionally relevant
            genetic regulators of lower-tract urogenital development
  JOURNAL   Proc Natl Acad Sci U S A 121 (6), e2309466121 (2024)
   PUBMED   38300866
REFERENCE   5  (bases 1 to 2162)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   6  (bases 1 to 2162)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2162)
  AUTHORS   MacKenzie,A., Ferguson,M.W. and Sharpe,P.T.
  TITLE     Expression patterns of the homeobox gene, Hox-8, in the mouse
            embryo suggest a role in specifying tooth initiation and shape
  JOURNAL   Development 115 (2), 403-420 (1992)
   PUBMED   1358591
REFERENCE   8  (bases 1 to 2162)
  AUTHORS   Davidson,D.R., Crawley,A., Hill,R.E. and Tickle,C.
  TITLE     Position-dependent expression of two related homeobox genes in
            developing vertebrate limbs
  JOURNAL   Nature 352 (6334), 429-431 (1991)
   PUBMED   1677742
REFERENCE   9  (bases 1 to 2162)
  AUTHORS   Monaghan,A.P., Davidson,D.R., Sime,C., Graham,E., Baldock,R.,
            Bhattacharya,S.S. and Hill,R.E.
  TITLE     The Msh-like homeobox genes define domains in the developing
            vertebrate eye
  JOURNAL   Development 112 (4), 1053-1061 (1991)
   PUBMED   1682128
REFERENCE   10 (bases 1 to 2162)
  AUTHORS   Holland,P.W.
  TITLE     Cloning and evolutionary analysis of msh-like homeobox genes from
            mouse, zebrafish and ascidian
  JOURNAL   Gene 98 (2), 253-257 (1991)
   PUBMED   1673109
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133846.1 and AV230604.1.
            
            On Sep 14, 2006 this sequence version replaced NM_013601.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133846.1, X59252.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1478              AK133846.1         3-1480
            1479-2159           AK133846.1         1482-2162
            2160-2162           AV230604.1         160-162
FEATURES             Location/Qualifiers
     source          1..2162
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 27.84 cM"
     gene            1..2162
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="msh homeobox 2"
                     /db_xref="GeneID:17702"
                     /db_xref="MGI:MGI:97169"
     exon            1..449
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    20..22
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="upstream in-frame stop codon"
     CDS             71..874
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="homeobox protein Hox-8-1; homeo box, msh-like 2;
                     homeobox, msh-like 2"
                     /codon_start=1
                     /product="homeobox protein MSX-2"
                     /protein_id="NP_038629.2"
                     /db_xref="CCDS:CCDS26522.1"
                     /db_xref="GeneID:17702"
                     /db_xref="MGI:MGI:97169"
                     /translation="

MASPTKGGDLFSSDEEGPAVLAGPGPGPGGAEGSAEERRVKVSSLPFSVEALMSDKKPPKESPAVPPDCASAGAVLRPLLLPGHGVRDAHSPGPLVKPFETASVKSENSEDGAPWIQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSGFSLPFPINSPLQAASIYGASYPFHRPVLPIPPVGLYATPVGYGMYHLS"

     misc_feature    71..196
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03358.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    380..466
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03358.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    497..667
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            450..2162
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1130..1135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="hexamer: AATAAA"
     polyA_site      1157
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="major polyA site"
ORIGIN      

aaaagttggagtcttcgcttgagagttgccagcggagtcgcgcgccgacagctacgcggcgcagaaagtcatggcttctccgactaaaggcggtgacttgttttcgtcggatgaggagggccccgcggtactggccggcccgggtcccgggcctggaggagccgagggcagcgcagaggaacgcagggtcaaggtctccagcctgcccttcagcgtggaggcgctcatgtccgacaagaagccgcccaaggaatcgcccgcggtgccacccgactgcgcctcggctggcgctgtcctgcggccgctgctgctgccgggacacggcgtccgggacgctcacagtcccgggcctctcgtcaagcccttcgagaccgcctcggtcaagtcggaaaattccgaagacggagcaccgtggatacaggagcccggcagatactccccgccgcccagacatatgagccccaccacctgcaccctgaggaaacacaagaccaaccggaagccacgcacacccttcaccacatcccagcttctagccttggagcgcaagttccgccagaaacagtacctgtccatagcagagcgggccgagttctccagctctctgaaccttacagagacccaggtcaaaatctggttccagaaccgaagggctaaggcgaaaagactgcaagaggcggaactggaaaagctgaaaatggctgccaagcctatgctgccctcaggcttcagtctgcccttccctatcaactcacccctgcaagcagcatccatatacggcgcatcctaccccttccatagacctgtgctccccatcccgcctgttggactctatgccacgccggttggatatggcatgtaccatctatcctaaggaagaccagatggaccagactccaggatggatgtttgcataaaagcatccccctccctctccgagaaggtggtgccaactctgctcctgaatgcgagccttgcattgtcaccctaagcgacagggccacttgatacagagtgaatttgttatttaggtgagaggcactaagacctgttttgttttcataattttccaaatgccccctttcctctcacaaatattggctctgctagtttttatgtataaatatataataaaatataagactttttatatgccagatgtaaaaattcaagttattttaaaaggcaaaatttatatatacatttatccattttctttttttttctagatagcatcttcctaagatattgtgttaagtccatttgctacattttcttaaagggaaagagattaattgcagaatttgcaaggatggtggacttgcttatggaaaacatagcagaagtagacacattccatacaggatgtcacttcagacagattcttgcaagtgaagggggaggtgtaacgtgtttatttgcatttctgtgcacaagaaaaagaaatctcttgatgcacatttgatcctattttttttctctttttctccattccatattattaaatctttgttgttgttttaagatcgatgaaaagaggatgagaataactctgagagttactcagggtaaagtagaaaataggaaactccatgtcaggtccctggagtgagagggggttagaaggtgaaatattgtttgtaagaattgatttctatgaaatgctatctacatcagtcctcacacggtacagaggtgattggaagaggacatggtaaatctcttcttaaaaatgagtgtcttataactgtggcctatattttaaatattcttcaacagtccatagaatgaggaaggaaaacatgccttctctctctctctctctctctctctctctctctctctctctctctctagctctctctgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtactttgtgtgctaaacttcttagggaaatttatatactctaacgtgttgggcagatggagaagccatgtgcttgagttgctggagatggcgttgtcagtcagcacctgggtgtctcaccttcctgtccatctcttcccccagtatatttttatcccgttgaatgggtatcttgtataattttatatattttattgaagagttatttcttatctcttactctgaattaaattaaaatattttattgcagt

//