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Previous release (v1)
2025-10-25 22:18:46, GGRNA.v2 : RefSeq release 232 (Sep, 2025)
LOCUS NM_012546 3426 bp mRNA linear ROD 27-APR-2025
DEFINITION Rattus norvegicus dopamine receptor D1 (Drd1), mRNA.
ACCESSION NM_012546
VERSION NM_012546.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3426)
AUTHORS Andreska,T., Luningschror,P., Wolf,D., McFleder,R.L.,
Ayon-Olivas,M., Rattka,M., Drechsler,C., Perschin,V., Blum,R.,
Aufmkolk,S., Granado,N., Moratalla,R., Sauer,M., Monoranu,C.,
Volkmann,J., Ip,C.W., Stigloher,C. and Sendtner,M.
TITLE DRD1 signaling modulates TrkB turnover and BDNF sensitivity in
direct pathway striatal medium spiny neurons
JOURNAL Cell Rep 42 (6), 112575 (2023)
PUBMED 37252844
REMARK GeneRIF: DRD1 signaling modulates TrkB turnover and BDNF
sensitivity in direct pathway striatal medium spiny neurons.
REFERENCE 2 (bases 1 to 3426)
AUTHORS Witt,K.M., Harper,D.N. and Ellenbroek,B.A.
TITLE Dopamine D1 receptor and effort-based decision making in rats: The
moderating effect of sex
JOURNAL Prog Neuropsychopharmacol Biol Psychiatry 120, 110651 (2023)
PUBMED 36191805
REMARK GeneRIF: Dopamine D1 receptor and effort-based decision making in
rats: The moderating effect of sex.
REFERENCE 3 (bases 1 to 3426)
AUTHORS Babushkina,N. and Manahan-Vaughan,D.
TITLE Frequency-dependency of the involvement of dopamine D1/D5 and
beta-adrenergic receptors in hippocampal LTD triggered by locus
coeruleus stimulation
JOURNAL Hippocampus 32 (6), 449-465 (2022)
PUBMED 35478421
REMARK GeneRIF: Frequency-dependency of the involvement of dopamine D1/D5
and beta-adrenergic receptors in hippocampal LTD triggered by locus
coeruleus stimulation.
REFERENCE 4 (bases 1 to 3426)
AUTHORS Mesgar,S., Jameie,S.B., Aliaghaei,A., Parvardeh,S., Torabi,A. and
Haghparast,A.
TITLE Dopamine D1 Receptor-Mediated Regulation of Per1, Per2, CLOCK, and
BMAL1 Expression in the Suprachiasmatic Nucleus in Adult Male Rats
JOURNAL J Mol Neurosci 72 (3), 618-625 (2022)
PUBMED 34751875
REMARK GeneRIF: Dopamine D1 Receptor-Mediated Regulation of Per1, Per2,
CLOCK, and BMAL1 Expression in the Suprachiasmatic Nucleus in Adult
Male Rats.
REFERENCE 5 (bases 1 to 3426)
AUTHORS Ramires Lima,K., de Souza da Rosa,A.C., Severo Picua,S., Souza E
Silva,S., Marks Soares,N. and Billig Mello-Carpes,P.
TITLE One single physical exercise session improves memory persistence by
hippocampal activation of D1 dopamine receptors and PKA signaling
in rats
JOURNAL Brain Res 1762, 147439 (2021)
PUBMED 33753064
REMARK GeneRIF: One single physical exercise session improves memory
persistence by hippocampal activation of D1 dopamine receptors and
PKA signaling in rats.
REFERENCE 6 (bases 1 to 3426)
AUTHORS Zhou,Q.Y., Li,C. and Civelli,O.
TITLE Characterization of gene organization and promoter region of the
rat dopamine D1 receptor gene
JOURNAL J Neurochem 59 (5), 1875-1883 (1992)
PUBMED 1402930
REFERENCE 7 (bases 1 to 3426)
AUTHORS Liu,Y.F., Civelli,O., Zhou,Q.Y. and Albert,P.R.
TITLE Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and
calcium signals of the human dopamine-D1 receptor: selective
potentiation by protein kinase A
JOURNAL Mol Endocrinol 6 (11), 1815-1824 (1992)
PUBMED 1282671
REFERENCE 8 (bases 1 to 3426)
AUTHORS Salkovic,M. and Lackovic,Z.
TITLE Brain D1 dopamine receptor in alloxan-induced diabetes
JOURNAL Diabetes 41 (9), 1119-1121 (1992)
PUBMED 1386820
REFERENCE 9 (bases 1 to 3426)
AUTHORS Tiberi,M., Jarvie,K.R., Silvia,C., Falardeau,P., Gingrich,J.A.,
Godinot,N., Bertrand,L., Yang-Feng,T.L., Fremeau,R.T. Jr. and
Caron,M.G.
TITLE Cloning, molecular characterization, and chromosomal assignment of
a gene encoding a second D1 dopamine receptor subtype: differential
expression pattern in rat brain compared with the D1A receptor
JOURNAL Proc Natl Acad Sci U S A 88 (17), 7491-7495 (1991)
PUBMED 1831904
REFERENCE 10 (bases 1 to 3426)
AUTHORS O'Dowd,B.F., Nguyen,T., Tirpak,A., Jarvie,K.R., Israel,Y.,
Seeman,P. and Niznik,H.B.
TITLE Cloning of two additional catecholamine receptors from rat brain
JOURNAL FEBS Lett 262 (1), 8-12 (1990)
PUBMED 2138567
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000017.1.
On Feb 3, 2015 this sequence version replaced NM_012546.2.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript is intronless :: M35077.1, SRR21887623.1696807.1
[ECO:0000345]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, longest protein
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-3426 JAXUCZ010000017.1 10546604-10550029
FEATURES Location/Qualifiers
source 1..3426
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="17"
/map="17p14"
gene 1..3426
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="dopamine receptor D1"
/db_xref="GeneID:24316"
/db_xref="RGD:2518"
exon 1..3426
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/inference="alignment:Splign:2.1.0"
misc_feature 316..318
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="upstream in-frame stop codon"
CDS 439..1779
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="Dopamine-1A receptor; dopamine receptor D1A"
/codon_start=1
/product="D(1A) dopamine receptor"
/protein_id="NP_036678.3"
/db_xref="GeneID:24316"
/db_xref="RGD:2518"
/translation="
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST"
misc_feature 448..450
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P18901.2); glycosylation site"
misc_feature 502..1461
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="seven-transmembrane G protein-coupled receptor
superfamily; Region: 7tm_GPCRs; cl28897"
/db_xref="CDD:475119"
misc_feature 505..582
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="propagated from UniProtKB/Swiss-Prot (P18901.2);
transmembrane region"
misc_feature 511..585
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="TM helix 1 [structural motif]; Region: TM helix 1"
/db_xref="CDD:320443"
misc_feature 613..681
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="TM helix 2 [structural motif]; Region: TM helix 2"
/db_xref="CDD:320443"
misc_feature 616..696
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="propagated from UniProtKB/Swiss-Prot (P18901.2);
transmembrane region"
misc_feature 724..792
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="TM helix 3 [structural motif]; Region: TM helix 3"
/db_xref="CDD:320443"
misc_feature 724..792
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="propagated from UniProtKB/Swiss-Prot (P18901.2);
transmembrane region"
misc_feature 850..924
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="propagated from UniProtKB/Swiss-Prot (P18901.2);
transmembrane region"
misc_feature 859..909
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="TM helix 4 [structural motif]; Region: TM helix 4"
/db_xref="CDD:320443"
misc_feature 1012..1083
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="TM helix 5 [structural motif]; Region: TM helix 5"
/db_xref="CDD:320443"
misc_feature 1015..1092
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="propagated from UniProtKB/Swiss-Prot (P18901.2);
transmembrane region"
misc_feature 1249..1317
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="TM helix 6 [structural motif]; Region: TM helix 6"
/db_xref="CDD:320443"
misc_feature 1255..1335
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="propagated from UniProtKB/Swiss-Prot (P18901.2);
transmembrane region"
misc_feature 1366..1443
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="TM helix 7 [structural motif]; Region: TM helix 7"
/db_xref="CDD:320443"
misc_feature 1375..1449
/gene="Drd1"
/gene_synonym="D1a; Drd-1; Drd1a"
/note="propagated from UniProtKB/Swiss-Prot (P18901.2);
transmembrane region"
ORIGIN
ggcatttggagagatgcggtgccaggggcttggaggagaaatgcatgtattttaggccgtgtctcagaaaaagaggcagcatccctgaaaagtgactagaattgacctggaagaggccatggactcagagtgtgcttaaaagccaatgctctccttggggaatgtagggaccagccgatgtcacagggacacactgtcacagggacagtgacctggagcaccaagcccagaagacagatgggaagcaggagagtctttaccccggcatggcttggattgctacggggaagctcctgatggaaccctaccatcctttagtccaggcagcaactggggctgaacaagaaggggctgggtggtgagtggttgggggaagtctggctaagcctggtcaagaacttgaggggcaagtccccggaagtgtgttccttctggaagatggctcctaacacttctaccatggatgaggccgggctgccagcggagagggatttctcctttcgcatcctcacggcctgtttcctgtcactgctcatcctgtccactctcctgggcaatacccttgtctgtgcggccgtcatccggtttcgacacctgaggtccaaggtgaccaacttctttgtcatctctttagctgtgtcagatctcttggtggctgtcctggtcatgccctggaaagctgtggccgagattgctggcttttggccctttgggtccttttgtaacatctgggtagcctttgacatcatgtgctctacggcgtccattctgaacctctgcgtgatcagcgtggacaggtactgggctatctccagccctttccagtatgagaggaagatgacccccaaagcagccttcatcctgattagcgtagcatggactctgtctgtccttatatccttcatcccagtacagctaagctggcacaaggcaaagcccacatggcccttggatggcaattttacctccctggaggacaccgaggatgacaactgtgacacaaggttgagcaggacgtatgccatttcatcgtccctcatcagcttttacatccccgtagccattatgatcgtcacctacaccagtatctacaggattgcccagaagcaaatccggcgcatctcagccttggagagggcagcagtccatgccaagaattgccagaccaccgcaggtaacgggaaccccgtcgaatgcgcccagtctgaaagttcctttaagatgtccttcaagagggagacgaaagttctaaagacgctgtctgtgatcatgggggtgtttgtgtgctgctggctccctttcttcatctcgaactgtatggtgcccttctgtggctctgaggagacccagccattctgcatcgattccatcaccttcgatgtgtttgtgtggtttgggtgggcgaattcttccctgaaccccattatttatgcttttaatgctgacttccagaaggcgttctcaaccctcttaggatgctacagactctgccctactacgaataatgccatagagacggtgagcattaacaacaatggggctgtggtgttttccagccaccatgagccccgaggctccatctccaaggactgtaatctggtttacctgatccctcatgccgtgggctcctctgaggacctgaagaaggaagaggctggtggaatagctaagccactggagaagctgtccccagccttatcggtcatattggactatgacaccgatgtctctctagaaaagatccaacctgtcacacacagtggacagcattccacttgaatattgggtcctcatctctgaggccacgagttcccttgggcttgctgttaaggaattaacaggagatccctctgctgcttttggacaattacgaagcttctcaaactcactgattccagtgtattctctagcttcaagggaaatgacttcggctctgaaatcagtttgggagtattatcttaggacattataaaacaacaacaaacaaacaaacaaacaaacaaatagggccaagagtcaactgtaaacagcttcacttaaaaatcgaactttccagaaaggaagggtaggagttgagtttgctgtccaaacaggtgctaaaactgtccgagcagttttcagattggaaaggtaggtgcatgcctttgttaattaacttctccaataataattgagccttacagcaggagtgggattcctttttctcagaattgacagatgcattgttgatgacggttttatttatttatttattgtactatatgaatattttaaatttatcatagtgaatctatatttaacatatttaacagagcaaaccaatgtgttatctgagactgacctctccatttgtactagcactttatgagccaatgaaacatacgcgtagactctgagattctgaattgtgagttacttctgggaacacagcaaagactgatgtggtggctccttaactcgacaaggacacaaagaaacgcaagaggagaagtgactaatgccaccaatgctccccctaaaaagattttgaaaagattagttttttttttttttaaaagaagctactattgtgttctgaatgttttaaatggcagaggctttccccggggcgaatttgcacttctgtaaatatctatgtaagaaccagctcaagaggaatacaactttatatttccgcttttggatggcgaggaagagcatatgccactttgtatttatgtaaaataattggccctccttgtcatttctcatttcatgcttgaaatagctttctgaaacaaacaaatgactgtccaggctggagatctgcagggtggagaatgagttgtaaattcacaggtcacagcagcccctccgatagctgggctcatcattggtcctttatctgcccaggtctaaccaagtcggctgcttaaggggctacttttgtagtgctttaatccgaatttagtatcctctctttaaaaaaaaaaagctctttaatgttagtggtaaactagctaatgaacggtacctcatcgctgcataatacacttctgttggtgggggcgtagacgagccccttcccggtgcgagcaccacaaagccatctgcatagctagtcacaaatgctgtttttctttctctgtgggtttgaatctagtttccttgttatcatagcctggactgcaaaaagaaccatcgagtcccctcttgtgggggcattgcaacagtgtttctttttgtttttgttttgtttttgaaatgtttacaaggtgttctttggaagcagttgcaacacgtggatggaactgaagaaaaggctgactggcttgctaacggtatctcctgcagggggtttgtactgcggactttgaatgttttctcagctctaaggcttgtatgctttcttacatacaataaacttattttgtgaattcaaatcaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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