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2021-10-17 14:46:06, GGRNA.v2 : RefSeq release 207 (Jul, 2021)

LOCUS       NM_012546               3426 bp    mRNA    linear   ROD 24-MAY-2021
DEFINITION  Rattus norvegicus dopamine receptor D1 (Drd1), mRNA.
ACCESSION   NM_012546
VERSION     NM_012546.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3426)
  AUTHORS   Morales-Mulia S, Magdaleno-Madrigal VM, Nicolini H, Genis-Mendoza A
            and Morales-Mulia M.
  TITLE     Orexin-A up-regulates dopamine D2 receptor and mRNA in the nucleus
            accumbens Shell
  JOURNAL   Mol Biol Rep 47 (12), 9689-9697 (2020)
   PUBMED   33170427
  REMARK    GeneRIF: Orexin-A up-regulates dopamine D2 receptor and mRNA in the
            nucleus accumbens Shell.
REFERENCE   2  (bases 1 to 3426)
  AUTHORS   Yarur HE, Gonzalez MP, Verbel-Vergara D, Andres ME and Gysling K.
  TITLE     Cross-talk between dopamine D1 and corticotropin releasing factor
            type 2 receptors leads to occlusion of their ERK1/2 signaling
  JOURNAL   J Neurochem 155 (3), 264-273 (2020)
   PUBMED   32215915
  REMARK    GeneRIF: Cross-talk between dopamine D1 and corticotropin releasing
            factor type 2 receptors leads to occlusion of their ERK1/2
            signaling.
REFERENCE   3  (bases 1 to 3426)
  AUTHORS   Kreisler AD, Terranova MJ, Somkuwar SS, Purohit DC, Wang S, Head BP
            and Mandyam CD.
  TITLE     In vivo reduction of striatal D1R by RNA interference alters
            expression of D1R signaling-related proteins and enhances
            methamphetamine addiction in male rats
  JOURNAL   Brain Struct Funct 225 (3), 1073-1088 (2020)
   PUBMED   32246242
  REMARK    GeneRIF: In vivo reduction of striatal D1R by RNA interference
            alters expression of D1R signaling-related proteins and enhances
            methamphetamine addiction in male rats.
REFERENCE   4  (bases 1 to 3426)
  AUTHORS   Sebastianutto I, Goyet E, Andreoli L, Font-Ingles J, Moreno-Delgado
            D, Bouquier N, Jahannault-Talignani C, Moutin E, Di Menna L,
            Maslava N, Pin JP, Fagni L, Nicoletti F, Ango F, Cenci MA and
            Perroy J.
  TITLE     D1-mGlu5 heteromers mediate noncanonical dopamine signaling in
            Parkinson's disease
  JOURNAL   J Clin Invest 130 (3), 1168-1184 (2020)
   PUBMED   32039920
  REMARK    GeneRIF: D1-mGlu5 heteromers mediate noncanonical dopamine
            signaling in Parkinson's disease.
REFERENCE   5  (bases 1 to 3426)
  AUTHORS   Hasbi A, Nguyen T, Rahal H, Manduca JD, Miksys S, Tyndale RF,
            Madras BK, Perreault ML and George SR.
  TITLE     Sex difference in dopamine D1-D2 receptor complex expression and
            signaling affects depression- and anxiety-like behaviors
  JOURNAL   Biol Sex Differ 11 (1), 8 (2020)
   PUBMED   32087746
  REMARK    GeneRIF: Sex difference in dopamine D1-D2 receptor complex
            expression and signaling affects depression- and anxiety-like
            behaviors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3426)
  AUTHORS   Zhou QY, Li C and Civelli O.
  TITLE     Characterization of gene organization and promoter region of the
            rat dopamine D1 receptor gene
  JOURNAL   J Neurochem 59 (5), 1875-1883 (1992)
   PUBMED   1402930
REFERENCE   7  (bases 1 to 3426)
  AUTHORS   Liu YF, Civelli O, Zhou QY and Albert PR.
  TITLE     Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and
            calcium signals of the human dopamine-D1 receptor: selective
            potentiation by protein kinase A
  JOURNAL   Mol Endocrinol 6 (11), 1815-1824 (1992)
   PUBMED   1282671
REFERENCE   8  (bases 1 to 3426)
  AUTHORS   Salkovic M and Lackovic Z.
  TITLE     Brain D1 dopamine receptor in alloxan-induced diabetes
  JOURNAL   Diabetes 41 (9), 1119-1121 (1992)
   PUBMED   1386820
REFERENCE   9  (bases 1 to 3426)
  AUTHORS   Tiberi M, Jarvie KR, Silvia C, Falardeau P, Gingrich JA, Godinot N,
            Bertrand L, Yang-Feng TL, Fremeau RT Jr and Caron MG.
  TITLE     Cloning, molecular characterization, and chromosomal assignment of
            a gene encoding a second D1 dopamine receptor subtype: differential
            expression pattern in rat brain compared with the D1A receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7491-7495 (1991)
   PUBMED   1831904
REFERENCE   10 (bases 1 to 3426)
  AUTHORS   O'Dowd BF, Nguyen T, Tirpak A, Jarvie KR, Israel Y, Seeman P and
            Niznik HB.
  TITLE     Cloning of two additional catecholamine receptors from rat brain
  JOURNAL   FEBS Lett 262 (1), 8-12 (1990)
   PUBMED   2138567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000284.1.
            On Feb 3, 2015 this sequence version replaced NM_012546.2.
            
            Summary: induces dopamine sensitive adenylate cyclase activation;
            plays a role in regulating food intake [RGD, Feb 2006].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: M35077.1 [ECO:0000345]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3426              JACYVU010000284.1  10541546-10544971
FEATURES             Location/Qualifiers
     source          1..3426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..3426
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="dopamine receptor D1"
                     /db_xref="GeneID:24316"
                     /db_xref="RGD:2518"
     exon            1..3426
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    316..318
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="upstream in-frame stop codon"
     CDS             439..1779
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="Dopamine-1A receptor; dopamine receptor D1A"
                     /codon_start=1
                     /product="D(1A) dopamine receptor"
                     /protein_id="NP_036678.3"
                     /db_xref="GeneID:24316"
                     /db_xref="RGD:2518"
                     /translation="
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST"
     misc_feature    448..450
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P18901.2); glycosylation site"
     misc_feature    505..582
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     misc_feature    553..1431
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="7 transmembrane receptor (rhodopsin family);
                     Region: 7tm_1; pfam00001"
                     /db_xref="CDD:278431"
     misc_feature    556..>909
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="Olfactory receptor; Region: 7tm_4; cl21561"
                     /db_xref="CDD:304433"
     misc_feature    616..696
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     misc_feature    724..792
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     misc_feature    850..924
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     misc_feature    1015..1092
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     misc_feature    1255..1335
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     misc_feature    1375..1449
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /note="propagated from UniProtKB/Swiss-Prot (P18901.2);
                     transmembrane region"
     STS             1036..1138
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /standard_name="Drd1a"
                     /db_xref="UniSTS:142863"
     STS             1847..2072
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /standard_name="D17Wox23"
                     /db_xref="UniSTS:518622"
     STS             3149..3330
                     /gene="Drd1"
                     /gene_synonym="D1a; Drd-1; Drd1a"
                     /standard_name="RH131896"
                     /db_xref="UniSTS:215179"
ORIGIN      
ggcatttggagagatgcggtgccaggggcttggaggagaaatgcatgtattttaggccgtgtctcagaaaaagaggcagcatccctgaaaagtgactagaattgacctggaagaggccatggactcagagtgtgcttaaaagccaatgctctccttggggaatgtagggaccagccgatgtcacagggacacactgtcacagggacagtgacctggagcaccaagcccagaagacagatgggaagcaggagagtctttaccccggcatggcttggattgctacggggaagctcctgatggaaccctaccatcctttagtccaggcagcaactggggctgaacaagaaggggctgggtggtgagtggttgggggaagtctggctaagcctggtcaagaacttgaggggcaagtccccggaagtgtgttccttctggaagatggctcctaacacttctaccatggatgaggccgggctgccagcggagagggatttctcctttcgcatcctcacggcctgtttcctgtcactgctcatcctgtccactctcctgggcaatacccttgtctgtgcggccgtcatccggtttcgacacctgaggtccaaggtgaccaacttctttgtcatctctttagctgtgtcagatctcttggtggctgtcctggtcatgccctggaaagctgtggccgagattgctggcttttggccctttgggtccttttgtaacatctgggtagcctttgacatcatgtgctctacggcgtccattctgaacctctgcgtgatcagcgtggacaggtactgggctatctccagccctttccagtatgagaggaagatgacccccaaagcagccttcatcctgattagcgtagcatggactctgtctgtccttatatccttcatcccagtacagctaagctggcacaaggcaaagcccacatggcccttggatggcaattttacctccctggaggacaccgaggatgacaactgtgacacaaggttgagcaggacgtatgccatttcatcgtccctcatcagcttttacatccccgtagccattatgatcgtcacctacaccagtatctacaggattgcccagaagcaaatccggcgcatctcagccttggagagggcagcagtccatgccaagaattgccagaccaccgcaggtaacgggaaccccgtcgaatgcgcccagtctgaaagttcctttaagatgtccttcaagagggagacgaaagttctaaagacgctgtctgtgatcatgggggtgtttgtgtgctgctggctccctttcttcatctcgaactgtatggtgcccttctgtggctctgaggagacccagccattctgcatcgattccatcaccttcgatgtgtttgtgtggtttgggtgggcgaattcttccctgaaccccattatttatgcttttaatgctgacttccagaaggcgttctcaaccctcttaggatgctacagactctgccctactacgaataatgccatagagacggtgagcattaacaacaatggggctgtggtgttttccagccaccatgagccccgaggctccatctccaaggactgtaatctggtttacctgatccctcatgccgtgggctcctctgaggacctgaagaaggaagaggctggtggaatagctaagccactggagaagctgtccccagccttatcggtcatattggactatgacaccgatgtctctctagaaaagatccaacctgtcacacacagtggacagcattccacttgaatattgggtcctcatctctgaggccacgagttcccttgggcttgctgttaaggaattaacaggagatccctctgctgcttttggacaattacgaagcttctcaaactcactgattccagtgtattctctagcttcaagggaaatgacttcggctctgaaatcagtttgggagtattatcttaggacattataaaacaacaacaaacaaacaaacaaacaaacaaatagggccaagagtcaactgtaaacagcttcacttaaaaatcgaactttccagaaaggaagggtaggagttgagtttgctgtccaaacaggtgctaaaactgtccgagcagttttcagattggaaaggtaggtgcatgcctttgttaattaacttctccaataataattgagccttacagcaggagtgggattcctttttctcagaattgacagatgcattgttgatgacggttttatttatttatttattgtactatatgaatattttaaatttatcatagtgaatctatatttaacatatttaacagagcaaaccaatgtgttatctgagactgacctctccatttgtactagcactttatgagccaatgaaacatacgcgtagactctgagattctgaattgtgagttacttctgggaacacagcaaagactgatgtggtggctccttaactcgacaaggacacaaagaaacgcaagaggagaagtgactaatgccaccaatgctccccctaaaaagattttgaaaagattagttttttttttttttaaaagaagctactattgtgttctgaatgttttaaatggcagaggctttccccggggcgaatttgcacttctgtaaatatctatgtaagaaccagctcaagaggaatacaactttatatttccgcttttggatggcgaggaagagcatatgccactttgtatttatgtaaaataattggccctccttgtcatttctcatttcatgcttgaaatagctttctgaaacaaacaaatgactgtccaggctggagatctgcagggtggagaatgagttgtaaattcacaggtcacagcagcccctccgatagctgggctcatcattggtcctttatctgcccaggtctaaccaagtcggctgcttaaggggctacttttgtagtgctttaatccgaatttagtatcctctctttaaaaaaaaaaagctctttaatgttagtggtaaactagctaatgaacggtacctcatcgctgcataatacacttctgttggtgggggcgtagacgagccccttcccggtgcgagcaccacaaagccatctgcatagctagtcacaaatgctgtttttctttctctgtgggtttgaatctagtttccttgttatcatagcctggactgcaaaaagaaccatcgagtcccctcttgtgggggcattgcaacagtgtttctttttgtttttgttttgtttttgaaatgtttacaaggtgttctttggaagcagttgcaacacgtggatggaactgaagaaaaggctgactggcttgctaacggtatctcctgcagggggtttgtactgcggactttgaatgttttctcagctctaaggcttgtatgctttcttacatacaataaacttattttgtgaattcaaatcaa
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]