LOCUS       NM_010461               2645 bp    mRNA    linear   ROD 08-JUL-2025
DEFINITION  Mus musculus homeobox B8 (Hoxb8), mRNA.
ACCESSION   NM_010461
VERSION     NM_010461.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2645)
  AUTHORS   Crowther,A.J., Kashem,S.W., Jewell,M.E., Le Chang,H., Midavaine,E.,
            Rosa Casillas,M., Danchine,V., Rodriguez,S., Kania,A., Chen,R.,
            Braz,J.M. and Basbaum,A.I.
  TITLE     Keratinocyte-TRPV1 sensory neuron interactions in a genetically
            controllable mouse model of chronic neuropathic itch
  JOURNAL   Proc Natl Acad Sci U S A 122 (24), e2411724122 (2025)
   PUBMED   40498457
REFERENCE   2  (bases 1 to 2645)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2645)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2645)
  AUTHORS   Wang,H., Liu,X., Liu,Y., Yang,C., Ye,Y., Yu,X., Sheng,N., Zhang,S.,
            Mao,B. and Ma,P.
  TITLE     The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression
            patterns through regulation of WDR5 stability
  JOURNAL   Elife 13, 94657 (2024)
   PUBMED   39526890
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2645)
  AUTHORS   Bohic,M., Upadhyay,A., Eisdorfer,J.T., Keating,J., Simon,R.C.,
            Briones,B.A., Azadegan,C., Nacht,H.D., Oputa,O., Martinez,A.M.,
            Bethell,B.N., Gradwell,M.A., Romanienko,P., Ramer,M.S., Stuber,G.D.
            and Abraira,V.E.
  TITLE     A new Hoxb8FlpO mouse line for intersectional approaches to dissect
            developmentally defined adult sensorimotor circuits
  JOURNAL   Front Mol Neurosci 16, 1176823 (2023)
   PUBMED   37603775
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2645)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2645)
  AUTHORS   Zwartkruis,F., Hoeijmakers,T., Deschamps,J. and Meijlink,F.
  TITLE     The murine Hox-2.4 promoter contains a functional octamer motif
  JOURNAL   Nucleic Acids Res 20 (7), 1599-1606 (1992)
   PUBMED   1349742
REFERENCE   8  (bases 1 to 2645)
  AUTHORS   Jones,F.S., Prediger,E.A., Bittner,D.A., De Robertis,E.M. and
            Edelman,G.M.
  TITLE     Cell adhesion molecules as targets for Hox genes: neural cell
            adhesion molecule promoter activity is modulated by cotransfection
            with Hox-2.5 and -2.4
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2086-2090 (1992)
   PUBMED   1347944
REFERENCE   9  (bases 1 to 2645)
  AUTHORS   Ben-David,L., Aberdam,D., Sachs,L. and Blatt,C.
  TITLE     A deletion and a rearrangement distinguish between the
            intracisternal A-particle of Hox-2.4 and that of interleukin-3 in
            the same leukemic cells
  JOURNAL   Virology 182 (1), 382-387 (1991)
   PUBMED   1673811
REFERENCE   10 (bases 1 to 2645)
  AUTHORS   Aberdam,D., Negreanu,V., Sachs,L. and Blatt,C.
  TITLE     The oncogenic potential of an activated Hox-2.4 homeobox gene in
            mouse fibroblasts
  JOURNAL   Mol Cell Biol 11 (1), 554-557 (1991)
   PUBMED   1670897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645478.15, AK083980.1 and AK131612.1.
            
            On Dec 21, 2006 this sequence version replaced NM_010461.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X13721.1, BC139209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               AL645478.15        96505-96970
            467-729             AK083980.1         2-264
            730-1482            AL645478.15        97234-97986
            1483-1585           AL645478.15        98763-98865
            1586-2635           AK131612.1         461-1510
            2636-2645           AL645478.15        99916-99925
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.82 cM"
     gene            1..2645
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="homeobox B8"
                     /db_xref="GeneID:15416"
                     /db_xref="MGI:MGI:96189"
     exon            1..1482
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    666..668
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="upstream in-frame stop codon"
     CDS             1059..1790
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="homeobox protein Hox-2.4; homeo box B8"
                     /codon_start=1
                     /product="homeobox protein Hox-B8"
                     /protein_id="NP_034591.1"
                     /db_xref="CCDS:CCDS25293.1"
                     /db_xref="GeneID:15416"
                     /db_xref="MGI:MGI:96189"
                     /translation="

MSSYFVNSLFSKYKTGESLRPNYYDCGFAQDLGGRPTVVYGPSSGGSFQHPSQIQEFYHGPSSLSTAPYQQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDPDLVQYADCKLAAASGLGEEAEGSEQSPSPTQLFPWMRPQAAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKEKLERAPETAEQGDAQKGDKK"

     misc_feature    1458..1475
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="propagated from UniProtKB/Swiss-Prot (P09632.2);
                     Region: Antp-type hexapeptide"
     misc_feature    1497..1667
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    1665..1787
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="propagated from UniProtKB/Swiss-Prot (P09632.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            1483..2645
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2619..2624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="hexamer: AATAAA"
     polyA_site      2644
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="major polyA site"
ORIGIN      

aagctttaaatatgactacctcgtttgtttgaaaatatgtttaggagaggaagctgtatgatttgataacttgtattaaaataccaattacatttataggaccttttaaaactcggtgcaattaaaccgtgttcttttacatttttccgaagcgaccctgacatttagaaagactccaattgcctcgttaaaatcgcgaaattaacagcgtgcctacgccaggctcagcgttgtggatgtgtgtgtatggtgtttttccgtgactcccccacatcagtctttgggggtggtctgcgaaggtatttgatttgttgtgaggcaagagatatctcattaatgtaggtagttaaacagatttaatccgtattcgttctctctctctcccccctccctctccccccctctccccctctttctccctgggtgtttttttctcttcccctcctttttttctgccctctcctcactccctggcgctctctcgctctagctctctctcgcactcgctctctctcgctctcaccctcgctctgcgttctgtccgggaggagtacccagaagccaataggatgcggggtctctaatggatgcaaatgatggtgaaaagacggggcaaaatatgaaacaactcatttggagggaagtaaatcaccgaaaactgtttatgaactggcatcccttcttcgaaatgtaaagcgaggacctctttaagtggcggtatatttttgtttggggggtggggggtggggggagggcgagcgagccgcggctgccatgcaggcttagacttttgcaggcttcgctcttctattcctggaaatcacaaaaagtgtggcggctttgagatcttcttcgtcttttctttcttttccttccttccttcttttttttcccctcctcccttttcctctcctttcctggcgagggtgactaggagccggcgaatccgcgtttttttttctctctctctccctcccttttccccctccccaccccctccccaacagcccccaactacagcctgcgccgccgccgccgccgcctcaaaattcaataaaatgagctcttatttcgtcaactcactgttctccaaatacaaaaccggggagtccctgcgccccaattattatgactgcggcttcgcccaggacctgggcggccgacccaccgtggtgtacggtcccagcagcggcggcagcttccagcacccttcgcaaatccaggagttctaccacgggccatcgtcgctgtccacagctccctaccagcagaacccgtgcgccgtggcgtgccacggcgaccccggcaacttctacggctacgaccctctgcagcgccagagcctgttcggtgcgcaggatccagacctggtgcagtacgcagactgcaagctcgcggcagccagcggcctgggcgaggaggccgaggggtctgagcagagcccgtcgcccacacagctctttccctggatgcgccctcaagcagccgccggacgcaggcgaggccgccagacctacagtcgctaccagaccctggagctggagaaggagttcctatttaatccctatctgactcgcaagcggaggatcgaggtatcgcacgcgctgggactgacagagagacaggtcaaaatctggttccagaatcggagaatgaagtggaaaaaggagaacaacaaagacaagtttcccagcagtaaatgcgagcaggaggagctggagaaagagaagctggagcgggcaccagagaccgccgagcagggcgatgcgcagaagggtgacaagaagtaggctccagctgggactgctcgggcccggactagcccgcacgtccgccggtcccccccgcgaccacgccgccgccgcccgccccccgcctccgagagctccggccccgcgagcggagccaggagctgggcctcccacagcagcgtcccccgccgcgccagtccccgctagtggtagtatctcgtaatagcttctgtgtgtgagctaccgtggatctccttcccttctcttgggggtccggggggaaaaaaagaaaaggattttaagcaaggactccctcgtcctgcgagggtgatcgactgcggcctggcagaaccccctcgcccccgccccatgtaaaaaagcctccttgtgcaatggtctgtttcctttgaacgtgcttctttgtaatgaccgaggtaccgatttctgctaagttttcccaacaacatgaaactgcctattcacgccgtaattctttctgtctcccgctcactttctctctttctctcgctctctttctctcaccgcgtccccatctttcctcgcaaccccctctccccgctgccctccctagctggctttctctcttgcttctctcttttcctcctgtccccccacccccaccccctttggtttgacaattttgtcttaagtgtttctcaaaagagattactttagttagcatgcgcgctgtgagcattgttaaaagtgttcttaggtttactgtgaagagaatgtatcctgtatctgtgaattgctttatgggggggagggagggctaattatatattttgttgttcctctatactttgttctgttgtctgcgcctgaaaagggcggaagagttacaataaagtttacaagcgagaacccgag

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