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2018-06-23 22:43:59, GGRNA.v2 : RefSeq release 88 (May, 2018)

LOCUS       NM_008770               1872 bp    mRNA    linear   ROD 28-MAR-2018
DEFINITION  Mus musculus claudin 11 (Cldn11), mRNA.
ACCESSION   NM_008770
VERSION     NM_008770.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Maheras KJ, Peppi M, Ghoddoussi F, Galloway MP, Perrine SA and Gow
            A.
  TITLE     Absence of Claudin 11 in CNS Myelin Perturbs Behavior and
            Neurotransmitter Levels in Mice
  JOURNAL   Sci Rep 8 (1), 3798 (2018)
   PUBMED   29491447
  REMARK    GeneRIF: Absence of claudin 11 in CNS myelin causes behavioral
            phenotypes and neurotransmitter imbalances in amygdala and auditory
            brainstem
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Rohacek AM, Bebee TW, Tilton RK, Radens CM, McDermott-Roe C, Peart
            N, Kaur M, Zaykaner M, Cieply B, Musunuru K, Barash Y, Germiller
            JA, Krantz ID, Carstens RP and Epstein DJ.
  TITLE     ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative
            Splicing that Disrupt Cochlear Development
  JOURNAL   Dev. Cell 43 (3), 318-331 (2017)
   PUBMED   29107558
REFERENCE   3  (bases 1 to 1872)
  AUTHORS   Shibata S, Miwa T, Wu HH, Levitt P and Ohyama T.
  TITLE     Hepatocyte Growth Factor-c-MET Signaling Mediates the Development
            of Nonsensory Structures of the Mammalian Cochlea and Hearing
  JOURNAL   J. Neurosci. 36 (31), 8200-8209 (2016)
   PUBMED   27488639
REFERENCE   4  (bases 1 to 1872)
  AUTHORS   Denninger AR, Breglio A, Maheras KJ, LeDuc G, Cristiglio V, Deme B,
            Gow A and Kirschner DA.
  TITLE     Claudin-11 Tight Junctions in Myelin Are a Barrier to Diffusion and
            Lack Strong Adhesive Properties
  JOURNAL   Biophys. J. 109 (7), 1387-1397 (2015)
   PUBMED   26445439
  REMARK    GeneRIF: Results show that the primary function of claudin-11 is to
            provide a barrier that impedes the diffusion of material through
            the intramyelinic compartment
REFERENCE   5  (bases 1 to 1872)
  AUTHORS   Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H,
            Liu W, Feng GS, Shuai J, Wang H and Lu Z.
  TITLE     Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes
            infertility in mice
  JOURNAL   Sci Rep 5, 12982 (2015)
   PUBMED   26265072
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1872)
  AUTHORS   Morita K, Sasaki H, Fujimoto K, Furuse M and Tsukita S.
  TITLE     Claudin-11/OSP-based tight junctions of myelin sheaths in brain and
            Sertoli cells in testis
  JOURNAL   J. Cell Biol. 145 (3), 579-588 (1999)
   PUBMED   10225958
REFERENCE   7  (bases 1 to 1872)
  AUTHORS   Rajan L, Kozak CA and Dudley JP.
  TITLE     Chromosomal localization of acquired MMTV proviral integration
            sites in T-cell lymphomas
  JOURNAL   Mamm. Genome 9 (1), 84-85 (1998)
   PUBMED   9434954
REFERENCE   8  (bases 1 to 1872)
  AUTHORS   Gay D, Lavi E, Zhao H, Mumin A and Bhandoola A.
  TITLE     OlP-1, a novel protein that distinguishes early oligodendrocyte
            precursors
  JOURNAL   J. Neurosci. Res. 50 (4), 591-604 (1997)
   PUBMED   9404721
REFERENCE   9  (bases 1 to 1872)
  AUTHORS   Bronstein JM, Popper P, Micevych PE and Farber DB.
  TITLE     Isolation and characterization of a novel oligodendrocyte-specific
            protein
  JOURNAL   Neurology 47 (3), 772-778 (1996)
   PUBMED   8797478
REFERENCE   10 (bases 1 to 1872)
  AUTHORS   Bronstein JM, Kozak CA, Chen XN, Wu S, Danciger M, Korenberg JR and
            Farber DB.
  TITLE     Chromosomal localization of murine and human
            oligodendrocyte-specific protein genes
  JOURNAL   Genomics 34 (2), 255-257 (1996)
   PUBMED   8661061
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY110541.1, AK005088.1 and
            BB798247.1.
            On Aug 10, 2010 this sequence version replaced NM_008770.2.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. The protein encoded by this gene is a major
            component of CNS (central nervous system) myelin and plays an
            important role in regulating proliferation and migration of
            oligodendrocytes. The basal cell tight junctions in stria
            vascularis are primarily composed of this protein, and the
            gene-null mice suffer severe deafness. This protein is also an
            obligatory protein for tight junction formation and barrier
            integrity in the testis and the gene deficiency results in loss of
            the Sertoli cell epithelial phenotype in the testis. [provided by
            RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005088.1, AK161698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY110541.1         2-27
            27-1540             AK005088.1         2-1515
            1541-1872           BB798247.1         66-397
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 15.14 cM"
     gene            1..1872
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="claudin 11"
                     /db_xref="GeneID:18417"
                     /db_xref="MGI:MGI:106925"
     exon            1..456
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    153..155
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="upstream in-frame stop codon"
     CDS             231..854
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="oligodendrocyte transmembrane protein;
                     oligodendrocyte-specific protein"
                     /codon_start=1
                     /product="claudin-11"
                     /protein_id="NP_032796.1"
                     /db_xref="CCDS:CCDS17290.1"
                     /db_xref="GeneID:18417"
                     /db_xref="MGI:MGI:106925"
                     /translation="
MVATCLQVVGFVTSFVGWIGIIVTTSTNDWVVTCSYTIPTCRKMDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGHEPGVAKYRRAQLAGVLLILLALCAIVATIWFPVCAHREITIVSFGYSLYAGWIGAVMCLVGGCVIVCCSGDAQSFGENRFYYSSGSSSPTHAKSAHV"
     misc_feature    234..296
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60771.1);
                     transmembrane region"
     misc_feature    246..746
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:328820"
     misc_feature    477..539
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60771.1);
                     transmembrane region"
     misc_feature    597..659
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60771.1);
                     transmembrane region"
     misc_feature    702..764
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60771.1);
                     transmembrane region"
     misc_feature    807..809
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:Q99P82};
                     propagated from UniProtKB/Swiss-Prot (Q60771.1);
                     phosphorylation site"
     misc_feature    810..812
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:21183079};
                     propagated from UniProtKB/Swiss-Prot (Q60771.1);
                     phosphorylation site"
     misc_feature    819..821
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:21183079};
                     propagated from UniProtKB/Swiss-Prot (Q60771.1);
                     phosphorylation site"
     misc_feature    822..824
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:21183079};
                     propagated from UniProtKB/Swiss-Prot (Q60771.1);
                     phosphorylation site"
     STS             231..700
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /standard_name="Cldn11"
                     /db_xref="UniSTS:465375"
     exon            457..621
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /inference="alignment:Splign:2.1.0"
     STS             511..947
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /standard_name="Cldn11"
                     /db_xref="UniSTS:495869"
     exon            622..1872
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /inference="alignment:Splign:2.1.0"
     STS             1182..1262
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /standard_name="U19582"
                     /db_xref="UniSTS:159102"
     STS             1485..1609
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
                     /standard_name="Cldn11"
                     /db_xref="UniSTS:256662"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
     polyA_site      1870
                     /gene="Cldn11"
                     /gene_synonym="Claudin-11; Claudin11; Osp; Otm"
ORIGIN      
gagggggcggggacgcgctgcccagcagcgctgcagtcccctccaggcgcacctgtccccgctgcacgctgtcgcagcagtgcttgcagccgctctctccccatctcgagtagcccggagccagcggctcgcgagggccaagagggcaagcctagggaaggctctgtccaggacgacacagggggcacaatccgtgtgagtcgagctgcgtggacgtcgctgcggccaccatggtagccacttgccttcaggtggtgggtttcgtcacgagcttcgtgggttggattggcatcatcgtcacaacgtccaccaatgactgggtggtgacctgcagctacaccatccccacctgccgaaaaatggacgaactgggctccaagggcctgtgggctgactgcgtcatggccactggtctctaccactgcaaacccctggtggacatcctcatccttccaggctacgtgcaggcttgtagagccctcatgattgctgcctccgttctgggcctgcccgccatcttgctgctgttgacagttctcccctgcatccgaatgggccacgagcctggagtggccaagtacaggcgagcccagctggctggggtgctccttattctgctggctctctgcgccattgtcgccaccatctggtttcctgtatgtgcccaccgcgagatcaccatcgtgagctttggctactcgctgtacgcaggttggatcggtgctgtgatgtgcctggtgggtggctgtgtcatcgtctgctgctccggggatgcacagtcatttggagaaaaccgtttctattactcttctggttccagctcgccaacgcatgccaagagtgcccatgtctaagagggctgctccactgcccgccgaggtgctgtaaatgctgggcctgggccctgggtttgctcgccacagtggggagaagcccacttccctgccaggcactaaagccaaagttctagaaagtatcctgccccggcattttgaagtcgtaacaccccacccacccacccaccacttcttggctgccttaaaagaaagctctagctcagttaatgcccacatagttttctcctggagttgcgggctgtggctgtttgctctttcctcgggcattccattgttgttgattaaaaaaatattttgtttctctcttaaattcaaatgtcttgggaacattgctgacttgggtgtggattgggaaagaaataaaagatgcttttcaaagggttaccaacgacagtggaagccttatagagacagctctcttctccctttcggcttagtttcaaggtcacttatatataagagatagaaatggatagattgggaacacgggtgggaggggaactcagagctttccctccacgggaagcttctcttttataagttgaggggttgggtgtctttttttttttagtttgcgattttacatttttctgtacgtactttttcaagattgatcatttttataaccacgggtttcctgaaaattctcaattcaccaatatgaaggaaatgaaccaagcagacgttaatatgcaataaataatagtacgaagattataactttaactgactgcccacggtttccaggtttgtatgctatagtttttaatcctatggttgcatatgcttcaaattaacacatttaaaaatcttttctccccttctatttctgtctccattctgttagagaccatgaagcagtattgtttaacataagttgtactgttaagtttggcttcatgggtgtaaacaccaatggtctgtcagtgtctaagactctggatactgcaagctccgtccggtgcatttgttcaggtaaaatctgtgcaataaaataacaaactgtctccaaagc
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]