LOCUS       NM_008098               4042 bp    mRNA    linear   ROD 27-APR-2025
DEFINITION  Mus musculus myotrophin (Mtpn), mRNA.
ACCESSION   NM_008098
VERSION     NM_008098.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4042)
  AUTHORS   Bourke,L.M., Del Monte-Nieto,G., Outhwaite,J.E., Bharti,V.,
            Pollock,P.M., Simmons,D.G., Adam,A., Hur,S.S., Maghzal,G.J.,
            Whitelaw,E., Stocker,R., Suter,C.M., Harvey,R.P. and Harten,S.K.
  TITLE     Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart
            development in the mouse
  JOURNAL   Differentiation 94, 8-20 (2017)
   PUBMED   27930960
REFERENCE   2  (bases 1 to 4042)
  AUTHORS   Fujiwara,I., Remmert,K., Piszczek,G. and Hammer,J.A.
  TITLE     Capping protein regulatory cycle driven by CARMIL and V-1 may
            promote actin network assembly at protruding edges
  JOURNAL   Proc Natl Acad Sci U S A 111 (19), E1970-E1979 (2014)
   PUBMED   24778263
  REMARK    GeneRIF: Our data argue that a large pool of freely diffusing,
            inactive capping protein (CP:V-1) feeds, via CARMIL-driven complex
            exchange, the formation of weak-capping complexes (CP:CARMIL) at
            the plasma membrane of protruding edges.
REFERENCE   3  (bases 1 to 4042)
  AUTHORS   Campbell,G.R., Baudhuin,A., Vranizan,K. and Ngai,J.
  TITLE     Transcription factors expressed in olfactory bulb local progenitor
            cells revealed by genome-wide transcriptome profiling
  JOURNAL   Mol Cell Neurosci 46 (2), 548-561 (2011)
   PUBMED   21194568
REFERENCE   4  (bases 1 to 4042)
  AUTHORS   Li,Y., Xu,X., Liang,Y., Liu,S., Xiao,H., Li,F., Cheng,H. and Fu,Z.
  TITLE     miR-375 enhances palmitate-induced lipoapoptosis in
            insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein
            expression
  JOURNAL   Int J Clin Exp Pathol 3 (3), 254-264 (2010)
   PUBMED   20224724
  REMARK    GeneRIF: miR-375 enhances palmitate-induced lipoapoptosis in
            insulin-secreting NIT-1 cells (a NOD-derived beta-cell line) by
            repressing myotrophin (V1) protein expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4042)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 4042)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 4042)
  AUTHORS   Fujigasaki,H., Song,S.Y., Kobayashi,T. and Yamakuni,T.
  TITLE     Murine central neurons express a novel member of the cdc10/SWI6
            motif-containing protein superfamily
  JOURNAL   Brain Res Mol Brain Res 40 (2), 203-213 (1996)
   PUBMED   8872304
REFERENCE   8  (bases 1 to 4042)
  AUTHORS   Pennica,D., Shaw,K.J., Luoh,S.M. and Wood,W.I.
  TITLE     Isolation of cDNA clones encoding the mouse protein V-1
  JOURNAL   Gene 158 (2), 305-306 (1995)
   PUBMED   7607560
REFERENCE   9  (bases 1 to 4042)
  AUTHORS   Taoka,M., Isobe,T., Okuyama,T., Watanabe,M., Kondo,H., Yamakawa,Y.,
            Ozawa,F., Hishinuma,F., Kubota,M., Minegishi,A. et al.
  TITLE     Murine cerebellar neurons express a novel gene encoding a protein
            related to cell cycle control and cell fate determination proteins
  JOURNAL   J Biol Chem 269 (13), 9946-9951 (1994)
   PUBMED   8144589
REFERENCE   10 (bases 1 to 4042)
  AUTHORS   Mukherjee,D.P., McTiernan,C.F. and Sen,S.
  TITLE     Myotrophin induces early response genes and enhances cardiac gene
            expression
  JOURNAL   Hypertension 21 (2), 142-148 (1993)
   PUBMED   8428777
  REMARK    GeneRIF: Rat neonatal cardiac myocytes incubated with myotrophin
            showed an increase in c-myc, c-fos, and c-jun RNA levels and an
            increase in connexin 43, atrial natriuretic factor, skeletal
            alpha-actin, and total myosin transcript levels.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA559569.1, BC054811.1, AK049398.1 and AC166251.6.
            
            On May 7, 2009 this sequence version replaced NM_008098.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054811.1, AK083888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                CA559569.1         1-87
            88-3806             BC054811.1         1-3719
            3807-3960           AK049398.1         3710-3863
            3961-4042           AC166251.6         33851-33932
FEATURES             Location/Qualifiers
     source          1..4042
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.27 cM"
     gene            1..4042
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="myotrophin"
                     /db_xref="GeneID:14489"
                     /db_xref="MGI:MGI:99445"
     exon            1..350
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    234..236
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="upstream in-frame stop codon"
     CDS             279..635
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="protein V-1; granule cell differentiation protein"
                     /codon_start=1
                     /product="myotrophin"
                     /protein_id="NP_032124.1"
                     /db_xref="CCDS:CCDS20002.1"
                     /db_xref="GeneID:14489"
                     /db_xref="MGI:MGI:99445"
                     /translation="

MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTALEATDNQAIKALLQ"

     misc_feature    282..368
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="propagated from UniProtKB/Swiss-Prot (P62774.2);
                     Region: ANK 1"
     misc_feature    282..284
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="N-acetylcysteine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P62774.2); acetylation site"
     misc_feature    288..290
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P62774.2); acetylation site"
     misc_feature    <294..>593
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    294..374
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(297..302,309..317,321..326,336..338,345..347,
                     372..374,378..380,384..386,396..401,408..416,420..425,
                     435..437,444..446,471..473,477..479,483..485,495..500,
                     507..515,519..524,534..536,543..545)
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    309..311
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P58546; propagated from
                     UniProtKB/Swiss-Prot (P62774.2); acetylation site"
     misc_feature    348..350
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P58546; propagated from
                     UniProtKB/Swiss-Prot (P62774.2); acetylation site"
     misc_feature    369..371
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P58546; propagated from
                     UniProtKB/Swiss-Prot (P62774.2); phosphorylation site"
     misc_feature    378..476
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="propagated from UniProtKB/Swiss-Prot (P62774.2);
                     Region: ANK 2"
     misc_feature    378..473
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    477..575
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="propagated from UniProtKB/Swiss-Prot (P62774.2);
                     Region: ANK 3"
     misc_feature    477..569
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     exon            351..464
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..548
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..4042
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3780..3785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="hexamer: AATAAA"
     polyA_site      3806
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="major polyA site"
     regulatory      3941..3946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="hexamer: ATTAAA"
     polyA_site      3961
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
     regulatory      3998..4003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
                     /note="hexamer: AATATA"
     polyA_site      4017
                     /gene="Mtpn"
                     /gene_synonym="5033418D15Rik; Gcdp; V1"
ORIGIN      

ccgagcagagctttctggagagaggaagaggaagaggaagtgggaggcgggccctagcggggcgtgaaccggaagtgtaagcgtcctgcttctcctcagctaggcggaacctgctctgctgggcccaacggctgcagaagaactttctcccgcccgaaccgtagccgcgacccgcagtctcgcccgctcagcggcctgaggcgcgtcgctttctcgtgtcccctcgtcgggcctaatcgccgctcctgcccggcccgccggcccaccccgctgcagtcatgtgcgacaaggagttcatgtgggccctgaaaaacggagacttggatgaggtgaaggactatgtggctaagggagaagatgtcaaccggacactagagggtggaaggaagcctcttcattatgctgcagattgtggacagcttgaaatcctggaatttctgctgctgaaaggagcagatattaatgctccagataaacatcatattacccctcttctgtctgctgtctatgagggtcatgtttcctgcgtgaaattgcttctgtcaaagggtgctgataagactgtgaaaggcccagatggactgaccgcccttgaagccactgacaaccaggcaatcaaagctcttctccagtgatagatggatggacggactgataacttgggaaggatgactctcctgtggcctcacactgctgcctgtctgtctgtcactttctatctgccagcttcttcagctaaatactttaagagggtgaagggagagagaaattcataacaaatcagactgccaggggaggggaataaaacatgttttggaggagcagtggggaatgtgatgagacttttactgggattcctgatcaaaccagcctgtttttcatttccagtaaaatatacagcttattcccaagggagagcaaaaatacagtctattggaatcattggaccttctcagctccctagctaatttattaattagtttattgaaggtctgactatacaaggccaactctacttatttggtagccctagctgtgagcagtagtggctgctgttatgtcaacatagggtgctgagataagcaattagctatagccttctgccttaagaatgcactctcctgggggctcctggctagttaagagcggttagtgaccaaaatctctctagaatgacgttaatctttacataagagcttagataaggtaaggagcagcgcactcctgaattgctggatgactaaactttggattttctctcccctttcacatcaatttcatgtctctttagataaaactgactagttttatttataaaatgttaaattctaggagcctaaaggaggaatcattccagtaggcttatttctttttttctcctttagactcagacatttatataacattgaaacactttgagactccttctggtagtaaaggagatttaaaaataaaatcatagccataagcgtgttagtatcttataaagagagaacagttgtcttagtacctatggagtttcttcatttgctatttgagtgagccagccttcgttgtgtttggagaatgaagaatattctttggaatgcctctcaaaaacccaccatggatgctgattttatagtgcaccaaaggtatcactggggtgagatgtactgtatttggacagatgggacctcatcccttcaaaaacattcttgttaccatgttctcctgagctggtaatagactcttgctgggccagtaccaccccacctgcatggtgtttttatcttaacaatcattctttgcatacatgtgacaacttcaaaatgcattctgtgttcttataatacagtgccctaaaacggtattcctaggacctgcagataagagaaacttatctctaactttttctttcatgaacaataaaatgaattaaaacatacaaccttaaatttgatggcctacactttaagtattaagatgtcttttgcttttaatttgccatctatacaggattacaaaaactattagaatctttccatagccaatcatgcaataattgaatgtacctcaaatttttaaagggtaggtgatgggatagggacttataatcacattagggataataatattaaaaacctaactgattttttttaaggcattgtagcattatatagcagggttaaactattactaagaacaatcagcctggctaataactattaatcagttgataattggttggggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgttctcccatgaactcttttttatcctgtggctttttcactttcaactagcctgcccctgtagtttttctatgtccaagaaaacaatcacaaaacagtagtttaaatactttgatatatttggctagctctgctgttttaatgcagcctactagagttggatatcctacacttaatcttaaccaaaaggccaagcagctatagagttggacattctgctaggaagtggaaggcacatgatcagtctatgagtcaatataatgcaacagggtgttttgagacctttgttttcacctcttggcatactattttaaaggcttgaattttaccctttacacaattttcaatttttctttcaaagtcttctgttatagttggctattgcagagtgtatattgtcttatcattccagaacttgggtctgctttctacagtcattatggtaccaaaaccatatgattctttgtacagtttatcccagtgttccttgtaatgcagtagaggctattttgccttccccctttgttggccattttgtaaacccatagctatgaagtgattgcttgagaaaatagcatataaacatagactaggatagactgaccaggatggtttacagtttctttaaaaaaataataaacaaaaataaacaaaaaaaaaactaggttatttataatgtatttctgaaccacttggcagagaaattcatgacacttaatgttaatatttttgaataaatgaagctaaaatgtctgcttttggtacaacacgcattaataaaaggttaagttttgttttccactgaagtactatttaacatctcagaaaaaaaccctgcatgttctatagttttatattaaaatccatcatttcatatgcactgtatcaaaaacaggttacttgcctgaacatggttagtgtactaacaggtctgcccacccctaccctcacccccagcttcatgccagcatatgtagatttgagttctaacacagcacttgcatatcccatgtgcacaagctcacctttccagaaccagctgggcgcagaagaaaggcagtaactgcagcatgtgaaagctaaaacaagtagccttctagtcatttctttctttccccagccagataaaaggagcttcaatatatgtgtacttgatttttattcacttcagctgagctgctgtttccttcatgtaatattgtatactgggttgtgtatagaagaagctggtaagagtgccctccttcataaataagcaattgcagtgttttgcatgcaaatttaaaaaaatttaaattgtcctgattctattttgtaaatggagaaacaatctttctaagcagtatggaggaagactagtgctttgtgcacttttggtatatttgagttcatgtttccacaatgtcattcccttgacacagttgggtttctcataagtatcctagttcatgtacatccgaatgctaactaatactgtgtttaagtttcgtgttgcaagaacaaatggaataaacttgaattgtgctatagataacatgttagcaacatatttatccccagtcactgttgccttcctttccagacgtccttaacgatatgaaaatcttgactaacttgagattttaataccattttatcctacttctagaagaaatgaagaaaccaattattaaagagctaacgatactagatgctgctcatagaaaagcttttttttttaacttcaatataagttttctgatacacattgttgctgtatatgggtccagg

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