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Previous release (v1)
2025-08-18 11:00:45, GGRNA.v2 : RefSeq release 230 (May, 2025)
LOCUS NM_001437563 4813 bp mRNA linear PRI 04-APR-2025
DEFINITION Homo sapiens semaphorin 5B (SEMA5B), transcript variant 10, mRNA.
ACCESSION NM_001437563 XM_047448344 XM_054346917
VERSION NM_001437563.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4813)
AUTHORS Maki-Nevala,S., Sarhadi,V.K., Knuuttila,A., Scheinin,I.,
Ellonen,P., Lagstrom,S., Ronty,M., Kettunen,E.,
Husgafvel-Pursiainen,K., Wolff,H. and Knuutila,S.
TITLE Driver Gene and Novel Mutations in Asbestos-Exposed Lung
Adenocarcinoma and Malignant Mesothelioma Detected by Exome
Sequencing
JOURNAL Lung 194 (1), 125-135 (2016)
PUBMED 26463840
REMARK GeneRIF: SEMA5B could possibly serve as a candidate gene for
alterations associated with asbestos exposure.
REFERENCE 2 (bases 1 to 4813)
AUTHORS Wu,C., Hu,Z., He,Z., Jia,W., Wang,F., Zhou,Y., Liu,Z., Zhan,Q.,
Liu,Y., Yu,D., Zhai,K., Chang,J., Qiao,Y., Jin,G., Liu,Z., Shen,Y.,
Guo,C., Fu,J., Miao,X., Tan,W., Shen,H., Ke,Y., Zeng,Y., Wu,T. and
Lin,D.
TITLE Genome-wide association study identifies three new susceptibility
loci for esophageal squamous-cell carcinoma in Chinese populations
JOURNAL Nat Genet 43 (7), 679-684 (2011)
PUBMED 21642993
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 4813)
AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
CONSRTM DREAM investigators
TITLE Variation at the NFATC2 locus increases the risk of
thiazolidinedione-induced edema in the Diabetes REduction
Assessment with ramipril and rosiglitazone Medication (DREAM) study
JOURNAL Diabetes Care 33 (10), 2250-2253 (2010)
PUBMED 20628086
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 4 (bases 1 to 4813)
AUTHORS Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium
TITLE Gene-centric association signals for lipids and apolipoproteins
identified via the HumanCVD BeadChip
JOURNAL Am J Hum Genet 85 (5), 628-642 (2009)
PUBMED 19913121
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 4813)
AUTHORS O'Connor,T.P., Cockburn,K., Wang,W., Tapia,L., Currie,E. and
Bamji,S.X.
TITLE Semaphorin 5B mediates synapse elimination in hippocampal neurons
JOURNAL Neural Dev 4, 18 (2009)
PUBMED 19463192
REMARK GeneRIF: Sema5B regulates the development and maintenance of
synapse size and number in hippocampal neurons.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4813)
AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE 7 (bases 1 to 4813)
AUTHORS Adams,R.H., Betz,H. and Puschel,A.W.
TITLE A novel class of murine semaphorins with homology to thrombospondin
is differentially expressed during early embryogenesis
JOURNAL Mech Dev 57 (1), 33-45 (1996)
PUBMED 8817451
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC083797.16, AC109130.8 and AC078794.13.
On or before Apr 4, 2025 this sequence version replaced
XM_047448344.1, XM_054346917.1.
Summary: This gene encodes a member of the semaphorin protein
family which regulates axon growth during development of the
nervous system. The encoded protein has a characteristic Sema
domain near the N-terminus, through which semaphorins bind to
plexin, and five thrombospondin type 1 repeats in the C-terminal
region of the protein. The protein product may be cleaved and exist
as a secreted molecule (PMID: 19463192). Multiple transcript
variants encoding different isoforms have been found for this gene.
[provided by RefSeq, Jan 2012].
##Evidence-Data-START##
Transcript exon combination :: SRR18074969.3103316.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-300 AC083797.16 147427-147726
301-462 AC109130.8 58774-58935
463-666 AC078794.13 3032-3235
667-766 AC078794.13 8206-8305
767-812 AC078794.13 12271-12316
813-875 AC078794.13 22683-22745
876-1046 AC078794.13 23054-23224
1047-1260 AC078794.13 23738-23951
1261-1546 AC078794.13 25064-25349
1547-1682 AC078794.13 27989-28124
1683-1890 AC078794.13 29294-29501
1891-2098 AC078794.13 29619-29826
2099-2216 AC078794.13 35851-35968
2217-2398 AC078794.13 36120-36301
2399-2542 AC078794.13 37740-37883
2543-2690 AC078794.13 38060-38207
2691-2916 AC078794.13 38317-38542
2917-3135 AC078794.13 38680-38898
3136-3306 AC078794.13 39399-39569
3307-3456 AC078794.13 39672-39821
3457-3501 AC078794.13 40206-40250
3502-3707 AC078794.13 40696-40901
3708-4813 AC078794.13 41440-42545
FEATURES Location/Qualifiers
source 1..4813
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q21.1"
gene 1..4813
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/note="semaphorin 5B"
/db_xref="GeneID:54437"
/db_xref="HGNC:HGNC:10737"
/db_xref="MIM:609298"
exon 1..300
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 301..462
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
CDS 339..3866
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/note="isoform 8 is encoded by transcript variant 10; sema
domain, seven thrombospondin repeats (type 1 and type
1-like), transmembrane domain (TM) and short cytoplasmic
domain, (semaphorin) 5B"
/codon_start=1
/product="semaphorin-5B isoform 8"
/protein_id="NP_001424492.1"
/db_xref="GeneID:54437"
/db_xref="HGNC:HGNC:10737"
/db_xref="MIM:609298"
/translation="
MPCGFSPSPVAHHLVPGPPDTPAQQLRCGWTVGGWLLSLVRGLLPCLPPGARTAEGPIMVLAGPLAVSLLLPSLTLLVSHLSSSQDVSSEPSSEQQLCALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTEWCEREISSIAPGELCCLLLSFLPQEECQNYVRVLIVAGRKVFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLRENAVEHDCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIANCSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVPIFWASWGSWSKCSSNCGGGMQSRRRACENGNSCLGCGVEFKTCNPEGCPEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACPEGWSPWSEWSKCTDDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSEIPVILPASSMEEATDCAGFNLIHLVATGISCFLGSGLLTLAVYLSCQHCQRQSQESTLVHPATPNHLHYKGGGTPKNEKYTPMEFKTLNKNNLIPDDRANFYPLQQTNVYTTTYYPSPLNKHSFRPEASPGQRCFPNS"
exon 463..666
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 667..766
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 767..812
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 813..875
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 876..1046
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 1047..1260
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 1261..1546
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 1547..1682
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 1683..1890
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 1891..2098
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 2099..2216
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 2217..2398
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 2399..2542
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 2543..2690
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 2691..2916
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 2917..3135
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 3136..3306
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 3307..3456
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 3457..3501
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 3502..3707
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
exon 3708..4813
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/inference="alignment:Splign:2.1.0"
regulatory 4794..4799
/regulatory_class="polyA_signal_sequence"
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/note="hexamer: ATTAAA"
polyA_site 4813
/gene="SEMA5B"
/gene_synonym="SEMAG; SemG"
/note="major polyA site"
ORIGIN
ctccctgctctctccgagcgccgggtcgggagctagttggagcgcgggggttggtgccagagcccagctccgccgagccgggcgggtcggcagcgcatccagcggctgctgggagcccgagcgcagcgggcgcgggcccgggtggggactgcaccggagcgctgagagctggaggccgttcctgcgcggccgccccattcccagaccggccgccagcccatctggttagctcccgccgctccgcgccgcccgggagtcgggagccgcggggaaccgggcacctgcacccgcctctgggagtgagtggttccagctggtgcctggcctgtgtctcttggatgccctgtggcttcagtccgtctcctgttgcccaccacctcgtccctgggccgcctgataccccagcccaacagctaaggtgtggatggacagtagggggctggcttctctcactggtcaggggtcttctcccctgtctgcctcccggagctaggactgcagaggggcctatcatggtgcttgcaggccccctggctgtctcgctgttgctgcccagcctcacactgctggtgtcccacctctccagctcccaggatgtctccagtgagcccagcagtgagcagcagctgtgcgcccttagcaagcaccccaccgtggcctttgaagacctgcagccgtgggtctctaacttcacctaccctggagcccgggatttctcccagctggctttggacccctccgggaaccagctcatcgtgggagccaggaactacctcttcagactcagccttgccaatgtctctcttcttcaggccacagagtgggcctccagtgaggacacgcgccgctcctgccaaagcaaagggaagactgagtggtgtgagcgtgagatatccagcatcgcacctggagagctgtgctgtctgctcctttccttcctgcctcaggaggagtgtcagaactacgtgcgagtcctgatcgtcgccggccggaaggtgttcatgtgtggaaccaatgccttttcccccatgtgcaccagcagacaggtggggaacctcagccggactattgagaagatcaatggtgtggcccgctgcccctatgacccacgccacaactccacagctgtcatctcctcccagggggagctctatgcagccacggtcatcgacttctcaggtcgggaccctgccatctaccgcagcctgggcagtgggccaccgcttcgcactgcccaatataactccaagtggcttaatgagccaaacttcgtggcagcctatgatattgggctgtttgcatacttcttcctgcgggagaacgcagtggagcacgactgtggacgcaccgtgtactctcgcgtggcccgcgtgtgcaagaatgacgtggggggccgattcctgctggaggacacatggaccacattcatgaaggcccggctcaactgctcccgcccgggcgaggtccccttctactataacgagctgcagagtgccttccacttgccggagcaggacctcatctatggagttttcacaaccaacgtaaacagcatcgcggcttctgctgtctgcgccttcaacctcagtgctatctcccaggctttcaatggcccatttcgctaccaggagaaccccagggctgcctggctccccatagccaaccccatccccaatttccagtgtggcaccctgcctgagaccggtcccaacgagaacctgacggagcgcagcctgcaggacgcgcagcgcctcttcctgatgagcgaggccgtgcagccggtgacacccgagccctgtgtcacccaggacagcgtgcgcttctcacacctcgtggtggacctggtgcaggctaaagacacgctctaccatgtactctacattggcaccgagtcgggcaccatcctgaaggcgctgtccacggcgagccgcagcctccacggctgctacctggaggagctgcacgtgctgccccccgggcgccgcgagcccctgcgcagcctgcgcatcctgcacagcgcccgcgcgctcttcgtggggctgagagacggcgtcctgcgggtcccactggagaggtgcgccgcctaccgcagccagggggcatgcctgggggcccgggacccgtactgtggctgggacgggaagcagcaacgttgcagcacactcgaggacagctccaacatgagcctctggacccagaacatcaccgcctgtcctgtgcggaatgtgacacgggatgggggcttcggcccatggtcaccatggcaaccatgtgagcacttggatggggacaactcaggctcttgcctgtgtcgagctcgatcctgtgattcccctcgaccccgctgtgggggccttgactgcctggggccagccatccacatcgccaactgctccaggaatggggcgtggaccccgtggtcatcgtgggcgctgtgcagcacgtcctgtggcatcggcttccaggtccgccagcgaagttgcagcaaccctgctccccgccacgggggccgcatctgcgtgggcaagagccgggaggaacggttctgtaatgagaacacgccttgcccggtgcccatcttctgggcttcctggggctcctggagcaagtgcagcagcaactgtggagggggcatgcagtcgcggcgtcgggcctgcgagaacggcaactcctgcctgggctgcggcgtggagttcaagacgtgcaaccccgagggctgccccgaagtgcggcgcaacaccccctggacgccgtggctgcccgtgaacgtgacgcagggcggggcacggcaggagcagcggttccgcttcacctgccgcgcgccccttgcagacccgcacggcctgcagttcggcaggagaaggaccgagacgaggacctgtcccgcggacggctccggctcctgcgacaccgacgccctggtggaggtcctcctgcgcagcgggagcacctccccgcacacggtgagcgggggctgggccgcctggggcccgtggtcgtcctgctcccgggactgcgagctgggcttccgcgtccgcaagagaacgtgcactaacccggagccccgcaacgggggcctgccctgcgtgggcgatgctgccgagtaccaggactgcaacccccaggcttgcccagttcggggtgcttggtcctgctggacctcatggtctccatgctcagcttcctgtggtgggggtcactatcaacgcacccgttcctgcaccagccccgcaccctccccaggtgaggacatctgtctcgggctgcacacggaggaggcactatgtgccacacaggcctgcccagaaggctggtcgccctggtctgagtggagtaagtgcactgacgacggagcccagagccgaagccggcactgtgaggagctcctcccagggtccagcgcctgtgctggaaacagcagccagagccgcccctgcccctacagcgagattcccgtcatcctgccagcctccagcatggaggaggccaccgactgtgcagggttcaatctcatccacttggtggccacgggcatctcctgcttcttgggctctgggctcctgaccctagcagtgtacctgtcttgccagcactgccagcgtcagtcccaggagtccacactggtccatcctgccacccccaaccatttgcactacaagggcggaggcaccccgaagaatgaaaagtacacacccatggaattcaagaccctgaacaagaataacttgatccctgatgacagagccaacttctacccattgcagcagaccaatgtgtacacgactacttactacccaagccccctgaacaaacacagcttccggcccgaggcctcacctggacaacggtgcttccccaacagctgataccgccgtcctggggacttgggcttcttgccttcataaggcacagagcagatggagatgggacagtggagccagtttggttttctccctctgcactaggccaagaacttgctgccttgcctgtggggggtcccatccggcttcagagagctctggctggcattgaccatgggggaaagggctggtttcaggctgacatatggccgcaggtccagttcagcccaggtctctcatggttatcttccaacccactgtcacgctgacactatgctgccatgcctgggctgtggacctactgggcatttgaggaattggagaatggagatggcaagagggcaggcttttaagtttgggttggagacaacttcctgtggcccccacaagctgagtctggccttctccagctggccccaaaaaaggcctttgctacatcctgattatctctgaaagtaatcaatcaagtggctccagtagctctggattttctgccagggctgggccattgtggtgctgccccagtatgacatgggaccaaggccagcgcaggttatccacctctgcctggaagtctatactctacccagggcatccctctggtcagaggcagtgagtactgggaactggaggctgacctgtgcttagaagtcctttaatctgggctggtacaggcctcagccttgccctcaatgcacgaaaggtggcccaggagagaggatcaatgccataggaggcagaagtctggcctctgtgcctctatggagactatcttccagttgctgctcaacagagttgttggctgagacctgcttgggagtctctgctggcccttcatctgttcaggaacacacacacacacacactcacacacgcacacacaatcacaatttgctacagcaacaaaaaagacattgggctgtggcattattaattaaagatgatatccagtc
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]