LOCUS       NM_001432311            4882 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Rattus norvegicus EDAR associated via death domain (Edaradd), mRNA.
ACCESSION   NM_001432311 XM_574055
VERSION     NM_001432311.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4882)
  AUTHORS   Del-Pozo,J., MacIntyre,N., Azar,A., Headon,D., Schneider,P. and
            Cheeseman,M.
  TITLE     Role of ectodysplasin signalling in middle ear and nasal pathology
            in rat and mouse models of hypohidrotic ectodermal dysplasia
  JOURNAL   Dis Model Mech 12 (4) (2019)
   PUBMED   31028034
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4882)
  AUTHORS   Kuramoto,T., Yokoe,M., Hashimoto,R., Hiai,H. and Serikawa,T.
  TITLE     A rat model of hypohidrotic ectodermal dysplasia carries a missense
            mutation in the Edaradd gene
  JOURNAL   BMC Genet 12, 91 (2011)
   PUBMED   22013926
  REMARK    GeneRIF: findings suggest that sparse-and-wavy (swh) is a
            loss-of-function mutation in the rat Edaradd gene
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4882)
  AUTHORS   Rawlins,E.L. and Hogan,B.L.
  TITLE     Intercellular growth factor signaling and the development of mouse
            tracheal submucosal glands
  JOURNAL   Dev Dyn 233 (4), 1378-1385 (2005)
   PUBMED   15973734
REFERENCE   4  (bases 1 to 4882)
  AUTHORS   Kuramoto,T., Morimura,K., Nomoto,T., Namiki,C., Hamada,S.,
            Fukushima,S., Sugimura,T., Serikawa,T. and Ushijima,T.
  TITLE     Sparse and wavy hair: a new model for hypoplasia of hair follicle
            and mammary glands on rat chromosome 17
  JOURNAL   J Hered 96 (4), 339-345 (2005)
   PUBMED   15829729
REFERENCE   5  (bases 1 to 4882)
  AUTHORS   Ohazama,A., Courtney,J.M., Tucker,A.S., Naito,A., Tanaka,S.,
            Inoue,J. and Sharpe,P.T.
  TITLE     Traf6 is essential for murine tooth cusp morphogenesis
  JOURNAL   Dev Dyn 229 (1), 131-135 (2004)
   PUBMED   14699584
REFERENCE   6  (bases 1 to 4882)
  AUTHORS   Crocker,M. and Cattanach,B.M.
  TITLE     The genetics of Sleek: a possible regulatory mutation of the
            tabby-crinkled-downless syndrome
  JOURNAL   Genet Res 34 (3), 231-238 (1979)
   PUBMED   544312
REFERENCE   7  (bases 1 to 4882)
  AUTHORS   Gruneberg,H.
  TITLE     Genes and genotypes affecting the teeth of the mouse
  JOURNAL   J Embryol Exp Morphol 14 (2), 137-159 (1965)
   PUBMED   5893447
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jul 30, 2024 this sequence version replaced XM_574055.9.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.49312.1,
                                           SRR26643294.56404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-471               JAXUCZ010000017.1  92894132-92894602   c
            472-530             JAXUCZ010000017.1  92883452-92883510   c
            531-570             JAXUCZ010000017.1  92882382-92882421   c
            571-629             JAXUCZ010000017.1  92876189-92876247   c
            630-675             JAXUCZ010000017.1  92859811-92859856   c
            676-4882            JAXUCZ010000017.1  92850791-92854997   c
FEATURES             Location/Qualifiers
     source          1..4882
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..4882
                     /gene="Edaradd"
                     /gene_synonym="RGD1564010"
                     /note="EDAR associated via death domain"
                     /db_xref="GeneID:498769"
                     /db_xref="RGD:1564010"
     exon            1..471
                     /gene="Edaradd"
                     /gene_synonym="RGD1564010"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    327..329
                     /gene="Edaradd"
                     /gene_synonym="RGD1564010"
                     /note="upstream in-frame stop codon"
     CDS             441..1058
                     /gene="Edaradd"
                     /gene_synonym="RGD1564010"
                     /note="EDAR (ectodysplasin-A receptor)-associated death
                     domain; EDAR-associated death domain"
                     /codon_start=1
                     /product="ectodysplasin-A receptor-associated adapter
                     protein"
                     /protein_id="NP_001419240.1"
                     /db_xref="GeneID:498769"
                     /db_xref="RGD:1564010"
                     /translation="

MASPDDPLRSDHMAKEPVEDTDPSTLSFAMSDKYPIQDTGLPKAKECDAVTSNCPPNSDDQHQGEENDFPDSTGDPLSGVSRNQPCKEGCPCSSCSPRAPTISDLLNDQDLLDVIRIKLDPCHPTVKNWRNFASKWGMPYDELCFLEQRPQSPTLEFLFRNSQRTVGQLMELCRLYHRADVEKILRRWVDEEWPHRGPLDGSMHF"

     misc_feature    795..1007
                     /gene="Edaradd"
                     /gene_synonym="RGD1564010"
                     /note="Death domain; Region: Death; pfam00531"
                     /db_xref="CDD:459845"
     exon            472..530
                     /gene="Edaradd"
                     /gene_synonym="RGD1564010"
                     /inference="alignment:Splign:2.1.0"
     exon            531..570
                     /gene="Edaradd"
                     /gene_synonym="RGD1564010"
                     /inference="alignment:Splign:2.1.0"
     exon            571..629
                     /gene="Edaradd"
                     /gene_synonym="RGD1564010"
                     /inference="alignment:Splign:2.1.0"
     exon            630..675
                     /gene="Edaradd"
                     /gene_synonym="RGD1564010"
                     /inference="alignment:Splign:2.1.0"
     exon            676..4882
                     /gene="Edaradd"
                     /gene_synonym="RGD1564010"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtgtcccagctgagggtgagattaggaaccgggaaagctacccgcgcatgcagcaaccagtggaaggtcagctgaaaggccctcccagctgggatcgcgtgggaaccccgtggtgggaccagcgttctacaccctaggtactgttccgggggcctcgcggggtcctctcgtgtccaaccgaaacccacgggatcctctccagagttctggagagacgctcgcgccaggaaggggctttgctaattgcaggaagtgagcacgaggaagaagtggcagagatcaagaggaggaagatagggaggaggaggagcagcagggcaaagcgctgagagagagtcgcgcattgccaggaggttgggtcccagcgatcctgctgttctcaggggtcccagagactgcctacccctgctcagacactcatctgtcctctcctggtcttcatggcttctccggatgaccctctgcgctcagatcacatggcaaaggagccagtggaggacacagaccccagcactttatcctttgccatgtcagacaagtatcccattcaagacactggcctccctaaagctaaggagtgtgatgcagtcacttccaactgcccaccaaattctgatgatcagcaccagggagaagaaaatgactttccagacagcactggggatcccctttcaggtgtcagcagaaaccagccatgcaaggaaggctgcccttgctcttcctgctctcctcgggctcccaccattagtgacttgctcaacgatcaagacttgctagatgtgatcaggataaagctggatccatgtcacccgactgtgaagaactggaggaattttgccagcaaatggggcatgccctatgatgagctctgcttcctggaacagaggccccagagccccacactggagttcttattccgaaacagccagaggactgtaggccaactgatggagctctgccgactttatcacagggctgacgtggagaagatcctgcgcaggtgggttgatgaggagtggccccacaggggacccttggacggttccatgcacttttagaatcccctcccctggcattggccgtactgcatgctggaacagcatggatcgcagggacctatgtgttcctgctgttaaggtcttcggatgagaatataacacaggcagtggttatccctgaagctggtggcttggggaaggacgggttgtttcaaaagcaggtgtttgtttccttttgcacatttgttttaatttaatatttgaacctggaactggggaagaatattttataggtcacatagggccacagcctatggctgggacagagccatgccaacatggaacgaaaactcttcttaaaaactgccaaagattgcagctttcccaaactgtcagtgtctctggacacgtgcacgtcatcccatacaggacctttgcattccctgcctagtggaggaaagcatgtagaagtcaccctggcctgttcactgttcacaacagtgtatttctgttgcaaaaggctttggagatcaagaagatactatgcaatgtggcccagatatatgggctcctttgttttattattatcaaatacttttgtaatctataggctatcaatactgtcattgaatttagcattttacaaaggaatacaaaatgtatggtttatgggagaagagagtgggttagtgtcttaggaatggcattgacaaagaatagtgctcaatatggccttttgggccctagggagctatctcagtggttacagtgctcaccaaataaagcatgagaaccagagtccaggtccctggaacccatataagtgagggagtgaatgatatggcagctcacctgtcattccggaagagataccaatcccgagaacaagatggatagctagactaggcacatggaccaacactgggttcaactgagagactctttctcaatgaacaatgtgcagagttgttgaggaaaactttcaacatcaactttgggagtctatatgcacacacatgtacatgtacatctgtatacatgtgcaacaacaatgtgtgtgcacactgctcatgcgaacacacagacacagacacagacagacaaacagacagagacagacagacagacagacagacagacagacacacacacacacacacacacacacacacacacaaacacagagtaaatctctaagagataaggtcaaggttggtctggaatgtagcccatttggtagagtccttgcctagcatgacaaaaggcctgagtttgttcccagcatgtaccaatgtgacgttacatgtctataattcaagcacttgtgggcagaagtagatgatcagaaattcaaagttatcattagcaacaaagtgagtgtgaggtcagccttcgatatatgagcccctgcctcaagaagaaaacaaaatgtcatgcaagccatgtgtgctcgtcccaattcatgtggccccagcattttactccgtgagaatttttaactaacatgggcacagaatcatcatcagagagatgaactgaaagatttcttcaagttaactctgactgtaaatgtaagatggcttggatctgggttgcccaaagaaagccaaggattattctcagctacagtacaaaatcagtttattgaaaggtagcttacagtcagtgatgtctacagaagcataaataccctggaacgtcacaaaggtgagacaagggagaaggaggttactgtatgttaaactgattaaataattactgaaagcttggtcatcatgttttaaacatgtgatcatttttagttacatatctctgcctgatatgtgcccatgagtataggtgtttgtagagaacttaggtattggaactcctggagctggagttgctagacatgggtgttgggaactgaacatgtcctcaacaaaagtaatatgagatcttaaccaatgagccatttctccaacatatcatattcacgcttaagaacttttggtcctggacacccgtattaaggtgagctgcttgggaatgatgttgttttcctagtaaaatgtcaagatctgcttaactatgtttccaaaggcatttttctttaagcaaagtttccccctgtaaaggtctataataaggtcatatataatatacattttatttgagtgcagtagagaagagtcaaatgaaagggaaggtcccaaagccacactggacagccatatacacagagacagattacacagtccgggggacccacaccagaggggcagacaaaagcacagcatgcaatattggcaccgtgaagttttaactagttagggctcggggctatgctaggatgtccaacctgtgcctctaagaacaaacaaacaaataacctctgtacaaagcagccacctactggaataatactgtaatctgtaataatacttagtaataatactggaaatctggccatctcaaacaataatcttatgtagtgctgccccctgctggaggatacagagtctggcttggttagctgccttccaagccttccaagcagaccacacagacagaaagagaaagcatgaattttttctgtaccttggcagacaaaggcactataacactggcatggctgagactgaggctcctgtctccaggatatgcccagcacagtgacctgggactcatctatcaccactgatggacttgcctcctccttggggactgagagtactgtcctgtctactaggtctcttcttttcccagttcagcaggcaaggatgccctgatgaagcagtcttagcctcacctgcattccaatcatgtacattacaaaaatgcatgcttctaaagacaggattagtaaccgaggctgaacagttttttttcttctggcctcttccttgtgtgcccctaagcagatctcatttggttttgagtgaagatttttgcccacgtctttttttaaaaaaatcaaccctactgtccctgctttataatttccctcccctttgaagccatggtattgctgtctgtggcacttgttcagagcaggctctatgcacatatcaaatcatcttcctccaccagcaaacagtattgccctctctgagatggcagcaaacctctgcttcatgttgtcatgtgcacacaaagaaacaacaatgccatggacctagcaatgccaaaccactctctgctctagaccaaagctggaggcacactgagagatatgtgtgctgtcccatcacctgcctgggacttgaaccccaccctgggactcatgggtacttggttaggaatgggcaaggaagggtgagtcttcctttactgtgtttagagagaatcaaagtcaagatgctggcctgagtgctggggctactgaagcctcatcatcagtgggtggagcacctgtgggttaccaagacttgaaggaccttggtggagtaggggctgcttccttccctcctgtagctgtagagggatatggctctgagagttatgtctggcaggggaatctctgggtgatcacatgtactgaagggcctggagtggtcagtgatgcaactggaaatgagatgatcgagtttcccagctctcttggaggttaagaaggatcttccccttggtatgactgtccaatgaccaccgttctctgcagcaccccctgggaatgtacagaagacatttcagcccaggaaggcaaagcttctgaaagtcttgcttccacagggatggcatctgtactcctcggtgctagccttttgaatctgtctacatcttcatctcctgtatgattctctaatcctgtatgtttttctaatgaataaggaaagatttttataactgtaataatgggtgctacaaaattaaagactgatgtcaactgtggttgcctccaa

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