2024-05-06 05:59:00, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001411124 4155 bp mRNA linear PRI 28-MAY-2023 DEFINITION Homo sapiens FERM domain containing 5 (FRMD5), transcript variant 9, mRNA. ACCESSION NM_001411124 XM_005254730 VERSION NM_001411124.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4155) AUTHORS Lu S, Ma M, Mao X, Bacino CA, Jankovic J, Sutton VR, Bartley JA, Wang X, Rosenfeld JA, Beleza-Meireles A, Chauhan J, Pan X, Li M, Liu P, Prescott K, Amin S, Davies G, Wangler MF, Dai Y and Bellen HJ. TITLE De novo variants in FRMD5 are associated with developmental delay, intellectual disability, ataxia, and abnormalities of eye movement JOURNAL Am J Hum Genet 109 (10), 1932-1943 (2022) PUBMED 36206744 REMARK GeneRIF: De novo variants in FRMD5 are associated with developmental delay, intellectual disability, ataxia, and abnormalities of eye movement. REFERENCE 2 (bases 1 to 4155) AUTHORS Gawel AM, Ratajczak M, Gajda E, Grzanka M, Paziewska A, Cieslicka M, Kulecka M, Oczko-Wojciechowska M and Godlewska M. TITLE Analysis of the Role of FRMD5 in the Biology of Papillary Thyroid Carcinoma JOURNAL Int J Mol Sci 22 (13), 6726 (2021) PUBMED 34201607 REMARK GeneRIF: Analysis of the Role of FRMD5 in the Biology of Papillary Thyroid Carcinoma. Publication Status: Online-Only REFERENCE 3 (bases 1 to 4155) AUTHORS Mao X, Tey SK, Ko FCF, Kwong EML, Gao Y, Ng IO, Cheung ST, Guan XY and Yam JWP. TITLE C-terminal truncated HBx protein activates caveolin-1/LRP6/beta-catenin/FRMD5 axis in promoting hepatocarcinogenesis JOURNAL Cancer Lett 444, 60-69 (2019) PUBMED 30583072 REMARK GeneRIF: High FRMD5 expression is associated with hepatocarcinogenesis. REFERENCE 4 (bases 1 to 4155) AUTHORS Zhu C, Yamaguchi K, Ohsugi T, Terakado Y, Noguchi R, Ikenoue T and Furukawa Y. TITLE Identification of FERM domain-containing protein 5 as a novel target of beta-catenin/TCF7L2 complex JOURNAL Cancer Sci 108 (4), 612-619 (2017) PUBMED 28117551 REMARK GeneRIF: Data show that FERM domain-containing protein 5 (FRMD5) is regulated by both beta-catenin and transcription factor 7-Like 2 protein (TCF7L2) in colon cancer cells. REFERENCE 5 (bases 1 to 4155) AUTHORS Guo T, Yin RX, Pan L, Yang S, Miao L and Huang F. TITLE Integrative variants, haplotypes and diplotypes of the CAPN3 and FRMD5 genes and several environmental exposures associate with serum lipid variables JOURNAL Sci Rep 7, 45119 (2017) PUBMED 28332615 REMARK GeneRIF: We conclude that integrative variants, haplotypes and diplotypes of the CAPN3 rs4344713 and FRMD5 rs524908, as well as DBP and BMI are associated with serum lipid variables in the Jing and Han populations. Publication Status: Online-Only REFERENCE 6 (bases 1 to 4155) AUTHORS Hu J, Niu M, Li X, Lu D, Cui J, Xu W, Li G, Zhan J and Zhang H. TITLE FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin beta5 subunit and ROCK1 JOURNAL FEBS Lett 588 (23), 4348-4356 (2014) PUBMED 25448675 REMARK GeneRIF: FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1 REFERENCE 7 (bases 1 to 4155) AUTHORS Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkila K, Hypponen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikainen LP, Magnusson PKE, Mangino M, Mihailov E, Montasser ME, Muller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney ASF, Doring A, Elliott P, Epstein SE, Ingi Eyjolfsson G, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJP, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimaki T, Lin SY, Lindstrom J, Loos RJF, Mach F, McArdle WL, Meisinger C, Mitchell BD, Muller G, Nagaraja R, Narisu N, Nieminen TVM, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stancakova A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YI, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrieres J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Jarvelin MR, Jula A, Kahonen M, Kaprio J, Kesaniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, Marz W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njolstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PEH, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BHR, Ordovas JM, Boerwinkle E, Palmer CNA, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E and Abecasis GR. CONSRTM Global Lipids Genetics Consortium TITLE Discovery and refinement of loci associated with lipid levels JOURNAL Nat Genet 45 (11), 1274-1283 (2013) PUBMED 24097068 REFERENCE 8 (bases 1 to 4155) AUTHORS Wang T, Pei X, Zhan J, Hu J, Yu Y and Zhang H. TITLE FERM-containing protein FRMD5 is a p120-catenin interacting protein that regulates tumor progression JOURNAL FEBS Lett 586 (19), 3044-3050 (2012) PUBMED 22846708 REMARK GeneRIF: FRMD5 may play a role in p120-catenin-based cell-cell contact and is involved in the regulation of tumor progression COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC073940.4 and AC023356.8. On Aug 22, 2022 this sequence version replaced XM_005254730.4. ##Evidence-Data-START## Transcript exon combination :: SRR14038196.3055021.1, SRR18074967.1626238.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA1966682, SAMEA1968189 [ECO:0006172] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-319 AC073940.4 23537-23855 c 320-424 AC023356.8 126049-126153 c 425-467 AC023356.8 121611-121653 c 468-546 AC023356.8 121303-121381 c 547-644 AC023356.8 111726-111823 c 645-768 AC023356.8 107672-107795 c 769-856 AC023356.8 104019-104106 c 857-945 AC023356.8 93825-93913 c 946-1009 AC023356.8 90653-90716 c 1010-1101 AC023356.8 90019-90110 c 1102-1176 AC023356.8 87525-87599 c 1177-1245 AC023356.8 86571-86639 c 1246-1352 AC023356.8 85547-85653 c 1353-1696 AC023356.8 75963-76306 c 1697-4155 AC023356.8 72608-75066 c FEATURES Location/Qualifiers source 1..4155 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="15" /map="15q15.3" gene 1..4155 /gene="FRMD5" /gene_synonym="NEDEMA" /note="FERM domain containing 5" /db_xref="GeneID:84978" /db_xref="HGNC:HGNC:28214" /db_xref="MIM:616309" exon 1..319 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" misc_feature 113..115 /gene="FRMD5" /gene_synonym="NEDEMA" /note="upstream in-frame stop codon" CDS 218..1771 /gene="FRMD5" /gene_synonym="NEDEMA" /note="isoform 9 is encoded by transcript variant 9; FERM domain-containing protein 5" /codon_start=1 /product="FERM domain-containing protein 5 isoform 9" /protein_id="NP_001398053.1" /db_xref="CCDS:CCDS91990.1" /db_xref="GeneID:84978" /db_xref="HGNC:HGNC:28214" /db_xref="MIM:616309" /translation="
MLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSTSHGDTFLPHVRSSRTDSNERVAVIADEAYSPADSVLPTPVAEHSLELMLLSRQINGATCSIEEEKESEASTPTATEVEALGGELRALCQGHSGPEEEQSGHLKGPPLQQQQHQGWGKSVPLV"
misc_feature 272..847 /gene="FRMD5" /gene_synonym="NEDEMA" /note="Band 4.1 homologues; Region: B41; smart00295" /db_xref="CDD:214604" misc_feature 788..1102 /gene="FRMD5" /gene_synonym="NEDEMA" /note="FERM domain C-lobe of FERM domain-containing protein 3 and 5 (FRMD3 and 5); Region: FERM_C_FRMD3_FRMD5; cd13192" /db_xref="CDD:270013" misc_feature order(857..859,908..910,914..916,932..934) /gene="FRMD5" /gene_synonym="NEDEMA" /note="putative phosphoinositide binding site [chemical binding]; other site" /db_xref="CDD:270013" misc_feature order(944..946,959..970,1067..1069,1079..1081,1088..1093) /gene="FRMD5" /gene_synonym="NEDEMA" /note="putative peptide binding site [polypeptide binding]; other site" /db_xref="CDD:270013" misc_feature 1067..1102 /gene="FRMD5" /gene_synonym="NEDEMA" /note="putative actin binding site 2 [polypeptide binding]; other site" /db_xref="CDD:270013" misc_feature 1139..1276 /gene="FRMD5" /gene_synonym="NEDEMA" /note="propagated from UniProtKB/Swiss-Prot (Q7Z6J6.1); Region: Interaction with ROCK1. /evidence=ECO:0000269|PubMed:25448675" misc_feature 1142..>1246 /gene="FRMD5" /gene_synonym="NEDEMA" /note="FERM adjacent (FA); Region: FA; pfam08736" /db_xref="CDD:430180" misc_feature 1247..1318 /gene="FRMD5" /gene_synonym="NEDEMA" /note="propagated from UniProtKB/Swiss-Prot (Q7Z6J6.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1340..1342 /gene="FRMD5" /gene_synonym="NEDEMA" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q6P5H6; propagated from UniProtKB/Swiss-Prot (Q7Z6J6.1); phosphorylation site" misc_feature 1370..1438 /gene="FRMD5" /gene_synonym="NEDEMA" /note="propagated from UniProtKB/Swiss-Prot (Q7Z6J6.1); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" exon 320..424 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 425..467 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 468..546 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 547..644 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 645..768 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 769..856 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 857..945 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 946..1009 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 1010..1101 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 1102..1176 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 1177..1245 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 1246..1352 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 1353..1696 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" exon 1697..4155 /gene="FRMD5" /gene_synonym="NEDEMA" /inference="alignment:Splign:2.1.0" regulatory 4137..4142 /regulatory_class="polyA_signal_sequence" /gene="FRMD5" /gene_synonym="NEDEMA" /note="hexamer: AATAAA" polyA_site 4155 /gene="FRMD5" /gene_synonym="NEDEMA" /note="major polyA site" ORIGIN
agagcccggcgcttgatctgggctggggggaggcggtggcggctgagggaaggaggaggataaggaggaggaacgaggccagcaggaggcaacggcagcgacggggccggggtgatggtgcaggtgcctggggtcggtgcggagctgccgggctgagggacgcctggtccagggtccgcagcgccgccgcgtcgctcccgggcgggcgggcgggaagatgctgagcaggttgatgagcggcagcagcaggagcctggagcgcgagtacagctgcaccgtgcggctgctggacgacagcgagtacacctgcaccatccagagagatgccaaaggccagtacctgtttgaccttctttgccaccatctgaacctacttgagaaagactattttggtatccgctttgtagacccagataagcagcggcattggctggaatttacaaagtctgtggtgaaacaattgagatcccagcctccattcaccatgtgcttccgtgtgaagttttatcctgcagaccctgctgctctgaaagaagaaataaccaggtatttagtcttcctgcagatcaaaagggatctctaccatggccgactcctctgtaaaacatcggatgctgccttgttagcagcttacatccttcaagcggagattggggattatgactcagggaaacaccctgaaggctacagctccaagttccagtttttccctaaacattcagagaagctggaaaggaaaattgctgagattcacaagacggaactgagtggtcaaacaccagcaacatcagagctgaacttcttaagaaaagcacagacattggaaacatatggagtggatcctcacccatgtaaggacgtgtcaggaaatgctgcatttctggccttcactccttttgggtttgttgttcttcaaggaaacaagagggtccacttcattaaatggaatgaggtgaccaagctgaaatttgaaggaaagactttctatttatacgtaagtcagaaagaggaaaagaaaattattcttacatattttgctccaactcctgaagcgtgtaagcacctctggaaatgtggaatcgagaaccaagccttctacaagctggagaagtcaagccaagtccgcacagtgtccagcagcaatttattctttaaagggagccggttccgatacagtggccgagttgcaaaggaagtcatggaatcaagtgctaagatcaaacgggagccaccggaaatacacagagcagggatggttcccagccggagctgtccctccataacccatggcccaaggctgagcagcgtccccaggacccgcagaagagctgttcacatctccatcatggaaggcctagagtccttacgggacagtgcccattccacaccagtgcgttccacttcccatggggacaccttcctgcctcacgtgagaagcagccggacagatagcaatgagcgagtagctgtgattgcagacgaggcctacagccctgcagacagcgtgctgcccacccctgtggctgagcacagcctggagctgatgttgctttcccggcagatcaatggagccacctgcagcattgaggaggagaaggaatctgaagccagcaccccaactgctacagaggtggaggcccttgggggagagctgagggccctgtgtcaggggcacagcgggcccgaggaggaacagagtgggcatctgaagggaccaccgctacagcaacagcagcatcaggggtggggtaagtctgtccccttagtctagagcctagtgggcatcaccatagttttgtataatgaaactagacttaacgtgattttttttttccgaagaacctcaagacttttatagtgctccaggggcgttaaacgaattcagtggtaccagagatagatagttctgtcagaaatgttggacaaagtgtagttaagagaaagcagagttaagttacctgagagactgttgagatttggatagcagtgcttattttatatacacccccttgacccaaagactatttcaatttatattttaacaacgaaatgttattttcttaacaattcatattttgtttttactttatggattaagaaaatagagcctgatgaactaaacgatgcaagaaagaaactgatcctgagaatgaaaagcttcagaaaatagaattccaagatcaacagccttagaagggaccaggaaaagaatcttttaaaatagatttctaagagatgcctacaaaacacagaatgtgaccgtggcagagaccaacacttagatgtagaaatgctgccccctagggtcatcctctgcataagttctaggaaagcatcaccatccttgcagagggaagtcctcgaagcacgcagcacaggcatatgaagggcgagtgtgggatcctaggcccaagctcttcaactctaaaaccaatcacacacaagatcctgttttcatctcagggagagatttctaagtcatctggggcttgagggcttatttaagggtggtcaatggacatattcctggacccacacaaaagtagagcagctgctgataccctaattggacagccccaaacgcagaacagaacaagtcacttgtagacttgacctcccctattttgtcccccgagatggtagaaccatgtccatgtttacaatatgacaactgtggaataattggggttcttagggagagatttgcataattttaaagacatcctttcatctggaccagaggtcaatcaacttatgtcaagtgctacacagtaaatattttggtttagcacgccatactgtgtcacaactgctcaattctgccatcacagcacaaaaacagccacagataatttgtaaatgaaggaacatggctgtgttccaataaaactttatgaaaacagtgagctgaatttagcctacaggccataatacgccaatcctgctctagacaataaaactgatccttaccagtatgttagcagaagagggtcagtcagctctgtttccatgcctgacatgtatcaaagatctgggacctcttcccagtggaggcactagggttgcttgtttaaagggtgcttgaacaactaaccagcaaagagatgtctgatgccaaatgggcaagatcaaatactggaatgctaaaacacagctggaatctaagaagggaagagggcttctctgaccattttcataccagcaacaatttaggcagaattataaacatctatttatcgagtgacaatacaaaccgaaggagatcctagtagagattaggggtcagttaaaatcaactagccactgccacttgtcatctacatagcaaaggctttatttagcacaggactaacgtgaaaagtagacccagagatgaaaaggctgtcaggagacagggggctggtgtccacctggtatctactgtcttatgcaacatagaagattaccttttagtgtagtgctcctacctcagtttgtagaatctggtgtttctatgcagtgagtgatagcctcaactctgacctttcatattcacattagagacagatgcagtattccatatcctagtatgttccttgtgtctagagttctaacagtacagtagtctatgccatttctaacagctaaattttgctctgtaaacagaaactttagggttgtttttttccagggctcatcccagaaaatatggatagaaaagtttccttcagtttgcttttcaaatagtgcttgaataataaacctcctttgattggtgactagtcttttttggtatatctccacctttaaaaattgttcaagtttttaacctggttatactgtgttctaacatgtctctcattttctctcaaaattagtttatctcattgtagaaaaagcaatggttttcatagcttcatctatcaggaaataaaactcttactaaagaatagcatactgcatctttaagcagtagagggtaaactacctgcaaatgtgaatttcttagatacatttaaaaatatatagttgttaaccttctgtgtgccaaaaactcttaagttacattttccttcaaagcaatgtacttttttctacatatgcagtatgtagttagcataaaatcattggtgccatgaagattatttttaaacttaaataaatatttaaatatca
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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