LOCUS       NM_001410791             692 bp    mRNA    linear   PRI 24-SEP-2023
DEFINITION  Homo sapiens ciliary microtubule associated protein 1B (CIMAP1B),
            transcript variant 4, mRNA.
ACCESSION   NM_001410791 XM_047441383
VERSION     NM_001410791.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 692)
  AUTHORS   Leung MR, Zeng J, Wang X, Roelofs MC, Huang W, Zenezini Chiozzi R,
            Hevler JF, Heck AJR, Dutcher SK, Brown A, Zhang R and
            Zeev-Ben-Mordehai T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 692)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 692)
  AUTHORS   Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J,
            Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L,
            Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L,
            Grundberg E, Waldenberger M, Richards JB, Mohney RP, Milburn MV,
            John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ,
            Gieger C, Kastenmuller G, Spector TD and Soranzo N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   4  (bases 1 to 692)
  AUTHORS   van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi
            J, Paul DS, Elling U, Allayee H, Li X, Radhakrishnan A, Tan ST,
            Voss K, Weichenberger CX, Albers CA, Al-Hussani A, Asselbergs FW,
            Ciullo M, Danjou F, Dina C, Esko T, Evans DM, Franke L, Gogele M,
            Hartiala J, Hersch M, Holm H, Hottenga JJ, Kanoni S, Kleber ME,
            Lagou V, Langenberg C, Lopez LM, Lyytikainen LP, Melander O, Murgia
            F, Nolte IM, O'Reilly PF, Padmanabhan S, Parsa A, Pirastu N, Porcu
            E, Portas L, Prokopenko I, Ried JS, Shin SY, Tang CS, Teumer A,
            Traglia M, Ulivi S, Westra HJ, Yang J, Zhao JH, Anni F, Abdellaoui
            A, Attwood A, Balkau B, Bandinelli S, Bastardot F, Benyamin B,
            Boehm BO, Cookson WO, Das D, de Bakker PI, de Boer RA, de Geus EJ,
            de Moor MH, Dimitriou M, Domingues FS, Doring A, Engstrom G,
            Eyjolfsson GI, Ferrucci L, Fischer K, Galanello R, Garner SF,
            Genser B, Gibson QD, Girotto G, Gudbjartsson DF, Harris SE,
            Hartikainen AL, Hastie CE, Hedblad B, Illig T, Jolley J, Kahonen M,
            Kema IP, Kemp JP, Liang L, Lloyd-Jones H, Loos RJ, Meacham S,
            Medland SE, Meisinger C, Memari Y, Mihailov E, Miller K, Moffatt
            MF, Nauck M, Novatchkova M, Nutile T, Olafsson I, Onundarson PT,
            Parracciani D, Penninx BW, Perseu L, Piga A, Pistis G, Pouta A, Puc
            U, Raitakari O, Ring SM, Robino A, Ruggiero D, Ruokonen A,
            Saint-Pierre A, Sala C, Salumets A, Sambrook J, Schepers H, Schmidt
            CO, Sillje HH, Sladek R, Smit JH, Starr JM, Stephens J, Sulem P,
            Tanaka T, Thorsteinsdottir U, Tragante V, van Gilst WH, van Pelt
            LJ, van Veldhuisen DJ, Volker U, Whitfield JB, Willemsen G,
            Winkelmann BR, Wirnsberger G, Algra A, Cucca F, d'Adamo AP, Danesh
            J, Deary IJ, Dominiczak AF, Elliott P, Fortina P, Froguel P,
            Gasparini P, Greinacher A, Hazen SL, Jarvelin MR, Khaw KT,
            Lehtimaki T, Maerz W, Martin NG, Metspalu A, Mitchell BD,
            Montgomery GW, Moore C, Navis G, Pirastu M, Pramstaller PP,
            Ramirez-Solis R, Schadt E, Scott J, Shuldiner AR, Smith GD, Smith
            JG, Snieder H, Sorice R, Spector TD, Stefansson K, Stumvoll M, Tang
            WH, Toniolo D, Tonjes A, Visscher PM, Vollenweider P, Wareham NJ,
            Wolffenbuttel BH, Boomsma DI, Beckmann JS, Dedoussis GV, Deloukas
            P, Ferreira MA, Sanna S, Uda M, Hicks AA, Penninger JM, Gieger C,
            Kooner JS, Ouwehand WH, Soranzo N and Chambers JC.
  TITLE     Seventy-five genetic loci influencing the human red blood cell
  JOURNAL   Nature 492 (7429), 369-375 (2012)
   PUBMED   23222517
REFERENCE   5  (bases 1 to 692)
  AUTHORS   Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA
            and Butte NF.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 692)
  AUTHORS   Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt
            TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M,
            Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ,
            Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S,
            Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD,
            Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE
            and Hingorani AD.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 692)
  AUTHORS   Ganesh SK, Zakai NA, van Rooij FJ, Soranzo N, Smith AV, Nalls MA,
            Chen MH, Kottgen A, Glazer NL, Dehghan A, Kuhnel B, Aspelund T,
            Yang Q, Tanaka T, Jaffe A, Bis JC, Verwoert GC, Teumer A, Fox CS,
            Guralnik JM, Ehret GB, Rice K, Felix JF, Rendon A, Eiriksdottir G,
            Levy D, Patel KV, Boerwinkle E, Rotter JI, Hofman A, Sambrook JG,
            Hernandez DG, Zheng G, Bandinelli S, Singleton AB, Coresh J, Lumley
            T, Uitterlinden AG, Vangils JM, Launer LJ, Cupples LA, Oostra BA,
            Zwaginga JJ, Ouwehand WH, Thein SL, Meisinger C, Deloukas P, Nauck
            M, Spector TD, Gieger C, Gudnason V, van Duijn CM, Psaty BM,
            Ferrucci L, Chakravarti A, Greinacher A, O'Donnell CJ, Witteman JC,
            Furth S, Cushman M, Harris TB and Lin JP.
  TITLE     Multiple loci influence erythrocyte phenotypes in the CHARGE
            Consortium
  JOURNAL   Nat Genet 41 (11), 1191-1198 (2009)
   PUBMED   19862010
REFERENCE   8  (bases 1 to 692)
  AUTHORS   Wistow G, Bernstein SL, Wyatt MK, Behal A, Touchman JW, Bouffard G,
            Smith D and Peterson K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 692)
  AUTHORS   Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE,
            Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida
            JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O,
            Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD,
            O'Brien KP et al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 692)
  AUTHORS   Usuki K, Gonez LJ, Wernstedt C, Moren A, Miyazono K, Claesson-Welsh
            L and Heldin CH.
  TITLE     Structural properties of 3.0 kb and 3.2 kb transcripts encoding
            platelet-derived endothelial cell growth factor/thymidine
            phosphorylase in A431 cells
  JOURNAL   Biochim Biophys Acta 1222 (3), 411-414 (1994)
   PUBMED   8038210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U62317.2.
            
            On Aug 16, 2022 this sequence version replaced XM_047441383.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM973820.1, DRR138515.747379.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159764 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               U62317.2           108297-108485
            190-294             U62317.2           109159-109263
            295-416             U62317.2           109396-109517
            417-557             U62317.2           109602-109742
            558-692             U62317.2           109894-110028
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..692
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /note="ciliary microtubule associated protein 1B"
                     /db_xref="GeneID:440836"
                     /db_xref="HGNC:HGNC:34388"
     exon            1..189
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    60..62
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /note="upstream in-frame stop codon"
     CDS             81..638
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /note="isoform 4 is encoded by transcript variant 4; orf2
                     5' to PD-ECGF/TP; outer dense fiber protein 3B; outer
                     dense fiber protein 3-like protein 3; outer dense fiber of
                     sperm tails 3B"
                     /codon_start=1
                     /product="ciliary microtubule associated protein 1B
                     isoform 4"
                     /protein_id="NP_001397720.1"
                     /db_xref="CCDS:CCDS93188.1"
                     /db_xref="GeneID:440836"
                     /db_xref="HGNC:HGNC:34388"
                     /translation="

MGSDAWVGLWRPHRPRGPIAAHYGGPGPKYKLPPNTGRYFPERAGNATYPSAPRHTIAPRNWGVQAEQQSPGPAAYTVPSLLGPRVIGKVSAPTCSIYGRRAAGSFFEDLSKTPGPCAYQVVSPGVYKSRAPQFTILARTSLPQDNTRKPGPAAYNVDQHRKPRGWSFGIRHSDYLAPLVTDADN"

     exon            190..294
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..416
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            417..557
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            558..692
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      692
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /note="major polyA site"
ORIGIN      

aagaatttgcggtgcaggggccgcggccaccgccttctgtccgcaggtgctgcgagccgtaagcgccccccacccgcgctatgggctcggacgcctgggtgggcctttggcggccacaccggccccgcggccccatcgcggcgcactacggaggccccgggcccaaatacaagctgccgcccaacaccggcaggtacttcccggagcgagcggggaacgcgacgtaccccagtgcgcctcggcacaccattgctccccgaaactggggtgtccaggcggaacagcagagcccaggtcccgcggcctatacggtgccctcgctcttgggtccgcgcgtcatcggcaaagtctccgccccaacttgctccatctacggccgcagagcggctggcagtttcttcgaggacctcagcaagaccccgggcccctgcgcctatcaggtcgtgagtccaggggtctacaagtcccgggccccccagttcacgattctggcgcggacttcgctcccccaagacaacactcggaagccagggcccgcggcctacaacgtggatcagcaccggaagccccgcggctggagtttcgggatccggcactcggactacctggccccgctggtgaccgacgcggacaactgacccgccaggcgggagcggccccacacgtgtttgcttaaagtctgcgagtccgca

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