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Previous release (v1)
2021-07-31 01:59:32, GGRNA.v2 : RefSeq release 206 (May, 2021)
LOCUS NM_001385457 8042 bp mRNA linear PRI 16-MAY-2021
DEFINITION Homo sapiens inositol polyphosphate-4-phosphatase type II B
(INPP4B), transcript variant 39, mRNA.
ACCESSION NM_001385457
VERSION NM_001385457.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8042)
AUTHORS Wu Y, Meng D, Xu X, Bao J, You Y, Sun Y, Li Y and Sun D.
TITLE Expression and functional characterization of INPP4B in gallbladder
cancer patients and gallbladder cancer cells
JOURNAL BMC Cancer 21 (1), 433 (2021)
PUBMED 33879096
REMARK GeneRIF: Expression and functional characterization of INPP4B in
gallbladder cancer patients and gallbladder cancer cells.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 8042)
AUTHORS Chaurasiya S, Wu W, Strom AM, Warner M and Gustafsson JA.
TITLE Estrogen receptor beta regulates AKT activity through up-regulation
of INPP4B and inhibits migration of prostate cancer cell line PC-3
JOURNAL Proc Natl Acad Sci U S A 117 (42), 26347-26355 (2020)
PUBMED 33020300
REMARK GeneRIF: Estrogen receptor beta regulates AKT activity through
up-regulation of INPP4B and inhibits migration of prostate cancer
cell line PC-3.
REFERENCE 3 (bases 1 to 8042)
AUTHORS Yang L, Ding C, Tang W, Yang T, Liu M, Wu H, Wen K, Yao X, Feng J
and Luo J.
TITLE INPP4B exerts a dual function in the stemness of colorectal cancer
stem-like cells through regulating Sox2 and Nanog expression
JOURNAL Carcinogenesis 41 (1), 78-90 (2020)
PUBMED 31179504
REMARK GeneRIF: INPP4B exerts a dual function in the stemness of
colorectal cancer stem-like cells through regulating Sox2 and Nanog
expression.
REFERENCE 4 (bases 1 to 8042)
AUTHORS Aki S, Yoshioka K, Takuwa N and Takuwa Y.
TITLE TGFbeta receptor endocytosis and Smad signaling require
synaptojanin1, PI3K-C2alpha-, and INPP4B-mediated phosphoinositide
conversions
JOURNAL Mol Biol Cell 31 (5), 360-372 (2020)
PUBMED 31913757
REMARK GeneRIF: TGFbeta receptor endocytosis and Smad signaling require
synaptojanin1, PI3K-C2alpha-, and INPP4B-mediated phosphoinositide
conversions.
REFERENCE 5 (bases 1 to 8042)
AUTHORS Chen X, Theobard R, Zhang J and Dai X.
TITLE Genetic interactions between INPP4B and RAD50 is prognostic of
breast cancer survival
JOURNAL Biosci Rep 40 (1) (2020)
PUBMED 31872854
REMARK GeneRIF: Genetic interactions between INPP4B and RAD50 is
prognostic of breast cancer survival.
REFERENCE 6 (bases 1 to 8042)
AUTHORS Rampersaud E, Damcott CM, Fu M, Shen H, McArdle P, Shi X, Shelton
J, Yin J, Chang YP, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell
J and Shuldiner AR.
TITLE Identification of novel candidate genes for type 2 diabetes from a
genome-wide association scan in the Old Order Amish: evidence for
replication from diabetes-related quantitative traits and from
independent populations
JOURNAL Diabetes 56 (12), 3053-3062 (2007)
PUBMED 17846126
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 7 (bases 1 to 8042)
AUTHORS Munday AD, Norris FA, Caldwell KK, Brown S, Majerus PW and Mitchell
CA.
TITLE The inositol polyphosphate 4-phosphatase forms a complex with
phosphatidylinositol 3-kinase in human platelet cytosol
JOURNAL Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
PUBMED 10097090
REFERENCE 8 (bases 1 to 8042)
AUTHORS Zhang X and Majerus PW.
TITLE Phosphatidylinositol signalling reactions
JOURNAL Semin Cell Dev Biol 9 (2), 153-160 (1998)
PUBMED 9599410
REMARK Review article
REFERENCE 9 (bases 1 to 8042)
AUTHORS Norris FA, Atkins RC and Majerus PW.
TITLE The cDNA cloning and characterization of inositol polyphosphate
4-phosphatase type II. Evidence for conserved alternative splicing
in the 4-phosphatase family
JOURNAL J Biol Chem 272 (38), 23859-23864 (1997)
PUBMED 9295334
REFERENCE 10 (bases 1 to 8042)
AUTHORS Norris FA, Auethavekiat V and Majerus PW.
TITLE The isolation and characterization of cDNA encoding human and rat
brain inositol polyphosphate 4-phosphatase
JOURNAL J Biol Chem 270 (27), 16128-16133 (1995)
PUBMED 7608176
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC093860.3 and AC108077.3.
Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
type II, one of the enzymes involved in phosphatidylinositol
signaling pathways. This enzyme removes the phosphate group at
position 4 of the inositol ring from inositol 3,4-bisphosphate.
There is limited data to suggest that the human type II enzyme is
subject to alternative splicing, as has been established for the
type I enzyme. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: SRR1803612.172946.1 [ECO:0000331]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-68 AC093860.3 178835-178902 c
69-148 AC093860.3 178416-178495 c
149-260 AC093860.3 143621-143732 c
261-333 AC093860.3 133450-133522 c
334-481 AC093860.3 110822-110969 c
482-612 AC093860.3 81854-81984 c
613-717 AC093860.3 81383-81487 c
718-826 AC093860.3 66045-66153 c
827-1004 AC093860.3 46590-46767 c
1005-1208 AC093860.3 33316-33519 c
1209-1365 AC093860.3 18798-18954 c
1366-1538 AC108077.3 102529-102701 c
1539-1662 AC108077.3 101233-101356 c
1663-1780 AC108077.3 100069-100186 c
1781-1921 AC108077.3 90483-90623 c
1922-2019 AC108077.3 86034-86131 c
2020-2132 AC108077.3 64085-64197 c
2133-2287 AC108077.3 59972-60126 c
2288-8042 AC108077.3 1101-6855 c
FEATURES Location/Qualifiers
source 1..8042
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q31.21"
gene 1..8042
/gene="INPP4B"
/note="inositol polyphosphate-4-phosphatase type II B"
/db_xref="GeneID:8821"
/db_xref="HGNC:HGNC:6075"
/db_xref="MIM:607494"
exon 1..68
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
misc_feature 36..38
/gene="INPP4B"
/note="upstream in-frame stop codon"
exon 69..148
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 149..260
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
CDS 201..2420
/gene="INPP4B"
/EC_number="3.1.3.66"
/note="isoform 10 is encoded by transcript variant 39;
inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
type II inositol 3,4-bisphosphate 4-phosphatase; inositol
polyphosphate-4-phosphatase, type II, 105kDa"
/codon_start=1
/product="inositol polyphosphate 4-phosphatase type II
isoform 10"
/protein_id="NP_001372386.1"
/db_xref="GeneID:8821"
/db_xref="HGNC:HGNC:6075"
/db_xref="MIM:607494"
/translation="
MGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT"
exon 261..333
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 334..481
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 482..612
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 613..717
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 718..826
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 827..1004
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1005..1208
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1209..1365
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1366..1538
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1539..1662
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1663..1780
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1781..1921
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1922..2019
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 2020..2132
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 2133..2287
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 2288..8042
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
regulatory 2436..2441
/regulatory_class="polyA_signal_sequence"
/gene="INPP4B"
/note="hexamer: AATAAA"
regulatory 2452..2457
/regulatory_class="polyA_signal_sequence"
/gene="INPP4B"
/note="hexamer: AATACA"
polyA_site 2462
/gene="INPP4B"
polyA_site 2477
/gene="INPP4B"
/note="major polyA site"
regulatory 8021..8026
/regulatory_class="polyA_signal_sequence"
/gene="INPP4B"
/note="hexamer: AATAAA"
polyA_site 8042
/gene="INPP4B"
ORIGIN
atatctggaatacaaagttgttgctgccagtgatttgaggaattctaataagaggaacaacagcattgcgaagtttcttgggctatgccagttttaaagtgggagagctgctgaagtcaaaggagcaattgctggtcctgagcctgagaacttcagatggtggcaaagtggttggcaccatagaagtcagtgtcgtgaagatgggggagattgaggatggggaagccgaccacatcaccacagatgtacagggacaaaagtgtgccctggtatgtgaatgtacagccccggaaagtgtgagcggaaaagataacttaccttttttgaattcagtgttaaagaacccagtatgtaaattatatagatttcccacatctgacaataagtggatgcgaattcgagagcagatgtcagagagcattctttcctttcatattcctaaggaattgatttcccttcacattaaagaagatttgtgcagaaaccaggagataaaagaacttggtgagctttctccacattgggacaatctgcgaaaaaatgtccttactcactgtgatcaaatggtgaatatgtaccaagacattctgacagaacttagcaaggaaacagggtcctctttcaaatcaagcagcagcaaaggagagaaaacattagaatttgttccaataaatctacatctgcaaagaatgcaggtacacagccctcacttgaaagatgctctctacgatgtcatcactgtgggagccccagctgcccattttcagggatttaagaatggtggtcttcggaagctactccatagatttgaaacagaaagaagaaataccggataccagtttatttactattcacctgaaaacacagccaaagcaaaggaagttctcagcaacatcaatcaactacaacctcttatagcaacccatgcagacctactgcttaattctgcaagccagcattctccagacagcttgaagaattctttaaagatgctttcagaaaaaacagagctttttgtacatgccttcaaggatcaacttgtcaggagtgctcttttagcactctacactgcaaggccaggaggcattcttaagaagccaccctctcctaagagcagcacagaggagagcagtccccaagaccaacccccagtgatgagagggcaggactccataccacatcattcagactatgatgaggaagagtgggacagggtgtgggccaatgtggggaagagcctgaactgcattattgctatggtggacaaactgattgaaagagatggtggcagtgaaggcagtggcggcaacaatgatggagaaaaggaaccttcattaacagatgccattccctctcacccaagagaggactggtatgaacagttgtatcccctcatccttaccctgaaggactgcatgggagaagtggtgaaccgagccaagcagtccctgacatttgtgctccttcaggaacttgcgtacagcttgccccagtgtctgatgctgacgctaagaagagacatcgtcttcagccaagcacttgctggattggtttgtggttttatcatcaaattacagacaagtctgtatgacccaggcttcctacagcagcttcacacagtggggttgatagtacaatatgaaggactgctaagtacatacagcgatgaaattggaatgctagaggacatggccgttggcatttccgatttaaagaaagttgcatttaaaataattgaagccaaatccaatgatgtgttgccagttataacaggaagacgagaacattacgtggtagaggtcaagcttccagccagaatgtttgagtcactacctctacagattaaagaaggacagttgcttcatgtgtatccagtactttttaatgttggaatcaatgaacagcaaactctggctgaaaggtttggagatgtctctttgcaagaaagtattaatcaggaaaacttcgaacttctacaagaatattacaagatatttatggaaaagatgcctcctgattatatttcacattttcaggaacaaaatgatttaaaagcattgctagaaaatctccttcaaaatatccaatccaaaaaaagaaagaatgtagaaattatgtggctggctgcaacgatttgccgcaaactgaatggtattcgtttcacctgttgtaaaagtgccaaagacaggacatcgatgtcagtgacacttgaacaatgctcaatcttgagagatgagcaccagttacacaaggacttctttatccgagcgctggattgcatgagaagagaaggatgccgcatagagaatgtactgaagaatatcaaatgcagaaagtatgctttcaacatgctacagctgatggctttccccaagtactacagacctccagaggggacttatggaaaagctgacacctaagtttaccaacatgttaataaacaggaacacaaatacatttcagttggataatcttcaccttggtcttttttgtttgtttttattgtcatgaatttgtggtgggggagatgatcacagatgtttcccaaaatctaggaactacttcaattcatcatcagcatattgctctgaaagaaatccattttaaaaaatcttacatgattcagtactgtcatttctagttctaagcttctatgtgttgagcctagctgattgagattggttcacaaagtgtaaatttcattcatgagtatttaaatgtttctgaggaaacatggatcatttcaataggactaggggtgattcacagagcaccactctccaaccaaatggaagagaggagagggggaaaaggaacatattttttttgtgatacaacttaatagcctatgagaacacagtcaacctgagaatcaatgtaagggatttaaaaaaaatgtgtagccactcaattaggtagagttaactcatgatctggaatactgaggcagtttgcaggtatgttccacaatgatctctatcatccagtcaaggtgtgactcctcccttgcaacaggcatatgcatggagtgagtaaagtggtcaacagacctttcaaaaccatggcatcttttcagaactctgacttgggttgtgtgatctagctgtgaatgtagcaatatagaacgtttaatagaatgataagcaaaacactgcaatgatctaaaattacaaataaaataaaaatgaacaacattttgatacccaaaatgaaaattcccatcagcctgaactttatgttgtgaagttcatgaatgtcagtgaggtatctctgagatgtttcttagcagtcatcctggtgtaagcatgcagttatggcataggtttgtgtgtgttaataagcctttaaaacatatgcaaccacaacaaatgataaagtaaaacaattattttctgttgccctgaatatcaaacttgcccttgcccttactcagcaaaataacatttataagttttccaaaatcccaaagtagaagtttccttaaaaaaatcatcttgtataataccagtattcaaacatgggtaaggttaatcacccccaatcactcaggagatagttgcagaatttgaattacaatctcttcttactttcctagcctgtggcttgtcacttctccaaattgccatgctaaatatgcatgaaaattgagggagaatgctagttaaaaagaaattaggatttatcactggaattgaaactaagagtacaaaagtctgaacgaatgaaacttttctccaaattttacaaattcttgttcctttctcattagaagagcatgctatccaaagcataaatctcccttgaaaataacagaggcttcttaagccctctcttagctatgatcaatggatgatattatgcttcccatagctaatgtgatagctccttgcctaggattcctgttgaaataaggattctagccccatgttaagtttttcaaattactacaaattttagataagcatttggagctttttatactagaattatcaattttttattttagctaattacctgtgggcattatacttgaggcaggtaccaaactacttacagcctttttaatgaaaatgtgctgtgtactttgaatccattcatagacaaaattaccttgatgttctcttaactcattctttattttagtgattaaatacaacctttgagttgttcaatatcatttgaaaatggtaggatttgtggttattttcattaccctattagatttaagataggctgggatgacagaggcctccttgaatagctatgaagcctcattcagcatatcaaatggtagtctgagttctaagaaaccttaagtaatttatcattctgtaaatactcttataagcaataatttttatttgtatttttgaaaacaaactacttaaatatggaaaaatattaactggaaagccagcagtagggttttctatttttaaaagacatttcaaggatttcctgtaatcccagcactttgggagccaaggtggatagatcacctgaggtcaggaattggagatcagcctggccaacatggtgaaaccccatctctactaaagatacaaaaattagctggatgtggtggcacacacgtgtaatcccagctacttgggaggctgaggcaagagaatcgcttgaaccccggaggcggaggttgcagtgagctgagatcatgccattgcactccagcctgggtgaaaagagcgaaactccatctttaaataagtaaataaatgaataatatagaagtctcaaattatagtgcttactgtaatacaaatgcttatgaattttcattcattaccatagtcatctgcatttccttatagaaagcctgtactggtgcaaacttctaaaagtggatttcatcaagaaaatgtgtttcatagagacaacaatattgcttttttcctgagaggcagttcattcttaaacaaccacttcactatttcttaagttattaaggctaaatcaaagagcaaatgttaaagtgtttaaatctctcttgaacaaacacagccacagtcatgctattctatctatattttcacttaaaagatacaccagcagacctattttaggaggtcatattgagccaaaaaatgaactgagcaaatgacatttccaaactctttttttgctcaaaaataatatgttcccctttgatattaaatgcagatatcaattctggattagctatttactgagccctaggaaaaacatatttaaagacaaggaaaccattcatttacatctcatatcattgctttttgcttttaaatatcgccttgaggtttgtctacactctgccaaaacaatccctgaacataagtttggtcagcctcataattcagtgagtcgagcaaccatttgttccaagtgataaattgtactaaatgacaaactgcccaatcagggcagagctccatggacccagcctccagcccttattttataagactaacccctcttctgaaaaactctgaaggcttaaaagctagcatttggatggaggatacttcctttttatccttcagctatgtatggcactttacataaaataagaggtaaaaaaggagagaaactgatgtgtataaagtaatgcctttcttcccaagcaaatcaaacctctccctatgtaaaagttgatagtgtaccaagagacacaataccactggtgggctggaactagctcgttctgatgcataaaagttgataattaaagtaccagaaattttgtaagctagttgttaaacattaccattattaaatatgaaattataaaacacagtggaatacattaaaaaccaatgtaataatcaaaacataccacttcccaattattttactaccttatactatttattagtactcttgagtctatttaggtctattacatctttacagtgaaaacaggatacaatattgtgctactgtgggtctcttcctgactgcagattcagtaacatggtgttcgtagcttgaaactgtccacagtgggagtatttaacaccatagaaactggctggcaaatgctacaaactagcaattttaattcctggaaaggcaattgttgagcatttaccagcacacaatgaatgccatattcttttttttttattaggaaataaattattggaggcagtataaaattatttaaaaagtatcaaatgcaatcccttatcttcagatggctataattttggttatataaatgttttggtttttaccttctttaaagactcctattaggttaaaagtcatatttgatgactatattttattcataattaaattattaaatcaccttttctcctgataatgctttgccagagaattcttagcaattcaactgtagtctaagcaataactcagggctaaattcagggaactgttagcccaatcagatatcactaaaaatgtacttcaccatctattttggagtttataattttggcatttgctaaaagtaggaaaaacagtaacatattactgtgcccagattctaataaatatagctcaattgaaaccaaaactgttacattaaacaaattacactctggcactatgctaaatcaccacagatgttttaggtgtttgatttccaagcaggatggtatatcatttgtttggttcaatatatgaggcaccatttgtagtcttttaggaaataaattagcttttatcacagatttaggaaacttgtctaaaaaaactgtgatcatcagttacagagggaaggaaacatattgaacacaaggcatcatagtagctggaggccttaaaaattatgcacgaccaaaaagaatgatttggtgagagatgtgtagctgattgacaattttagtgtgaattcatattcatttaacccagcagcaatctacataagctatgctttttcccacctgtatttatgtttcttagcttataaagtcccaatatattatatcttttgttgctttggcagttttaatttagagctctgcgttcacagagatgccacctatagcaaaaactatctttaagaattggaaaataaaatgaatgttttagataaaatattgcaagccattatgtgtagagttaatgtatggaaatttgcatttgtttttctgaatcatggtgtacattaatcactcattgaattctatttctaagcaaataagagaatcaaacatttctaaaaggaacatatgtcttgctattaataacaaggagacaggaaaaatagtaaggtaatataagcaaaaaaaaaaatgtaatgaatttagctatcctaaattggaatttttacagattgcatgcatacttagaattttaaatttttaaaagatttacaattgagtatggtacccacagagagtgagtaccaagggaaggaagacctaatacaagtgatgttgcctgataaatcacatcttgccaaaaaaaatatattttagtaaatacagttctttaggaagaaaaatgttgccctttcacactcacagtgtaaatacattcataatattccttcaatcatctaaattaccgccaggtcatgaaaggacgcgatcaatgatgacctattgcactcacaggtaacattgactcaaattttggcaatattgctatattatctagataattcttgtgatgtttttatgtcactatcaacattaaaaatattttgttaaacaactatgaaactttcaaaagtttgcatataactgtatgggcactctcatttcactgcatacatacaatactttgtatacacatacttctcgtgtggatattttataattttatttaatctaacatttaacttttaggtttttgtggtactcatctgaaaggttggcatttgttttctttttatgttatatatgtattttagatgaatcaataatgtgtattcctagaaattttttctaggcataaatagatcattttatgttggcatttaagagatatcatttttgttttattgttctgtgtaaaccatattcattgtacactgtgtgtatatttttgtttaaataaatgatttttatttttta
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]