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Previous release (v1)
2021-07-31 01:02:59, GGRNA.v2 : RefSeq release 206 (May, 2021)
LOCUS NM_001385341 8783 bp mRNA linear PRI 16-MAY-2021
DEFINITION Homo sapiens inositol polyphosphate-4-phosphatase type II B
(INPP4B), transcript variant 11, mRNA.
ACCESSION NM_001385341
VERSION NM_001385341.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8783)
AUTHORS Wu Y, Meng D, Xu X, Bao J, You Y, Sun Y, Li Y and Sun D.
TITLE Expression and functional characterization of INPP4B in gallbladder
cancer patients and gallbladder cancer cells
JOURNAL BMC Cancer 21 (1), 433 (2021)
PUBMED 33879096
REMARK GeneRIF: Expression and functional characterization of INPP4B in
gallbladder cancer patients and gallbladder cancer cells.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 8783)
AUTHORS Chaurasiya S, Wu W, Strom AM, Warner M and Gustafsson JA.
TITLE Estrogen receptor beta regulates AKT activity through up-regulation
of INPP4B and inhibits migration of prostate cancer cell line PC-3
JOURNAL Proc Natl Acad Sci U S A 117 (42), 26347-26355 (2020)
PUBMED 33020300
REMARK GeneRIF: Estrogen receptor beta regulates AKT activity through
up-regulation of INPP4B and inhibits migration of prostate cancer
cell line PC-3.
REFERENCE 3 (bases 1 to 8783)
AUTHORS Yang L, Ding C, Tang W, Yang T, Liu M, Wu H, Wen K, Yao X, Feng J
and Luo J.
TITLE INPP4B exerts a dual function in the stemness of colorectal cancer
stem-like cells through regulating Sox2 and Nanog expression
JOURNAL Carcinogenesis 41 (1), 78-90 (2020)
PUBMED 31179504
REMARK GeneRIF: INPP4B exerts a dual function in the stemness of
colorectal cancer stem-like cells through regulating Sox2 and Nanog
expression.
REFERENCE 4 (bases 1 to 8783)
AUTHORS Aki S, Yoshioka K, Takuwa N and Takuwa Y.
TITLE TGFbeta receptor endocytosis and Smad signaling require
synaptojanin1, PI3K-C2alpha-, and INPP4B-mediated phosphoinositide
conversions
JOURNAL Mol Biol Cell 31 (5), 360-372 (2020)
PUBMED 31913757
REMARK GeneRIF: TGFbeta receptor endocytosis and Smad signaling require
synaptojanin1, PI3K-C2alpha-, and INPP4B-mediated phosphoinositide
conversions.
REFERENCE 5 (bases 1 to 8783)
AUTHORS Chen X, Theobard R, Zhang J and Dai X.
TITLE Genetic interactions between INPP4B and RAD50 is prognostic of
breast cancer survival
JOURNAL Biosci Rep 40 (1) (2020)
PUBMED 31872854
REMARK GeneRIF: Genetic interactions between INPP4B and RAD50 is
prognostic of breast cancer survival.
REFERENCE 6 (bases 1 to 8783)
AUTHORS Rampersaud E, Damcott CM, Fu M, Shen H, McArdle P, Shi X, Shelton
J, Yin J, Chang YP, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell
J and Shuldiner AR.
TITLE Identification of novel candidate genes for type 2 diabetes from a
genome-wide association scan in the Old Order Amish: evidence for
replication from diabetes-related quantitative traits and from
independent populations
JOURNAL Diabetes 56 (12), 3053-3062 (2007)
PUBMED 17846126
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 7 (bases 1 to 8783)
AUTHORS Munday AD, Norris FA, Caldwell KK, Brown S, Majerus PW and Mitchell
CA.
TITLE The inositol polyphosphate 4-phosphatase forms a complex with
phosphatidylinositol 3-kinase in human platelet cytosol
JOURNAL Proc Natl Acad Sci U S A 96 (7), 3640-3645 (1999)
PUBMED 10097090
REFERENCE 8 (bases 1 to 8783)
AUTHORS Zhang X and Majerus PW.
TITLE Phosphatidylinositol signalling reactions
JOURNAL Semin Cell Dev Biol 9 (2), 153-160 (1998)
PUBMED 9599410
REMARK Review article
REFERENCE 9 (bases 1 to 8783)
AUTHORS Norris FA, Atkins RC and Majerus PW.
TITLE The cDNA cloning and characterization of inositol polyphosphate
4-phosphatase type II. Evidence for conserved alternative splicing
in the 4-phosphatase family
JOURNAL J Biol Chem 272 (38), 23859-23864 (1997)
PUBMED 9295334
REFERENCE 10 (bases 1 to 8783)
AUTHORS Norris FA, Auethavekiat V and Majerus PW.
TITLE The isolation and characterization of cDNA encoding human and rat
brain inositol polyphosphate 4-phosphatase
JOURNAL J Biol Chem 270 (27), 16128-16133 (1995)
PUBMED 7608176
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC139720.1, AC108060.3,
AC093860.3 and AC108077.3.
Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase
type II, one of the enzymes involved in phosphatidylinositol
signaling pathways. This enzyme removes the phosphate group at
position 4 of the inositol ring from inositol 3,4-bisphosphate.
There is limited data to suggest that the human type II enzyme is
subject to alternative splicing, as has been established for the
type I enzyme. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: BC133005.1, U96922.1 [ECO:0000331]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-196 AC139720.1 19442-19637 c
197-260 AC139720.1 7879-7942 c
261-477 AC108060.3 112687-112903 c
478-522 AC108060.3 110691-110735 c
523-641 AC108060.3 86724-86842 c
642-758 AC108060.3 84456-84572 c
759-809 AC093860.3 187670-187720 c
810-889 AC093860.3 178416-178495 c
890-1001 AC093860.3 143621-143732 c
1002-1074 AC093860.3 133450-133522 c
1075-1222 AC093860.3 110822-110969 c
1223-1353 AC093860.3 81854-81984 c
1354-1458 AC093860.3 81383-81487 c
1459-1567 AC093860.3 66045-66153 c
1568-1745 AC093860.3 46590-46767 c
1746-1949 AC093860.3 33316-33519 c
1950-2106 AC093860.3 18798-18954 c
2107-2279 AC108077.3 102529-102701 c
2280-2403 AC108077.3 101233-101356 c
2404-2521 AC108077.3 100069-100186 c
2522-2662 AC108077.3 90483-90623 c
2663-2760 AC108077.3 86034-86131 c
2761-2873 AC108077.3 64085-64197 c
2874-3028 AC108077.3 59972-60126 c
3029-8783 AC108077.3 1101-6855 c
FEATURES Location/Qualifiers
source 1..8783
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q31.21"
gene 1..8783
/gene="INPP4B"
/note="inositol polyphosphate-4-phosphatase type II B"
/db_xref="GeneID:8821"
/db_xref="HGNC:HGNC:6075"
/db_xref="MIM:607494"
exon 1..196
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 197..260
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 261..477
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
misc_feature 375..377
/gene="INPP4B"
/note="upstream in-frame stop codon"
CDS 387..3161
/gene="INPP4B"
/EC_number="3.1.3.66"
/note="isoform 1 is encoded by transcript variant 11;
inositol polyphosphate 4-phosphatase II; 4-phosphatase II;
type II inositol 3,4-bisphosphate 4-phosphatase; inositol
polyphosphate-4-phosphatase, type II, 105kDa"
/codon_start=1
/product="inositol polyphosphate 4-phosphatase type II
isoform 1"
/protein_id="NP_001372270.1"
/db_xref="GeneID:8821"
/db_xref="HGNC:HGNC:6075"
/db_xref="MIM:607494"
/translation="
MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT"
misc_feature 501..911
/gene="INPP4B"
/note="C2 domain first repeat in Copine; Region:
C2A_Copine; cd04048"
/db_xref="CDD:176013"
exon 478..522
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 523..641
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 642..758
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 759..809
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 810..889
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 890..1001
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1002..1074
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1075..1222
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1223..1353
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1354..1458
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1459..1567
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1568..1745
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1746..1949
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 1950..2106
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 2107..2279
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 2280..2403
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 2404..2521
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 2522..2662
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 2663..2760
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 2761..2873
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 2874..3028
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
exon 3029..8783
/gene="INPP4B"
/inference="alignment:Splign:2.1.0"
regulatory 3177..3182
/regulatory_class="polyA_signal_sequence"
/gene="INPP4B"
/note="hexamer: AATAAA"
regulatory 3193..3198
/regulatory_class="polyA_signal_sequence"
/gene="INPP4B"
/note="hexamer: AATACA"
polyA_site 3203
/gene="INPP4B"
polyA_site 3218
/gene="INPP4B"
/note="major polyA site"
regulatory 8762..8767
/regulatory_class="polyA_signal_sequence"
/gene="INPP4B"
/note="hexamer: AATAAA"
polyA_site 8783
/gene="INPP4B"
ORIGIN
gccttctgagctcagacagcagaaggatcactgggctggaagctctaacaggcattgccagcctagctacctgcagtttgaggcaagggcagggtcacttaccctgctgtctgaatgtctcctgggacaacaggaggctgcactcactggctgagttcagacagaagagggatcatcggactggaagctctggcagagccttgaaaccagcgaaacaataatcaaagagcagttctgtcaaagaaaacaacataaatcaggtacagaatttcagagtgggatatcagatctttagtgtgaagatacatctacattaaaccaggaatcactagaactgacatttggacaagaaaatttggaaaattttaaaactgtgaaggttgatcatggaaattaaagaggaaggggcatcagaagaagggcagcactttcttcctacagcccaggccaatgatcccggggactgtcagttcacaagtatccagaagactccaaatgaaccgcagttggaattcatccttgcatgcaaggatctcgtggctcctgtccgtgatcgtaaactgaatacactggtgcagatctccgtaatccaccccgtggagcagagtctgacaagatactccagcaccgaaattgtggagggaacaagggacccactgtttttgactggtgtcacattcccatctgagtatcccatctatgaggagaccaaaataaaactaacagtctatgatgtcaaggataagtctcatgacaccgttcgaaccagtgtcctaccagaacataaggatcccccgccagaagttgggcgaagtttcttgggctatgccagttttaaagtgggagagctgctgaagtcaaaggagcaattgctggtcctgagcctgagaacttcagatggtggcaaagtggttggcaccatagaagtcagtgtcgtgaagatgggggagattgaggatggggaagccgaccacatcaccacagatgtacagggacaaaagtgtgccctggtatgtgaatgtacagccccggaaagtgtgagcggaaaagataacttaccttttttgaattcagtgttaaagaacccagtatgtaaattatatagatttcccacatctgacaataagtggatgcgaattcgagagcagatgtcagagagcattctttcctttcatattcctaaggaattgatttcccttcacattaaagaagatttgtgcagaaaccaggagataaaagaacttggtgagctttctccacattgggacaatctgcgaaaaaatgtccttactcactgtgatcaaatggtgaatatgtaccaagacattctgacagaacttagcaaggaaacagggtcctctttcaaatcaagcagcagcaaaggagagaaaacattagaatttgttccaataaatctacatctgcaaagaatgcaggtacacagccctcacttgaaagatgctctctacgatgtcatcactgtgggagccccagctgcccattttcagggatttaagaatggtggtcttcggaagctactccatagatttgaaacagaaagaagaaataccggataccagtttatttactattcacctgaaaacacagccaaagcaaaggaagttctcagcaacatcaatcaactacaacctcttatagcaacccatgcagacctactgcttaattctgcaagccagcattctccagacagcttgaagaattctttaaagatgctttcagaaaaaacagagctttttgtacatgccttcaaggatcaacttgtcaggagtgctcttttagcactctacactgcaaggccaggaggcattcttaagaagccaccctctcctaagagcagcacagaggagagcagtccccaagaccaacccccagtgatgagagggcaggactccataccacatcattcagactatgatgaggaagagtgggacagggtgtgggccaatgtggggaagagcctgaactgcattattgctatggtggacaaactgattgaaagagatggtggcagtgaaggcagtggcggcaacaatgatggagaaaaggaaccttcattaacagatgccattccctctcacccaagagaggactggtatgaacagttgtatcccctcatccttaccctgaaggactgcatgggagaagtggtgaaccgagccaagcagtccctgacatttgtgctccttcaggaacttgcgtacagcttgccccagtgtctgatgctgacgctaagaagagacatcgtcttcagccaagcacttgctggattggtttgtggttttatcatcaaattacagacaagtctgtatgacccaggcttcctacagcagcttcacacagtggggttgatagtacaatatgaaggactgctaagtacatacagcgatgaaattggaatgctagaggacatggccgttggcatttccgatttaaagaaagttgcatttaaaataattgaagccaaatccaatgatgtgttgccagttataacaggaagacgagaacattacgtggtagaggtcaagcttccagccagaatgtttgagtcactacctctacagattaaagaaggacagttgcttcatgtgtatccagtactttttaatgttggaatcaatgaacagcaaactctggctgaaaggtttggagatgtctctttgcaagaaagtattaatcaggaaaacttcgaacttctacaagaatattacaagatatttatggaaaagatgcctcctgattatatttcacattttcaggaacaaaatgatttaaaagcattgctagaaaatctccttcaaaatatccaatccaaaaaaagaaagaatgtagaaattatgtggctggctgcaacgatttgccgcaaactgaatggtattcgtttcacctgttgtaaaagtgccaaagacaggacatcgatgtcagtgacacttgaacaatgctcaatcttgagagatgagcaccagttacacaaggacttctttatccgagcgctggattgcatgagaagagaaggatgccgcatagagaatgtactgaagaatatcaaatgcagaaagtatgctttcaacatgctacagctgatggctttccccaagtactacagacctccagaggggacttatggaaaagctgacacctaagtttaccaacatgttaataaacaggaacacaaatacatttcagttggataatcttcaccttggtcttttttgtttgtttttattgtcatgaatttgtggtgggggagatgatcacagatgtttcccaaaatctaggaactacttcaattcatcatcagcatattgctctgaaagaaatccattttaaaaaatcttacatgattcagtactgtcatttctagttctaagcttctatgtgttgagcctagctgattgagattggttcacaaagtgtaaatttcattcatgagtatttaaatgtttctgaggaaacatggatcatttcaataggactaggggtgattcacagagcaccactctccaaccaaatggaagagaggagagggggaaaaggaacatattttttttgtgatacaacttaatagcctatgagaacacagtcaacctgagaatcaatgtaagggatttaaaaaaaatgtgtagccactcaattaggtagagttaactcatgatctggaatactgaggcagtttgcaggtatgttccacaatgatctctatcatccagtcaaggtgtgactcctcccttgcaacaggcatatgcatggagtgagtaaagtggtcaacagacctttcaaaaccatggcatcttttcagaactctgacttgggttgtgtgatctagctgtgaatgtagcaatatagaacgtttaatagaatgataagcaaaacactgcaatgatctaaaattacaaataaaataaaaatgaacaacattttgatacccaaaatgaaaattcccatcagcctgaactttatgttgtgaagttcatgaatgtcagtgaggtatctctgagatgtttcttagcagtcatcctggtgtaagcatgcagttatggcataggtttgtgtgtgttaataagcctttaaaacatatgcaaccacaacaaatgataaagtaaaacaattattttctgttgccctgaatatcaaacttgcccttgcccttactcagcaaaataacatttataagttttccaaaatcccaaagtagaagtttccttaaaaaaatcatcttgtataataccagtattcaaacatgggtaaggttaatcacccccaatcactcaggagatagttgcagaatttgaattacaatctcttcttactttcctagcctgtggcttgtcacttctccaaattgccatgctaaatatgcatgaaaattgagggagaatgctagttaaaaagaaattaggatttatcactggaattgaaactaagagtacaaaagtctgaacgaatgaaacttttctccaaattttacaaattcttgttcctttctcattagaagagcatgctatccaaagcataaatctcccttgaaaataacagaggcttcttaagccctctcttagctatgatcaatggatgatattatgcttcccatagctaatgtgatagctccttgcctaggattcctgttgaaataaggattctagccccatgttaagtttttcaaattactacaaattttagataagcatttggagctttttatactagaattatcaattttttattttagctaattacctgtgggcattatacttgaggcaggtaccaaactacttacagcctttttaatgaaaatgtgctgtgtactttgaatccattcatagacaaaattaccttgatgttctcttaactcattctttattttagtgattaaatacaacctttgagttgttcaatatcatttgaaaatggtaggatttgtggttattttcattaccctattagatttaagataggctgggatgacagaggcctccttgaat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//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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