LOCUS       NM_001384265             786 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus claudin 25 (Cldn25), mRNA.
ACCESSION   NM_001384265
VERSION     NM_001384265.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 786)
  AUTHORS   Tanaka H, Yamamoto Y, Kashihara H, Yamazaki Y, Tani K, Fujiyoshi Y,
            Mineta K, Takeuchi K, Tamura A and Tsukita S.
  TITLE     Claudin-21 Has a Paracellular Channel Role at Tight Junctions
  JOURNAL   Mol Cell Biol 36 (6), 954-964 (2016)
   PUBMED   26729464
  REMARK    GeneRIF: Claudin-21, which is more highly expressed in the
            embryonic than the postnatal stages, acts as a paracellular channel
            for small cations, such as Na(+), similar to the typical
            channel-type claudins claudin-2 and -15.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 786)
  AUTHORS   Mineta K, Yamamoto Y, Yamazaki Y, Tanaka H, Tada Y, Saito K, Tamura
            A, Igarashi M, Endo T, Takeuchi K and Tsukita S.
  TITLE     Predicted expansion of the claudin multigene family
  JOURNAL   FEBS Lett 585 (4), 606-612 (2011)
   PUBMED   21276448
REFERENCE   3  (bases 1 to 786)
  AUTHORS   Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J and Blasig
            IE.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160137.2.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-786               AC160137.2         175577-176362       c
FEATURES             Location/Qualifiers
     source          1..786
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 26.58 cM"
     gene            1..786
                     /gene="Cldn25"
                     /gene_synonym="Cldn21; Cldn21-ps; Cldn25-ps; Gm16492;
                     Gm513"
                     /note="claudin 25"
                     /db_xref="GeneID:100042785"
                     /db_xref="MGI:MGI:3642767"
     exon            1..786
                     /gene="Cldn25"
                     /gene_synonym="Cldn21; Cldn21-ps; Cldn25-ps; Gm16492;
                     Gm513"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..741
                     /gene="Cldn25"
                     /gene_synonym="Cldn21; Cldn21-ps; Cldn25-ps; Gm16492;
                     Gm513"
                     /note="claudin 21, pseudogene; claudin 25, pseudogene"
                     /codon_start=1
                     /product="putative claudin-25"
                     /protein_id="NP_001371194.1"
                     /db_xref="GeneID:100042785"
                     /db_xref="MGI:MGI:3642767"
                     /translation="

MACSFRGRVQLGGLLLSVLGWVCSCVTTVLPQWKTLTLDLNEMETWVSGLWEACVNQEEAGTVCKAFESFLSLPQELQVARILMVASHGLGLLGLLLSSCGLECFRFHRPGGVFKTRLCLLGGTLEASASATTLFPVSWVAYATFQDFWDDSIPEIVPRWEFGDALFLGWAAGLFLAVGGLLLIFSACLENEDGSSSWMADATAPQACAPVEEEFDGSFHLTPRPVNQVI"

     misc_feature    124..597
                     /gene="Cldn25"
                     /gene_synonym="Cldn21; Cldn21-ps; Cldn25-ps; Gm16492;
                     Gm513"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:451326"
ORIGIN      

gctgaccagtccctgagctcattatcccctcctccagagggcacaaccatggcctgtagcttccgtgggagagtccagcttggaggtctgctcctctctgtccttggctgggtgtgctcctgtgtcaccaccgttcttccccagtggaagactctcactctggatctgaatgaaatggaaacctgggtctcgggactctgggaggcatgcgtgaatcaggaggaagctggcactgtatgcaaagccttcgagtcgtttttgtctctgccccaagagctacaggtagcccgaattctcatggtggcttcccatgggctgggactattgggacttctgctgtctagctgcgggttggaatgcttccggtttcacaggcctggaggagttttcaagactcggctgtgcctcctgggagggactctggaagcatcagcttcagctactaccctctttccagtctcctgggtggcctatgccacatttcaagacttctgggatgacagcatccctgagattgtgccccggtgggagtttggagacgccttgttcctgggctgggctgctgggcttttcctagctgtgggtggactcctcctcatcttttcagcttgcctggaaaatgaagatggatcttcttcctggatggctgatgccacggccccacaagcctgtgctccagtagaggaagaatttgatggttccttccatctcacaccaagaccggtgaaccaggtcatctagagctacagtctgcctaggactctctataataaaggaatgccagta

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