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Previous release (v1)
2026-01-22 22:05:27, GGRNA.v2 : RefSeq release 232 (Sep, 2025)
LOCUS NM_001379454 2715 bp mRNA linear ROD 30-APR-2025
DEFINITION Mus musculus WASP family, member 1 (Wasf1), transcript variant 2,
mRNA.
ACCESSION NM_001379454 XM_006512933
VERSION NM_001379454.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 2715)
AUTHORS Zhang,Y., Kang,H.R., Jun,Y., Kang,H., Bang,G., Ma,R., Ju,S.,
Yoon,D.E., Kim,Y., Kim,K., Kim,J.Y. and Han,K.
TITLE Neurodevelopmental disorder-associated CYFIP2 regulates
membraneless organelles and eIF2alpha phosphorylation via protein
interactors and actin cytoskeleton
JOURNAL Hum Mol Genet 33 (19), 1671-1687 (2024)
PUBMED 38981622
REFERENCE 2 (bases 1 to 2715)
AUTHORS Longatti,A., Ponzoni,L., Moretto,E., Giansante,G., Lattuada,N.,
Colombo,M.N., Francolini,M., Sala,M., Murru,L. and Passafaro,M.
TITLE Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting
Hippocampal Glutamatergic Synapses and Cognition in Mice
JOURNAL Mol Neurobiol 58 (12), 6092-6110 (2021)
PUBMED 34455539
REFERENCE 3 (bases 1 to 2715)
AUTHORS Zhang,Y., Kang,H., Lee,Y., Kim,Y., Lee,B., Kim,J.Y., Jin,C.,
Kim,S., Kim,H. and Han,K.
TITLE Smaller Body Size, Early Postnatal Lethality, and Cortical
Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null
Embryonic Mice
JOURNAL Front Mol Neurosci 11, 482 (2019)
PUBMED 30687000
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 2715)
AUTHORS Chen,Y., Milenkovic,M., Horsfall,W., Salahpour,A., Soderling,S.H.
and Ramsey,A.J.
TITLE Restoring striatal WAVE-1 improves maze exploration performance of
GluN1 knockdown mice
JOURNAL PLoS One 13 (10), e0199341 (2018)
PUBMED 30352064
REMARK GeneRIF: WAVE-1 restoration improves maze exploration performance
of GluN1 knockdown mice
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 2715)
AUTHORS Fan,L., Lu,Y., Shen,X., Shao,H., Suo,L. and Wu,Q.
TITLE Alpha protocadherins and Pyk2 kinase regulate cortical neuron
migration and cytoskeletal dynamics via Rac1 GTPase and WAVE
complex in mice
JOURNAL Elife 7, e35242 (2018)
PUBMED 29911975
REMARK GeneRIF: Data indicate a molecular protocadherin alpha
(Pcdhalpha)/Wiskott-Aldrich syndrome potein Family
(WAVE)/proline-rich tyrosine kinase 2 (Pyk2)/Rac1 axis from
protocadherin cell-surface receptors to actin cytoskeletal dynamics
in cortical neuron migration and dendrite morphogenesis in mouse
brain.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2715)
AUTHORS Soderling,S.H., Langeberg,L.K., Soderling,J.A., Davee,S.M.,
Simerly,R., Raber,J. and Scott,J.D.
TITLE Loss of WAVE-1 causes sensorimotor retardation and reduced learning
and memory in mice
JOURNAL Proc Natl Acad Sci U S A 100 (4), 1723-1728 (2003)
PUBMED 12578964
REMARK GeneRIF: role in causing sensorimotor retardation and reduced
learning and memory in mice
REFERENCE 7 (bases 1 to 2715)
AUTHORS Benachenhou,N., Massy,I. and Vacher,J.
TITLE Characterization and expression analyses of the mouse
Wiskott-Aldrich syndrome protein (WASP) family member Wave1/Scar
JOURNAL Gene 290 (1-2), 131-140 (2002)
PUBMED 12062808
REFERENCE 8 (bases 1 to 2715)
AUTHORS Chalhoub,N., Benachenhou,N. and Vacher,J.
TITLE Physical and transcriptional map of the mouse Chromosome 10
proximal region syntenic to human 6q16-q21
JOURNAL Mamm Genome 12 (12), 887-892 (2001)
PUBMED 11707774
REFERENCE 9 (bases 1 to 2715)
AUTHORS Westphal,R.S., Soderling,S.H., Alto,N.M., Langeberg,L.K. and
Scott,J.D.
TITLE Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an
actin-associated multi-kinase scaffold
JOURNAL EMBO J 19 (17), 4589-4600 (2000)
PUBMED 10970852
REFERENCE 10 (bases 1 to 2715)
AUTHORS Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
TITLE Exchangeable gene trap using the Cre/mutated lox system
JOURNAL Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
PUBMED 10512203
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC174452.2.
On Apr 3, 2020 this sequence version replaced XM_006512933.3.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR7345562.2067443.1,
SRR7652917.1221145.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849381, SAMN01164131
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-244 AC174452.2 112685-112928 c
245-405 AC174452.2 76347-76507 c
406-540 AC174452.2 70137-70271 c
541-694 AC174452.2 65971-66124 c
695-812 AC174452.2 64722-64839 c
813-982 AC174452.2 63470-63639 c
983-1162 AC174452.2 62099-62278 c
1163-1791 AC174452.2 60017-60645 c
1792-2715 AC174452.2 58186-59109 c
FEATURES Location/Qualifiers
source 1..2715
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="10"
/map="10 22.07 cM"
gene 1..2715
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="WASP family, member 1"
/db_xref="GeneID:83767"
/db_xref="MGI:MGI:1890563"
exon 1..244
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 245..405
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
misc_feature 246..248
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="upstream in-frame stop codon"
CDS 273..1949
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="isoform 2 is encoded by transcript variant 2;
wiskott-Aldrich syndrome protein family member 1; protein
WAVE-1; WASP family protein member 1; WASP family 1; WAS
protein family, member 1; actin-binding protein WASF1"
/codon_start=1
/product="actin-binding protein WASF1 isoform 2"
/protein_id="NP_001366383.1"
/db_xref="GeneID:83767"
/db_xref="MGI:MGI:1890563"
/translation="
MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQKKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDADLLHKHIEVANGPASHYETRPQTYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPTPTCISSATGLIENRPQSPAAGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVAVAALAHPPSGLHPAPSTAPGPHAPLMPPSPPSQVLPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIAVEYSDSEDDSEFDEVDWLE"
misc_feature 1086..1469
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1290..1292
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="Asymmetric dimethylarginine, alternate.
/evidence=ECO:0007744|PubMed:24129315;
Omega-N-methylarginine, alternate.
/evidence=ECO:0007744|PubMed:24129315; propagated from
UniProtKB/Swiss-Prot (Q8R5H6.2); methylation site"
misc_feature <1452..>1736
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="Topoisomerase II-associated protein PAT1; Region:
PAT1; pfam09770"
/db_xref="CDD:401645"
misc_feature 1503..1742
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1722..1946
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="Wiskott Aldrich syndrome homology region 2 (WH2
motif) found in Wiskott-Aldrich Syndrome Protein Family
Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1); Region:
WH2_WAVE-1; cd22071"
/db_xref="CDD:409214"
misc_feature 1734..1736
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q92558; propagated from
UniProtKB/Swiss-Prot (Q8R5H6.2); phosphorylation site"
misc_feature order(1758..1763,1767..1775,1779..1787,1800..1811)
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="actin-binding motif [polypeptide binding]; other
site"
/db_xref="CDD:409214"
misc_feature order(1761..1766,1770..1775,1782..1787,1803..1808,
1860..1865,1872..1877,1884..1886,1896..1898)
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="Nap1 binding interface [polypeptide binding]; other
site"
/db_xref="CDD:409214"
misc_feature 1800..1811
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="actin-binding sequence [structural motif]; Region:
actin-binding sequence"
/db_xref="CDD:409214"
exon 406..540
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 541..694
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 695..812
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 813..982
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 983..1162
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 1163..1791
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
exon 1792..2715
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/inference="alignment:Splign:2.1.0"
regulatory 2692..2697
/regulatory_class="polyA_signal_sequence"
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="hexamer: AATAAA"
polyA_site 2715
/gene="Wasf1"
/gene_synonym="Scar; WAVE; WAVE-1"
/note="major polyA site"
ORIGIN
agggcagcggctgctcgcggtgttgttcgctcgcgcgtcgagcgcaccgcggctcgggcgagcagtgggcgcccccggcggcattcccggcggcccggcgcctcagccagtgcccggcgcggcttccatcccgcagcccgacgctcccgaggggctcctggtggcgccccagtgcggagccggaccggcggcagccgccgaagcatgtagaaggggtacggcgcgagccccccacggtttcgcggtgagctggttcagtggctgagctcaagatgccgttggtgaaaagaaacatcgaccctcggcacttgtgccacacagcactgcccaggggcattaagaacgaactggaatgtgtaaccaacatttccctggcaaatataattagacaactgagtagcctaagtaagtatgctgaagacatatttggagaattattcaatgaagcacacagtttttccttcagagttaactcgttgcaagagcgcgtggaccgattgtctgttagtgtcacacagcttgatcctaaggaggaagaactgtctttgcaagatataacgatgagaaaggctttccggagctccacaattcaagatcagcagcttttcgaccgcaagacgttgcctattccattgcaagaaacatacgatgtgtgtgagcaacctccgcctctcaatatcctcaccccttacagggatgatggtaaggaagggctgaagttttataccaatccttcatatttctttgatctgtggaaagaaaagatgttgcaagatacagaggacaagaggaaggaaaagagaaagcagaagaaaaatctagaccgtcctcatgaaccagagaaagtgccaagagcacctcatgacaggcggcgggaatggcagaagctggcccaaggtccagagctggctgaggatgacgctgacctcctacacaagcatattgaagttgccaatggcccagcctctcattatgagacaaggccacagacatacgtggatcatatggacggatcgtactcactctctgccttgccattcagtcagatgagtgaacttctgaccagagctgaggagagggtcttagtcagaccccatgaacctcctccgcctccaccaatgcatggagcaggagatgcaaagcccacacccacctgtatcagttctgctacaggtttgatagagaatcgcccccagtccccagctgcaggcagaacacctgtgtttgtgagccccactcccccacctcctcccccacctcttccgtctgccttgtccacttcttcactaagagcttcaatgacctcaactcctcccccaccagtccctcctccgcctcctcccccagccactgctttgcaggccccagcagtgcccccacctccggctcctcttcagattgcccctggtgttcttcacccagctcctcctccaattgctcctcctctagtgcagccctctcccccagtagctcgagctgccccagtatgcgagactgtgccagttcacccactcccgcaaggtgaagtgcaggggctgcctccacccccaccaccgcctcctctacctccgcctggcatccggccatcatctcctgtcgcagttgcagctcttgctcatcctccctctgggctccatccagcaccatctactgccccgggtccccatgctccattaatgcctccatctcctccatcacaagttctacctgcctctgagccaaagcgccatccatccaccctgcctgtaatcagtgacgcaaggagtgtgctgctggaagccatccgaaaaggtattcagcttcgcaaagtggaagagcagcgtgaacaggaagcaaaacacgagcggattgaaaacgacgtggccaccatcctgtctcgccgcattgctgtggagtatagcgactcggaagatgactcggagttcgatgaagtagactggctggagtaagaaagccacagtgacttggaagatgactcggagttcgatgaagtagactggatggagtaagacagccgccttgctctgtattgcaaggctgaatgcacatgtccctcgtggcgcttgttctttgaaaatgttcggtcattctagtgttttgcttcctattcctcataatgaataacccttttcctccattatttttgatttctatgaaaagtattagcatatatttcaaactaaatattttgtggcttaccttaatttttccccctggaaaaatataatttggtccaataaactactaagtattaagcatggaaagccgttattagagtagcagattcagtttttgatattccttaattgtgcactttgtgatttttttttttttttttaaatttgaagaacgcaactgagactggaatcttgaaggcagctgtgtctgggaacgagccttattccgtttcttgatgttttaaatgaagaaacactgcctcgattatatgaatacactcagaaggaacatgtagcttgtagtgttgaattctcttaaaggaatggttagctttggttatcattttgttgtttttgaatacttgccttatttgaacgtttagcagaaccccttcccacttatatattgtgtggtacagttttgcttgcctatagaagtttaaatttttccatgtgaaatactcagaataagcatatgtgtgacttacataatgtgagaattacaatctgatgtaataaacggttcattttaaaggct
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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