2024-05-02 15:21:31, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001379453 2718 bp mRNA linear ROD 28-DEC-2022 DEFINITION Mus musculus WASP family, member 1 (Wasf1), transcript variant 3, mRNA. ACCESSION NM_001379453 XM_006512932 VERSION NM_001379453.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 2718) AUTHORS Longatti A, Ponzoni L, Moretto E, Giansante G, Lattuada N, Colombo MN, Francolini M, Sala M, Murru L and Passafaro M. TITLE Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice JOURNAL Mol Neurobiol 58 (12), 6092-6110 (2021) PUBMED 34455539 REFERENCE 2 (bases 1 to 2718) AUTHORS Zhang Y, Kang H, Lee Y, Kim Y, Lee B, Kim JY, Jin C, Kim S, Kim H and Han K. TITLE Smaller Body Size, Early Postnatal Lethality, and Cortical Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null Embryonic Mice JOURNAL Front Mol Neurosci 11, 482 (2019) PUBMED 30687000 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 2718) AUTHORS Chen Y, Milenkovic M, Horsfall W, Salahpour A, Soderling SH and Ramsey AJ. TITLE Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice JOURNAL PLoS One 13 (10), e0199341 (2018) PUBMED 30352064 REMARK GeneRIF: WAVE-1 restoration improves maze exploration performance of GluN1 knockdown mice Publication Status: Online-Only REFERENCE 4 (bases 1 to 2718) AUTHORS Fan L, Lu Y, Shen X, Shao H, Suo L and Wu Q. TITLE Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice JOURNAL Elife 7, e35242 (2018) PUBMED 29911975 REMARK GeneRIF: Data indicate a molecular protocadherin alpha (Pcdhalpha)/Wiskott-Aldrich syndrome potein Family (WAVE)/proline-rich tyrosine kinase 2 (Pyk2)/Rac1 axis from protocadherin cell-surface receptors to actin cytoskeletal dynamics in cortical neuron migration and dendrite morphogenesis in mouse brain. Publication Status: Online-Only REFERENCE 5 (bases 1 to 2718) AUTHORS Ceglia I, Lee KW, Cahill ME, Graves SM, Dietz D, Surmeier DJ, Nestler EJ, Nairn AC, Greengard P and Kim Y. TITLE WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine JOURNAL Proc Natl Acad Sci U S A 114 (6), 1395-1400 (2017) PUBMED 28115704 REMARK GeneRIF: Wiskott-Aldrich syndrome protein family (WAVE1) knocked out (KO) in neurons expressing the D1 dopamine receptor (D1-KO) exhibited a significant decrease in place preference associated with cocaine. REFERENCE 6 (bases 1 to 2718) AUTHORS Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J and Scott JD. TITLE Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice JOURNAL Proc Natl Acad Sci U S A 100 (4), 1723-1728 (2003) PUBMED 12578964 REMARK GeneRIF: role in causing sensorimotor retardation and reduced learning and memory in mice REFERENCE 7 (bases 1 to 2718) AUTHORS Benachenhou N, Massy I and Vacher J. TITLE Characterization and expression analyses of the mouse Wiskott-Aldrich syndrome protein (WASP) family member Wave1/Scar JOURNAL Gene 290 (1-2), 131-140 (2002) PUBMED 12062808 REFERENCE 8 (bases 1 to 2718) AUTHORS Chalhoub N, Benachenhou N and Vacher J. TITLE Physical and transcriptional map of the mouse Chromosome 10 proximal region syntenic to human 6q16-q21 JOURNAL Mamm Genome 12 (12), 887-892 (2001) PUBMED 11707774 REFERENCE 9 (bases 1 to 2718) AUTHORS Westphal RS, Soderling SH, Alto NM, Langeberg LK and Scott JD. TITLE Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold JOURNAL EMBO J 19 (17), 4589-4600 (2000) PUBMED 10970852 REFERENCE 10 (bases 1 to 2718) AUTHORS Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki M, Miura K, Araki M and Yamamura K. TITLE Exchangeable gene trap using the Cre/mutated lox system JOURNAL Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999) PUBMED 10512203 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC174452.2. On Apr 3, 2020 this sequence version replaced XM_006512932.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.4262466.1, SRR7652917.988268.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-244 AC174452.2 112685-112928 c 245-405 AC174452.2 76347-76507 c 406-540 AC174452.2 70137-70271 c 541-694 AC174452.2 65971-66124 c 695-812 AC174452.2 64722-64839 c 813-985 AC174452.2 63470-63642 c 986-1165 AC174452.2 62099-62278 c 1166-1794 AC174452.2 60017-60645 c 1795-2718 AC174452.2 58186-59109 c FEATURES Location/Qualifiers source 1..2718 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="10" /map="10 22.07 cM" gene 1..2718 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="WASP family, member 1" /db_xref="GeneID:83767" /db_xref="MGI:MGI:1890563" exon 1..244 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 245..405 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" misc_feature 246..248 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="upstream in-frame stop codon" CDS 273..1952 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="isoform 1 is encoded by transcript variant 3; wiskott-Aldrich syndrome protein family member 1; protein WAVE-1; WASP family protein member 1; WASP family 1; WAS protein family, member 1; actin-binding protein WASF1" /codon_start=1 /product="actin-binding protein WASF1 isoform 1" /protein_id="NP_001366382.1" /db_xref="GeneID:83767" /db_xref="MGI:MGI:1890563" /translation="
MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQKQKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDADLLHKHIEVANGPASHYETRPQTYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPPPPPMHGAGDAKPTPTCISSATGLIENRPQSPAAGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVAVAALAHPPSGLHPAPSTAPGPHAPLMPPSPPSQVLPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIAVEYSDSEDDSEFDEVDWLE"
misc_feature 780..878 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1089..1472 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1293..1295 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="Asymmetric dimethylarginine, alternate. /evidence=ECO:0007744|PubMed:24129315; Omega-N-methylarginine, alternate. /evidence=ECO:0007744|PubMed:24129315; propagated from UniProtKB/Swiss-Prot (Q8R5H6.2); methylation site" misc_feature 1506..1745 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="propagated from UniProtKB/Swiss-Prot (Q8R5H6.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1725..1949 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 1 (WASP1 or WAVE1 or WASF1 or SCAR1); Region: WH2_WAVE-1; cd22071" /db_xref="CDD:409214" misc_feature 1737..1739 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q92558; propagated from UniProtKB/Swiss-Prot (Q8R5H6.2); phosphorylation site" misc_feature order(1761..1766,1770..1778,1782..1790,1803..1814) /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="actin-binding motif [polypeptide binding]; other site" /db_xref="CDD:409214" misc_feature order(1764..1769,1773..1778,1785..1790,1806..1811, 1863..1868,1875..1880,1887..1889,1899..1901) /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="Nap1 binding interface [polypeptide binding]; other site" /db_xref="CDD:409214" misc_feature 1803..1814 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /note="actin-binding sequence [structural motif]; Region: actin-binding sequence" /db_xref="CDD:409214" exon 406..540 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 541..694 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 695..812 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 813..985 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 986..1165 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 1166..1794 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" exon 1795..2718 /gene="Wasf1" /gene_synonym="Scar; WAVE; WAVE-1" /inference="alignment:Splign:2.1.0" ORIGIN
agggcagcggctgctcgcggtgttgttcgctcgcgcgtcgagcgcaccgcggctcgggcgagcagtgggcgcccccggcggcattcccggcggcccggcgcctcagccagtgcccggcgcggcttccatcccgcagcccgacgctcccgaggggctcctggtggcgccccagtgcggagccggaccggcggcagccgccgaagcatgtagaaggggtacggcgcgagccccccacggtttcgcggtgagctggttcagtggctgagctcaagatgccgttggtgaaaagaaacatcgaccctcggcacttgtgccacacagcactgcccaggggcattaagaacgaactggaatgtgtaaccaacatttccctggcaaatataattagacaactgagtagcctaagtaagtatgctgaagacatatttggagaattattcaatgaagcacacagtttttccttcagagttaactcgttgcaagagcgcgtggaccgattgtctgttagtgtcacacagcttgatcctaaggaggaagaactgtctttgcaagatataacgatgagaaaggctttccggagctccacaattcaagatcagcagcttttcgaccgcaagacgttgcctattccattgcaagaaacatacgatgtgtgtgagcaacctccgcctctcaatatcctcaccccttacagggatgatggtaaggaagggctgaagttttataccaatccttcatatttctttgatctgtggaaagaaaagatgttgcaagatacagaggacaagaggaaggaaaagagaaagcagaagcagaaaaatctagaccgtcctcatgaaccagagaaagtgccaagagcacctcatgacaggcggcgggaatggcagaagctggcccaaggtccagagctggctgaggatgacgctgacctcctacacaagcatattgaagttgccaatggcccagcctctcattatgagacaaggccacagacatacgtggatcatatggacggatcgtactcactctctgccttgccattcagtcagatgagtgaacttctgaccagagctgaggagagggtcttagtcagaccccatgaacctcctccgcctccaccaatgcatggagcaggagatgcaaagcccacacccacctgtatcagttctgctacaggtttgatagagaatcgcccccagtccccagctgcaggcagaacacctgtgtttgtgagccccactcccccacctcctcccccacctcttccgtctgccttgtccacttcttcactaagagcttcaatgacctcaactcctcccccaccagtccctcctccgcctcctcccccagccactgctttgcaggccccagcagtgcccccacctccggctcctcttcagattgcccctggtgttcttcacccagctcctcctccaattgctcctcctctagtgcagccctctcccccagtagctcgagctgccccagtatgcgagactgtgccagttcacccactcccgcaaggtgaagtgcaggggctgcctccacccccaccaccgcctcctctacctccgcctggcatccggccatcatctcctgtcgcagttgcagctcttgctcatcctccctctgggctccatccagcaccatctactgccccgggtccccatgctccattaatgcctccatctcctccatcacaagttctacctgcctctgagccaaagcgccatccatccaccctgcctgtaatcagtgacgcaaggagtgtgctgctggaagccatccgaaaaggtattcagcttcgcaaagtggaagagcagcgtgaacaggaagcaaaacacgagcggattgaaaacgacgtggccaccatcctgtctcgccgcattgctgtggagtatagcgactcggaagatgactcggagttcgatgaagtagactggctggagtaagaaagccacagtgacttggaagatgactcggagttcgatgaagtagactggatggagtaagacagccgccttgctctgtattgcaaggctgaatgcacatgtccctcgtggcgcttgttctttgaaaatgttcggtcattctagtgttttgcttcctattcctcataatgaataacccttttcctccattatttttgatttctatgaaaagtattagcatatatttcaaactaaatattttgtggcttaccttaatttttccccctggaaaaatataatttggtccaataaactactaagtattaagcatggaaagccgttattagagtagcagattcagtttttgatattccttaattgtgcactttgtgatttttttttttttttttaaatttgaagaacgcaactgagactggaatcttgaaggcagctgtgtctgggaacgagccttattccgtttcttgatgttttaaatgaagaaacactgcctcgattatatgaatacactcagaaggaacatgtagcttgtagtgttgaattctcttaaaggaatggttagctttggttatcattttgttgtttttgaatacttgccttatttgaacgtttagcagaaccccttcccacttatatattgtgtggtacagttttgcttgcctatagaagtttaaatttttccatgtgaaatactcagaataagcatatgtgtgacttacataatgtgagaattacaatctgatgtaataaacggttcattttaaaggct
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]