LOCUS       NM_001292315            1679 bp    mRNA    linear   VRT 18-JUL-2021
DEFINITION  Callorhinchus milii homeobox B8a (hoxb8a), mRNA.
ACCESSION   NM_001292315 XM_007904373
VERSION     NM_001292315.1
KEYWORDS    RefSeq.
SOURCE      Callorhinchus milii (elephant shark)
  ORGANISM  Callorhinchus milii
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
            Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus.
REFERENCE   1  (bases 1 to 1679)
  AUTHORS   Tan YY, Kodzius R, Tay BH, Tay A, Brenner S and Venkatesh B.
  TITLE     Sequencing and analysis of full-length cDNAs, 5'-ESTs and 3'-ESTs
            from a cartilaginous fish, the elephant shark (Callorhinchus milii)
  JOURNAL   PLoS ONE 7 (10), e47174 (2012)
   PUBMED   23056606
REFERENCE   2  (bases 1 to 1679)
  AUTHORS   Ravi V, Lam K, Tay BH, Tay A, Brenner S and Venkatesh B.
  TITLE     Elephant shark (Callorhinchus milii) provides insights into the
            evolution of Hox gene clusters in gnathostomes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 106 (38), 16327-16332 (2009)
   PUBMED   19805301
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from JX053006.1.
            
            On May 23, 2014 this sequence version replaced XM_007904373.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JX053006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02699932 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1679
                     /organism="Callorhinchus milii"
                     /mol_type="mRNA"
                     /db_xref="taxon:7868"
     gene            1..1679
                     /gene="hoxb8a"
                     /gene_synonym="hoxb8"
                     /note="homeobox B8a"
                     /db_xref="GeneID:103185721"
     exon            1..759
                     /gene="hoxb8a"
                     /gene_synonym="hoxb8"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    321..323
                     /gene="hoxb8a"
                     /gene_synonym="hoxb8"
                     /note="upstream in-frame stop codon"
     CDS             333..1043
                     /gene="hoxb8a"
                     /gene_synonym="hoxb8"
                     /note="homeobox protein HoxB8; homeobox B8"
                     /codon_start=1
                     /product="homeobox protein Hox-B8a"
                     /protein_id="NP_001279244.1"
                     /db_xref="GeneID:103185721"
                     /translation="

MSSYFVNSLFSKYKSGETLRPSYYDCGFTSDLSGRPTVVYGPGTGGSFQHPSQIQEFYHHGASSLSTSAYQQNPCAVTCHGDPGNFYGYDALQRQPIFAAQQETDLIQYSDCKSTANSLGEEAEHSEQSSSPTQLFPWMRPQVAGGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKSESEETPKEKEGKEEPEEEKD"

     misc_feature    order(774..788,792..794,843..845,861..863,900..902,
                     906..911,918..923,927..935,939..944)
                     /gene="hoxb8a"
                     /gene_synonym="hoxb8"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(780..782,789..791,909..911,918..923,930..932)
                     /gene="hoxb8a"
                     /gene_synonym="hoxb8"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    783..941
                     /gene="hoxb8a"
                     /gene_synonym="hoxb8"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     exon            760..1679
                     /gene="hoxb8a"
                     /gene_synonym="hoxb8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cattccctctctctctcaccattcctctttcacgaggtgcggtgtccgtacggagtaagcgaagccaataggacgtggttgaggtaataaatgcaaattatcacgaaaagagactgcaaaatatgaaacaactcatttgggctgaagtaaatcacagaaaactgtttatgaggtgcacctctccacaatgatgtgatccaagaacattgtatatggcaatcaataggatgaaggcgtaattttaacatttgtttttgtttgttcgcctcatagactgtgcactaaagcactaagttgcttcctttgtacagagacacttttaattcttcccaatgagctcgtactttgtgaattcgctgttttctaagtataaaagtggggagactttgcgccccagttattatgactgtggcttcacttcggatctcagcggcagacccaccgtggtttatggacccggcaccgggggaagcttccagcatccaagccagattcaggagttttaccaccatggagcatcttccctctctacctccgcgtatcaacaaaatccatgtgccgtgacgtgtcacggggatcccggcaatttctacggctacgatgctttgcagagacagccaattttcgccgcccaacaagagaccgacctgatccaatattccgattgcaaatcaaccgccaacagcttaggagaagaggcagagcattcagagcagagttcctctccaacgcagctctttccctggatgagaccgcaagtagctggaggaaggcggagaggcagacagacctacagccgctatcagacactagaacttgaaaaggaatttttgttcaatccctacctgacccgcaaaagacggatcgaagtatcacacgccctgggactgaccgagaggcaagtcaaaatttggttccagaaccgacgaatgaaatggaagaaagagaacaacaaagacaagtttccaagcagcaagtctgaatcagaagagactccgaaggagaaggagggtaaagaagaaccagaggaagaaaaagattaataaactaataactcaaaacatttaacaaaagtggtgataaatagaatgatgtagacagattttaaaaagagaaatccgaacaaattttattgattgccgtttgatactaaatattgtacgaaaatgtattgaggtgtagagtaaatgaacatttcaactttttaccaggtgtaaacattgcgtagtgtaacatgctatttgttttaagtgggttcttgtaacatcgtttaatgtgaagtttttgggaagcgtgcgctagtgtgtgttgatgctttgactgctctagaatattcaagccaagtgtgcactatttcagctaataatcattagcttaaaagagaataaaacaacccaacaacatgaagctgcctatttagattttctagattgtgttattgtttacgtctgtactgtatttataagaatgtttccagttgggatgtgcaaagtggagataggttttttaaggaaaaaagtgatccttaaaaattttaactgtgagaaaagtctactgtacacgttacttgcttttatggggagggccggtgctgcattattgttatacataaggtcggtctgttgtttgaacgcgcaagcggcggaaaaggacacaataaactttacaagcgaaaacgt

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