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Previous release (v1)
2025-07-10 17:11:20, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_001271193 3150 bp mRNA linear ROD 31-MAR-2024
DEFINITION Rattus norvegicus argonaute RISC catalytic component 3 (Ago3),
mRNA.
ACCESSION NM_001271193 XM_001058231
VERSION NM_001271193.1
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3150)
AUTHORS Park,M.S., Phan,H.D., Busch,F., Hinckley,S.H., Brackbill,J.A.,
Wysocki,V.H. and Nakanishi,K.
TITLE Human Argonaute3 has slicer activity
JOURNAL Nucleic Acids Res 45 (20), 11867-11877 (2017)
PUBMED 29040713
REFERENCE 2 (bases 1 to 3150)
AUTHORS Sun,S., Ma,J., Zhang,Q., Wang,Q., Zhou,L., Bai,F., Hu,H., Chang,P.,
Yu,J. and Gao,B.
TITLE Argonaute proteins in cardiac tissue contribute to the heart injury
during viral myocarditis
JOURNAL Cardiovasc Pathol 25 (2), 120-126 (2016)
PUBMED 26764146
REFERENCE 3 (bases 1 to 3150)
AUTHORS Hu,Q., Tanasa,B., Trabucchi,M., Li,W., Zhang,J., Ohgi,K.A.,
Rose,D.W., Glass,C.K. and Rosenfeld,M.G.
TITLE DICER- and AGO3-dependent generation of retinoic acid-induced DR2
Alu RNAs regulates human stem cell proliferation
JOURNAL Nat Struct Mol Biol 19 (11), 1168-1175 (2012)
PUBMED 23064648
REFERENCE 4 (bases 1 to 3150)
AUTHORS Gu,S., Jin,L., Huang,Y., Zhang,F. and Kay,M.A.
TITLE Slicing-independent RISC activation requires the argonaute PAZ
domain
JOURNAL Curr Biol 22 (16), 1536-1542 (2012)
PUBMED 22795694
REFERENCE 5 (bases 1 to 3150)
AUTHORS Modzelewski,A.J., Holmes,R.J., Hilz,S., Grimson,A. and Cohen,P.E.
TITLE AGO4 regulates entry into meiosis and influences silencing of sex
chromosomes in the male mouse germline
JOURNAL Dev Cell 23 (2), 251-264 (2012)
PUBMED 22863743
REFERENCE 6 (bases 1 to 3150)
AUTHORS Yoda,M., Kawamata,T., Paroo,Z., Ye,X., Iwasaki,S., Liu,Q. and
Tomari,Y.
TITLE ATP-dependent human RISC assembly pathways
JOURNAL Nat Struct Mol Biol 17 (1), 17-23 (2010)
PUBMED 19966796
REFERENCE 7 (bases 1 to 3150)
AUTHORS Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
TITLE Defining the membrane proteome of NK cells
JOURNAL J Mass Spectrom 45 (1), 1-25 (2010)
PUBMED 19946888
REFERENCE 8 (bases 1 to 3150)
AUTHORS Chi,S.W., Zang,J.B., Mele,A. and Darnell,R.B.
TITLE Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
JOURNAL Nature 460 (7254), 479-486 (2009)
PUBMED 19536157
REFERENCE 9 (bases 1 to 3150)
AUTHORS Wu,L., Fan,J. and Belasco,J.G.
TITLE Importance of translation and nonnucleolytic ago proteins for
on-target RNA interference
JOURNAL Curr Biol 18 (17), 1327-1332 (2008)
PUBMED 18771919
REFERENCE 10 (bases 1 to 3150)
AUTHORS Meister,G., Landthaler,M., Patkaniowska,A., Dorsett,Y., Teng,G. and
Tuschl,T.
TITLE Human Argonaute2 mediates RNA cleavage targeted by miRNAs and
siRNAs
JOURNAL Mol Cell 15 (2), 185-197 (2004)
PUBMED 15260970
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000005.1.
On Sep 6, 2012 this sequence version replaced XM_001058231.3.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR26360172.2219688.1,
SRR26360176.2406544.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760386 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-270 JAXUCZ010000005.1 143998468-143998737 c
271-442 JAXUCZ010000005.1 143986344-143986515 c
443-563 JAXUCZ010000005.1 143977859-143977979 c
564-772 JAXUCZ010000005.1 143975791-143975999 c
773-909 JAXUCZ010000005.1 143974762-143974898 c
910-1044 JAXUCZ010000005.1 143953355-143953489 c
1045-1132 JAXUCZ010000005.1 143948438-143948525 c
1133-1280 JAXUCZ010000005.1 143948176-143948323 c
1281-1400 JAXUCZ010000005.1 143946859-143946978 c
1401-1523 JAXUCZ010000005.1 143945539-143945661 c
1524-1657 JAXUCZ010000005.1 143944724-143944857 c
1658-1842 JAXUCZ010000005.1 143942851-143943035 c
1843-2002 JAXUCZ010000005.1 143936816-143936975 c
2003-2093 JAXUCZ010000005.1 143935184-143935274 c
2094-2288 JAXUCZ010000005.1 143932288-143932482 c
2289-2423 JAXUCZ010000005.1 143931441-143931575 c
2424-2525 JAXUCZ010000005.1 143929492-143929593 c
2526-2725 JAXUCZ010000005.1 143927656-143927855 c
2726-3150 JAXUCZ010000005.1 143926489-143926913 c
FEATURES Location/Qualifiers
source 1..3150
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="5"
/map="5q36"
gene 1..3150
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="argonaute RISC catalytic component 3"
/db_xref="GeneID:313593"
/db_xref="RGD:1309163"
exon 1..270
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
misc_feature 249..251
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="upstream in-frame stop codon"
CDS 252..2834
/gene="Ago3"
/gene_synonym="Eif2c3"
/EC_number="3.1.26.n2"
/note="eukaryotic translation initiation factor 2C, 3;
argonaute 3, RISC catalytic component"
/codon_start=1
/product="protein argonaute-3"
/protein_id="NP_001258122.1"
/db_xref="GeneID:313593"
/db_xref="RGD:1309163"
/translation="
MEIGSAGPIGAQPLLIVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSVKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"
misc_feature 468..752
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="N-terminal domain of argonaute; Region: ArgoN;
pfam16486"
/db_xref="CDD:465134"
misc_feature 780..932
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="Argonaute linker 1 domain; Region: ArgoL1;
pfam08699"
/db_xref="CDD:462567"
misc_feature 933..1295
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="PAZ domain, argonaute_like subfamily. Argonaute is
part of the RNA-induced silencing complex (RISC), and is
an endonuclease that plays a key role in the RNA
interference pathway. The PAZ domain has been named after
the proteins Piwi,Argonaut, and Zwille; Region:
PAZ_argonaute_like; cd02846"
/db_xref="CDD:239212"
misc_feature order(1089..1091,1134..1136,1176..1178,1188..1190,
1242..1244,1263..1265,1269..1271)
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="nucleic acid-binding interface [nucleotide
binding]; other site"
/db_xref="CDD:239212"
misc_feature 1428..2705
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="PIWI domain, Argonaute-like subfamily. Argonaute is
the central component of the RNA-induced silencing complex
(RISC) and related complexes. The PIWI domain is the
C-terminal portion of Argonaute and consists of two
subdomains, one of which provides the...; Region:
Piwi_ago-like; cd04657"
/db_xref="CDD:240015"
misc_feature order(1839..1841,1851..1853,1887..1898,1905..1907,
1929..1931,1938..1940,1950..1952,1962..1964)
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="5' RNA guide strand anchoring site [active]"
/db_xref="CDD:240015"
misc_feature order(2043..2045,2049..2051,2259..2261,2673..2675)
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="active site"
/db_xref="CDD:240015"
exon 271..442
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 443..563
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 564..772
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 773..909
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 910..1044
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1045..1132
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1133..1280
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1281..1400
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1401..1523
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1524..1657
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1658..1842
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1843..2002
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 2003..2093
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 2094..2288
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 2289..2423
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 2424..2525
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 2526..2725
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 2726..3150
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
ORIGIN
gacccgggagagcgaaaagcggcggcggcggggcggctggagggtcccggaggtgcgcgcgtcagcagctgtaggcgacgcaagttccggacccggcttcagcgtcctcacctcaggactgtcgccgctcttaccttgctgctgactgtctccggacagtgcctcttctgcctggagctttcagagggcgtccgctcctcacctctgtggtggcacctttctcttgtgaagcactccccacagctccatgaatggaaatcggctccgcaggacccattggggcccagcccctactcatagtgcccagaagacctgggtatggcactatgggcaaacccattaaactgttggctaactgttttcaagttgaaatcccaaagatcgatgtctacctctatgaggtcgacatcaaacccgacaagtgtcctcgaagagtgaacagagaagtagttgactcaatggttcagcattttaaagtgactatatttggagaccgtagaccagtttatgatggaaaaagaagcctttacacagccaatccacttcctgtggcaactactggggtagatttagatgttactttacctggggaaggtggaaaagatcgccctttcaaggtgtcagtgaagtttgtgtccagagtcagttggcacctactacatgaagttctgactggtcggactttgcctgagccactggaattagacaagccaatcagcactaacccggtccatgccgttgatgtggtgctccgacatctgccctctatgaaatatacgcctgtggggcgctcctttttctcagctccagaaggatacgaccaccctcttggagggggcagggaagtatggtttggattccatcaatctgttcggcctgccatgtggaaaatgatgctcaatattgatgtttctgccactgccttttacaaagcacagcctgtcattcagttcatgtgtgaagttcttgacattcacaacatcgatgagcaacccagacccctgaccgattctcatcgggtaaaattcactaaggagataaaaggtctgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtctgtaatgtaacaagaaggcctgccagccaccaaacatttcctttacagctagaaaatggccaaactgtggagagaactgtagctcagtatttccgagaaaagtacacacttcagctgaagtacccacaccttccctgtctgcaagtggggcaggagcagaagcatacatacctgccactagaagtctgtaatattgtggctggacagaggtgtatcaagaaactaacagacaatcagacttctactatgattaaggcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcagtttaaagtgcgggatgagatggcccatgtgaccggtcgagtactgccagcacctatgctccagtatggaggacggaaccggacagtagcaacaccaagccacggagtatgggacatgagaggaaaacagttccacacaggagttgaaatcaaaatgtgggctatcgcttgctttgccacacagaggcagtgcagagaagaaatactgaaaggattcacagaccagcttcggaagatctccaaggatgcagggatgcccatccagggtcagccatgtttctgcaaatacgcacagggggcagacagcgtggagcccatgttccggcatctcaagaatacctactcaggactgcagctcattatcgtcatcctgcctgggaagacgccggtatatgcggaggtgaagcgtgtaggagacacacttttgggtatggccacacagtgtgtgcaagtcaagaatgtaataaaaacatctcctcaaactctttcaaacttgtgcctaaagatcaatgttaaacttggaggaatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatcttcctgggcgcagatgtcacacacccgcctgctggtgacgggaagaagccttccattgctgctgttgtaggcagtatggatgcccatccaagcagatactgtgccacagtgagagttcagagaccccgacaggaaatcatccaggacttggcctccatggtccgggaactgctcatccaattttacaagtcaacccgattcaaacctactcggatcatcttttatcgggatggtgtttccgaaggacagtttagacaggtattatattatgagctcctggcaattcgagaagcctgtatcagtttggaaaaagactatcaacctggaataacctacattgtcgttcagaagagacatcatacgcgattgttctgtgctgatagaacagaaagggtgggaagaagcggcaacatcccagctggaaccacagtggatacagacatcactcacccgtatgaattcgacttttatctctgcagccatgctggaatacagggaaccagccgtccttctcactatcacgttctgtgggatgacaactgcttcactgcggatgaactgcagctgctgacctaccagctctgccacacctacgtgcgctgtaccaggtccgtgtcgatccctgcaccagcgtactatgctcacctggtggcgttcagagccaggtaccatctggtggacaaggagcatgacagtgctgaaggaagccatgtgtcaggacagagcaatggacgagatccacaagctcttgccaaggctgtccagattcaccaagataccttacgcacaatgtacttcgcttagcaagtccaagtgatctccgagaggaagagctggagctcgtatgtttccagtggactcagttcactggggaggcctccagccgcacagaagccaatactatgtaggggtctggaccttacgttgatccgaggaaaaatgtttactctgtcaaagaacacagcactgttgtataccagggagccagcccgctgcttttttgcagtgtcctgtagaagaagcatcacggttgttcgttctcacttcttacagtctaaccccattaatacctttacctcaagttgcttagcggcacaaccgtctctgcaaaaaaagtaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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