2025-07-04 11:11:04, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_001271193 3150 bp mRNA linear ROD 31-MAR-2024 DEFINITION Rattus norvegicus argonaute RISC catalytic component 3 (Ago3), mRNA. ACCESSION NM_001271193 XM_001058231 VERSION NM_001271193.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 3150) AUTHORS Park,M.S., Phan,H.D., Busch,F., Hinckley,S.H., Brackbill,J.A., Wysocki,V.H. and Nakanishi,K. TITLE Human Argonaute3 has slicer activity JOURNAL Nucleic Acids Res 45 (20), 11867-11877 (2017) PUBMED 29040713 REFERENCE 2 (bases 1 to 3150) AUTHORS Sun,S., Ma,J., Zhang,Q., Wang,Q., Zhou,L., Bai,F., Hu,H., Chang,P., Yu,J. and Gao,B. TITLE Argonaute proteins in cardiac tissue contribute to the heart injury during viral myocarditis JOURNAL Cardiovasc Pathol 25 (2), 120-126 (2016) PUBMED 26764146 REFERENCE 3 (bases 1 to 3150) AUTHORS Hu,Q., Tanasa,B., Trabucchi,M., Li,W., Zhang,J., Ohgi,K.A., Rose,D.W., Glass,C.K. and Rosenfeld,M.G. TITLE DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation JOURNAL Nat Struct Mol Biol 19 (11), 1168-1175 (2012) PUBMED 23064648 REFERENCE 4 (bases 1 to 3150) AUTHORS Gu,S., Jin,L., Huang,Y., Zhang,F. and Kay,M.A. TITLE Slicing-independent RISC activation requires the argonaute PAZ domain JOURNAL Curr Biol 22 (16), 1536-1542 (2012) PUBMED 22795694 REFERENCE 5 (bases 1 to 3150) AUTHORS Modzelewski,A.J., Holmes,R.J., Hilz,S., Grimson,A. and Cohen,P.E. TITLE AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline JOURNAL Dev Cell 23 (2), 251-264 (2012) PUBMED 22863743 REFERENCE 6 (bases 1 to 3150) AUTHORS Yoda,M., Kawamata,T., Paroo,Z., Ye,X., Iwasaki,S., Liu,Q. and Tomari,Y. TITLE ATP-dependent human RISC assembly pathways JOURNAL Nat Struct Mol Biol 17 (1), 17-23 (2010) PUBMED 19966796 REFERENCE 7 (bases 1 to 3150) AUTHORS Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A. TITLE Defining the membrane proteome of NK cells JOURNAL J Mass Spectrom 45 (1), 1-25 (2010) PUBMED 19946888 REFERENCE 8 (bases 1 to 3150) AUTHORS Chi,S.W., Zang,J.B., Mele,A. and Darnell,R.B. TITLE Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps JOURNAL Nature 460 (7254), 479-486 (2009) PUBMED 19536157 REFERENCE 9 (bases 1 to 3150) AUTHORS Wu,L., Fan,J. and Belasco,J.G. TITLE Importance of translation and nonnucleolytic ago proteins for on-target RNA interference JOURNAL Curr Biol 18 (17), 1327-1332 (2008) PUBMED 18771919 REFERENCE 10 (bases 1 to 3150) AUTHORS Meister,G., Landthaler,M., Patkaniowska,A., Dorsett,Y., Teng,G. and Tuschl,T. TITLE Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs JOURNAL Mol Cell 15 (2), 185-197 (2004) PUBMED 15260970 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAXUCZ010000005.1. On Sep 6, 2012 this sequence version replaced XM_001058231.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR26360172.2219688.1, SRR26360176.2406544.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-270 JAXUCZ010000005.1 143998468-143998737 c 271-442 JAXUCZ010000005.1 143986344-143986515 c 443-563 JAXUCZ010000005.1 143977859-143977979 c 564-772 JAXUCZ010000005.1 143975791-143975999 c 773-909 JAXUCZ010000005.1 143974762-143974898 c 910-1044 JAXUCZ010000005.1 143953355-143953489 c 1045-1132 JAXUCZ010000005.1 143948438-143948525 c 1133-1280 JAXUCZ010000005.1 143948176-143948323 c 1281-1400 JAXUCZ010000005.1 143946859-143946978 c 1401-1523 JAXUCZ010000005.1 143945539-143945661 c 1524-1657 JAXUCZ010000005.1 143944724-143944857 c 1658-1842 JAXUCZ010000005.1 143942851-143943035 c 1843-2002 JAXUCZ010000005.1 143936816-143936975 c 2003-2093 JAXUCZ010000005.1 143935184-143935274 c 2094-2288 JAXUCZ010000005.1 143932288-143932482 c 2289-2423 JAXUCZ010000005.1 143931441-143931575 c 2424-2525 JAXUCZ010000005.1 143929492-143929593 c 2526-2725 JAXUCZ010000005.1 143927656-143927855 c 2726-3150 JAXUCZ010000005.1 143926489-143926913 c FEATURES Location/Qualifiers source 1..3150 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="BN" /db_xref="taxon:10116" /chromosome="5" /map="5q36" gene 1..3150 /gene="Ago3" /gene_synonym="Eif2c3" /note="argonaute RISC catalytic component 3" /db_xref="GeneID:313593" /db_xref="RGD:1309163" exon 1..270 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" misc_feature 249..251 /gene="Ago3" /gene_synonym="Eif2c3" /note="upstream in-frame stop codon" CDS 252..2834 /gene="Ago3" /gene_synonym="Eif2c3" /EC_number="3.1.26.n2" /note="eukaryotic translation initiation factor 2C, 3; argonaute 3, RISC catalytic component" /codon_start=1 /product="protein argonaute-3" /protein_id="NP_001258122.1" /db_xref="GeneID:313593" /db_xref="RGD:1309163" /translation="
MEIGSAGPIGAQPLLIVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSVKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"
misc_feature 468..752 /gene="Ago3" /gene_synonym="Eif2c3" /note="N-terminal domain of argonaute; Region: ArgoN; pfam16486" /db_xref="CDD:465134" misc_feature 780..932 /gene="Ago3" /gene_synonym="Eif2c3" /note="Argonaute linker 1 domain; Region: ArgoL1; pfam08699" /db_xref="CDD:462567" misc_feature 933..1295 /gene="Ago3" /gene_synonym="Eif2c3" /note="PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846" /db_xref="CDD:239212" misc_feature order(1089..1091,1134..1136,1176..1178,1188..1190, 1242..1244,1263..1265,1269..1271) /gene="Ago3" /gene_synonym="Eif2c3" /note="nucleic acid-binding interface [nucleotide binding]; other site" /db_xref="CDD:239212" misc_feature 1428..2705 /gene="Ago3" /gene_synonym="Eif2c3" /note="PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the...; Region: Piwi_ago-like; cd04657" /db_xref="CDD:240015" misc_feature order(1839..1841,1851..1853,1887..1898,1905..1907, 1929..1931,1938..1940,1950..1952,1962..1964) /gene="Ago3" /gene_synonym="Eif2c3" /note="5' RNA guide strand anchoring site [active]" /db_xref="CDD:240015" misc_feature order(2043..2045,2049..2051,2259..2261,2673..2675) /gene="Ago3" /gene_synonym="Eif2c3" /note="active site" /db_xref="CDD:240015" exon 271..442 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 443..563 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 564..772 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 773..909 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 910..1044 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 1045..1132 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 1133..1280 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 1281..1400 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 1401..1523 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 1524..1657 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 1658..1842 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 1843..2002 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 2003..2093 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 2094..2288 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 2289..2423 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 2424..2525 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 2526..2725 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" exon 2726..3150 /gene="Ago3" /gene_synonym="Eif2c3" /inference="alignment:Splign:2.1.0" ORIGIN
gacccgggagagcgaaaagcggcggcggcggggcggctggagggtcccggaggtgcgcgcgtcagcagctgtaggcgacgcaagttccggacccggcttcagcgtcctcacctcaggactgtcgccgctcttaccttgctgctgactgtctccggacagtgcctcttctgcctggagctttcagagggcgtccgctcctcacctctgtggtggcacctttctcttgtgaagcactccccacagctccatgaatggaaatcggctccgcaggacccattggggcccagcccctactcatagtgcccagaagacctgggtatggcactatgggcaaacccattaaactgttggctaactgttttcaagttgaaatcccaaagatcgatgtctacctctatgaggtcgacatcaaacccgacaagtgtcctcgaagagtgaacagagaagtagttgactcaatggttcagcattttaaagtgactatatttggagaccgtagaccagtttatgatggaaaaagaagcctttacacagccaatccacttcctgtggcaactactggggtagatttagatgttactttacctggggaaggtggaaaagatcgccctttcaaggtgtcagtgaagtttgtgtccagagtcagttggcacctactacatgaagttctgactggtcggactttgcctgagccactggaattagacaagccaatcagcactaacccggtccatgccgttgatgtggtgctccgacatctgccctctatgaaatatacgcctgtggggcgctcctttttctcagctccagaaggatacgaccaccctcttggagggggcagggaagtatggtttggattccatcaatctgttcggcctgccatgtggaaaatgatgctcaatattgatgtttctgccactgccttttacaaagcacagcctgtcattcagttcatgtgtgaagttcttgacattcacaacatcgatgagcaacccagacccctgaccgattctcatcgggtaaaattcactaaggagataaaaggtctgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtctgtaatgtaacaagaaggcctgccagccaccaaacatttcctttacagctagaaaatggccaaactgtggagagaactgtagctcagtatttccgagaaaagtacacacttcagctgaagtacccacaccttccctgtctgcaagtggggcaggagcagaagcatacatacctgccactagaagtctgtaatattgtggctggacagaggtgtatcaagaaactaacagacaatcagacttctactatgattaaggcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcagtttaaagtgcgggatgagatggcccatgtgaccggtcgagtactgccagcacctatgctccagtatggaggacggaaccggacagtagcaacaccaagccacggagtatgggacatgagaggaaaacagttccacacaggagttgaaatcaaaatgtgggctatcgcttgctttgccacacagaggcagtgcagagaagaaatactgaaaggattcacagaccagcttcggaagatctccaaggatgcagggatgcccatccagggtcagccatgtttctgcaaatacgcacagggggcagacagcgtggagcccatgttccggcatctcaagaatacctactcaggactgcagctcattatcgtcatcctgcctgggaagacgccggtatatgcggaggtgaagcgtgtaggagacacacttttgggtatggccacacagtgtgtgcaagtcaagaatgtaataaaaacatctcctcaaactctttcaaacttgtgcctaaagatcaatgttaaacttggaggaatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatcttcctgggcgcagatgtcacacacccgcctgctggtgacgggaagaagccttccattgctgctgttgtaggcagtatggatgcccatccaagcagatactgtgccacagtgagagttcagagaccccgacaggaaatcatccaggacttggcctccatggtccgggaactgctcatccaattttacaagtcaacccgattcaaacctactcggatcatcttttatcgggatggtgtttccgaaggacagtttagacaggtattatattatgagctcctggcaattcgagaagcctgtatcagtttggaaaaagactatcaacctggaataacctacattgtcgttcagaagagacatcatacgcgattgttctgtgctgatagaacagaaagggtgggaagaagcggcaacatcccagctggaaccacagtggatacagacatcactcacccgtatgaattcgacttttatctctgcagccatgctggaatacagggaaccagccgtccttctcactatcacgttctgtgggatgacaactgcttcactgcggatgaactgcagctgctgacctaccagctctgccacacctacgtgcgctgtaccaggtccgtgtcgatccctgcaccagcgtactatgctcacctggtggcgttcagagccaggtaccatctggtggacaaggagcatgacagtgctgaaggaagccatgtgtcaggacagagcaatggacgagatccacaagctcttgccaaggctgtccagattcaccaagataccttacgcacaatgtacttcgcttagcaagtccaagtgatctccgagaggaagagctggagctcgtatgtttccagtggactcagttcactggggaggcctccagccgcacagaagccaatactatgtaggggtctggaccttacgttgatccgaggaaaaatgtttactctgtcaaagaacacagcactgttgtataccagggagccagcccgctgcttttttgcagtgtcctgtagaagaagcatcacggttgttcgttctcacttcttacagtctaaccccattaatacctttacctcaagttgcttagcggcacaaccgtctctgcaaaaaaagtaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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