ver.2
Home
|
Help
|
Advanced search
Previous release (v1)
2021-10-17 16:07:27, GGRNA.v2 : RefSeq release 207 (Jul, 2021)
LOCUS NM_001271193 3150 bp mRNA linear ROD 03-FEB-2021
DEFINITION Rattus norvegicus argonaute RISC catalytic component 3 (Ago3),
mRNA.
ACCESSION NM_001271193 XM_001058231
VERSION NM_001271193.1
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3150)
AUTHORS Park MS, Phan HD, Busch F, Hinckley SH, Brackbill JA, Wysocki VH
and Nakanishi K.
TITLE Human Argonaute3 has slicer activity
JOURNAL Nucleic Acids Res 45 (20), 11867-11877 (2017)
PUBMED 29040713
REFERENCE 2 (bases 1 to 3150)
AUTHORS Sun S, Ma J, Zhang Q, Wang Q, Zhou L, Bai F, Hu H, Chang P, Yu J
and Gao B.
TITLE Argonaute proteins in cardiac tissue contribute to the heart injury
during viral myocarditis
JOURNAL Cardiovasc Pathol 25 (2), 120-126 (2016)
PUBMED 26764146
REFERENCE 3 (bases 1 to 3150)
AUTHORS Hu Q, Tanasa B, Trabucchi M, Li W, Zhang J, Ohgi KA, Rose DW, Glass
CK and Rosenfeld MG.
TITLE DICER- and AGO3-dependent generation of retinoic acid-induced DR2
Alu RNAs regulates human stem cell proliferation
JOURNAL Nat Struct Mol Biol 19 (11), 1168-1175 (2012)
PUBMED 23064648
REFERENCE 4 (bases 1 to 3150)
AUTHORS Gu S, Jin L, Huang Y, Zhang F and Kay MA.
TITLE Slicing-independent RISC activation requires the argonaute PAZ
domain
JOURNAL Curr Biol 22 (16), 1536-1542 (2012)
PUBMED 22795694
REFERENCE 5 (bases 1 to 3150)
AUTHORS Modzelewski AJ, Holmes RJ, Hilz S, Grimson A and Cohen PE.
TITLE AGO4 regulates entry into meiosis and influences silencing of sex
chromosomes in the male mouse germline
JOURNAL Dev Cell 23 (2), 251-264 (2012)
PUBMED 22863743
REFERENCE 6 (bases 1 to 3150)
AUTHORS Yoda M, Kawamata T, Paroo Z, Ye X, Iwasaki S, Liu Q and Tomari Y.
TITLE ATP-dependent human RISC assembly pathways
JOURNAL Nat Struct Mol Biol 17 (1), 17-23 (2010)
PUBMED 19966796
REFERENCE 7 (bases 1 to 3150)
AUTHORS Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
TITLE Defining the membrane proteome of NK cells
JOURNAL J Mass Spectrom 45 (1), 1-25 (2010)
PUBMED 19946888
REFERENCE 8 (bases 1 to 3150)
AUTHORS Chi SW, Zang JB, Mele A and Darnell RB.
TITLE Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
JOURNAL Nature 460 (7254), 479-486 (2009)
PUBMED 19536157
REFERENCE 9 (bases 1 to 3150)
AUTHORS Wu L, Fan J and Belasco JG.
TITLE Importance of translation and nonnucleolytic ago proteins for
on-target RNA interference
JOURNAL Curr Biol 18 (17), 1327-1332 (2008)
PUBMED 18771919
REFERENCE 10 (bases 1 to 3150)
AUTHORS Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G and
Tuschl T.
TITLE Human Argonaute2 mediates RNA cleavage targeted by miRNAs and
siRNAs
JOURNAL Mol Cell 15 (2), 185-197 (2004)
PUBMED 15260970
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JACYVU010000162.1.
On Sep 6, 2012 this sequence version replaced XM_001058231.3.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support SAMD00132261,
SAMD00132262 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-270 JACYVU010000162.1 53263260-53263529 c
271-442 JACYVU010000162.1 53251134-53251305 c
443-563 JACYVU010000162.1 53242649-53242769 c
564-772 JACYVU010000162.1 53240580-53240788 c
773-909 JACYVU010000162.1 53239551-53239687 c
910-1044 JACYVU010000162.1 53218140-53218274 c
1045-1132 JACYVU010000162.1 53213223-53213310 c
1133-1280 JACYVU010000162.1 53212961-53213108 c
1281-1400 JACYVU010000162.1 53211644-53211763 c
1401-1523 JACYVU010000162.1 53210324-53210446 c
1524-1657 JACYVU010000162.1 53209509-53209642 c
1658-1842 JACYVU010000162.1 53207638-53207822 c
1843-2002 JACYVU010000162.1 53201603-53201762 c
2003-2093 JACYVU010000162.1 53199969-53200059 c
2094-2288 JACYVU010000162.1 53197073-53197267 c
2289-2423 JACYVU010000162.1 53196226-53196360 c
2424-2525 JACYVU010000162.1 53194277-53194378 c
2526-2725 JACYVU010000162.1 53192441-53192640 c
2726-3150 JACYVU010000162.1 53191274-53191698 c
FEATURES Location/Qualifiers
source 1..3150
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="5"
/map="5q36"
gene 1..3150
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="argonaute RISC catalytic component 3"
/db_xref="GeneID:313593"
/db_xref="RGD:1309163"
exon 1..270
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
misc_feature 249..251
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="upstream in-frame stop codon"
CDS 252..2834
/gene="Ago3"
/gene_synonym="Eif2c3"
/EC_number="3.1.26.n2"
/note="eukaryotic translation initiation factor 2C, 3;
argonaute 3, RISC catalytic component"
/codon_start=1
/product="protein argonaute-3"
/protein_id="NP_001258122.1"
/db_xref="GeneID:313593"
/db_xref="RGD:1309163"
/translation="
MEIGSAGPIGAQPLLIVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSVKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"
misc_feature 468..752
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="N-terminal domain of argonaute; Region: ArgoN;
pfam16486"
/db_xref="CDD:406799"
misc_feature 780..932
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="Argonaute linker 1 domain; Region: ArgoL1;
pfam08699"
/db_xref="CDD:400854"
misc_feature 933..1295
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="PAZ domain, argonaute_like subfamily. Argonaute is
part of the RNA-induced silencing complex (RISC), and is
an endonuclease that plays a key role in the RNA
interference pathway. The PAZ domain has been named after
the proteins Piwi,Argonaut, and Zwille; Region:
PAZ_argonaute_like; cd02846"
/db_xref="CDD:239212"
misc_feature 1428..2705
/gene="Ago3"
/gene_synonym="Eif2c3"
/note="PIWI domain, Argonaute-like subfamily. Argonaute is
the central component of the RNA-induced silencing complex
(RISC) and related complexes. The PIWI domain is the
C-terminal portion of Argonaute and consists of two
subdomains, one of which provides the...; Region:
Piwi_ago-like; cd04657"
/db_xref="CDD:240015"
exon 271..442
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 443..563
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 564..772
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 773..909
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 910..1044
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1045..1132
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1133..1280
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1281..1400
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1401..1523
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1524..1657
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1658..1842
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 1843..2002
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 2003..2093
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 2094..2288
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 2289..2423
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 2424..2525
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 2526..2725
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
exon 2726..3150
/gene="Ago3"
/gene_synonym="Eif2c3"
/inference="alignment:Splign:2.1.0"
ORIGIN
gacccgggagagcgaaaagcggcggcggcggggcggctggagggtcccggaggtgcgcgcgtcagcagctgtaggcgacgcaagttccggacccggcttcagcgtcctcacctcaggactgtcgccgctcttaccttgctgctgactgtctccggacagtgcctcttctgcctggagctttcagagggcgtccgctcctcacctctgtggtggcacctttctcttgtgaagcactccccacagctccatgaatggaaatcggctccgcaggacccattggggcccagcccctactcatagtgcccagaagacctgggtatggcactatgggcaaacccattaaactgttggctaactgttttcaagttgaaatcccaaagatcgatgtctacctctatgaggtcgacatcaaacccgacaagtgtcctcgaagagtgaacagagaagtagttgactcaatggttcagcattttaaagtgactatatttggagaccgtagaccagtttatgatggaaaaagaagcctttacacagccaatccacttcctgtggcaactactggggtagatttagatgttactttacctggggaaggtggaaaagatcgccctttcaaggtgtcagtgaagtttgtgtccagagtcagttggcacctactacatgaagttctgactggtcggactttgcctgagccactggaattagacaagccaatcagcactaacccggtccatgccgttgatgtggtgctccgacatctgccctctatgaaatatacgcctgtggggcgctcctttttctcagctccagaaggatacgaccaccctcttggagggggcagggaagtatggtttggattccatcaatctgttcggcctgccatgtggaaaatgatgctcaatattgatgtttctgccactgccttttacaaagcacagcctgtcattcagttcatgtgtgaagttcttgacattcacaacatcgatgagcaacccagacccctgaccgattctcatcgggtaaaattcactaaggagataaaaggtctgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtctgtaatgtaacaagaaggcctgccagccaccaaacatttcctttacagctagaaaatggccaaactgtggagagaactgtagctcagtatttccgagaaaagtacacacttcagctgaagtacccacaccttccctgtctgcaagtggggcaggagcagaagcatacatacctgccactagaagtctgtaatattgtggctggacagaggtgtatcaagaaactaacagacaatcagacttctactatgattaaggcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcagtttaaagtgcgggatgagatggcccatgtgaccggtcgagtactgccagcacctatgctccagtatggaggacggaaccggacagtagcaacaccaagccacggagtatgggacatgagaggaaaacagttccacacaggagttgaaatcaaaatgtgggctatcgcttgctttgccacacagaggcagtgcagagaagaaatactgaaaggattcacagaccagcttcggaagatctccaaggatgcagggatgcccatccagggtcagccatgtttctgcaaatacgcacagggggcagacagcgtggagcccatgttccggcatctcaagaatacctactcaggactgcagctcattatcgtcatcctgcctgggaagacgccggtatatgcggaggtgaagcgtgtaggagacacacttttgggtatggccacacagtgtgtgcaagtcaagaatgtaataaaaacatctcctcaaactctttcaaacttgtgcctaaagatcaatgttaaacttggaggaatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatcttcctgggcgcagatgtcacacacccgcctgctggtgacgggaagaagccttccattgctgctgttgtaggcagtatggatgcccatccaagcagatactgtgccacagtgagagttcagagaccccgacaggaaatcatccaggacttggcctccatggtccgggaactgctcatccaattttacaagtcaacccgattcaaacctactcggatcatcttttatcgggatggtgtttccgaaggacagtttagacaggtattatattatgagctcctggcaattcgagaagcctgtatcagtttggaaaaagactatcaacctggaataacctacattgtcgttcagaagagacatcatacgcgattgttctgtgctgatagaacagaaagggtgggaagaagcggcaacatcccagctggaaccacagtggatacagacatcactcacccgtatgaattcgacttttatctctgcagccatgctggaatacagggaaccagccgtccttctcactatcacgttctgtgggatgacaactgcttcactgcggatgaactgcagctgctgacctaccagctctgccacacctacgtgcgctgtaccaggtccgtgtcgatccctgcaccagcgtactatgctcacctggtggcgttcagagccaggtaccatctggtggacaaggagcatgacagtgctgaaggaagccatgtgtcaggacagagcaatggacgagatccacaagctcttgccaaggctgtccagattcaccaagataccttacgcacaatgtacttcgcttagcaagtccaagtgatctccgagaggaagagctggagctcgtatgtttccagtggactcagttcactggggaggcctccagccgcacagaagccaatactatgtaggggtctggaccttacgttgatccgaggaaaaatgtttactctgtcaaagaacacagcactgttgtataccagggagccagcccgctgcttttttgcagtgtcctgtagaagaagcatcacggttgttcgttctcacttcttacagtctaaccccattaatacctttacctcaagttgcttagcggcacaaccgtctctgcaaaaaaagtaaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]