LOCUS       NM_001266053            3577 bp    mRNA    linear   PRI 22-FEB-2022
DEFINITION  Macaca mulatta nuclear factor kappa B subunit 1 (NFKB1), mRNA.
ACCESSION   NM_001266053 XM_001109277 XM_002804153
VERSION     NM_001266053.1
KEYWORDS    RefSeq.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 3577)
  AUTHORS   Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S,
            Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Marcais G,
            Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA
            and Norgren RB Jr.
  TITLE     A new rhesus macaque assembly and annotation for next-generation
            sequencing analyses
  JOURNAL   Biol Direct 9 (1), 20 (2014)
   PUBMED   25319552
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3577)
  AUTHORS   Gong J, Shen XH, Qiu H, Chen C and Yang RG.
  TITLE     Rhesus monkey TRIM5alpha represses HIV-1 LTR promoter activity by
            negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated
            NF-kappaB activation
  JOURNAL   Arch Virol 156 (11), 1997-2006 (2011)
   PUBMED   21918865
  REMARK    GeneRIF: TRIM5alpha represses HIV-1 LTR promoter activity by
            negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated
            NF-kappaB activation.
REFERENCE   3  (bases 1 to 3577)
  AUTHORS   Yan G, Zhang G, Fang X, Zhang Y, Li C, Ling F, Cooper DN, Li Q, Li
            Y, van Gool AJ, Du H, Chen J, Chen R, Zhang P, Huang Z, Thompson
            JR, Meng Y, Bai Y, Wang J, Zhuo M, Wang T, Huang Y, Wei L, Li J,
            Wang Z, Hu H, Yang P, Le L, Stenson PD, Li B, Liu X, Ball EV, An N,
            Huang Q, Zhang Y, Fan W, Zhang X, Li Y, Wang W, Katze MG, Su B,
            Nielsen R, Yang H, Wang J, Wang X and Wang J.
  TITLE     Genome sequencing and comparison of two nonhuman primate animal
            models, the cynomolgus and Chinese rhesus macaques
  JOURNAL   Nat Biotechnol 29 (11), 1019-1023 (2011)
   PUBMED   22002653
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from JV043229.1.
            
            On or before May 25, 2012 this sequence version replaced
            XM_002804153.1, XM_001109277.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JV043229.1, JU472947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4688317, SAMEA4688321
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3577
                     /organism="Macaca mulatta"
                     /mol_type="mRNA"
                     /db_xref="taxon:9544"
                     /chromosome="5"
                     /map="5"
     gene            1..3577
                     /gene="NFKB1"
                     /note="nuclear factor kappa B subunit 1"
                     /db_xref="GeneID:710324"
                     /db_xref="VGNC:VGNC:75339"
     exon            1..122
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            123..168
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..3039
                     /gene="NFKB1"
                     /note="nuclear factor of kappa light polypeptide gene
                     enhancer in B-cells 1 (p105)"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p105 subunit"
                     /protein_id="NP_001252982.1"
                     /db_xref="GeneID:710324"
                     /db_xref="VGNC:VGNC:75339"
                     /translation="

MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDSEGCDRSDDRNTVNLFGKVIETTEHNQEPSEATDGNGEVTLTYATRAKEESARVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAASWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQAHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGGSLLTLNKMPHDYGQEGPLEGKI"

     misc_feature    256..861
                     /gene="NFKB1"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of kappa B1 (NF-kappa B1); Region:
                     RHD-n_NFkB1; cd07935"
                     /db_xref="CDD:143651"
     misc_feature    order(298..300,304..309,313..318,325..336,559..561,
                     565..570,859..861)
                     /gene="NFKB1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143651"
     misc_feature    880..1185
                     /gene="NFKB1"
                     /note="IPT domain of the transcription factor NFkappaB and
                     related transcription factors. NFkappaB is considered a
                     central regulator of stress responses, activated by
                     different stressful conditions, including physical stress,
                     oxidative stress, and exposure to...; Region:
                     IPT_NFkappaB; cd01177"
                     /db_xref="CDD:238582"
     misc_feature    order(883..885,889..897,901..909,1027..1035,1072..1074,
                     1108..1110,1165..1167,1174..1176,1180..1182)
                     /gene="NFKB1"
                     /note="ankyrin protein binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238582"
     misc_feature    order(889..894,898..900,937..939,943..945,949..951,
                     1048..1053,1060..1062,1066..1068)
                     /gene="NFKB1"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238582"
     misc_feature    order(952..954,958..960,1051..1056)
                     /gene="NFKB1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238582"
     misc_feature    1579..2247
                     /gene="NFKB1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:223738"
     misc_feature    order(1756..1758,1762..1764,1774..1779,1786..1794,
                     1798..1803,1813..1815,1822..1824,1867..1869,1873..1875,
                     1879..1881,1891..1896,1903..1911,1915..1920,1930..1932,
                     1939..1941,1966..1968,1972..1974,1978..1980,1990..1995,
                     2002..2010,2014..2019,2029..2031,2038..2040)
                     /gene="NFKB1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1756..1869
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1873..1968
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1888..2172
                     /gene="NFKB1"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2;
                     pfam12796"
                     /db_xref="CDD:432791"
     misc_feature    2080..2172
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2182..2280
                     /gene="NFKB1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2197..>2328
                     /gene="NFKB1"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2; cl39094"
                     /db_xref="CDD:453966"
     misc_feature    2575..2802
                     /gene="NFKB1"
                     /note="Death domain of the Nuclear Factor-KappaB1
                     precursor protein p105; Region: Death_NFkB1_p105; cd08797"
                     /db_xref="CDD:260063"
     exon            169..247
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..288
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..387
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..536
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..700
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..859
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..964
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1056
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1195
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1339
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1429
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1624
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1766
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1881
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2083
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2253
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2356
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2481
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2548
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2721
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2878
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3577
                     /gene="NFKB1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccgcacccgggcccgctcgggctccggccggccaccgcctcttccctctccagcccgcaggcccgcgccgcccaggagggagagacccgcgccaggaggccgaacgcggactcgccaccaggcttcagaatggcagaagatgatccatatttgggaaggcctgaacaaatgtttcatttggatccttctttgactcatacaatatttaacccagaagtatttcaaccacagatggcactgccaacagcagatggcccatatcttcaaatattagagcaacctaaacagagaggatttcgtttccgttatgtttgtgaaggcccatcccatggtggactacctggtgcctctagcgaaaagaacaagaagtcttaccctcaggtcaaaatctgcaactatgtgggaccagcaaaggttattgttcagttggtcacaaatggaaaaaatatccacctgcatgcccacagcctggtgggaaaacactgtgaggatgggatctgcactgtaactgctggacccaaggacatggtggtcggcttcgcaaacctgggtatacttcatgtaacaaagaaaaaagtatttgaaacactggaagcacgaatgacagaggcgtgtataaggggctataatcctggactcttggtgcaccctgaccttgcctatttgcaagcagaaggtggaggggaccggcagttgggagatcgggaaaaagagctaatccgccaagcagctctgcagcaaaccaaggagatggacctcagcgtggtgcggctcatgtttacagcttttcttccggatagcactggcagcttcacaaggcgcctggaacccgtggtatcagacgccatctatgacagtaaagcccccaacgcatccaacttgaaaattgtaagaatggacaggacagctggatgtgtgactggaggggaggaaatttatcttctctgtgacaaagttcagaaagatgacatccagattcgattttatgaagaggaggaaaatggtggagtctgggaaggatttggagatttttcccccacagatgttcatagacaatttgccatcgtcttcaaaactccaaagtataaagatgttaatattacgaaaccagcctctgtgttcgtccagcttcggaggaaatctgacttggaaactagtgaaccaaaacctttcctctactatcctgaaatcaaagataaagaagaagtacagaggaaacggcagaagctcatgcccaatttttcggatagtttcggcggtgggagtggcgctggagctggaggcggaggcatgtttggtagtggcgggggaggagggggcactggaagtacagggccagggtatagcttcccgcactatggatttcctacttatggtgggattaccttccatcctggaactactaaatctaatgctgggatgaagcatggaaccatggacactgaatctaaaaaggattctgaaggttgtgacagaagtgatgacagaaacactgtaaacctctttgggaaagtcattgaaaccacagagcacaatcaggagcccagcgaggccactgatgggaatggtgaggtcactctaacgtatgcaacaagagcaaaagaagagagtgctagggttcaggataacctctttctagagaaggctatgcagcttgcaaagaggcatgccaatgcccttttcgactacgcagtgacaggagacgtgaagatgctgctggccgtccagcgccatctcactgccgtgcaggatgagaatggggacagtgtcttacacttagcaatcatccaccttcattctcaacttgtgagggatctactagaagtcacatctggtttgatttctgatgacattatcaacatgagaaatgacctgtaccagacgcccttgcacttggcagtgatcactaagcaggaagatgtggtggaggatttgctgagggctggggccgacctgagccttctggaccgcttgggtaactctgttttgcacctagctgccaaagaaggacatgataaagttctcagtatcttactcaagcacaaaaaggcagcactacttcttgaccaccccaatggggacggtctgaatgccattcatctagccatgatgagcaatagcctgccatgtttgctgctgctggtggccgctggggccgacgtcaatgctcaggagcaaaagtccgggcgcacagcactgcacctggctgtggagcacgacaacatctcattggcaggctgcctgctcctggagggtgatgcccatgtggacagtactacctacgatggaaccacacccctgcatatagcagctgggagagggtccaccaggctggcagctcttctcaaagcagcaggagcagatcccctggtggagaactttgagcctctctatgacctggatgactcttgggaaaatgcaggagaggatgaaggagttgtgcctggaaccacgcctctagatatggccgccagctggcaggtatttgacatattaaatgggaaaccatatgaaccagagtttacatctgatgatttactagcacaaggagacatgaaacagctggctgaagatgtgaagctgcagctctataagttgctagaaattcctgatccagacaaaaactgggctactctggcacagaaattaggtctggggatacttaataatgccttccggctgagtcctgctccttccaaaacacttatggacaactatgaggtctctggggggacagtcagagagctggtggaggccctgagacaaatgggctacactgaagcgattgaagtgatccaggcagcctccagcccagtgaagaccacctctcaggcccactcgctgcctctctcgcctgcctccacaaggcagcaaatagatgagctccgagacagcgacagtgtctgcgacagcggcgtggagacctccttccgcaaactcagctttactgagtctctgaccagtggtggctcactgctaactctcaacaaaatgccccatgattatgggcaggaaggacctctagaaggcaaaatttagcctgcagacaatttcccacaccgtataaaccaaagccctaaaattctactgcattgtccacaaaacagaagctgaagcgcatccagaggtgctcagagagccggcctgcctgaatcattctcgatataactcgagaccttttcaacttggcttcctttcttggttcataaatgaattttagtttggttcacttacagatagtatctagcaatcacagcactggctgagcggatgcatctggggatgaggttgcttactaagctttgccggctgctgccggatcacagctgctttctgttgtcattgctattgtccctctgctacgttcctattgtcattaaaggtatcactgtccccacctggcattccttctgaccatccacagcatcgttttgcattcaaattaagggttaagaaaagggatattttaaaatgagagtcacttgacgtgccattttttaaaaaggcatattgctttttctaatgtggttatttctctgatttgaaaaaaaaaaaaagtactcgtcaatatttaaac

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