LOCUS       NM_001257872           10198 bp    mRNA    linear   PRI 29-DEC-2025
DEFINITION  Macaca mulatta dicer 1, ribonuclease III (DICER1), mRNA.
ACCESSION   NM_001257872 XM_001100868
VERSION     NM_001257872.1
KEYWORDS    RefSeq.
SOURCE      Macaca mulatta (Rhesus monkey)
  ORGANISM  Macaca mulatta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
REFERENCE   1  (bases 1 to 10198)
  AUTHORS   Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S,
            Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Marcais G,
            Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA
            and Norgren RB Jr.
  TITLE     A new rhesus macaque assembly and annotation for next-generation
            sequencing analyses
  JOURNAL   Biol. Direct 9 (1), 20 (2014)
   PUBMED   25319552
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from JU333682.1.
            
            On Apr 12, 2012 this sequence version replaced XM_001100868.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JU333680.1, JU333682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN30957720 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..10198
                     /organism="Macaca mulatta"
                     /mol_type="mRNA"
                     /db_xref="taxon:9544"
                     /chromosome="7"
                     /map="7"
     gene            1..10198
                     /gene="DICER1"
                     /note="dicer 1, ribonuclease III"
                     /db_xref="GeneID:702516"
                     /db_xref="VGNC:VGNC:71638"
     exon            1..39
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            40..140
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            141..329
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    183..185
                     /gene="DICER1"
                     /note="upstream in-frame stop codon"
     CDS             186..5948
                     /gene="DICER1"
                     /EC_number="3.1.26.3"
                     /codon_start=1
                     /product="endoribonuclease Dicer"
                     /protein_id="NP_001244801.1"
                     /db_xref="GeneID:702516"
                     /db_xref="VGNC:VGNC:71638"
                     /translation="

MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFNRNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCENCPACPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIMLADTDKMKSFEEDLKTYKAIEKILRNKCSKSVDTGETDIDPVVDDDDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRDSYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLPADFRYPNLDFGWKKSIDSKSFISISNSSSAENDNYCKHSTIVPENAAHQGANRTSSLENHDQMSVNCRTLLSESPGKLHVEVSADLTAINGLSYNQNLANGSYDLANRDFCQGNQLNYYKQEIPVQPTTSYSIQNLYNYENQPSDECTLLSNKYLDGNANKSTSDGSPMMAVMPGTTDAIQVLKGRMDSEQSPSIGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQDKSNTDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYEDDFLEYDQEHIRFIDNMLMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSLGSMPFSSDFEDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKALCPTRENFNSQQKNLSVSCAAASMASSRSSVLKDLEYGCLKIPPRCMFDHPDADKTLNHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVPNS"

     misc_feature    309..902
                     /gene="DICER1"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(309..320,327..329,378..401,522..524,711..713,
                     804..806)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(486..491,558..563,636..638,642..647,654..656,
                     729..737)
                     /gene="DICER1"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    996..1280
                     /gene="DICER1"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1011..1016,1023..1025,1029..1034,1209..1214,
                     1221..1226,1233..1235,1242..1247,1254..1256)
                     /gene="DICER1"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1299..1877
                     /gene="DICER1"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(1530..1538,1746..1748,1803..1805,1809..1811)
                     /gene="DICER1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(1758..1760,1764..1766,1839..1841,1845..1847)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2073..2339
                     /gene="DICER1"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:460900"
     misc_feature    2841..3209
                     /gene="DICER1"
                     /note="PAZ domain, dicer_like subfamily. Dicer is an RNAse
                     involved in cleaving dsRNA in the RNA interference
                     pathway. It generates dsRNAs which are approximately 20 bp
                     long (siRNAs), which in turn target hydrolysis of
                     homologous RNAs. PAZ domains are named...; Region:
                     PAZ_dicer_like; cd02843"
                     /db_xref="CDD:239209"
     misc_feature    order(3030..3032,3069..3071,3087..3089,3099..3101,
                     3153..3155,3177..3179,3183..3185)
                     /gene="DICER1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239209"
     misc_feature    4065..>4340
                     /gene="DICER1"
                     /note="Ribonuclease III family; Region: RIBOc; smart00535"
                     /db_xref="CDD:197778"
     misc_feature    order(4116..4121,4128..4133,4140..4142,4149..4154,
                     4161..4166,4170..4178,4206..4208)
                     /gene="DICER1"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    5223..5717
                     /gene="DICER1"
                     /note="Ribonuclease III C terminal domain. This group
                     consists of eukaryotic, bacterial and archeal ribonuclease
                     III (RNAse III) proteins. RNAse III is a double stranded
                     RNA-specific endonuclease. Prokaryotic RNAse III is
                     important in post-transcriptional...; Region: RIBOc;
                     cd00593"
                     /db_xref="CDD:238333"
     misc_feature    order(5283..5288,5295..5300,5307..5309,5316..5321,
                     5328..5333,5337..5345,5373..5375,5637..5639,5670..5672)
                     /gene="DICER1"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    order(5283..5285,5292..5294,5304..5306,5607..5609,
                     5616..5618)
                     /gene="DICER1"
                     /note="active site"
                     /db_xref="CDD:238333"
     misc_feature    order(5292..5294,5607..5609,5616..5618)
                     /gene="DICER1"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:238333"
     misc_feature    5730..5918
                     /gene="DICER1"
                     /note="double-stranded RNA binding motif of
                     endoribonuclease Dicer and similar proteins; Region:
                     DSRM_DICER; cd10843"
                     /db_xref="CDD:380680"
     misc_feature    order(5730..5735,5739..5744,5751..5756,5763..5768,
                     5778..5780,5793..5801,5805..5807,5811..5813,5862..5873,
                     5880..5882)
                     /gene="DICER1"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:380680"
     exon            330..492
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..623
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..758
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..919
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1088
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1561
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1694
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1937
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2092
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2225
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2301
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2441
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2621
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2835
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2989
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3172
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3278
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..3454
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..4229
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            4230..4385
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            4386..5274
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            5275..5543
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            5544..5706
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            5707..5782
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
     exon            5783..10198
                     /gene="DICER1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cttggaaactctgaaagaacttagaatcagcattttgagagcagaagcttgggcatgctgtgattttccaataaactgctatcacaatgtcaaaatgcagttcagacaacagcaacacagagatctcaaacattaaaacgtaagctgtgctagaacaaaaatgcaatgaaagaaacactggatgaatgaaaagccctgctttgcaacccctcagcatggcaggcctgcagctcatgacccctgcttcctcaccaatgggtcctttctttggactgccatggcaacaagaagcaattcatgataacatttatacgccaagaaaatatcaggttgaactgctcgaagcagctctggatcataataccatcgtctgtttaaacactggctcagggaagacatttattgcagtactactcactaaagagctgtcctatcagatcaggggagacttcaacagaaatggaaaaaggacggtgttcttggtcaactctgcaaaccaggttgctcaacaagtgtcagctgtcagaactcattcagatctcaaggttggggaatactcaaacctagaagtaaatgcatcttggacaaaagagagatggaaccaagagtttactaagcaccaggttcttattatgacttgctatgtcgccttgaatgttttgaaaaatggttacttatcactgtcagacattaaccttttggtgtttgatgagtgtcatcttgcaatcctagaccacccctatcgagaaattatgaagctctgtgaaaattgtccagcatgtcctcgcatattgggactaactgcttccattttaaatgggaaatgtgatccagaggaattggaagaaaagattcagaaactagagaaaattcttaagagtaatgctgaaactgcaacggacctggtggtcttagacaggtatacttctcagccatgtgagattgtggtggattgtggaccatttactgacagaagtgggctttatgaaagactgctgatggaattagaagaagcacttaattttatcaatgattgtaatatatctgtacattcaaaagaaagagattctactttaatttcaaaacagatactatcagactgtcgtgccgtattggtagttctgggaccctggtgtgcagataaagtggctggaatgatggtaagagaactacagaaatacatcaaacatgagcaagaggagctgcacaggaaatttttattgtttacagacactttcctaaggaaaatacatgcactatgtgaagagcacttctcacctgcctcacttgacctgaaatttgtaactcctaaagtaatcaaactgctcgaaatcttacgcaaatataaaccatatgagcgacagcagtttgaaagtgttgagtggtataataataggaatcaggataattatgtgtcatggagtgattctgaggatgatgatgaggatgaagaaattgaagaaaaagagaagccagagacaaattttccttctccttttaccaacattttatgtggaattatttttgtggaaagaagatacacagcagttgtcttaaacagattgataaaggaagctggcaaacaagatcctgagctggcttatatcagtagcaattttataactggacatggcattgggaagaatcagcctcgcaacaagcagatggaagcagaattcagaaaacaggaagaggtacttaggaaatttcgagcacatgagaccaacctgcttattgcaacaagtattgtagaagagggtgttgatataccaaaatgcaacttggtggttcgttttgatttgcccacagaatatcgatcctatgttcaatctaaaggaagagcaagggcacccatctctaattatataatgttagcagatacagacaaaatgaaaagttttgaagaagaccttaaaacctacaaagctattgaaaagatcttgagaaacaagtgttccaagtcggttgatactggtgagactgacattgatcctgtcgtggatgatgatgacgttttcccaccatatgtgttgaggcctgacgatggtggtccacgagtcacaatcaacacggccattggacacatcaatagatactgtgctagattaccaagtgatccgtttactcatctagctcctaaatgcagaacccgagagttgcctgatggtacattttattcaactctttacctgccaattaactcacctcttcgagcctccattgttggtccaccaatgagctgtgtacgattggctgaaagagttgtagctctcatttgctgtgagaaactgcacaaaattggggaactggatgaccatttgatgccagttgggaaagagactgttaaatatgaagaagagcttgatttgcatgatgaagaagagaccagtgttccaggaaggccaggttccacgaaacgaaggcagtgctacccaaaagcaattccagagtgtttgagggatagttatcccaaacctgatcagccctgttacctgtatgtgataggaatggttttaactacacctttacctgatgaactcaactttagaaggcggaagctctaccctcctgaagataccacaagatgctttggaatactgacagccaaacccatacctcagattccacattttcctgtgtacacacgctctggagaggttaccatatccattgagttgaagaagtctggtttcatgttgtctctacaaatgcttgagttgattacaagacttcaccagtatatattctcacatattcttcggcttgaaaaacctgcactagaatttaaacctacagacgctgattcagcatactgtgttctacctcttaatgttgttaatgactccagcactttggatattgactttaaattcatggaagatattgagaagtctgaagctcgcataggcattcccagtacaaaatatacaaaagaaacaccctttgtttttaaattagaagattaccaagatgcagttatcattccaagatatcgtaattttgatcagcctcatcgattttatgtagctgatgtgtacactgatcttaccccactcagtaaatttccttcccctgagtatgaaacttttgcagaatattataaaacaaagtataaccttgacctaaccaatctcaaccagccactgctggatgtggaccatacatcttcaagacttaatcttttgacacctcgacatttgaatcagaaggggaaagctcttcctttaagcagtgctgagaagaggaaagccaaatgggaaagtctgcagaataaacagatactggttccagaactctgtgctatacatccgattccagcatcactgtggagaaaagcagtttgtctccccagcatcctttatcgccttcactgccttttgactgcagaggagctgagagcccagactgccagcgatgctggcgtgggagtcagatcacttcctgcggattttagataccctaacttagacttcgggtggaaaaaatctatcgacagcaaatctttcatctcaatttctaactcctcttcagcggaaaatgataattactgtaagcacagcacaattgtccctgaaaatgctgcacatcaaggtgctaatagaacctcctctctagaaaatcatgaccaaatgtctgtgaactgcagaacgttgctcagcgagtcccctggtaagctccatgttgaagtttcagcagatcttacagcaattaatggtctttcttacaatcaaaatctcgccaatggcagttatgacttagctaacagagacttttgccaaggaaatcagctgaattactataagcaggaaatacccgtgcaaccaactacctcatattccattcagaatttatacaattatgagaaccagcccagcgatgaatgtactctcctgagtaataaataccttgatggaaatgctaacaaatctacctcagatggaagtcccatgatggccgtaatgcctggtacgacagacgctattcaagtgctcaagggcaggatggattctgagcagagcccttctattgggtactcctcaaggactcttggccccaatcctggacttattcttcaggctttgactctgtcaaacgctagtgatggatttaacctggagcggcttgaaatgcttggcgactcctttttaaagcatgccatcaccacgtatctgttttgcacttaccctgatgctcatgagggccgcctttcatatatgagaagcaaaaaggtcagcaactgtaatctgtatcgccttggaaaaaagaagggactgcccagccgcatggtggtgtcaatatttgatccccctgtaaactggcttcctcctggttatgtagtaaatcaagacaaaagcaacacagataaatgggaaaaagatgaaatgacaaaagactgcatgctggcgaatggtaaactggatgaggactacgaggaggaggatgaggaggaagagagcctgatgtggagggctccgaaggaagaggctgactatgaagatgatttcctggagtatgatcaggaacatatcagatttatagataatatgttaatggggtcaggagcttttgtaaagaaaatctctctttctcctttttcaaccactgattctgcatatgaatggaaaatgcccaaaaaatcctccttaggtagtatgccattttcatcagattttgaggattttgactacagctcttgggatgcaatgtgctatctggatcctagcaaagctgttgaagaagatgactttgtggtggggttctggaatccatcagaagaaaactgtggtgttgacacgggaaagcagtccatttcttacgacttgcacactgagcagtgtattgctgacaaaagcatagcggactgtgtggaagccctgctgggctgctatttaaccagctgtggggagagggctgctcagcttttcctctgttcactggggctgaaggtgctcccggtaattaaaaggactgatcgggaaaaggccctgtgccctactcgggagaatttcaacagccaacaaaagaacctttcagtgagctgtgctgctgcttctatggccagttcacgctcttctgtattgaaagacttggaatatggttgtttgaagattccaccaagatgtatgtttgatcatccagatgcagataaaacactgaatcaccttatatcggggtttgaaaattttgaaaagaaaatcaactacagattcaagaataaggcttaccttctccaggcttttacacatgcctcctaccactacaatactatcactgattgttaccagcgcttagaattcctaggagatgcgattttggactacctcataaccaagcacctttatgaagacccgcggcagcactccccgggggtcctgacggacctgcggtctgccctggtcaacaacaccatctttgcatcgctggctgtaaagtacgactaccacaaatacttcaaagctgtctctcctgagctcttccacgtcatcgatgactttgtgcagtttcagcttgagaagaatgaaatgcaaggaatggattctgagcttaggagatccgaggaggatgaagagaaagaagaggatattgaagttccaaaggccatgggggatatttttgagtcgcttgctggtgccatttacatggatagtgggatgtcgctggagacagtctggcaggtgtactaccccatgatgcggccactcatagaaaagttttctgcaaatgtaccccgttcccctgtgcgagaattgcttgaaatggaaccagaaactgccaaatttagcccggctgagagaacttatgacgggaaggtcagagtcaccgtggaagtagtaggaaaggggaaatttaaaggtgttggtcgaagttacaggattgccaaatctgcagcagcaagaagagccctccgaagcctcaaagctaatcaacctcaggttcccaatagctgaaacccctttttaaaattcaaaacaaaaaacaaaaaaattaaggggaaaattatttaaatcggaaaggatgacttaaagttgatattgagtggaatgaattgaaggcagaatttaaagtttgtttggtaacaagatagataacagaataaaacatttaacatatgtataaaattttggaactaattgtagttttagttttttgcgcaaacacaatcttgtcttctttcctcacttctgctttgtttaaatcacaagagtgctttaatgatgacttttagcaagtgttcaaaataatggacaggtttgtttttttttgttttttttttttgagttttatttatgtcagctttgcttagtgttagaaggccatggagcttcaacttaactccagcagtcctaggatgatgtagattcttctccatctctccgtgtgtgcagtggtgccagtcctgcagtagttgataagctgaatagaatgataaggttttcgagaggagaagtgcaccagtgttgtcttttctttccatgttatactgtataaggtgatgttcctggtcgctgcctgttcctggtcattgcacctgatagtaagggacagatttttaatgaacattggctggcatgttggtgaatcacattttagttttccaatgccacatagtcttggataaaaaaggttcttgccttaaaagtaaaaccttcatggatattctttaatctctgatctttttggaacaaactgttttacattcccttcattttattatgcattagacgttgagacagcgtgatacttacaactcactagtatagttgtaacttattataggatcatcctaaaatttctgtcatacgtatactgaagacattttaaaaaccagaatatgtagtctacggatattttttatcataaaaatgatctttggctaaacaccccattttactaaagacctcctgctaggtagttccactgatggaaatgtttatggcaaataattttgccttctaggctattgctctaacaaaataaaccttagacatatcacacctaaaatatgctgcagattttataattgattggttacttatttaaagaagcaaaacacagagcacctttacccttagtctcctcacataaatttcttactgtacttttcataatgttgcatgcatatttcacctaccaaagctgtgctgttaatgccatgaaagtttaacgtttgcgataaactgccgtaattttgatacatctgtgatttaggtcattaatttagataaactagctcattatttccatctttggaaaacgaaaaaaaaacttttaggcatttgcctaagtttctttaattagacttgtaggcactcttcacttaaatacctcagttcttcttttcttttgcatgcatttttcccctgtttggtgctatgtttatgtattatgcttgaaattttaattttttttttttttgcactgtaactataatacctcttaatttacctttttaaaagctgtgggtcagtcttgcactcccatcaacataccagtagaggtttgctgcaatttgccctgttaattatgcttgaagtttaagaaagctgagcagaggtgtctcgtatttcccagcacatgattctgaagttgatgcttcatggaatgctgcatttatgtgtaagtgacatttgaatactgtccttcctgctttatctgcatcatccacccacagagaaatgcctctgtgcgagtgcacccacagaaaactgtcagctctgctttctaaggaaccctgagtgagggggatgttaagcttctccggtgttttttgttatctccaatcttaaacttaaattgagatctaaattattaaatgagtttttgagcaaattaggtgacttgttttaaaactatttcattctgatttggaaccttaagatgtctgtttgatttttataaaaaccttaatgtaagatatggccagttaaaacaaagcaattcttgaattatataactgtaaaagtgcagttaacaagtaaggctggatgtgaattttattgtgagggtgatttgtgatcaagtttaatcacaaatctcttaatatttataaactacctgatgccaggagcttagggctttgcattgtgtctaatacattgattccaatgttacgggattctcttgattcctggcaccaaaatcagattgttttcacagctacgattcccagtgggagaaaaatgcctcaatatatttgtaaccttaagaagagtatttttttgttaatactaagatgttcagacttagacatgattaggtcatacattctcaggggttgaaatttccttctaccattcaaaatgttttatcaacagcaaacttcagctatttcactttttgttggagaaaaatagtggattttaatttgactcacagtttgaagcattctatgatcccctggttactaagttaaaaaataaaaaagtacgagttagacatatgaaatggttatgaacgcttttgtgctgctgatttttaatgctgtaaagttttcctctgtttagcttgttgaaatgttttgcatctgtcaattaagaaaaaaaaaatcactctatgttgccccactttagaaccctatgtgccacccttctgttcccgtgattgcaatgtgagaccgaatgtaatatggaaaacctaccagtggggtgtggttgtgctctgagcacatgtgtaaaggactggggaggcgtatcttgaaaaagcaactgcagaaattccgtatgatgattgtgtgcaagttagttgacatgaaccttcatttgtaaatttttaaaaatttcttttataatatactttccgcagtcctaactatgctgcgttttataatagctttttcccttctgttctgttcatgtagcacagataagcattgcacttggtaccatgctttacctcatttcaagaaaatatgcttaacagagaggaaaaaaatgtggtttggccttgctgctgttttgatttatggaatttgaaaatgataattataatgcctgcaatgtgtcatatactcgcacaacttaaataggtcatttttgtctgtggcatttttactgtttgtcaaagtatgaaaaagatttgttaactgaactcttatgtttttaaaatgtttgttatatttgttttcttttttcttttatattatgtgaggtgatgaaatgtagaatgacctctaacactcctgtaattgtcttttaaaatactgatatttttatttgttaataatactttgccctcagaaagattctaataccctgccctgacaacacgagacttgaggctctttggttcatgagtccaggtgttcccctggcagtcggtgccttcagtcgctccctggaggcaggtggggactgcagagggtcactggaatccagactgagcgcagttgatgcacaaggccctgttgatttttaaagtattggatcttgttctgttagggtgtctaatccctttacacaagatttaagccaccaaactgagaccttgataccgttttttaactgcatctgaaattctgttaagagtccttaacccatttgcattatctgcggaagagaaactcctgtcatgtataatacttacctatatggttgttttaattacatttgaataattatatttttccaaccactgattacttttcaggaatttaattatttccagatgaatttctttattttatattgtacatggaaagttttaaagatatgtttaagaccaagactattaaaatgatttttaaagttgttggagacgccaatagcaatatctaggaaatttgcattgagaccattgtattttccactagcagtgaaaatgatttttcacaactaacttgtaaatatattttaatcattacttgtttttttttttctagtccatttttatttggacatcaaccacagacaatttaaattttatagatgcactaagaattcactgcagcagcaggttacatagcaaaaatgcaaaagtgaacaggaagtaaatttctggcttt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