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2024-03-29 20:55:15, GGRNA.v2 : RefSeq release 222 (Jan, 2024)

LOCUS       NM_001194975            2583 bp    mRNA    linear   MAM 20-FEB-2022
DEFINITION  Sus scrofa argonaute RISC catalytic component 2 (AGO2), mRNA.
ACCESSION   NM_001194975
VERSION     NM_001194975.1
KEYWORDS    RefSeq.
SOURCE      Sus scrofa (pig)
  ORGANISM  Sus scrofa
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae;
            Sus.
REFERENCE   1  (bases 1 to 2583)
  AUTHORS   Chen J, Shi X, Zhang X, Wang L, Luo J, Xing G, Deng R, Yang H, Li
            J, Wang A and Zhang G.
  TITLE     Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)
            Inhibits RNA-Mediated Gene Silencing by Targeting Ago-2
  JOURNAL   Viruses 7 (10), 5539-5552 (2015)
   PUBMED   26512690
  REMARK    GeneRIF: The viral non-structure protein 1alpha (nsp-1alpha) and
            nsp11 of porcine reproductive and respiratory syndrome virus were
            identified as the suppressors for cellular RNA silencing (RSSs) via
            downregulation of the host Ago-2 protein.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2583)
  AUTHORS   Zhou X, Guo H, Chen K, Cheng H and Zhou R.
  TITLE     Identification, chromosomal mapping and conserved synteny of
            porcine Argonaute family of genes
  JOURNAL   Genetica 138 (7), 805-812 (2010)
   PUBMED   20454920
  REMARK    GeneRIF: Data show that Ago4- Ago1-Ago3 genes are linked together
            at the p12 of the chromosome 6, while Ago2 is located at the p15 of
            the chromosome 4.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from GQ329715.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ329715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103886111, SAMEA103886114
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2583
                     /organism="Sus scrofa"
                     /mol_type="mRNA"
                     /db_xref="taxon:9823"
                     /chromosome="4"
                     /map="4"
     gene            1..2583
                     /gene="AGO2"
                     /gene_synonym="EIF2C2"
                     /note="argonaute RISC catalytic component 2"
                     /db_xref="GeneID:100155245"
                     /db_xref="VGNC:VGNC:97871"
     CDS             1..2583
                     /gene="AGO2"
                     /gene_synonym="EIF2C2"
                     /EC_number="3.1.26.n2"
                     /note="argonaute-2; eukaryotic translation initiation
                     factor 2C, 2; argonaute 2, RISC catalytic component"
                     /codon_start=1
                     /product="protein argonaute-2"
                     /protein_id="NP_001181904.1"
                     /db_xref="GeneID:100155245"
                     /db_xref="VGNC:VGNC:97871"
                     /translation="
MYSGAGPVLAPPAPPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRAAARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAGVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA"
     misc_feature    277..501
                     /gene="AGO2"
                     /gene_synonym="EIF2C2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    529..681
                     /gene="AGO2"
                     /gene_synonym="EIF2C2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    682..1044
                     /gene="AGO2"
                     /gene_synonym="EIF2C2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(838..840,883..885,925..927,937..939,991..993,
                     1012..1014,1018..1020)
                     /gene="AGO2"
                     /gene_synonym="EIF2C2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1177..2454
                     /gene="AGO2"
                     /gene_synonym="EIF2C2"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1588..1590,1600..1602,1636..1647,1654..1656,
                     1678..1680,1687..1689,1699..1701,1711..1713)
                     /gene="AGO2"
                     /gene_synonym="EIF2C2"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1792..1794,1798..1800,2008..2010,2422..2424)
                     /gene="AGO2"
                     /gene_synonym="EIF2C2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      
atgtactcgggagccggccccgtgctcgcgcctcctgcaccgccaccgccgcccatccaaggatatgccttcaagcctccacctagacccgacttcgggacctccgggagaacaatcaagttacaggccaacttctttgaaatggacattccaaaaattgacatctatcattatgagttggatatcaagccagagaaatgcccaaggagagttaacagggaaatagtggaacatatggttcagcactttaaaacacagatctttggggatcggaaaccagtgtttgatggaaggaagaatctgtacacagcgatgccgcttcccatcgggagggataaggtggagctggaggtcacactgcccggagaggggaaggaccgcatcttcaaggtgtccatcaagtgggtgtcctgcgtgagcttacaggcgttacacgatgcactttcggggcggctgcccagcgtccccttcgagacgatccaggccctggatgtggtcatgaggcatttgccgtccatgaggtacacccctgtgggccgctccttcttcacggcgtctgagggctgctccaaccccctgggcgggggccgagaagtgtggttcggcttccatcagtcggtgcggccttccctctggaagatgatgctgaacattgacgtctcggcaacagcgttttataaggcacagccagtcatcgagtttgtgtgtgaagtcttggattttaaaagtattgaagaacaacaaaaacctctgacagattcccaaagggtaaagtttaccaaagaaatcaaaggtctcaaggtggaaataacgcactgcgggcagatgaagaggaagtaccgcgtctgcaatgtgacccggcggcccgccagtcaccaaacgttcccgctgcagcaggagagcgggcagacagtcgaatgcacggtggcccagtacttcaaggacaggcacaagctggttctgcgctacccccacctcccatgtttacaagttggacaggagcagaaacacacctaccttcccctcgaggtctgtaacatagtggcgggacagagatgtataaaaaagctgaccgacaatcagacctcaaccatgatcagagccgcagccaggtcagcccctgatcggcaggaagagattagcaaattgatgagaagtgccagtttcaacacagacccatatgttcgtgaatttggaatcatggtcaaagacgagatgacagatgtgaccggccgggtcctccagccgccctccatcctctacgggggcaggaataaagcgatcgccaccccggtccagggcgtctgggacatgaggaacaagcagttccacacgggcatcgagatcaaggtgtgggccatcgcgtgcttcgccccccagcgccagtgcacggaggtgcacctcaagtccttcacggagcagctcagaaagatctcgagagacgcgggaatgccaatccagggccagccgtgcttctgtaaatacgcccagggggcggacagcgtggagcccatgttcaggcacctgaagaacacgtacgccggcctgcagctggtcgtggtcatcctgcccgggaaaacccccgtttacgccggggtcaagcgtgtgggagacacggtgctgggcatggccacgcagtgcgtgcagatgaagaacgtgcagaggaccacgccgcagaccctgtccaacctctgcctgaagatcaacgtcaaactggggggcgtcaacaacatcctgctgccgcagggcaggcctccagtgttccagcagcccgtcatctttctgggagcggatgtcactcacccacccgccggggacggcaagaagccttccatcgccgccgttgtgggcagcatggacgcccaccccaaccgctactgcgccaccgtccgtgtccagcagcaccggcaggagatcatccaggacctggcggccatggtgcgcgagctgctcatccagttctacaagtccacgcgcttcaagcccacgcgcatcatcttctaccgcgacggcgtctccgagggccagttccagcaggtccttcaccacgagttgctggccatccgcgaggcgtgcatcaagctagagaaggactaccagccggggatcacgttcatcgtggtccagaagaggcaccacacgcggctcttctgcacggacaagaacgagcgggttggcaaaagcggaaacattccagcaggcacaaccgtggacacgaaaatcacccaccccacggagtttgacttctacctgtgtagccatgctggcatccagggaacaagcaggccttcccactatcacgtgctttgggatgacaatcgtttctcttccgatgagctgcagattctcacctaccagctgtgtcacacgtatgtgcgctgtacgcgctccgtgtccatcccggcgccagcctactatgctcacctggtggccttccgggccaggtaccacctggtggataaagaacatgatagtgccgaaggaagccatacctccgggcagagcaatggacgcgaccatcaggccttggccaaggccgtgcaggtccaccaggacacgctgcgcaccatgtactttgcgtga
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]