LOCUS       NM_001183421            1635 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C
            dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol
            alpha-1,3-glucosyltransferase (ALG6), partial mRNA.
ACCESSION   NM_001183421
VERSION     NM_001183421.1
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 1635)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 1635)
  AUTHORS   Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W.,
            Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R.,
            Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G.,
            Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H.,
            Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome XV
  JOURNAL   Nature 387 (6632 SUPPL), 98-102 (1997)
   PUBMED   9169874
REFERENCE   3  (bases 1 to 1635)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (bases 1 to 1635)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1635)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 1635)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (bases 1 to 1635)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (bases 1 to 1635)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (27-MAY-2010) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   9  (bases 1 to 1635)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001147).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1635
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XV"
     gene            <1..>1635
                     /gene="ALG6"
                     /locus_tag="YOR002W"
                     /db_xref="GeneID:854163"
     CDS             1..1635
                     /gene="ALG6"
                     /locus_tag="YOR002W"
                     /EC_number="2.4.1.267"
                     /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
                     reticulum [PMID:26928762]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0005783
                     endoplasmic reticulum [PMID:8877369]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein
                     glycosylation [PMID:8877369]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006488
                     dolichol-linked oligosaccharide biosynthetic process
                     [PMID:10336995]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic
                     respiration [PMID:15794922]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0016758
                     hexosyltransferase activity [PMID:8877369]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0042281
                     dolichyl pyrophosphate Man9GlcNAc2
                     alpha-1,3-glucosyltransferase activity [PMID:10336995]"
                     /note="ER-luminal alpha 1,3 glucosyltransferase; involved
                     in transfer of oligosaccharides from dolichyl
                     pyrophosphate to asparagine residues of proteins during
                     N-linked protein glycosylation; C998T transition in human
                     ortholog ALG6 causes carbohydrate-deficient glycoprotein
                     syndrome type-Ic; wild-type human ortholog ALG6 can
                     partially complement yeast alg6 mutant"
                     /codon_start=1
                     /product="dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol
                     alpha-1,3-glucosyltransferase"
                     /protein_id="NP_014644.1"
                     /db_xref="GeneID:854163"
                     /db_xref="SGD:S000005528"
                     /translation="

MAIGKRLLVNKPAEESFYASPMYDFLYPFRPVGNQWLPEYIIFVCAVILRCTIGLGPYSGKGSPPLYGDFEAQRHWMEITQHLPLSKWYWYDLQYWGLDYPPLTAFHSYLLGLIGSFFNPSWFALEKSRGFESPDNGLKTYMRSTVIISDILFYFPAVIYFTKWLGRYRNQSPIGQSIAASAILFQPSLMLIDHGHFQYNSVMLGLTAYAINNLLDEYYAMAAVCFVLSICFKQMALYYAPIFFAYLLSRSLLFPKFNIARLTVIAFATLATFAIIFAPLYFLGGGLKNIHQCIHRIFPFARGIFEDKVANFWCVTNVFVKYKERFTIQQLQLYSLIATVIGFLPAMIMTLLHPKKHLLPYVLIACSMSFFLFSFQVHEKTILIPLLPITLLYSSTDWNVLSLVSWINNVALFTLWPLLKKDGLHLQYAVSFLLSNWLIGNFSFITPRFLPKSLTPGPSISSINSDYRRRSLLPYNVVWKSFIIGTYIAMGFYHFLDQFVAPPSKYPDLWVLLNCAVGFICFSIFWLWSYYKIFTSGSKSMKDL"

     misc_feature    190..1584
                     /gene="ALG6"
                     /locus_tag="YOR002W"
                     /note="ALG6, ALG8 glycosyltransferase family; Region:
                     Alg6_Alg8; pfam03155"
                     /db_xref="CDD:460831"
ORIGIN      

atggccattggcaaaaggttactggtgaacaaaccagcagaagaatcattttatgcttctccaatgtatgattttttgtatccgtttaggccagtggggaaccaatggctgccagaatatattatctttgtatgtgctgtaatactgaggtgcacaattggacttggtccatattctgggaaaggcagtccaccgctgtacggcgattttgaggctcagagacattggatggaaattacgcaacatttaccgctttctaagtggtactggtatgatttgcaatactggggattggactatccaccattaacagcatttcattcgtaccttctgggcctaattggatcttttttcaatccatcttggtttgcactagaaaagtcacgtggctttgaatcccccgataatggcctgaaaacatatatgcgttctactgtcatcattagcgacatattgttttactttcctgcagtaatatactttactaagtggcttggtagatatcgaaaccagtcgcccataggacaatctattgcggcatcagcgattttgttccaaccttcattaatgctcattgaccatgggcactttcaatataattcagtcatgcttggccttactgcttatgccataaataacttattagatgagtattatgctatggcggccgtttgttttgtcctatccatttgttttaaacaaatggcattgtattatgcaccgattttttttgcttatctattaagtcgatcattgctgttccccaaatttaacatagctagattgacggttattgcgtttgcaacactcgcaacttttgctataatatttgcgccattatatttcttgggaggaggattaaagaatattcaccaatgtattcacaggatattcccttttgccaggggcatcttcgaagacaaggttgctaacttctggtgcgttacgaacgtgtttgtaaaatacaaggaaagattcactatacaacaactccagctatattcattgattgccaccgtgattggtttcttaccagccatgataatgacattacttcatcccaaaaagcatcttctcccatacgtgttaatcgcatgttcgatgtccttttttctttttagctttcaagtacatgagaaaactatcctcatcccacttttgcctattacactactctactcctctactgattggaatgttctatctcttgtaagttggataaacaatgtggctttgtttacgctatggcctttgttgaaaaaggacggtcttcatttacagtatgccgtatctttcttactaagcaattggctgattggaaatttcagttttattacaccaaggttcttgccaaaatctttaactcctggcccttctatcagcagcatcaatagcgactatagaagaagaagcttactgccatataatgtggtttggaaaagttttatcataggaacgtatattgctatgggcttttatcatttcttagatcaatttgtagcacctccatcgaaatatccagacttgtgggtgttgttgaactgtgctgttgggttcatttgctttagcatattttggctatggtcttattacaagatattcacttccggtagcaaatccatgaaggacttgtag

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