LOCUS       NM_001182491            1542 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C Msc1p (MSC1), partial mRNA.
ACCESSION   NM_001182491
VERSION     NM_001182491.1
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T.,
            Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S.,
            Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M.,
            Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII
  JOURNAL   Nature 387 (6632 SUPPL), 90-93 (1997)
   PUBMED   9169872
REFERENCE   3  (bases 1 to 1542)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (bases 1 to 1542)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1542)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 1542)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (bases 1 to 1542)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001145).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XIII"
     gene            <1..>1542
                     /gene="MSC1"
                     /locus_tag="YML128C"
                     /db_xref="GeneID:854911"
     CDS             1..1542
                     /gene="MSC1"
                     /locus_tag="YML128C"
                     /experiment="EXISTENCE:direct assay:GO:0005635 nuclear
                     envelope [PMID:39021806]"
                     /experiment="EXISTENCE:direct assay:GO:0005739
                     mitochondrion
                     [PMID:16823961|PMID:24769239|PMID:14576278|PMID:11502169]"
                     /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
                     reticulum [PMID:14562095|PMID:26928762]"
                     /experiment="EXISTENCE:direct assay:GO:0005886 plasma
                     membrane [PMID:16622836]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0007131
                     reciprocal meiotic recombination [PMID:10511544]"
                     /experiment="EXISTENCE:mutant phenotype:GO:1990166 protein
                     localization to site of double-strand break
                     [PMID:39021806]"
                     /note="Nuclear envelope protein involved in DSB repair
                     during late mitosis; forms nuclear envelope patches
                     associated with Rad52p-containing DNA repair foci, and
                     accelerates homologous recombination downstream of DNA end
                     resection; mutant is defective in directing meiotic
                     recombination events to homologous chromatids; upregulated
                     after DNA damage in late mitosis; null mutant is
                     hypersensitive to DSBs; non-tagged protein is detected in
                     highly purified mitochondria and is phosphorylated"
                     /codon_start=1
                     /product="Msc1p"
                     /protein_id="NP_013578.1"
                     /db_xref="GeneID:854911"
                     /db_xref="SGD:S000004597"
                     /translation="

MKQFKLVNAVSASFVLIGLVLANSDSVFDKWTQEDLADYLRDNKKSLEKYATDSIEDLKTEASQVWDKHAQPKPWWQVWSSDSSSVSNSNPGWFGYTGSSDHPVSDWLFDTWSTDSLRNFLKKNGVDVDDAKASKDSLVKTAKENFNKISKSLKSSGYYPSSSYFDSWSTKDLQNWLNDNGIDYDKAVQSKDELVQKVKENIYRTSEKAEQQRLGLLESLDLAHQQILDTSGQIKDTVFDKWSSDQLTNWLESHKVNIDKNMAKKHDYLVRMAKENSANLKDDIYWYLDYMKRESSPFLTKTPEYVGSVWDSSKNFLTNLYSKFRGKTDNVINDTFLVGLDSWPKDKLKMFLDARGIKYSMLSTEHQLRELVKKSRNEKLKILPKDYQKYFDNSNWSLDDIKGWFADKKDDFQDSQTYSTIMQDFDKVSKNTNDAKDQIAKTWSNTFQSWSQEDLLQYLKSFGVPVKQTSTKDDLINLAKQNTQWLFGTVKEPAYKRYLHNVKNWSKSILGFN"

     misc_feature    325..435
                     /gene="MSC1"
                     /locus_tag="YML128C"
                     /note="Putative nuclear envelope organization protein;
                     Region: Ish1; pfam10281"
                     /db_xref="CDD:431195"
     misc_feature    493..603
                     /gene="MSC1"
                     /locus_tag="YML128C"
                     /note="Putative nuclear envelope organization protein;
                     Region: Ish1; pfam10281"
                     /db_xref="CDD:431195"
     misc_feature    715..828
                     /gene="MSC1"
                     /locus_tag="YML128C"
                     /note="Putative nuclear envelope organization protein;
                     Region: Ish1; pfam10281"
                     /db_xref="CDD:431195"
     misc_feature    1339..1446
                     /gene="MSC1"
                     /locus_tag="YML128C"
                     /note="Putative nuclear envelope organization protein;
                     Region: Ish1; pfam10281"
                     /db_xref="CDD:431195"
ORIGIN      

atgaagcaattcaagttggttaatgcggtttccgcatcatttgtgcttattggcttagtgttggccaattcagattcagtgttcgacaagtggacgcaggaagacctggccgattatttacgtgataataagaagagcttggaaaagtacgctacagactccattgaggacttgaaaacggaggcatcgcaggtatgggacaaacacgcgcagcccaaaccatggtggcaggtgtggtctagtgacagcagtagcgtgagcaacagtaaccccggatggtttggttatactggttcttcggatcacccagtttctgactggctctttgacacctggtccacagacagtctacgtaacttcttgaagaaaaacggcgtggatgttgacgacgctaaggcttccaaggactcgctggtgaagactgctaaggagaacttcaacaagatttccaaatctttgaagtcgtcgggatactatccttctagctcttactttgatagctggtcaaccaaagatttgcaaaactggttgaatgacaatggtatcgactacgacaaggcagttcaaagcaaggacgagctagttcagaaagtcaaggaaaacatctaccgaacttcagaaaaggcagaacagcagcgtctgggtttgctagaaagcttggatttggctcaccaacaaatattagacacatcgggacaaataaaagacactgtatttgacaagtggtctagtgatcagttaaccaattggttggagagccacaaggtcaatattgacaagaacatggccaagaaacacgactatttggttagaatggccaaagaaaattctgccaatttgaaagatgatatctactggtacctggactatatgaaaagagagtcttctccatttttgaccaagaccccagaatacgttggttccgtttgggactcttctaaaaatttcctcacaaatttgtactccaagttcagaggtaagactgacaatgtgatcaatgatacttttttggttggcctagactcttggccaaaggacaaattgaaaatgtttttagatgctcgtggtattaagtactcaatgctgtctactgaacatcaattgagagaattagtcaaaaaatccagaaacgaaaaactcaagatcctgccaaaagactaccaaaaatactttgacaacagtaactggtctttggatgacataaagggttggtttgctgacaaaaaggacgacttccaagattctcagacttactccacaattatgcaggattttgacaaggtttccaaaaacacaaatgatgctaaggaccaaatcgctaagacctggtcaaatacctttcagagctggtctcaagaagacctattgcagtacctaaaatcattcggtgttccggttaaacagacttctacgaaggacgacttaatcaacttggccaagcagaatacgcaatggttgttcggcactgttaaggagcctgcttacaagaggtacctacataacgttaaaaactggtcgaaaagcatattagggttcaactaa

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