LOCUS       NM_001181746            2865 bp    mRNA    linear   PLN 15-SEP-2023
DEFINITION  Saccharomyces cerevisiae S288C survivin (BIR1), partial mRNA.
ACCESSION   NM_001181746
VERSION     NM_001181746.3
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 2865)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 2865)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (bases 1 to 2865)
  AUTHORS   Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N.,
            Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H.,
            Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A.,
            Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P.,
            Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C.,
            Karpfinger-Hartl,L. et al.
  TITLE     Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
            X
  JOURNAL   EMBO J. 15 (9), 2031-2049 (1996)
   PUBMED   8641269
REFERENCE   4  (bases 1 to 2865)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-SEP-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 2865)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 2865)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (12-APR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (bases 1 to 2865)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001142).
            
            On Jul 30, 2012 this sequence version replaced NM_001181746.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..2865
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="X"
     gene            <1..>2865
                     /gene="BIR1"
                     /locus_tag="YJR089W"
                     /db_xref="GeneID:853551"
     CDS             1..2865
                     /gene="BIR1"
                     /locus_tag="YJR089W"
                     /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
                     [PMID:16608876]"
                     /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
                     [PMID:16608876]"
                     /experiment="EXISTENCE:direct assay:GO:0005739
                     mitochondrion [PMID:14576278|PMID:16823961]"
                     /experiment="EXISTENCE:direct assay:GO:0005819 spindle
                     [PMID:16381814]"
                     /experiment="EXISTENCE:direct assay:GO:0005874 microtubule
                     [PMID:22842922]"
                     /experiment="EXISTENCE:direct assay:GO:0032133 chromosome
                     passenger complex [PMID:19158380]"
                     /experiment="EXISTENCE:direct assay:GO:0051233 spindle
                     midzone [PMID:16381814]"
                     /experiment="EXISTENCE:genetic interaction:GO:0000776
                     kinetochore [PMID:10557299]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic
                     spindle elongation [PMID:16381814]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006915
                     apoptotic process [PMID:16608876]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0007059
                     chromosome segregation [PMID:10557299]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic
                     spindle assembly checkpoint signaling [PMID:22908045]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0031134 sister
                     chromatid biorientation [PMID:19528231]"
                     /note="Subunit of chromosomal passenger complex (CPC); CPC
                     is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates
                     chromosome segregation; required for chromosome
                     bi-orientation and for spindle assembly checkpoint
                     activation upon reduced sister kinetochore tension;
                     relative distribution to shortened microtubules increases
                     upon DNA replication stress; sumoylated in an
                     Mms21p-dependent manner; human survivin homolog"
                     /codon_start=1
                     /product="survivin"
                     /protein_id="NP_012622.3"
                     /db_xref="GeneID:853551"
                     /db_xref="SGD:S000003849"
                     /translation="

MDGQIDKMEKRYSMTKLENRLRTFQDGVALEKKKLKWSFKVIPYQAMAKLGFYFDPVIDPKTSKLKKDSVRCCYCHRQTYNVRDCRSKRKDVLETLSNIMRQHLTVTDNKQVCLLIYLRNKLLTDYSFHMGVSDWKNDKYFSNPDDENVINLRKFTFQDNWPHSGSQNEHPLGIEKMVNAGLMRYDSSIEGLGDPSMDKTLMNDTCYCIYCKQLLQGWSINDDPMSRHYKVSQNGNCYFFQTRNRFERIKNDNDSITKNCEVSPTLGENGKREVINTKTASQRQCPLFESPPSSTGPQLDDYNEKTDISVIQHNISVLDGAQGENVKRNSVEEKEQINMENGSTTLEEGNINRDVLADKKEVISTPTAKEIKRPNVQLTQSSSPIKKKRKFKRISPRKIFDEEDSEHSLNNNSANGDNKDKDLVIDFTSHIIKNRDVGRKNAILDDSTDEFSFSNQGHNTFDIPIPTSSHLLKGIDSDNDNVIREDDTGINTDTKGASSKHEKFSVNSEEDLNFSEVKLTGRDSSTNILIRTQIVDQNLGDIDRDKVPNGGSPEVPKTHELIRDNSEKREAQNGEFRHQKDSTVRQSPDILHSNKSGDNSSNITAIPKEEQRRGNSKTSSIPADIHPKPRKNLQEPRSLSISGKVVPTERKLDNINIDLNFSASDFSPSSQSEQSSKSSSVISTPVASPKINLTRSLHAVKELSGLKKETDDGKYFTNKQETIKILEDVSVKNETPNNEMLLFETGTPIASQENKSRKLFDEEFSGKELDIPIDSSTVEIKKVIKPEFEPVPSVARNLVSGTSSYPRNSRLEEQRKETSTSLADNSKKGSSFNEGNNEKEPNAAEWFKIDENRHLVKNYFHDLLKYINNNDATLANDKDGDLAFLIKQMPAEELDMTFNNWVNLKVQSIKREFIDDCDKKLDILRRDYYTATNFIETLEDDNQLIDIAKKMGIL"

     misc_feature    52..>228
                     /gene="BIR1"
                     /locus_tag="YJR089W"
                     /note="Baculoviral inhibition of apoptosis protein repeat
                     domain; Found in inhibitors of apoptosis proteins (IAPs)
                     and other proteins. In higher eukaryotes, BIR domains
                     inhibit apoptosis by acting as direct inhibitors of the
                     caspase family of protease enzymes; Region: BIR; cl00035"
                     /db_xref="CDD:444665"
     misc_feature    451..723
                     /gene="BIR1"
                     /locus_tag="YJR089W"
                     /note="Baculoviral inhibition of apoptosis protein repeat;
                     Region: BIR; smart00238"
                     /db_xref="CDD:197595"
     misc_feature    order(553..555,613..615,619..621,640..648,652..654,
                     664..666,679..681,691..696)
                     /gene="BIR1"
                     /locus_tag="YJR089W"
                     /note="peptide binding groove [active]"
                     /db_xref="CDD:237989"
     misc_feature    order(622..624,631..633,682..684,709..711)
                     /gene="BIR1"
                     /locus_tag="YJR089W"
                     /note="Zn2+ binding site [ion binding]; other site"
                     /db_xref="CDD:237989"
ORIGIN      

atggatggtcaaatagataaaatggagaagcgatatagcatgaccaaactggagaataggttaaggactttccaagatggtgttgcacttgaaaaaaaaaagttaaagtggagttttaaagttattccgtatcaggcaatggccaagcttggattttactttgatccagtgatcgatcctaagacatctaaactgaaaaaagactctgtaagatgttgctattgtcatcgtcaaacatacaatgtgagagactgcagatccaaaagaaaagatgttcttgagactctaagcaatataatgaggcaacatctgactgttactgataacaaacaagtttgcctccttatttacttgcgcaataagctattgacggactatagcttccatatgggggtttcggactggaaaaatgacaagtacttcagcaatccagatgatgaaaacgtgataaacctaagaaaatttacttttcaagataactggcctcacagtggttctcaaaatgaacatccgctgggtatagaaaagatggtgaatgcaggactcatgcgatacgactccagcatagaaggcttaggcgatccaagcatggataaaacacttatgaacgatacctgttattgtatttattgcaaacagttgttacaaggttggtcaataaatgacgatccgatgagccgacattataaggtttctcaaaatgggaactgttatttctttcagacacgtaatcgatttgagagaataaaaaatgacaatgacagtatcacgaaaaattgcgaagtctctccaactttaggcgaaaatgggaaaagagaagtgatcaacacgaaaaccgcttctcaaaggcagtgtcctttatttgagtcacctccatctagtactggtcctcaacttgacgattataatgagaagacagatatatctgttattcaacataatataagtgtgcttgatggagcacaaggcgaaaatgtaaaacgtaatagtgtggaagaaaaagaacaaatcaacatggaaaatggaagcactacattagaagagggcaatataaatcgtgatgttttagcagataagaaagaagttatttcgacaccaactgcaaaagaaatcaaacgtccaaatgtccagctaacccaatcatcgtcacctataaaaaagaaaagaaagtttaagagaatatcgcctagaaaaatctttgatgaggaagatagcgaacactcccttaataataattctgccaacggagacaacaaagataaggatttggttatagattttacaagccatatcataaaaaatagagatgtagggagaaagaatgctattttagatgacagcacagatgaattcagtttcagtaaccaaggacataacacatttgacatacctataccaacctcatcacatttgctcaaaggtatagattcagataatgacaatgttatacgagaagatgatactggcataaatacagacacaaaaggagcgtcttctaaacacgaaaaattttctgttaattctgaagaagatttaaatttcagtgaagtgaaactcacaggtagagacagtagtactaatattcttataagaacgcaaattgtagatcagaatttgggtgatatcgacagagataaggtccccaatggtggatccccagaagttccaaagacacatgagttaattagagataactctgaaaagagggaagcacaaaacggggaatttcgacatcaaaaagattcaactgtacggcaatctccagatatattacattctaataaaagtggtgataattccagtaatattaccgcaatacccaaagaggaacaaaggagaggcaatagcaaaacatccagcattcccgctgatattcatcctaaaccaaggaaaaacttgcaagaaccaagaagcctatcaataagtggaaaagttgttccaacagaaagaaaattagataacatcaatatagatctaaatttttcggcgtccgatttttcaccatcatcacaatctgagcaatcatcaaaaagctcaagcgttatttcaacgccggtagcgagccctaaaattaatctcacacgcagtttgcatgcagtcaaagagctttctggcctcaaaaaagaaactgacgatggtaagtattttactaataagcaggaaactataaaaatactggaagatgtgtctgtgaagaatgagaccccaaataatgaaatgttactttttgagactggaaccccgatcgcatctcaagaaaacaagtcaagaaaattatttgatgaagagttttctgggaaggaattggatatacctatagattcatcaactgtagaaataaaaaaggttattaaacccgaatttgagccagtcccatcagttgcaaggaatttggtgtctggaacctcttcatatccacggaattcacgtttagaagaacaaagaaaggaaacaagcacaagtttggctgataattctaagaaaggaagttcatttaatgagggcaacaacgaaaaagaaccgaatgcagcagaatggtttaaaattgatgaaaatagacaccttgtaaaaaattacttccatgatttgttaaaatatataaataataatgatgctacgctagctaatgacaaagacggtgatctggcttttttgattaagcaaatgcctgcagaagagttggacatgacattcaacaattgggtgaacctaaaagtgcaatctattaagcgcgaatttatagatgactgtgataagaaattggacatattgagaagggattactatactgccacaaattttattgaaactttggaagatgacaatcaattgatcgatattgctaagaaaatgggcattttatag

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