LOCUS       NM_001181068            2190 bp    mRNA    linear   PLN 15-SEP-2023
DEFINITION  Saccharomyces cerevisiae S288C serine-type carboxypeptidase (KEX1),
            partial mRNA.
ACCESSION   NM_001181068
VERSION     NM_001181068.1
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 2190)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 2190)
  AUTHORS   Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M.,
            Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J.,
            Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E.,
            Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E.,
            Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B.,
            Kleine,K. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome VII
  JOURNAL   Nature 387 (6632 SUPPL), 81-84 (1997)
   PUBMED   9169869
REFERENCE   3  (bases 1 to 2190)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (bases 1 to 2190)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-SEP-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 2190)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 2190)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (bases 1 to 2190)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (bases 1 to 2190)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001139).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..2190
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="VII"
     gene            <1..>2190
                     /gene="KEX1"
                     /locus_tag="YGL203C"
                     /db_xref="GeneID:852670"
     CDS             1..2190
                     /gene="KEX1"
                     /locus_tag="YGL203C"
                     /EC_number="3.4.16.6"
                     /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
                     vacuole [PMID:26928762]"
                     /experiment="EXISTENCE:direct assay:GO:0004185 serine-type
                     carboxypeptidase activity [PMID:2668738]"
                     /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi
                     network [PMID:8308064]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006915
                     apoptotic process [PMID:23656787]"
                     /note="Cell death protease essential for
                     hypochlorite-induced apoptosis; involved in the processing
                     of killer toxin and alpha factor precursor; cleaves Lys
                     and Arg residues from the C-terminus of peptides and
                     proteins"
                     /codon_start=1
                     /product="serine-type carboxypeptidase"
                     /protein_id="NP_011312.1"
                     /db_xref="GeneID:852670"
                     /db_xref="SGD:S000003171"
                     /translation="

MFYNRWLGTWLAMSALIRISVSLPSSEEYKVAYELLPGLSEVPDPSNIPQMHAGHIPLRSEDADEQDSSDLEYFFWKFTNNDSNGNVDRPLIIWLNGGPGCSSMDGALVESGPFRVNSDGKLYLNEGSWISKGDLLFIDQPTGTGFSVEQNKDEGKIDKNKFDEDLEDVTKHFMDFLENYFKIFPEDLTRKIILSGESYAGQYIPFFANAILNHNKFSKIDGDTYDLKALLIGNGWIDPNTQSLSYLPFAMEKKLIDESNPNFKHLTNAHENCQNLINSASTDEAAHFSYQECENILNLLLSYTRESSQKGTADCLNMYNFNLKDSYPSCGMNWPKDISFVSKFFSTPGVIDSLHLDSDKIDHWKECTNSVGTKLSNPISKPSIHLLPGLLESGIEIVLFNGDKDLICNNKGVLDTIDNLKWGGIKGFSDDAVSFDWIHKSKSTDDSEEFSGYVKYDRNLTFVSVYNASHMVPFDKSLVSRGIVDIYSNDVMIIDNNGKNVMITTDDDSDQDATTESGDKPKENLEEEEQEAQNEEGKEKEGNKDKDGDDDNDNDDDDEDDHNSEGDDDDDDDDDEDDNNEKQSNQGLEDSRHKSSEYEQEEEEVEEFAEEISMYKHKAVVVTIVTFLIVVLGVYAYDRRVRRKARHTILVDPNNRQHDSPNKTVSWADDLESGLGAEDDLEQDEQLEGGAPISSTSNKAGSKLKTKKKKKYTSLPNTEIDESFEMTDF"

     misc_feature    1..1494
                     /gene="KEX1"
                     /locus_tag="YGL203C"
                     /note="Carboxypeptidase C (cathepsin A) [Amino acid
                     transport and metabolism]; Region: Kex1; COG2939"
                     /db_xref="CDD:225490"
ORIGIN      

atgttttacaataggtggctcggaacgtggctagccatgtctgctttaataaggatctcagtatcccttccgtcatctgaggagtacaaagtggcatatgagctgttgccagggttatctgaagtgccagacccttcaaatattccacagatgcatgctggccatattcctttacgttccgaagatgcggatgaacaggatagctctgacttggagtactttttttggaagtttaccaataacgactctaatggcaatgtcgaccgtcccttaattatatggttaaatggtggacccggttgctcttccatggatggtgccttggtcgaatccggcccttttagggtgaattcagacggtaaactttatctaaatgaagggtcctggatatccaaaggcgatcttttatttatcgaccaacctactggtactgggttttctgtcgaacaaaataaagacgaaggtaaaatcgacaaaaacaaatttgacgaagacctagaagatgtgaccaagcattttatggattttctggagaactatttcaagatttttccagaagacctcactaggaaaatcatactatcgggtgaaagttacgctggccaatacataccattctttgccaatgcaattttgaaccataacaaattttcaaagatcgacggggatacatacgacttgaaggcgctattgattggtaacggttggattgaccccaatacacagtccctatcgtaccttccgtttgctatggagaagaaactgattgatgaaagcaaccccaatttcaaacacttaacgaacgcacacgagaattgccagaatctgataaactctgccagtacagatgaggcagcccatttttcgtatcaggaatgtgagaatattttaaaccttctattgtcttataccagggaatcttcgcaaaagggaacagcggattgcttgaacatgtataacttcaatttaaaagatagttatccatcttgtggtatgaattggccgaaagatatttcctttgtcagtaaattcttcagcacacctggtgttattgattcgttgcatcttgattctgataaaattgatcattggaaggaatgcactaatagcgttggaactaaattgtctaatcctatttcaaagccatctatccatttattacctggtctacttgaaagtggaatagagattgtcttgttcaatggtgacaaagacttgatttgtaataacaagggcgtattagatactatagacaatctaaaatggggtggaataaagggatttagcgacgatgctgtttcgttcgattggatccataaatcgaagagtacagacgacagcgaagaatttagcggatacgtgaagtatgatagaaatttgacgtttgttagcgtttataatgcttctcacatggtacccttcgataaaagtttagtgagtagaggcattgtcgatatttactcgaacgatgttatgatcattgacaacaatgggaaaaatgttatgattactactgacgacgatagtgatcaagatgctactactgaaagcggtgataagccaaaagaaaacctcgaagaggaagaacaggaagcgcagaatgaggaaggaaaggaaaaagaaggcaataaagataaagatggcgatgatgataacgacaatgatgacgacgatgaagacgatcacaactccgagggcgacgacgatgatgacgatgacgatgatgaagacgataataatgaaaaacaaagtaatcaaggcctcgaggatagtagacataaatcttcagaatatgaacaagaagaggaagaggtagaagaatttgcagaagagatttcaatgtataaacacaaagcggtagtagttaccatcgttacatttttgatagtggttttaggagtttatgcgtatgatagaagagtgaggagaaaagcgcgtcacacaattttagttgatccaaataatagacaacatgacagtcccaataagacagtttcatgggcagatgatctggaaagcggactcggggcagaagatgatttagaacaagatgagcagttagaaggcggagcacccataagtagcacttctaacaaagcaggatctaaattgaaaactaagaaaaagaagaagtatactagccttccgaacactgaaatcgatgaatcttttgagatgactgatttttaa

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