LOCUS       NM_001181025            1713 bp    mRNA    linear   PLN 15-SEP-2023
DEFINITION  Saccharomyces cerevisiae S288C putative metalloreductase (AIM14),
            partial mRNA.
ACCESSION   NM_001181025
VERSION     NM_001181025.1
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 1713)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 1713)
  AUTHORS   Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M.,
            Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J.,
            Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E.,
            Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E.,
            Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B.,
            Kleine,K. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome VII
  JOURNAL   Nature 387 (6632 SUPPL), 81-84 (1997)
   PUBMED   9169869
REFERENCE   3  (bases 1 to 1713)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (bases 1 to 1713)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (14-SEP-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1713)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 1713)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (bases 1 to 1713)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (bases 1 to 1713)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001139).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1713
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="VII"
     gene            <1..>1713
                     /gene="AIM14"
                     /locus_tag="YGL160W"
                     /gene_synonym="YNO1"
                     /db_xref="GeneID:852716"
     CDS             1..1713
                     /gene="AIM14"
                     /locus_tag="YGL160W"
                     /gene_synonym="YNO1"
                     /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
                     reticulum [PMID:26928762]"
                     /experiment="EXISTENCE:direct assay:GO:0097038 perinuclear
                     endoplasmic reticulum [PMID:22586098]"
                     /experiment="EXISTENCE:genetic interaction:GO:0006915
                     apoptotic process [PMID:22586098]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0016175
                     superoxide-generating NAD(P)H oxidase activity
                     [PMID:22586098]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0032956
                     regulation of actin cytoskeleton organization
                     [PMID:22586098]"
                     /note="NADPH oxidase localized to the perinuclear ER;
                     produces superoxide from NADPH; overexpression causes MCA1
                     dependent apoptosis; likely involved in
                     superoxide-mediated regulation of the actin cytoskeleton;
                     member of a conserved superfamily of NADPH oxidases (NOX
                     enzymes); has similarity to iron/copper reductases
                     (FRE1-8), particularly Fre8p"
                     /codon_start=1
                     /product="putative metalloreductase"
                     /protein_id="NP_011355.1"
                     /db_xref="GeneID:852716"
                     /db_xref="SGD:S000003128"
                     /translation="

MKESPLITLVKRHSETHFANIKYGYYVLIISLVYLIGLALLRAFGRRTPSRSSSAFKNKIIYRLYDIDPAIHLGILFFAVLIPFYYHYSLTTQSTVYLKRLGRLSYALIPLNLFLTLRPNWFLRKNCTYTDFIPFHKWFSRIITVIGLLHGIFFIIKWAIDDNVSLKQKLILKTFNFAGFIISILVLFLLICSIGPMRRYNYRLFYIVHNLVNVAFILLTPIHSRPGVKFPFLLLNCTLLFIHIINRIVFAKSLMILNKNANYSKTNLVHVRLPRAILPDYFEPGSHIRISPYRRINPLYWLLPSHPYTIASLAEDNSIDLIIKETSTAEPGSQIESLRSNPKSFHLDQEKTYTLINSYPPSVPEECYSQGTNIAIICGGSGISFALPLFRHFFNKENVKYLKMIWLIKDYSEYELVLDYLKTNGLTFEKKLSNNKRISVFISGEYTAETRLDEITTNIDDENSEYEMGSFNNEDEDLSISNFNSENADSNDNTPETSHSPTKENGSMIEVKSKHSFTLSNELKSFNNESAQVNQNETWLFSCGPPSLLQLSKKYCNDERINFVCETYGL"

     misc_feature    301..660
                     /gene="AIM14"
                     /locus_tag="YGL160W"
                     /gene_synonym="YNO1"
                     /note="Ferric reductase like transmembrane component;
                     Region: Ferric_reduct; pfam01794"
                     /db_xref="CDD:426438"
     misc_feature    757..1095
                     /gene="AIM14"
                     /locus_tag="YGL160W"
                     /gene_synonym="YNO1"
                     /note="FAD-binding domain; Region: FAD_binding_8;
                     pfam08022"
                     /db_xref="CDD:285293"
     misc_feature    order(859..861,916..927,964..972,982..987,1141..1143)
                     /gene="AIM14"
                     /locus_tag="YGL160W"
                     /gene_synonym="YNO1"
                     /note="FAD binding pocket [chemical binding]; other site"
                     /db_xref="CDD:99783"
     misc_feature    order(916..918,922..927)
                     /gene="AIM14"
                     /locus_tag="YGL160W"
                     /gene_synonym="YNO1"
                     /note="FAD binding motif [chemical binding]; other site"
                     /db_xref="CDD:99783"
     misc_feature    1114..1668
                     /gene="AIM14"
                     /locus_tag="YGL160W"
                     /gene_synonym="YNO1"
                     /note="Ferric reductase NAD binding domain; Region:
                     NAD_binding_6; pfam08030"
                     /db_xref="CDD:429792"
     misc_feature    1126..1158
                     /gene="AIM14"
                     /locus_tag="YGL160W"
                     /gene_synonym="YNO1"
                     /note="NAD pyrophosphate binding region [chemical
                     binding]; other site"
                     /db_xref="CDD:99783"
     misc_feature    order(1126..1128,1138..1149,1153..1155)
                     /gene="AIM14"
                     /locus_tag="YGL160W"
                     /gene_synonym="YNO1"
                     /note="beta-alpha-beta stucture motif; other site"
                     /db_xref="CDD:99783"
     misc_feature    order(1213..1218,1225..1227)
                     /gene="AIM14"
                     /locus_tag="YGL160W"
                     /gene_synonym="YNO1"
                     /note="NADP ribose binding motif [chemical binding]; other
                     site"
                     /db_xref="CDD:99783"
ORIGIN      

atgaaagaatcccctctcataacgttggttaaaagacattccgagacacattttgccaatatcaagtatgggtattatgtgttgataatatcattggtctatctcattggattggctcttttgagagctttcggaaggagaaccccatccagatcgtcgtcagctttcaaaaataagataatttatcggttgtatgatatagatcctgcaattcacttaggtatattgttttttgcagtcttgattccattttattaccattactctttgactacccaatctacggtctatctcaaaagattagggaggttgagttacgccttgatcccgctgaacctattcctcactttaaggcctaattggttccttaggaaaaattgcacctacactgattttataccgttccataaatggttttcacgtattatcaccgtgattggtttgcttcatgggattttcttcatcattaagtgggcgatagacgataatgtctctctaaagcaaaaattgattctgaaaactttcaattttgcgggattcataatatcaatattggtactttttttacttatttgctcgattgggccaatgagaagatacaactatcgtttgttttacatcgtacataacctggtgaacgtggccttcatcttactcaccccaatacactctaggccaggtgttaagttcccatttcttctactaaactgtaccctattattcattcatattatcaatagaatagtatttgcgaaatccttgatgattttgaataagaatgcgaattattcaaaaacaaatttagtccatgtaagattgcccagggctattcttccagattattttgaaccagggtcgcatattagaataagcccttacagaagaattaatcccctctattggttgctaccatcgcatccatacacaattgcgtctttggcagaagacaattcaattgatcttattataaaggaaacctctacagccgagccaggtagccagatagagtctcttcgtagtaatccaaaatcctttcatttagatcaagaaaaaacctatactttgattaatagttatcctccctctgtacccgaagaatgttattctcaaggcacgaatatagctattatatgtggtgggtctggtatatcttttgccctaccactatttaggcatttttttaacaaggagaatgtaaaatacttgaaaatgatctggctgataaaagattactctgaatatgaacttgttttggattatctcaagacaaatgggttgacttttgagaaaaaactctcgaataataagaggatttcagtatttattagtggagaatacacggcggaaacacggttagacgaaattacgaccaatatcgacgatgaaaactcagaatatgaaatgggatctttcaacaatgaagacgaagacctttcgatttctaatttcaattcagaaaatgcggacagcaatgacaatacgccagagacaagtcatagccccacaaaagagaatggaagcatgatcgaggtaaaatccaaacacagttttactctttccaacgaattgaagagcttcaacaatgaaagtgcacaagtgaaccaaaatgaaacatggttgttttcatgtggtcctccctcgttattacaattgtctaaaaaatattgtaacgatgaaaggatcaactttgtctgtgagacttacggattatga

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